Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease

Polyphenols in Human Health and Disease

Volumn 1, Issue , 2013, Pages 393-408

  Kim, Jiyoung ^a,b   Lee, Ki Won ^a   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Aging; Chronic diseases; Health; Inflammation; Polyphenol

Indexed keywords

EID: 84902571349     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-398456-2.00029-3     Document Type: Chapter

References (228)

1. Willcox D.C., Willcox B.J., Todoriki H., Suzuki M. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr 2009, 28(Suppl.):500S-516S.
2. Trichopoulou A., Critselis E. Mediterranean diet and longevity. Eur J Cancer Prev 2004, 13(5):453-456.
3. Jenny N.S. Inflammation in aging: cause, effect, or both?. Discov Med 2012, 13(73):451-460.
4. Hunter P. The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO Rep 2012, 13(11):968-970.
5. Dall'olio F., Vanhooren V., Chen C.C., Slagboom P.E., Wuhrer M., Franceschi C. N-glycomic biomarkers of biological aging and longevity: a link with inflammaging. Ageing Res Rev 2013, 12(2):685-698.
6. Galland L. Diet and inflammation. Nutr Clin Pract 2010, 25(6):634-640.
7. Rahman I., Biswas S.K., Kirkham P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006, 72(11):1439-1452.
8. Santangelo C., Vari R., Scazzocchio B., Di Benedetto R., Filesi C., Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita 2007, 43(4):394-405.
9. Yoon J.H., Baek S.J. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J 2005, 46(5):585-596.
10. Enomoto T., Nagasako-Akazome Y., Kanda T., Ikeda M., Dake Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: a randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol 2006, 16(5):283-289.
11. Singh A., Holvoet S., Mercenier A. Dietary polyphenols in the prevention and treatment of allergic diseases. Clini Exp Allergy 2011, 41(10):1346-1359.
12. Kishi K., Saito M., Saito T., Kumemura M., Okamatsu H., Okita M., et al. Clinical efficacy of apple polyphenol for treating cedar pollinosis. Biosci Biotechnol Biochem 2005, 69(4):829-832.
13. Yoshimura M., Enomoto T., Dake Y., Okuno Y., Ikeda H., Cheng L., et al. An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int 2007, 56(3):225-230.
14. Okoko B.J., Burney P.G., Newson R.B., Potts J.F., Shaheen S.O. Childhood asthma and fruit consumption. Eur Respir J 2007, 29(6):1161-1168.
15. Allan K., Devereux G. Diet and asthma: nutrition implications from prevention to treatment. J Am Diet Assoc 2011, 111(2):258-268.
16. Chatzi L., Torrent M., Romieu I., Garcia-Esteban R., Ferrer C., Vioque J., et al. Diet, wheeze, and atopy in school children in Menorca, Spain. Pediatr Allergy Immunol 2007, 18(6):480-485.
17. Chatzi L., Apostolaki G., Bibakis I., Skypala I., Bibaki-Liakou V., Tzanakis N., et al. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax 2007, 62(8):677-683.
18. Forastiere F., Pistelli R., Sestini P., Fortes C., Renzoni E., Rusconi F., et al. Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. SIDRIA Collaborative Group, Italy (Italian Studies on Respiratory Disorders in Children and the Environment). Thorax 2000, 55(4):283-288.
19. de Batlle J., Garcia-Aymerich J., Barraza-Villarreal A., Anto J.M., Romieu I. Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy 2008, 63(10):1310-1316.
20. Shaheen S.O., Sterne J.A., Thompson R.L., Songhurst C.E., Margetts B.M., Burney P.G. Dietary antioxidants and asthma in adults: population-based case-control study. Am J Respir Crit Care Med 2001, 164(10 Pt 1):1823-1828.
21. Knekt P., Kumpulainen J., Järvinen R., Rissanen H., Heliövaara M., Reunanen A., et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002, 76(3):560-568.
22. Watson R.R., Zibadi S., Rafatpanah H., Jabbari F., Ghasemi R., Ghafari J., et al. Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma. Nutr Res 2008, 28(3):166-171.
23. Woods R.K., Walters E.H., Raven J.M., Wolfe R., Ireland P.D., Thien F.C., et al. Food and nutrient intakes and asthma risk in young adults. Am J Clin Nutr 2003, 78(3):414-421.
24. Magrone T., Jirillo E. Influence of polyphenols on allergic immune reactions: mechanisms of action. Proc Nutr Soc 2012, 71(2):316-321.
25. Osiecki H. The role of chronic inflammation in cardiovascular disease and its regulation by nutrients. Altern Med Rev 2004, 9(1):32-53.
