Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production

British Journal of Pharmacology

Volumn 154, Issue 1, 2008, Pages 165-173

  Kim, Y W ^a   Zhao, R J ^b   Park, S J ^c   Lee, J R ^c   Cho, I J ^a   Yang, C H ^c   Kim, S G ^a   Kim, S C ^c  

^a Seoul National University   (South Korea)

^b MUDANJIANG MEDICAL UNIVERSITY   (China)

^c Daegu Haany University   (South Korea)

Author keywords

iNOS; Interleukin 1 ; Interleukin 6; Liquiritigenin; Nuclear factor B; TNF

Indexed keywords

CARRAGEENAN; CYTOKINE; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIQUIRITIGENIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLYCYRRHIZA; MACROPHAGE; MALE; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 42949164997     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.79     Document Type: Article

References (46)

1. Abebe W (2003). An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent Hyg 77: 37–46.
2. Baldwin Jr AS (1996). The NF‐kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14: 649–681.
3. Beutler B, Cerami A (1989). The biology of cachectin/TNF‐α primary mediator of the host response. Annu Rev Immunol 7: 625–655.
4. Bogdan C (2001). Nitric oxide and the immune response. Nat Immunol 2: 907–916.
5. Bonizzi G, Karin M (2004). The two NF‐κB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280–288.
6. Bose S, Kar N, Maitra R, Didonato JA, Banerjee AK (2003). Temporal activation of NF‐kappaB regulates an interferon‐independent innate antiviral response against cytoplasmic RNA viruses. Proc Natl Acad Sci USA 100: 10890–10895.
7. Chen F, Kuhn DC, Sun SC, Gaydos LJ, Demers LM (1995). Dependence and reversal of nitric oxide production on NF‐kappa B in silica and lipopolysaccharide‐induced macrophages. Biochem Biophys Res Commun 214: 839–846.
8. Cho MK, Suh SH, Lee CH, Kim SG (2005). Bovine type I collagen inhibits Raw264.7 cell proliferation through phosphoinositide 3‐kinase‐ and mitogen‐activated protein kinase‐dependent down‐regulation of cyclins D1, A and B1. Biochim Biophys Acta 1744: 47–57.
9. Coffey M, Phare S, Peters‐Golden M (2004). Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down‐regulates 5‐lipoxygenase metabolism in murine alveolar macrophages. Exp Lung Res 30: 615–633.
10. Corriveau CC, Danner RL (1993). Endotoxin as a therapeutic target in septic shock. Infect Agents Dis 2: 35–43.
11. Cruz MT, Duarte CB, Gonçalo M, Figueiredo A, Carvalho AP, Lopes MC (2001). Granulocyte–macrophage colony‐stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line. Immunol and Cell Biol 79: 590–596.
12. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992). The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107: 660–664.
13. Cvoro A, Tatomer D, Tee MK, Zogovic T, Harris HA, Leitman DC (2008). Selective estrogen receptor‐agonists repress transcription of proinflammatory genes. J Immunol 180: 630–636.
14. Dietrich W, Haitel A, Holzer G, Huber JC, Kolbus A, Tschugguel W (2006). Estrogen receptor‐beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig 13: 512–517.
15. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R (2007). Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF‐7 cells by the treatment with an extract of Glycyrrhiza glabra root. Food Chem Toxicol 45: 2470–2478.
16. Ghosh S, Ksarin M (2002). Missing pieces in the NF‐κB puzzle. Cell 109: S81–S96.
17. Handy RL, Moore PK (1998). A comparison of the effects of L‐NAME, 7‐NI and L‐NIL on carrageenan‐induced hindpaw oedema and NOS activity. Br J Pharmacol 123: 1119–1126.
18. Hayden MS, Ghosh S (2004). Signaling to NF‐κB. Genes Dev 18: 2195–2224.
19. Huang WC, Chen JJ, Chen CC (2003). c‐Src‐dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor‐alpha‐induced intercellular adhesion molecule‐1 expression. J Biol Chem 278: 9944–9952.
20. Jean‐Baptiste E (2007). Cellular mechanisms in sepsis. J Intensive Care Med 22: 63–72.
21. Jimi E, Ghosh S (2005). Role of nuclear factor‐kappaB in the immune system and bone. Immunol Rev 208: 80–87.
22. Kamei J, Nakamura R, Ichiki H, Kubo M (2003). Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo‐to (Mai‐men‐dong‐tang). Eur J Pharmaco 469: 159–163.
23. Kamei J, Saitoh A, Asano T, Nakamura R, Ichiki H, Iiduka A et al. (2005). Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo‐to (Mai‐men‐dong‐tang). Eur J Pharmacol 507: 163–168.
