메뉴 건너뛰기




Volumn 135, Issue 6, 2005, Pages 1359-1365

Quercetin attenuates nuclear factor-κB activation and nitric oxide production in interleukin-1β-activated rat hepatocytes

Author keywords

Interleukin 1 ; Nitric oxide; Nuclear factor B; Quercetin; Rat cultured hepatocytes

Indexed keywords

DICHLORODIHYDROFLUORESCEIN DIACETATE; GLUTATHIONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; QUERCETIN; REACTIVE OXYGEN METABOLITE;

EID: 20444424991     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.6.1359     Document Type: Article
Times cited : (144)

References (55)
  • 2
    • 3342980733 scopus 로고    scopus 로고
    • Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation
    • Dinarello, C. A. (2004) Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation. Curr. Opin. Pharmacol. 4: 4378-4385.
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 4378-4385
    • Dinarello, C.A.1
  • 3
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and inflammation
    • Hanada, A. & Yoshimura, A. (2002) Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev. 13: 413-421.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 413-421
    • Hanada, A.1    Yoshimura, A.2
  • 4
    • 0026021473 scopus 로고
    • Effects of cytokines on the liver
    • Andus, T. & Bauer, J. (1991) Effects of cytokines on the liver. Hepatology 13: 364-375.
    • (1991) Hepatology , vol.13 , pp. 364-375
    • Andus, T.1    Bauer, J.2
  • 6
    • 0032866610 scopus 로고    scopus 로고
    • Cytokines and the molecular mechanisms of alcoholic liver disease
    • Diehl, A. M. (1999) Cytokines and the molecular mechanisms of alcoholic liver disease. Alcohol Clin. Exp. Res. 23: 1419-1424.
    • (1999) Alcohol Clin. Exp. Res. , vol.23 , pp. 1419-1424
    • Diehl, A.M.1
  • 8
    • 0035988729 scopus 로고    scopus 로고
    • Long-term stable cultures of rat hepatocytes: An in vitro model to study acute and chronic hepatic inflammation
    • Kang, Y. H., Berthiaume, F. & Yarmush, M. L. (2002) Long-term stable cultures of rat hepatocytes: an in vitro model to study acute and chronic hepatic inflammation. Tissue Eng. 8: 681-693.
    • (2002) Tissue Eng. , vol.8 , pp. 681-693
    • Kang, Y.H.1    Berthiaume, F.2    Yarmush, M.L.3
  • 9
    • 0344327080 scopus 로고    scopus 로고
    • Quercetin inhibits LPS-induced nitric oxide and tumour necrosis factor-α production in murine macrophages
    • Manjeet, R. & Ghosh, K. B. (1999) Quercetin inhibits LPS-induced nitric oxide and tumour necrosis factor-α production in murine macrophages. Int. J. Immunopharmacol. 21: 435-443.
    • (1999) Int. J. Immunopharmacol. , vol.21 , pp. 435-443
    • Manjeet, R.1    Ghosh, K.B.2
  • 13
    • 0037458581 scopus 로고    scopus 로고
    • Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin 1-beta via two NF-kappa B elements in rat leptomeningeal cells
    • Fujimori, K., Fujitani, Y., Kadoyama, K., Kumanogoh, H., Ishikawa, K. & Urade, Y. (2003) Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin 1-beta via two NF-kappa B elements in rat leptomeningeal cells. J. Biol. Chem. 278: 6018-6026.
    • (2003) J. Biol. Chem. , vol.278 , pp. 6018-6026
    • Fujimori, K.1    Fujitani, Y.2    Kadoyama, K.3    Kumanogoh, H.4    Ishikawa, K.5    Urade, Y.6
  • 14
    • 0036847362 scopus 로고    scopus 로고
    • Growth factors enhance interleukin 1-beta induced persistent activation of nuclear factor kappa B in rat vascular smooth muscle cells
    • Jiang, B., Xu, S., Brecher, P. & Cohen, R. A. (2002) Growth factors enhance interleukin 1-beta induced persistent activation of nuclear factor kappa B in rat vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 22: 1811-1816.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1811-1816
    • Jiang, B.1    Xu, S.2    Brecher, P.3    Cohen, R.A.4
  • 15
    • 0028174061 scopus 로고
    • Function and activation of NF-kappaB in the immune system
    • Baeuerle, P. A. & Henkel, T. (1994) Function and activation of NF-kappaB in the immune system. Annu. Rev. Cell Biol. 12: 141-179.
