Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

European Journal of Medicinal Chemistry

Volumn 46, Issue 3, 2011, Pages 927-933

  Praveen Kumar, S ^a   Gut, Jiri ^b   Guedes, Rita C ^a   Rosenthal, Philip J ^b   Santos, Maria M M ^a   Moreira, Rui ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiplasmodial activity; Falcipain inhibitor; Indolin 2 ones; Malaria

Indexed keywords

3 METHYLENE SUBSTITUTED INDOLINONE; ANTIMALARIAL AGENT; CHLOROQUINE; CYSTEINE PROTEINASE; FALCIPAIN 2; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PLASMODIUM FALCIPARUM;

ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; INDOLES; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM;

EID: 79951677625     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.008     Document Type: Article

References (23)

1. A. Martinelli, R. Moreira, and P.V.L. Cravo Mini Rev. Med. Chem. 8 2008 201 212
2. D.A. Fidock, R.T. Eastman, S.A. Ward, and S.R. Meshnick Trends Parasitol. 24 2008 537 544
3. M. Schlitzer Arch. Pharm. Chem. Life Sci. 341 2008 149 163
4. C. Valente, R.C. Guedes, R. Moreira, J. Iley, J. Gut, and P.J. Rosenthal Bioorg. Med. Chem. Lett. 16 2006 4115 4119
5. I.D. Kerr, J.H. Lee, K.C. Pandey, A. Harrison, M. Sajid, P.J. Rosenthal, and L.S. Brinen J. Med. Chem. 52 2009 852 857
6. R. Ettari, F. Bova, M. Zappal, S. Grasso, and N. Micale Med. Res. Rev. 30 2010 136 167
7. M.M.M. Santos, and R. Moreira Mini Rev. Med. Chem. 7 2007 1040 1050
8. R. Capela, R. Oliveira, L.M. Gonalves, A. Domingos, J. Gut, P.J. Rosenthal, F. Lopes, and R. Moreira Bioorg. Med. Chem. Lett. 19 2009 3229 3232
9. A.S. Newton, L.M. Gonalves, P.M.C. Glória, D.J.V.A. dos Santos, R. Moreira, R.C. Guedes, and M.M.M. Santos Eur. J. Med. Chem. 45 2010 3858 3863
10. A. Arora, and E.M. Scholar J. Pharmacol. Exp. Ther. 315 2005 971 979
11. E.R. Wood, L. Kuyper, K.G. Petrov, R.N. Hunter, P.A. Harris, and K. Lackey Bioorg. Med. Chem. Lett. 14 2004 953 957
12. H.N. Bramson, J. Corona, S.T. Davis, S.H. Dickerson, M. Edelstein, S.V. Frye, R.T. Gampe Jr., P.A. Harris, A. Hassell, W.D. Holmes, R.N. Hunter, K.E. Lackey, B. Lovejoy, M.J. Luzzio, V. Montana, W.J. Rocque, D. Rusnak, L. Shewchuk, J.M. Veal, D.H. Walker, and L.F. Kuyper J. Med. Chem. 44 2001 4339 4353
13. K.-C. Luk, M.E. Simcox, A. Schutt, K. Rowan, T. Thompson, Y. Chen, U. Kammlott, W. DePinto, P. Dunten, and A. Dermatakis Bioorg. Med. Chem. Lett. 14 2004 913 917
14. C.L. Woodard, Z. Li, A.K. Kathcart, J. Terrell, L. Gerena, M. Lopez-Sanchez, D.E. Kyle, A.K. Bhattacharjee, D.A. Nichols, W. Ellis, S.T. Prigge, J.A. Geyer, and N.C. Waters J. Med. Chem. 46 2003 3877 3882
15. M. Sassatelli, E. Debiton, B. Aboab, M. Prudhomme, and P. Moreau Eur. J. Med. Chem. 41 2006 709 716
16. F. Bouchikhi, E. Rossignol, M. Sancelme, B. Aboab, F. Anizon, D. Fabbro, M. Prudhomme, and P. Moreau Eur. J. Med. Chem. 43 2008 2316 2322
17. M. Abass, and B.B. Mostafa Bioorg. Med. Chem. 13 2005 6133 6144
18. C.C. Musonda, D. Taylor, J. Lehman, J. Gut, P.J. Rosenthal, and K. Chibale Bioorg. Med. Chem. Lett. 14 2004 3901 3905
19. I. Chiyanzu, E. Hansell, J. Gut, P.J. Rosenthal, J.H. McKerrow, and K. Chibale Bioorg. Med. Chem. Lett. 13 2003 3527 3530
20. G. Jones, P. Willett, and R.C. Glen J. Mol. Biol. 245 1995 43 53
21. G. Jones, P. Willett, R.C. Glen, A.R. Leach, and R. Taylor J. Mol. Biol. 267 1997 727 748
22. http://www.chemcomp.com/software-moe2009.htm.
23. http://www.ccdc.cam.ac.uk/support/documentation/gold/3-2/doc/ portable-html/gold-portable-3-077.html.