26. Habauzit V., Morand C. Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Ther Adv Chronic Dis 2012, 3(2):87-106.
27. Zern T.L., Fernandez M.L. Cardioprotective effects of dietary polyphenols. J Nutr 2005, 135(10):2291-2294.
28. Johnston C. Functional foods as modifiers of cardiovascular disease. Am J Lifestyle Med 2009, 3(1 Suppl.):39S-43S.
29. Curin Y., Andriantsitohaina R. Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 2005, 57(Suppl.):97-107.
30. Sears B., Ricordi C. Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome and diabetes. Eur Rev Med Pharmacol Sci 2012, 16(9):1137-1154.
31. Thomas T., Pfeiffer A.F. Foods for the prevention of diabetes: how do they work?. Diabetes Metab Res Rev 2012, 28(1):25-49.
32. Nagao T., Meguro S., Hase T., Otsuka K., Komikado M., Tokimitsu I., et al. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity (Silver Spring) 2009, 17(2):310-317.
33. Brown A.L., Lane J., Coverly J., Stocks J., Jackson S., Stephen A., et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr 2009, 101(6):886-894.
34. Grassi D., Lippi C., Necozione S., Desideri G., Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 2005, 81(3):611-614.
35. Grassi D., Desideri G., Necozione S., Lippi C., Casale R., Properzi G., et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr 2008, 138(9):1671-1676.
36. Kar P., Laight D., Rooprai H.K., Shaw K.M., Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med 2009, 26(5):526-531.
37. Nahas R., Moher M. Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam Physician 2009, 55(6):591-596.
38. Albini A., Tosetti F., Li V.W., Noonan D.M., Li W.W. Cancer prevention by targeting angiogenesis. Nat Rev Clin Oncol 2012, 9(9):498-509.
39. Timmers S., Konings E., Bilet L., Houtkooper R.H., van de Weijer T., Goossens G.H., et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011, 14(5):612-622.
40. de Visser K.E., Eichten A., Coussens L.M. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 2006, 6(1):24-37.
41. Harris R.E. Cyclooxygenase-2 (COX-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology 2009, 17(2):55-67.
42. Rothwell P.M., Fowkes F.G., Belch J.F., Ogawa H., Warlow C.P., Meade T.W. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011, 377(9759):31-41.
43. William W.N., Heymach J.V., Kim E.S., Lippman S.M. Molecular targets for cancer chemoprevention. Nat Rev Drug Discov 2009, 8(3):213-225.
44. Guo W., Kong E., Meydani M. Dietary polyphenols, inflammation, and cancer. Nutr Cancer 2009, 61(6):807-810.
45. Lee K.W., Bode A.M., Dong Z. Molecular targets of phytochemicals for cancer prevention. Nat Rev Cancer 2011, 11(3):211-218.
46. Knekt P., Järvinen R., Seppänen R., Hellövaara M., Teppo L., Pukkala E., et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997, 146(3):223-230.
47. Rossi M., Garavello W., Talamini R., La Vecchia C., Franceschi S., Lagiou P., et al. Flavonoids and risk of squamous cell esophageal cancer. Int J Cancer 2007, 120(7):1560-1564.
48. Bosetti C., Rossi M., McLaughlin J.K., Negri E., Talamini R., Lagiou P., et al. Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 2007, 16(1):98-101.
49. Rossi M., Negri E., Talamini R., Bosetti C., Parpinel M., Gnagnarella P., et al. Flavonoids and colorectal cancer in Italy. Cancer Epidemiol Biomarkers Prev 2006, 15(8):1555-1558.
50. Albini A., Sporn M.B. The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 2007, 7(2):139-147.
51. Bettuzzi S., Brausi M., Rizzi F., Castagnetti G., Peracchia G., Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006, 66(2):1234-1240.
52. Cao Y., Cao R., Brakenhielm E. Antiangiogenic mechanisms of diet-derived polyphenols. J Nutr Biochem 2002, 13(7):380-390.
53. Imai K., Suga K., Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 1997, 26(6):769-775.
54. Shimizu M., Fukutomi Y., Ninomiya M., Nagura K., Kato T., Araki H., et al. Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev 2008, 17(11):3020-3025.
55. Carroll R.E., Benya R.V., Turgeon D.K., Vareed S., Neuman M., Rodriguez L., et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila) 2011, 4(3):354-364.
56. Cruz-Correa M., Shoskes D.A., Sanchez P., Zhao R., Hylind L.M., Wexner S.D., et al. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2006, 4(8):1035-1038.
57. Agostinho P., Cunha R.A., Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des 2010, 16(25):2766-2778.
58. Hirsch E.C., Hunot S., Hartmann A. Neuroinflammatory processes in Parkinson's disease. Parkinsonism Relat Disord 2005, 11(Suppl. 1):S9-S15.