    • (1994) Annu. Rev. Cell Biol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 16
    • 0030583120 scopus 로고    scopus 로고
    • Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor κB dependent mechanism
    • Nunokawa, Y., Oikawa, S. & Tanaka, S. (1996) Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor κB dependent mechanism. Biochem. Biophys. Res. Commun. 223: 347-352.
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 347-352
    • Nunokawa, Y.1    Oikawa, S.2    Tanaka, S.3
  • 17
    • 0030021661 scopus 로고    scopus 로고
    • Potential health effects of the dietary fiavonol quercetin
    • Hertog, M.G.L. & Hollman, P.C.H. (1996) Potential health effects of the dietary fiavonol quercetin. Eur. J. Clin. Nutr. 50: 63-71.
    • (1996) Eur. J. Clin. Nutr. , vol.50 , pp. 63-71
    • Hertog, M.G.L.1    Hollman, P.C.H.2
  • 18
    • 0029065391 scopus 로고
    • The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation in eicosanoid synthesis: Implication for protection against coronary heart disease
    • Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. & Goldberg, D. M. (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation in eicosanoid synthesis: implication for protection against coronary heart disease. Clin. Chim. Acta 23: 207-219.
    • (1995) Clin. Chim. Acta , vol.23 , pp. 207-219
    • Pace-Asciak, C.R.1    Hahn, S.2    Diamandis, E.P.3    Soleas, G.4    Goldberg, D.M.5
  • 20
    • 0001293501 scopus 로고    scopus 로고
    • Antioxidant properties of flavonoids: Reduction potentials and electron transfer reactions of flavonoid radicals
    • (Rice-Evans, C. & Packer, L., eds.). Marcel Dekker, New York, NY
    • Jovanovic, S. V., Steenken, S., Simic, M. G. & Hara, Y. (1998) Antioxidant properties of flavonoids: reduction potentials and electron transfer reactions of flavonoid radicals. In: Flavonoids in Health and Disease (Rice-Evans, C. & Packer, L., eds.), pp. 137-161. Marcel Dekker, New York, NY.
    • (1998) Flavonoids in Health and Disease , pp. 137-161
    • Jovanovic, S.V.1    Steenken, S.2    Simic, M.G.3    Hara, Y.4
  • 21
    • 3543084042 scopus 로고    scopus 로고
    • Concentration-dependent differential effects of quercetin on rat aortic smooth muscle cells
    • Shih, C. M., Lin, H., Liang, Y. C., Lee, W. S., Bi, W. F. & Juan, S. H. (2004) Concentration-dependent differential effects of quercetin on rat aortic smooth muscle cells. Eur. J. Pharmacol. 496: 41-48.
    • (2004) Eur. J. Pharmacol. , vol.496 , pp. 41-48
    • Shih, C.M.1    Lin, H.2    Liang, Y.C.3    Lee, W.S.4    Bi, W.F.5    Juan, S.H.6
  • 22
    • 0034900898 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expression by rutin, quercetin, and quercetin pentacetate in RAW 264.7 macrophages
    • Chen, Y. C., Shen, S. C., Lee, W. R., Hou, W. C., Yang, L. L. & Lee, T. J. (2001) Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expression by rutin, quercetin, and quercetin pentacetate in RAW 264.7 macrophages. J. Cell Biochem. 82: 537-548.
    • (2001) J. Cell Biochem. , vol.82 , pp. 537-548
    • Chen, Y.C.1    Shen, S.C.2    Lee, W.R.3    Hou, W.C.4    Yang, L.L.5    Lee, T.J.6
  • 23
    • 0035846885 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A. 1
    • Raso, G. M., Meli, R., Di Carlo, G., Pacilio, M. & Di Carlo, R. (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A. 1. Life Sci. 68: 921-931.
