Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 1, 2013, Pages 269-277

  Pretorius, Stefan I ^a   Breytenbach, Wilma J ^a   De Kock, Carmen ^b   Smith, Peter J ^b   N'Da, David D ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Chinese Hamster Ovarian (CHO); Chloroquine (CQ); Hybrid drugs; Malaria; Plasmodium falciparum (P. f.); Pyrimethamine (PM)

Indexed keywords

6 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTOXY]PYRIMIDINE 2,4 DIAMINE; 6 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHOXY]PYRIMIDINE 2,4 DIAMINE; 6 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPOXY]PYRIMIDINE 2,4 DIAMINE; 6 [2 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHOXY]ETHOXY]PYRIMIDINE 2,4 DIAMINE; 6 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPOXY]PYRIMIDINE 2,4 DIAMINE; 6 [4 (7 CHLOROQUINOLIN 4 YL)PIPERAZIN 1 YL]PYRIMIDINE 2,4 DIAMINE; CHLOROQUINE; N [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL]PYRIMIDINE 2,4,6 TRIAMINE; N [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL]PYRIMIDINE 2,4,6 TRIAMINE; N [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTYL]PYRIMIDINE 2,4,6 TRIAMINE; N [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]PHENYL]PYRIMIDINE 2,4,6 TRIAMINE; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION;

ANIMALS; ANTIMALARIALS; CELL SURVIVAL; CHO CELLS; CRICETINAE; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PYRIMIDINES; QUINOLINES;

CRICETULUS GRISEUS; MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 84870868769     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.019     Document Type: Article

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