59. Pratico D., Trojanowski J.Q. Inflammatory hypotheses: novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets?. Neurobiol Aging 2000, 21(3):441-445. discussion 451-3.
60. Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev 2012 2012, 914273.
61. Ceulemans A.G., Zgavc T., Kooijman R., Hachimi-Idrissi S., Sarre S., Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J Neuroinflammation 2010, 7:74.
62. Szekely C.A., Thorne J.E., Zandi P.P., Ek M., Messias E., Breitner J.C., et al. Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 2004, 23(4):159-169.
63. Pandey K.B., Rizvi S.I. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009, 2(5):270-278.
64. Scarmeas N., Luchsinger J.A., Mayeux R., Stern Y. Mediterranean diet and Alzheimer disease mortality. Neurology 2007, 69(11):1084-1093.
65. Dai Q., Borenstein A.R., Wu Y., Jackson J.C., Larson E.B. Fruit and vegetable juices and Alzheimer's disease: the Kame project. Am J Med 2006, 119(9):751-759.
66. Commenges D., Scotet V., Renaud S., Jacqmin-Gadda H., Barberger-Gateau P., Dartigues J.F. Intake of flavonoids and risk of dementia. Eur J Epidemiol 2000, 16(4):357-363.
67. Scalbert A., Manach C., Morand C., Remesy C., Jimenez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005, 45(4):287-306.
68. Aquilano K., Baldelli S., Rotilio G., Ciriolo M.R. Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res 2008, 33(12):2416-2426.
69. Dias G.P., Cavegn N., Nix A., do Nascimento Bevilaqua M.C., Stangl D., Zainuddin M.S., et al. The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety. Oxid Med Cell Longev 2012; 2012, 541971.
70. Sathyapalan T., Beckett S., Rigby A.S., Mellor D.D., Atkin S.L. High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome. Nutr J 2010, 9:55.
71. Xu Y., Wang Z., You W., Zhang X., Li S., Barish P.A., et al. Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol 2010, 20(6):405-413.
72. Marzocchella L., Fantini M., Benvenuto M., Masuelli L., Tresoldi I., Modesti A., et al. Dietary flavonoids: molecular mechanisms of action as anti-inflammatory agents. Recent Pat Inflamm Allergy Drug Discov 2011, 5(3):200-220.
73. Chun O.K., Chung S.J., Claycombe K.J., Song W.O. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr 2008, 138(4):753-760.
74. Karlsen A., Retterstøl L., Laake P., Paur I., Bøhn S.K., Sandvik L., et al. Anthocyanins inhibit nuclear factor-κB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr 2007, 137(8):1951-1954.
75. Nanri A., Yoshida D., Yamaji T., Mizoue T., Takayanagi R., Kono S. Dietary patterns and C-reactive protein in Japanese men and women. Am J Clin Nutr 2008, 87(5):1488-1496.
76. Salas-Salvadó J., Garcia-Arellano A., Estruch R., Marquez-Sandoval F., Corella D., Fiol M., et al. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 2008, 62(5):651-659.
77. Schoen C., Schulz A., Schweikart J., Schutt S., von Baehr V. Regulatory effects of a fermented food concentrate on immune function parameters in healthy volunteers. Nutrition 2009, 25(5):499-505.
78. Estruch R., Sacanella E., Badia E., Antúnez E., Nicolás J.M., Fernández-Solá J., et al. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004, 175(1):117-123.
79. Zern T.L., Wood R.J., Greene C., West K.L., Liu Y., Aggarwal D., et al. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005, 135(8):1911-1917.
80. Gonzalez-Gallego J., Garcia-Mediavilla M.V., Sanchez-Campos S., Tunon M.J. Fruit polyphenols, immunity and inflammation. Br J Nutr 2010, 104(Suppl. 3):S15-27.
81. Kelley D.S., Rasooly R., Jacob R.A., Kader A.A., Mackey B.E. Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr 2006, 136(4):981-986.
82. De Bacquer D., Clays E., Delanghe J., De Backer G. Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation. Atherosclerosis 2006, 189(2):428-435.
83. Steptoe A., Gibson E.L., Vuononvirta R., Hamer M., Wardle J., Rycroft J.A., et al. The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial. Atherosclerosis 2007, 193(2):277-282.
84. Ziyan L., Yongmei Z., Nan Z., Ning T., Baolin L. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med 2007, 73(3):221-226.
85. Kao E.S., Hsu J.D., Wang C.J., Yang S.H., Cheng S.Y., Lee H.J. Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating cyclooxygenase-2 expression. Biosci Biotechnol Biochem 2009, 73(2):385-390.