    • (2001) Life Sci. , vol.68 , pp. 921-931
    • Raso, G.M.1    Meli, R.2    Di Carlo, G.3    Pacilio, M.4    Di Carlo, R.5
  • 24
    • 0031969571 scopus 로고    scopus 로고
    • Effect of antioxidants, resveratrol, quercetin and N-acetylcysteine on the function of cultured rat hepatic stellate cells and Kupffer cells
    • Kawada, N., Skei, S., Inoue, M. & Kuroki, T. (1998) Effect of antioxidants, resveratrol, quercetin and N-acetylcysteine on the function of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27: 1265-1274.
    • (1998) Hepatology , vol.27 , pp. 1265-1274
    • Kawada, N.1    Skei, S.2    Inoue, M.3    Kuroki, T.4
  • 25
    • 0031855756 scopus 로고    scopus 로고
    • In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds
    • Soliman, K.F.A. & Mazzio, E. A. (1998) In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med. 218: 390-397.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 390-397
    • Soliman, K.F.A.1    Mazzio, E.A.2
  • 26
    • 0030867845 scopus 로고    scopus 로고
    • Quercetin, a bioflavonoid, inhibits the induction of interleukin-monocyte chemoattractant protein-1 expression by tumour necrosis factor-alpha in cultured human synovial cells
    • Sato, M., Miyazaki, T., Kambe, F., Maeda, K. & Seo, H. (1997) Quercetin, a bioflavonoid, inhibits the induction of interleukin-monocyte chemoattractant protein-1 expression by tumour necrosis factor-alpha in cultured human synovial cells. J. Rheumatol. 24: 1680-1684.
    • (1997) J. Rheumatol. , vol.24 , pp. 1680-1684
    • Sato, M.1    Miyazaki, T.2    Kambe, F.3    Maeda, K.4    Seo, H.5
  • 27
    • 0032759115 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation with antioxidants is correlated with reduced cytokine transcription in PTC
    • Rangan, G. K., Wang, Y., Tay, Y. & Harris, D.C.H. (1999) Inhibition of NF-κB activation with antioxidants is correlated with reduced cytokine transcription in PTC. Am. J. Physiol. 46: F779-F789.
    • (1999) Am. J. Physiol. , vol.46
    • Rangan, G.K.1    Wang, Y.2    Tay, Y.3    Harris, D.C.H.4
  • 28
    • 0033561579 scopus 로고    scopus 로고
    • Effects of the wine polyphenols quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages
    • Wadsworth, T. L. & Koop, D. R. (1999) Effects of the wine polyphenols quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem. Pharmacol. 57: 941-949.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 941-949
    • Wadsworth, T.L.1    Koop, D.R.2
  • 30
    • 0041695625 scopus 로고    scopus 로고
    • Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappaB activation in rat hepatocytes
    • Tuñón, M. J., Sánchez-Campos, S., Gutiérrez, B. & González-Gallego, J. (2003) Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappaB activation in rat hepatocytes. Biochem. Pharmacol. 66: 439-445.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 439-445
    • Tuñón, M.J.1    Sánchez-Campos, S.2    Gutiérrez, B.3    González-Gallego, J.4
  • 31
    • 0017064979 scopus 로고
    • Fluorimetric method for determination of oxidised and reduced glutathione in tissues
    • Hissin, J. & Hill, R. A. (1976) Fluorimetric method for determination of oxidised and reduced glutathione in tissues. Anal. Biochem. 74: 214-226.
    • (1976) Anal. Biochem. , vol.74 , pp. 214-226
    • Hissin, J.1    Hill, R.A.2
  • 32
    • 0030584781 scopus 로고    scopus 로고
    • Endotoxin-induced activation of the nuclear transcription factor NF-κB in hepatocytes, Kupffer cells and endothelial cells in vivo
    • Essani, N. A., McGuire, G. M., Manning, A. M. & Jaeschke, H. (1996) Endotoxin-induced activation of the nuclear transcription factor NF-κB in hepatocytes, Kupffer cells and endothelial cells in vivo. J. Immunol. 156: 2956-2963.
