Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 22, 2005, Pages 6226-6232

  Agarwal, Anu ^a   Srivastava, Kumkum ^a   Puri, S K ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimalarial; Dihydrofolate reductase; Pyrimidine

Indexed keywords

(3 IMIDAZOL 1 YLPROPYL)(4 PHENYL 6 PYRIDIN 4 YLPYRIMIDIN 2 YL)AMINE; (3 IMIDAZOL 1 YLPROPYL)[4 (4 METHOXYPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL]AMINE; (3 IMIDAZOL 1 YLPROPYL)[4 PYRIDIN 4 YL 6 (4 TOLYL)PYRIMIDIN 2 YL]AMINE; (3 IMIDAZOYL 1 YLPROPYL)[4 PYRIDIN 4 YL 6 (2,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL]AMINE; (3 IMIDAZOYL 1 YLPROPYL)[4 PYRIDIN 4 YL 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL]AMINE; (3 MORPHOLIN 4 YLPROPYL)(4 PHENYL 6 PYRIDIN 4 YLPYRIMIDIN 2 YL)AMINE; (3 MORPHOLIN 4 YLPROPYL)[4 PYRIDIN 4 YL 6 (2,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL]AMINE; (3 MORPHOLIN 4 YLPROPYL)[4 PYRIDIN 4 YL 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL]AMINE; (3 MORPHOLIN 4 YLPROPYL)[4 PYRIDIN 4 YL 6 (4 TOLYL)PYRIMIDIN 2 YL]AMINE; [4 (2,5 DIMETHOXYPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 IMIDAZOL 1 YLPROPYL)AMINE; [4 (2,5 METHOXYPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 MORPHOLIN 4 YLPROPYL)AMINE; [4 (3,4 DIMETHYLPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 IMIDAZOL 1 YLPROPYL)AMINE; [4 (3,4 DIMETHYLPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 MORPHOLIN 4 YLPROPYL)AMINE; [4 (4 CHLOROPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 IMIDAZOL 1 YLPROPYL)AMINE; [4 (4 CHLOROPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 MORPHOLIN 4 YLPROPYL)AMINE; [4 (4 METHOXYPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 MORPHOLIN 4 YLPROPYL)AMINE; [4 (4 METHYLSULFANYLPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 IMIDAZOL 1 YLPROPYL)AMINE; [4 (4 METHYLSULFANYLPHENYL) 6 PYRIDIN 4 YLPYRIMIDIN 2 YL](3 MORPHOLIN 4 YLPROPYL)AMINE; ANTIMALARIAL AGENT; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DIAMINES; MODELS, CHEMICAL; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PYRIDINES; PYRIMETHAMINE; PYRIMIDINES;

PLASMODIUM FALCIPARUM;

EID: 25844455259     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.06.052     Document Type: Article

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