86. Kostyuk V.A., Potapovich A.I., Suhan T.O., de Luca C., Korkina L.G. Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation. Eur J Pharmacol 2011, 658(2-3):248-256.
87. Kim D.O., Lee K.W., Lee H.J., Lee C.Y. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem 2002, 50(13):3713-3717.
88. Heijnen C.G., Haenen G.R., van Acker F.A., van der Vijgh W.J., Bast A. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol In vitro 2001, 15(1):3-6.
89. Perron N.R., Brumaghim J.L. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys 2009, 53(2):75-100.
90. Girard P., Sercombe R., Sercombe C., Le Lem G., Seylaz J., Potier P. A new synthetic flavonoid protects endothelium-derived relaxing factor-induced relaxation in rabbit arteries in vitro: evidence for superoxide scavenging. Biochem Pharmacol 1995, 49(10):1533-1539.
91. Moridani M.Y., Pourahmad J., Bui H., Siraki A., O'Brien P.J. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic Biol Med 2003, 34(2):243-253.
92. Lin J.K., Chen P.C., Ho C.T., Lin-Shiau S.Y. Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate. J Agric Food Chem 2000, 48(7):2736-2743.
93. Chow S.E., Hshu Y.C., Wang J.S., Chen J.K. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol 2007, 102(4):1520-1527.
94. Fang J., Lu J., Holmgren A. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem 2005, 280(26):25284-25290.
95. Alvarez-Suarez J.M., Dekanski D., Ristić S., Radonjić N.V., Petronijević N.D., Giampieri F., et al. Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PloS One 2011, 6(10):e25878.
96. Calabrese V., Cornelius C., Dinkova-Kostova A.T., Iavicoli I., Di Paola R., Koverech A., et al. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta 2012, 1822(5):753-783.
97. Du Y., Guo H., Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J Agric Food Chem 2007, 55(5):1695-1701.
98. Giovannini C., Filesi C., D'Archivio M., Scazzocchio B., Santangelo C., Masella R. Polyphenols and endogenous antioxidant defences: effects on glutathione and glutathione related enzymes. Ann Ist Super Sanita 2006, 42(3):336-347.
99. Khan S.G., Katiyar S.K., Agarwal R., Mukhtar H. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res 1992, 52(14):4050-4052.
100. Vayalil P.K., Elmets C.A., Katiyar S.K. Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin. Carcinogenesis 2003, 24(5):927-936.
101. Dinkova-Kostova A.T., Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 2008, 52(Suppl. 1):S128-138.
102. Satoh T., Lipton S.A. Redox regulation of neuronal survival mediated by electrophilic compounds. Trends Neurosci 2007, 30(1):37-45.
103. Kim J., Cha Y.N., Surh Y.J. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 2010, 690(1-2):12-23.
104. Koh K., Cha Y., Kim S., Kim J. tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation. Biochem Biophys Res Commun 2009, 380(3):449-453.
105. Koh K., Kim J., Jang Y.J., Yoon K., Cha Y., Lee H.J., et al. Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells. J Neuroimmunol 2011, 233(1-2):160-167.
106. Tunon M.J., Garcia-Mediavilla M.V., Sanchez-Campos S., Gonzalez-Gallego J. Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways. Curr Drug Metab 2009, 10(3):256-271.
107. Rathee P., Chaudhary H., Rathee S., Rathee D., Kumar V., Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflamm Allergy Drug Targets 2009, 8(3):229-235.
108. Lee T.P., Matteliano M.L., Middleton E. Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism. Life Sci 1982, 31(24):2765-2774.
109. Baek S.H., Yun S.S., Kwon T.K., Kim J.R., Chang H.W., Kwak J.Y., et al. The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages. Shock 1999, 12(6):473-478.
110. 2, cyclooxygenases and 5-lipoxygenase. Carcinogenesis 2004, 25(9):1671-1679.
111. Narumiya S. Prostanoids and inflammation: a new concept arising from receptor knockout mice. J Mol Med (Berl) 2009, 87(10):1015-1022.
112. Mutoh M., Takahashi M., Fukuda K., Matsushima-Hibiya Y., Mutoh H., Sugimura T., et al. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis 2000, 21(5):959-963.
113. Lin N., Sato T., Takayama Y., Mimaki Y., Sashida Y., Yano M., et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 2003, 65(12):2065-2071.
114. Raso G.M., Meli R., Di Carlo G., Pacilio M., Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 2001, 68(8):921-931.
115. Chu S.J., Tang L.O., Watney E., Chi E.Y., Henderson W.R. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. J Immunol 2000, 165(8):4640-4648.