    • (1996) J. Immunol. , vol.156 , pp. 2956-2963
    • Essani, N.A.1    McGuire, G.M.2    Manning, A.M.3    Jaeschke, H.4
  • 34
  • 36
    • 0034670172 scopus 로고    scopus 로고
    • Synergy between ethanol and grape polyphenols, quercetin and resveratrol, in the inhibition of inducible nitric oxide synthase pathway
    • Chan, M.M.Y., Mattiacci, J. A., Hwang, H. S., Shah, A. & Fong, D. (2000) Synergy between ethanol and grape polyphenols, quercetin and resveratrol, in the inhibition of inducible nitric oxide synthase pathway. Biochem. Pharmacol. 60: 1439-1448.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1439-1448
    • Chan, M.M.Y.1    Mattiacci, J.A.2    Hwang, H.S.3    Shah, A.4    Fong, D.5
  • 37
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer
    • Middleton, E., Kandaswami, C. & Theoharides, T. C. (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol. Rev. 52: 673-751.
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 38
    • 0024081401 scopus 로고
    • Screening of the influence of flavonoids on lypoxygenase and cyclooxygenase activity, as well as nonenzymic lipid oxidation
    • Robak, J., Shridi, F., Wolbis, M. & Krolikowska, M. (1988) Screening of the influence of flavonoids on lypoxygenase and cyclooxygenase activity, as well as nonenzymic lipid oxidation. Pol. J. Pharmacol. Pharm. 40: 451-458.
    • (1988) Pol. J. Pharmacol. Pharm. , vol.40 , pp. 451-458
    • Robak, J.1    Shridi, F.2    Wolbis, M.3    Krolikowska, M.4
  • 39
    • 0347723892 scopus 로고    scopus 로고
    • Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1 beta-induced gene expression
    • Jiang, B., Xu, S., Hou, X., Pimentel, D. R., Brecher, P. & Cohen, R. A. (2004) Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1 beta-induced gene expression. J. Biol. Chem. 279: 1323-1329.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1323-1329
    • Jiang, B.1    Xu, S.2    Hou, X.3    Pimentel, D.R.4    Brecher, P.5    Cohen, R.A.6
  • 41
    • 0036187213 scopus 로고    scopus 로고
    • Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease
    • Rangan, G. K., Wang, Y. & Harris, D. C. (2002) Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease. Nephron 90: 313-319.
    • (2002) Nephron , vol.90 , pp. 313-319
    • Rangan, G.K.1    Wang, Y.2    Harris, D.C.3
  • 42
    • 0031003969 scopus 로고    scopus 로고
    • Gingko biloba extract (EGb 761): Inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7
    • Kobuchi, H., Droy-Lefaix, M. T., Christen, Y. & Packer, L. (1997) Gingko biloba extract (EGb 761): inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7. Biochem. Pharmacol. 53: 897-903.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 897-903
    • Kobuchi, H.1    Droy-Lefaix, M.T.2    Christen, Y.3    Packer, L.4
  • 43
    • 0037072618 scopus 로고    scopus 로고
    • Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: Structural requirements and mechanisms of action
    • Cho, D. I., Koo, N. Y., Chung, W. J., Kim, T. S., Ryu, S. Y., Im, S. Y. & Kim, K. M. (2002) Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanisms of action. Life Sci. 71: 2071-2082.
    • (2002) Life Sci. , vol.71 , pp. 2071-2082
    • Cho, D.I.1    Koo, N.Y.2    Chung, W.J.3    Kim, T.S.4    Ryu, S.Y.5    Im, S.Y.6    Kim, K.M.7
  • 44
    • 0001255456 scopus 로고    scopus 로고
    • 2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells
    • 2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells. Carcinogenesis 19: 1583-1589.
    • (1998) Carcinogenesis , vol.19 , pp. 1583-1589
    • Musonda, C.A.1    Chipman, J.K.2
  • 46
    • 0026590541 scopus 로고
    • Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cell
    • Schreck, R., Meier, D. N., Mannel, W., Droge, W. & Bauerle, P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cell. J. Exp. Med. 175: 1185-1194.
