Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5329-5336

  Gangjee, Aleem ^a   Zeng, Yibin ^a,d   McGuire, John J ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPTERIN; CARBON; DEOXYCYTIDINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; FOLINATE CALCIUM; FOLYLPOLYGLUTAMATE SYNTHASE; FURO[2,3 D]PYRIMIDINE DERIVATIVE; GLUTAMIC ACID DERIVATIVE; HYPOXANTHINE; METHOTREXATE; N [4 [4 (2 AMINO 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDIN 6 YL)BUTYL]BENZOYL]GLUTAMIC ACID; N [4 [4 (2,4 DIAMINOFURO[2,3 D]PYRIMIDIN 5 YL)BUTYL]BENZOYL]GLUTAMIC ACID; PEMETREXED; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; THYMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME SUBSTRATE; FOLATE METABOLISM; HUMAN; HUMAN CELL; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID ANTAGONISTS; FURANS; GLUTAMIC ACID; HUMANS; PEPTIDE SYNTHASES; PYRIMIDINES; PYRIMIDINONES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 23444431982     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058213s     Document Type: Article

References (30)

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