116. Ikai K. Psoriasis and the arachidonic acid cascade. J Dermatol Sci 1999, 21(3):135-146.
117. Chi Y.S., Jong H.G., Son K.H., Chang H.W., Kang S.S., Kim H.P. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem Pharmacol 2001, 62(9):1185-1191.
118. Ferrandiz M.L., Alcaraz M.J. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions 1991, 32(3-4):283-288.
119. Kim H.P., Son K.H., Chang H.W., Kang S.S. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 2004, 96(3):229-245.
120. Kalhan R., Smith L.J., Nlend M.C., Nair A., Hixon J.L., Sporn P.H. A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis. Clini Exp Allergy 2008, 38(1):103-112.
121. Serafini M., Peluso I., Raguzzini A. Flavonoids as anti-inflammatory agents. Proc Nutr Soc 2010, 69(3):273-278.
122. Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001, 2(10):907-916.
123. Liang Y.C., Huang Y.T., Tsai S.H., Lin-Shiau S.Y., Chen C.F., Lin J.K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 1999, 20(10):1945-1952.
124. Hou D.X., Luo D., Tanigawa S., Hashimoto F., Uto T., Masuzaki S., et al. Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-κB pathway. Biochem Pharmacol 2007, 74(5):742-751.
125. Ciz M., Pavelkova M., Gallova L., Kralova J., Kubala L., Lojek A. The influence of wine polyphenols on reactive oxygen and nitrogen species production by murine macrophages RAW 264.7. Physiol Res 2008, 57(3):393-402.
126. Chen Y., Yang L., Lee T.J. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation. Biochem Pharmacol 2000, 59(11):1445-1457.
127. 2 production. Eur J Pharmacol 2002, 446(1-3):187-194.
128. Punathil T., Tollefsbol T.O., Katiyar S.K. EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase. Biochem Biophys Res Commun 2008, 375(1):162-167.
129. Krakauer T., Li B.Q., Young H.A. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Lett 2001, 500(1-2):52-55.
130. Park H.H., Lee S., Son H.Y., Park S.B., Kim M.S., Choi E.J., et al. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res 2008, 31(10):1303-1311.
131. Hirano T., Higa S., Arimitsu J., Naka T., Shima Y., Ohshima S., et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 2004, 134(2):135-140.
132. Kowalski J., Samojedny A., Paul M., Pietsz G. Apigenin inhibits release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774.2 macrophages. Wiad Lek 2006, 59(9-10):634-638.
133. Ahn H.Y., Xu Y., Davidge S.T. Epigallocatechin-3-O-gallate inhibits TNFα-induced monocyte chemotactic protein-1 production from vascular endothelial cells. Life Sci 2008, 82(17-18):964-968.
134. Chen P.C., Wheeler D.S., Malhotra V., Odoms K., Denenberg A.G., Wong H.R. A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IκB kinase activation and IL-8 gene expression in respiratory epithelium. Inflammation 2002, 26(5):233-241.
135. Lee S.H., Seo G.S., Jin X.Y., Ko G., Sohn D.H. Butein blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. Life Sci 2007, 81(21-22):1535-1543.
136. Schober A. Chemokines in vascular dysfunction and remodeling. Arterioscler Thromb Vasc Biol 2008, 28(11):1950-1959.
137. Castilla P., Echarri R., Dávalos A., Cerrato F., Ortega H., Teruel J.L., et al. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr 2006, 84(1):252-262.
138. Gerritsen M.E., Carley W.W., Ranges G.E., Shen C.P., Phan S.A., Ligon G.F., et al. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 1995, 147(2):278-292.
139. Lotito S.B., Frei B. Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. J Biol Chem 2006, 281(48):37102-37110.
140. Kang J.S., Yoon Y.D., Han M.H., Han S.B., Lee K., Lee K.H., et al. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-κB/Rel signaling pathways. Mol Pharmacol 2006, 69(3):941-949.
141. Nowakowska Z. A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem 2007, 42(2):125-137.
142. Nasca M.M., Zhou J.R., Welty F.K. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol 2008, 102(1):84-86.
143. Mortensen R.F. C-reactive protein, inflammation, and innate immunity. Immunol Res 2001, 24(2):163-176.
144. Liang Y.J., Shyu K.G., Wang B.W., Lai L.P. C-reactive protein activates the nuclear factor-κB pathway and induces vascular cell adhesion molecule-1 expression through CD32 in human umbilical vein endothelial cells and aortic endothelial cells. J Mol Cell Cardiol 2006, 40(3):412-420.
145. Holt E.M., Steffen L.M., Moran A., Basu S., Steinberger J., Ross J.A., et al. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diet Assoc 2009, 109(3):414-421.
