Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 430-438

  Acharya, Badri Narayan ^a   Saraswat, Deepika ^a   Tiwari, Mugdha ^a   Shrivastava, Asish Kumar ^a   Ghorpade, Ramarao ^a   Bapna, Saroj ^b   Kaushik, Mahabir Parshad ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

^b Research and Testing   (India)

Author keywords

Antimalarial; Haem detoxification; Plasmodium falciparum; Pyrazoline

Indexed keywords

[3 (4 HYDROXYPHENYL) 5 (3 NITROPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [3 (4 HYDROXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [3 (4 HYDROXYPHENYL) 5 2 TOLYL 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [3 (4 HYDROXYPHENYL) 5 4 TOLYL 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [3 (4 HYDROXYPHENYL) 5 PHENYL 4,5 DIHYDROPYRAZOL 1 YL ]PYRIDIN 3 YL METHANONE; [5 (2 BROMOPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [5 (2,4 DICHLOROPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [5 (3 BROMOPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [5 (4 ETHOXY 3 METHOXYPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; [5 (5 BROMO 2 METHOXYPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDROPYRAZOL 1 YL]PYRIDIN 3 YL METHANONE; ANTIMALARIAL AGENT; CHLOROQUINE; HEMATIN; HEMOZOIN; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; HELA CELLS; HEMIN; HUMANS; HYDROPHOBICITY; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRAZOLES;

EID: 73549104790     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.023     Document Type: Article

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