    • (1992) J. Exp. Med. , vol.175 , pp. 1185-1194
    • Schreck, R.1    Meier, D.N.2    Mannel, W.3    Droge, W.4    Bauerle, P.A.5
  • 48
    • 2842570563 scopus 로고    scopus 로고
    • Suppressive effects of genistein on oxidative stress and NFkappaB activation in RAW 264.7 macrophages
    • Choi, C., Cho, H., Park, J., Cho, C. & Song, Y. (2003) Suppressive effects of genistein on oxidative stress and NFkappaB activation in RAW 264.7 macrophages. Biosci. Biotechnol. Biochem. 67: 1916-1922.
    • (2003) Biosci. Biotechnol. Biochem. , vol.67 , pp. 1916-1922
    • Choi, C.1    Cho, H.2    Park, J.3    Cho, C.4    Song, Y.5
  • 49
    • 0033027275 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status
    • Vos, T. A., Van Goor, H., Tuyt, L., Jager-Krikken, A., Leuvenink, R., Kuipers, F., Jansen, P. L. & Moshage, H. (1999) Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status. Hepatology 29: 421-426.
    • (1999) Hepatology. , vol.29 , pp. 421-426
    • Vos, T.A.1    Van Goor, H.2    Tuyt, L.3    Jager-Krikken, A.4    Leuvenink, R.5    Kuipers, F.6    Jansen, P.L.7    Moshage, H.8
  • 50
    • 0036489186 scopus 로고    scopus 로고
    • Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter
    • Myhrstad, M.C.W., Carlsen, H., Nordstrom, O., Blomhoff, R., Moskaug, J. O. (2002) Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter. Free Radic. Biol. Med. 32: 386-93.
    • (2002) Free Radic. Biol. Med , vol.32 , pp. 386-393
    • Myhrstad, M.C.W.1    Carlsen, H.2    Nordstrom, O.3    Blomhoff, R.4    Moskaug, J.O.5
  • 51
    • 0025677250 scopus 로고
    • Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus
    • Staal, F.J.T., Roederer, M., Herzenberg, L. A. & Herzeneberg, L. A. (1990) Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 87: 9943-9947.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 9943-9947
    • Staal, F.J.T.1    Roederer, M.2    Herzenberg, L.A.3    Herzeneberg, L.A.4
  • 52
    • 4043109947 scopus 로고    scopus 로고
    • Diverse regulation of NF-κB and peroxisome proliferators-activated receptors in murine non-alcoholic fatty liver
    • Romics, L., Kodys, K., Dolganiuc, A., Graham, L., Velayudham, A., Mandrekar, P. & Szabo, G. (2004) Diverse regulation of NF-κB and peroxisome proliferators-activated receptors in murine non-alcoholic fatty liver. Hepatology 40: 376-385.
    • (2004) Hepatology , vol.40 , pp. 376-385
    • Romics, L.1    Kodys, K.2    Dolganiuc, A.3    Graham, L.4    Velayudham, A.5    Mandrekar, P.6    Szabo, G.7
  • 53
    • 0028035106 scopus 로고
    • The high-output nitric oxide pathway: Role and regulation
    • Xie, Q. & Nathan, C. (1994) The high-output nitric oxide pathway: role and regulation. J. Leukoc. Biol. 56: 576-682.
    • (1994) J. Leukoc. Biol. , vol.56 , pp. 576-682
    • Xie, Q.1    Nathan, C.2
  • 54
    • 0032585932 scopus 로고    scopus 로고
    • IKappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporin and quercetin
    • Peet, G. W. & Li, J. (1999) IKappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporin and quercetin. J. Biol. Chem. 274: 32655-32661.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32655-32661
    • Peet, G.W.1    Li, J.2
  • 55
    • 13244275108 scopus 로고    scopus 로고
    • Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
    • Hubbard, G. P., Wolffram, S., Lovegrove, J. A. & Gibbins, J. M. (2004) Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J. Thromb. Haemost. 2: 2138-2145.
    • (2004) J. Thromb. Haemost. , vol.2 , pp. 2138-2145
    • Hubbard, G.P.1    Wolffram, S.2    Lovegrove, J.A.3    Gibbins, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.