146. Gomes A., Fernandes E., Lima J.L., Mira L., Corvo M.L. Molecular mechanisms of anti-inflammatory activity mediated by flavonoids. Curr Med Chem 2008, 15(16):1586-1605.
147. Mackenzie G.G., Carrasquedo F., Delfino J.M., Keen C.L., Fraga C.G., Oteiza P.I. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-κB activation at multiple steps in Jurkat T cells. FASEB J 2004, 18(1):167-169.
148. Shaulian E., Karin M. AP-1 in cell proliferation and survival. Oncogene 2001, 20(19):2390-2400.
149. Daikonya A., Katsuki S., Kitanaka S. Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae). Chem Pharm Bull (Tokyo) 2004, 52(11):1326-1329.
150. Chen C.C., Tsai P.C., Wei B.L., Chiou W.F. 8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages. Eur J Pharmacol 2008, 590(1-3):430-436.
151. Jang S., Kelley K.W., Johnson R.W. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci USA 2008, 105(21):7534-7539.
152. Sikorski K., Czerwoniec A., Bujnicki J.M., Wesoly J., Bluyssen H.A. STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease. Cytokine Growth Factor Rev 2011, 22(4):211-219.
153. Hamalainen M., Nieminen R., Vuorela P., Heinonen M., Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007, 2007:45673.
154. Cai F., Li C.R., Wu J.L., Chen J.G., Liu C., Min Q., et al. Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm 2006, 2006(5):30490.
155. Rezai-Zadeh K., Ehrhart J., Bai Y., Sanberg P.R., Bickford P., Tan J., et al. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation 2008, 5:41.
156. Kim B.H., Cho S.M., Reddy A.M., Kim Y.S., Min K.R., Kim Y. Down-regulatory effect of quercitrin gallate on nuclear factor-κ B-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7. Biochem Pharmacol 2005, 69(11):1577-1583.
157. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 1998, 273(45):29279-29282.
158. Huber R., Pietsch D., Panterodt T., Brand K. Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage. Cell Signal 2012, 24(6):1287-1296.
159. Roos A.B., Nord M. The emerging role of C/EBPs in glucocorticoid signaling: lessons from the lung. J Endocrinol 2012, 212(3):291-305.
160. Kim A.R., Cho J.Y., Zou Y., Choi J.S., Chung H.Y. Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells. Arch Pharm Res 2005, 28(3):297-304.
161. Woo K.J., Lim J.H., Suh S.I., Kwon Y.K., Shin S.W., Kim S.C., et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPβ DNA-binding activity. Immunobiology 2006, 211(5):359-368.
162. Jiang C., Ting A.T., Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998, 391(6662):82-86.
163. Ricote M., Li A.C., Willson T.M., Kelly C.J., Glass C.K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998, 391(6662):79-82.
164. Banerjee T., Valacchi G., Ziboh V.A., van der Vliet A. Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol Cell Biochem 2002, 238(1-2):105-110.
165. Ma L., Gao H.Q., Li B.Y., Ma Y.B., You B.A., Zhang F.L. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J Cardiovasc Pharmacol 2007, 49(5):293-298.
166. Chiarugi A., Moskowitz M.A. Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation: implication for neurodegenerative disorders. J Neurochem 2003, 85(2):306-317.
167. Geraets L., Moonen H.J., Brauers K., Wouters E.F., Bast A., Hageman G.J. Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. J Nutr 2007, 137(10):2190-2195.
168. Weseler A.R., Geraets L., Moonen H.J., Manders R.J., van Loon L.J., Pennings H.J., et al. Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J Nutr 2009, 139(5):952-957.
169. Rahman I., Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. J Nutrigenet Nutrigenomics 2010, 3(4-6):220-230.
170. Murakami A., Shigemori T., Ohigashi H. Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. J Nutr 2005, 135(12 Suppl.):2987S-2992S.
171. Ruiz P.A., Braune A., Holzlwimmer G., Quintanilla-Fend L., Haller D. Quercetin inhibits TNF-induced NF-κB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr 2007, 137(5):1208-1215.
172. Choi K.C., Jung M.G., Lee Y.H., Yoon J.C., Kwon S.H., Kang H.B., et al. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res 2009, 69(2):583-592.
173. Don M.J., Liao J.F., Lin L.Y., Chiou W.F. Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 2007, 151(5):638-646.
174. Pan M.H., Lai C.S., Wang Y.J., Ho C.T. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol 2006, 72(10):1293-1303.
175. Wadsworth T.L., Koop D.R. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Interact 2001, 137(1):43-58.
176. Wadsworth T.L., McDonald T.L., Koop D.R. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α. Biochem Pharmacol 2001, 62(7):963-974.