24. Katz LB, Theobald HM, Bookstaff RC, Peterson RE (1984). Characterization of the enhanced paw edema response to carrageenan and dextran in 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin‐treated rats. J Pharmacol Exp Ther 230: 670–677.
25. Kim SC, Byun SH, Yang CH, Kim CY, Kim JW, Kim SG (2004). Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium‐induced toxicity (effects on bad translocation and cytochrome c ‐mediated PARP cleavage). Toxicology 197: 239–251.
26. Kim SG, Kim HJ, Choi SH, Ryu JY (2000). Inhibition of lipopolysaccharide‐induced I‐kB degradation and tumor necrosis factor‐α expression by dimethyl‐4, 40‐dimethoxy‐5, 6, 50, 60‐dimethylene dioxybiphenyl‐2, 20‐dicarboxylate (DDB): minor role in hepatic detoxifying enzyme expression. Liver 20: 319–329.
27. Kim YW, Ki SH, Lee JR, Lee SJ, Kim CW, Kim SC et al. (2006). Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chem Biol Interact 161: 125–138.
28. Kleinert H, Schwarz PM, Forstermann U (2003). Regulation of the expression of inducible nitric oxide synthase. J Biol Chem 384: 1343–1364.
29. Kubes P, McCafferty DM (2000). Nitric oxide and intestinal inflammation. Am J Med 109: 150–158.
30. Lee AK, Sung SH, Kim YC, Kim SG (2003). Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐alpha and COX‐2 expression by sauchinone effects on I‐kappaBalpha phosphorylation, C/EBP and AP‐1 activation. Br J Pharmacol 139: 11–20.
31. Leventhal L, Brandt MR, Cummons TA, Piesla MJ, Rogers KE, Harris HA (2006). An estrogen receptor‐beta agonist is active in models of inflammatory and chemical‐induced pain. Eur J Pharmacol 553: 146–148.
32. Lin AW, Chang CC, Mccormick CC (1996). Molecular cloning and expression of an avian macrophage nitric‐oxide synthase cDNA and the analysis of the genomic 5′‐flanking region. J Biol Chem 271: 11911–11919.
33. Liu H, Sidiropoulos P, Song G, Pagliari LJ, Birrer MJ, Stein B et al. (2000). TNF‐α gene expression in macrophages: regulation by NF‐κB is independent of c‐Jun or C/EBPβ. J Immunol 164: 4277–4285.
34. Macmicking J, Xie QW, Nathan C (1997). Nitric oxide and macrophage function. Annu Rev Immunol 15: 323–350.
35. Mersereau JE, Levy N, Staub RE, Baggett S, Zogric T, Chow S et al. (2008). Liquiritigenin is a plant‐derived highly selective estrogen receptor beta agonist. Mol Cel Endocrinol 283: 49–57.
36. Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T et al. (1994). Novel mechanism of glucocorticoid‐mediated gene repression. Nuclear factor‐kappa B is target for glucocorticoid‐mediated interleukin‐8 gene repression. J Biol Chem 269: 13289–13295.
37. Omote K, Hazama K, Kawamata T, Kawamata M, Nakayaka Y, Toriyabe M et al. (2001). Peripheral nitric oxide in carrageenan‐induced inflammation. Brain Res 912: 171–175.
38. Roshak AK, Jackson JR, Mcgough K, Chabot‐Fletcher M, Mochan E, Marshall LA (1996). Manipulation of distinct NF‐kappaB proteins alters interleukin‐1beta‐induced human rheumatoid synovial fibroblast prostaglandin E2 formation. J Biol Chem 271: 31496–31501.
39. Schreiber E, Harshman K, Kemler I, Malipiero U, Schaffner W (1990). Astrocytes and glioblastoma cells express novel octamer‐DNA binding proteins distinct from the ubiquitous Oct‐1 and B cell type Oct‐2 proteins. Nucleic Acids Res 18: 5495–5503.
40. Shimamura H, Suzuki H, Hanano M, Suzuki A, Sugiyama Y (1993). Identification of tissues responsible for the conjugative metabolism of liquiritigenin in rats: an analysis based on metabolite kinetics. Biol Pharm Bull 16: 899–907.
41. Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD et al. (2003). Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF‐kappaB in T lymphocytes. Mol Cell Biol 23: 7068–7081.
42. Wang ZY, Nixon DW (2001). Licorice and cancer. Nutr Cancer 39: 1–11.
43. Watson WH, Zhao Y, Chawla RK (1999). S‐ adenosylmethionine attenuates the lipopolysaccharide‐induced expression of the gene for the tumour necrosis factor‐α. Biochem J 342: 21–25.
44. West MA, Seatter SC, Bellingham J, Clair L (1995). Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment. Surgery 118: 220–228.
45. Yokozawa T, Cho EJ, Rhyu DY, Shibahara N, Aoyagi K (2005). Glycyrrhizae radix attenuates peroxynitrite‐induced renal oxidative damage through inhibition of protein nitration. Free Radic Res 39: 203–211.
46. Yoshimura A (2006). Signal transduction of inflammatory cytokines and tumor development. Cancer Sci 97: 439–447.