177. Cho S.Y., Park S.J., Kwon M.J., Jeong T.S., Bok S.H., Choi W.Y., et al. Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem 2003, 243(1-2):153-160.
178. Xagorari A., Roussos C., Papapetropoulos A. Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br J Pharmacol 2002, 136(7):1058-1064.
179. Ferriola P.C., Cody V., Middleton E. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol 1989, 38(10):1617-1624.
180. Nishioka H., Imoto M., Sawa T., Hamada M., Naganawa H., Takeuchi T., et al. Screening of phosphatidylinositol kinase inhibitors from Streptomyces. J Antibiot (Tokyo) 1989, 42(5):823-825.
181. Huang Y.T., Kuo M.L., Liu J.Y., Huang S.Y., Lin J.K. Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin. Eur J Cancer 1996, 32A(1):146-151.
182. Lin J.K., Chen Y.C., Huang Y.T., Lin-Shiau S.Y. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J Cell Biochem Suppl 1997, 28-29:39-48.
183. 2 by naturally occurring biflavonoid, ochnaflavone. Biochem Biophys Res Commun 1994, 205(1):843-849.
184. de Pascual-Teresa S., Johnston K.L., DuPont M.S., O'Leary K.A., Needs P.W., Morgan L.M., et al. Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo. J Nutr 2004, 134(3):552-557.
185. Xu L., Zhang L., Bertucci A.M., Pope R.M., Datta S.K. Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-κB activation pathway. Immunol Lett 2008, 121(1):74-83.
186. Kim I.B., Kim D.Y., Lee S.J., Sun M.J., Lee M.S., Li H., et al. Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and A549 epithelial cells. Biol Pharm Bull 2006, 29(6):1120-1125.
187. Kim J.S., Kim J.C., Shim S.H., Lee E.J., Jin W., Bae K., et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res 2006, 29(8):617-623.
188. Kang H.K., Ecklund D., Liu M., Datta S.K. Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res Ther 2009, 11(2):R59.
189. Rao C.V. Regulation of COX and LOX by curcumin. Adv Exp Med Biol 2007, 595:213-226.
190. 2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci 2004, 95(5):448-453.
191. Kim J.Y., Park S.J., Yun K.J., Cho Y.W., Park H.J., Lee K.T. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7 macrophages. Eur J Pharmacol 2008, 584(1):175-184.
192. García-Mediavilla V., Crespo I., Collado P.S., Esteller A., Sánchez-Campos S., Tuñón M.J., et al. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor κB pathway in Chang liver cells. Eur J Pharmacol 2007, 557(2-3):221-229.
193. Chen C.Y., Peng W.H., Tsai K.D., Hsu S.L. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci 2007, 81(23-24):1602-1614.
194. Kim D.W., Chi Y.S., Son K.H., Chang H.W., Kim J.S., Kang S.S., et al. Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch Pharm Res 2002, 25(3):329-335.
195. Sivaramakrishnan V., Niranjali Devaraj S. Morin regulates the expression of NF-κB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem-Biol Interact 2009, 180(3):353-359.
196. Chi Y.S., Kim H.P. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostaglandins Leukot Essent Fatty Acids 2005, 72(1):59-66.
197. Bednar W., Holzmann K., Marian B. Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme. Food Chem Toxicol 2007, 45(3):508-514.
198. Kim J.M., Lee E.K., Park G., Kim M.K., Yokozawa T., Yu B.P., et al. Morin modulates the oxidative stress-induced NF-κB pathway through its anti-oxidant activity. Free Radic Res 2010, 44(4):454-461.
199. Thuillier P., Brash A.R., Kehrer J.P., Stimmel J.B., Leesnitzer L.M., Yang P., et al. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. Biochem J 2002, 366(Pt 3):901-910.
200. Chan M.M., Fong D., Ho C.T., Huang H.I. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochem Pharmacol 1997, 54(12):1281-1286.
201. Kim J.S., Kim J.M., O J.J., Jeon B.S. Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Clin Neurosci 2010, 17(9):1165-1168.
202. Song X.Z., Bi Z.G., Xu A.E. Green tea polyphenol epigallocatechin-3-gallate inhibits the expression of nitric oxide synthase and generation of nitric oxide induced by ultraviolet B in HaCaT cells. Chin Med J (Engl) 2006, 119(4):282-287.
203. Erlejman A.G., Jaggers G., Fraga C.G., Oteiza P.I. TNFα-induced NF-κB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells. Arch Biochem Biophys 2008, 476(2):186-195.
204. Martinez-Florez S., Gutierrez-Fernandez B., Sanchez-Campos S., Gonzalez-Gallego J., Tunon M.J. Quercetin attenuates nuclear factor-κB activation and nitric oxide production in interleukin-1β-activated rat hepatocytes. J Nutr 2005, 135(6):1359-1365.
205. Nicholas C., Batra S., Vargo M.A., Voss O.H., Gavrilin M.A., Wewers M.D., et al. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. J Immunol 2007, 179(10):7121-7127.
206. Park H.J., Lee C.M., Jung I.D., Lee J.S., Jeong Y.I., Chang J.H., et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol 2009, 9(3):261-267.
207. Sternberg Z., Chadha K., Lieberman A., Hojnacki D., Drake A., Zamboni P., et al. Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients. J Neuroimmunol 2008, 205(1-2):142-147.
208. Wang J., Zhang Q., Jin S., He D., Zhao S., Liu S. Genistein modulate immune responses in collagen-induced rheumatoid arthritis model. Maturitas 2008, 59(4):405-412.
209. Lee J.S., Kim S.G., Kim H.K., Lee T.H., Jeong Y.I., Lee C.M., et al. Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J Cell Physiol 2007, 210(2):385-397.
210. Chen C.C., Chow M.P., Huang W.C., Lin Y.C., Chang Y.J. Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships. Mol Pharmacol 2004, 66(3):683-693.
211. Nizamutdinova I.T., Jeong J.J., Xu G.H., Lee S.H., Kang S.S., Kim Y.S., et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells. Int Immunopharmacol 2008, 8(5):670-678.
212. Crespo I., Garcia-Mediavilla M.V., Gutierrez B., Sanchez-Campos S., Tunon M.J., Gonzalez-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr 2008, 100(5):968-976.
213. Ying B., Yang T., Song X., Hu X., Fan H., Lu X., et al. Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Mol Biol Rep 2009, 36(7):1825-1832.
214. Suzuki J., Isobe M., Morishita R., Nagai R. Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases. Mediators Inflamm 2009 2009, 494928.
215. Aneja R., Hake P.W., Burroughs T.J., Denenberg A.G., Wong H.R., Zingarelli B. Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med 2004, 10(1-6):55-62.
216. Giakoustidis D.E., Giakoustidis A.E., Iliadis S., Koliakou K., Antoniadis N., Kontos N., et al. Attenuation of liver ischemia/reperfusion induced apoptosis by epigallocatechin-3-gallate via down-regulation of NF-κB and c-Jun expression. J Surg Res 2010, 159(2):720-728.
217. Kim Y.W., Zhao R.J., Park S.J., Lee J.R., Cho I.J., Yang C.H., et al. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production. Br J Pharmacol 2008, 154(1):165-173.
218. Kim J.B., Han A.R., Park E.Y., Kim J.Y., Cho W., Lee J., et al. Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW264.7 macrophage cells. Biol Pharm Bull 2007, 30(12):2345-2351.
219. Muraoka K., Shimizu K., Sun X., Tani T., Izumi R., Miwa K., et al. Flavonoids exert diverse inhibitory effects on the activation of NF-κB. Transplant Proc 2002, 34(4):1335-1340.
220. 2)-induced NF-κB DNA binding activity and DNA damage in HepG2 cells. Carcinogenesis 1998, 19(9):1583-1589.
221. Nair M.P., Mahajan S., Reynolds J.L., Aalinkeel R., Nair H., Schwartz S.A., et al. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system. Clin Vaccine Immunol 2006, 13(3):319-328.
222. Comalada M., Camuesco D., Sierra S., Ballester I., Xaus J., Gálvez J., et al. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-κB pathway. Eur J Immunol 2005, 35(2):584-592.
223. Rangan G.K., Wang Y., Harris D.C. Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-κB in the renal cortex of rats with established chronic glomerular disease. Nephron 2002, 90(3):313-319.
224. Kaul D., Sikand K., Shukla A.R. Effect of green tea polyphenols on the genes with atherosclerotic potential. Phytother Res 2004, 18(2):177-179.
225. Walker E.H., Pacold M.E., Perisic O., Stephens L., Hawkins P.T., Wymann M.P., et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 2000, 6(4):909-919.
226. Chang Y.L., Shen J.J., Wung B.S., Cheng J.J., Wang D.L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol Pharmacol 2001, 60(3):507-513.
227. Tokuda H., Takai S., Hanai Y., Matsushima-Nishiwaki R., Hosoi T., Harada A., et al. (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation. FEBS Lett 2007, 581(7):1311-1316.
228. Choi J.S., Choi Y.J., Shin S.Y., Li J., Kang S.W., Bae J.Y., et al. Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: role of MAPK- and JAK/STAT-signaling. J Nutr 2008, 138(6):983-990.