Quercetin regulates Th1/Th2 balance in a murine model of asthma

International Immunopharmacology

Volumn 9, Issue 3, 2009, Pages 261-267

  Park, Hee ju ^a   Lee, Chang Min ^b,g   Jung, In Duk ^b   Lee, Jun Sik ^b,g   Jeong, Young il ^c   Chang, Jeong Hyun ^d   Chun, Sung Hak ^b,g   Kim, Min Jae ^b,g   Choi, Il Whan ^e   Ahn, Soon Cheol ^a   Shin, Yong Kyoo ^f   Yeom, Seok Ran ^a   Park, Yeong Min ^b  

^a Pusan National University School of Medicine   (South Korea)

^b National Research Laboratory of Dendritic Cell Differentiation and Regulation   (South Korea)

^c Pusan National University   (South Korea)

^d Daegu Haany University   (South Korea)

^e Inje University College of Medicine   (South Korea)

^f Chung Ang University College of Medicine   (South Korea)

^g Bk21 Medical Science Education Center   (South Korea)

Author keywords

Airway hyper responsiveness; Asthma; GATA 3; IL 4; IL 5; MMP 9; Ovalbumin; Quercetin; T bet

Indexed keywords

CYTOKINE; EOSINOPHIL PEROXIDASE; GAMMA INTERFERON; INTERLEUKIN 4; OVALBUMIN; QUERCETIN; TRANSCRIPTION FACTOR GATA 3;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IMMUNOPATHOGENESIS; IMMUNOPHARMACOLOGY; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; EOSINOPHIL PEROXIDASE; EOSINOPHILS; FEMALE; GATA3 TRANSCRIPTION FACTOR; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-5; LUNG; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; OVALBUMIN; QUERCETIN; T-BOX DOMAIN PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 60249086845     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.10.021     Document Type: Article

References (42)

1. Ohshima M., Yokoyama A., Ohnishi H., Hamada H., Kohno N., Higaki J., et al. Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice. Clin Exp Allergy 37 5 (2007) 735-742
2. Busse W.W., and Lemanske Jr. R.F. Asthma. N Engl J Med 344 (2001) 350-362
3. Larche M., Robinson D.S., and Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111 (2003) 450-463
4. Zimmermann N., Hershey G.K., Foster P.S., and Rothenberg M.E. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 111 (2003) 227-242
5. Katayama H., Yokoyama A., Kohno N., Sakai K., Hiwada K., Yamada H., and Hirai K. Production of eosinophilic chemokines by normal pleural mesothelial cells. Am J Respir Cell Mol Biol 26 (2002) 398-403
6. Tanaka H., Komai M., Nagao K., Ishizaki M., Kajiwara D., Takatsu K., Delespesse G., and Nagai H. Role of interleukin-5 and Eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol 31 (2004) 62-68
7. Gleich G.J., and Kita H. Bronchial asthma: lessons from murine models. Proc Natl Acad Sci U S A 94 (1997) 2101-2102
8. Mappe C.E., Boschetto P., Zocca E., Milani G.F., Pivirotto F., Teggazin V., et al. Pathogenesis of late asthmatic reactions induced by exposure to isocyanates. Bull Eur Physiopathol Respir 23 6 (1987) 583-586
9. Boschetto P., Fabbri L.M., Zocca E., Milani G., Pivirotto F., Dal Vecchio A., et al. Prednisone inhibits late asthmatic reactions and airway inflammation induced by toluene diisocyanate in sensitized subjects. J Allergy Clin Immunol 81 2 (1988) 454
10. Bousquet J., Chanez P., Lacoste J.Y., Barneon G., Ghavanian N., Enander I., et al. Eosinophilic inflammation in asthma. N Engl J Med 323 15 (1990) 1033-1039
11. Busse W.W., William F.C., and Sedgwick J.D. Mechanism of airway inflammation in asthma. Am Rev Respir Dis 147 (1993) 20-24
12. Kay A.B. Asthma and inflammation. J Allergy Clin Immunol 87 (1991) 893-910
13. Nagase H. Activation mechanisms of matrix metalloproteinases. Biol Chem 378 3-4 (1997) 151-160
14. Murphy G., and Docherty A.J. The matrix metalloproteinases and their inhibitors. Am J Respir Cell Mol Biol 7 2 (1992) 120-125
15. Yao P.M., Maitre B., Delacourt C., Buhler J.M., Harf A., and Lafuma C. Divergent regulation of 92-kDa gelatinase and TIMP-1 by HBECs in response to IL-1beta and TNF-alpha. Am J Physiol 273 (1997) 866-874
16. Delclaux C., Delacourt C., D'Ortho M.P., Boyer V., Lafuma C., and Harf A. Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane. Am J Respir Cell Mol Biol 14 (1996) 288-295
17. Leppert D., Waubant E., Galardy R., Bunnett N.W., and Hauser S.L. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol 154 9 (1995) 4379-4389
18. Mautino G., Oliver N., Chanez P., Bousquet J., and Capony F. Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar Macrophages of asthmatics. Am J Respir Cell Mol Biol 17 5 (1997) 583-591
19. Stahle-Backdahl M., Inoue M., Guidice G.J., and Parks W.C. 92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. J Clin Invest 93 5 (1994) 2022-2030
20. Matrisian L.M. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6 4 (1990) 121-125
21. Okada S., Kita H., George T.J., Gleich G.J., and Leiferman K.M. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 17 4 (1997) 519-528
22. Ratzinger G., Stoitzner P., Ebner S., Lutz M.B., Layton G.T., Rainer C., et al. Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol 168 9 (1992) 4361-4371
23. Kim G.Y., Cho H., Ahn S.C., Oh Y.H., Lee C.M., and Park Y.M. Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 4 (2004) 245-253
24. Kim G.Y., Oh W.K., Shin B.C., Shin Y.I., Park Y.C., Ahn S.C., et al. ProteogQctan Isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+ CD8+ DC and type I helper T cell-dominant immune state. FEBS Lett 576 (2004) 391-400
25. Giovannucci E. Tomatoes, tomato-based products, Quercetin, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 91 (1999) 317-331
26. Gann P.H., Ma J., Giovannucci E., Willett W., Sacks F.M., Hennekens C.H., et al. Lower prostate cancer risk in men with elevated plasma Quercetin levels: results of a prospective analysis. Cancer Res 59 (1999) 1225-1230
27. Mills P.K., Beeson W.L., Phillips R.L., and Fraser G.E. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 64 (1989) 598-604
28. Di Mascio P., Kaiser S., and Sies H. Quercetin as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274 (1989) 532-538
29. Harwood M., Danielewska-Nikiel B., Borzelleca J.F., Flamm G.W., Williams G.M., and Lines T.C. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45 (2007) 2179-2205
30. Stahl W., Schwarz W., Sundquist A.R., and Sies H. cis-trans isomers of Quercetin and beta-carotene in human serum and tissues. Arch Biochem Biophys 294 (1992) 173-177
31. T. Bian, K.S. Yin, S.X. Jin, X.L. Zhang, J.Y. Zhou, X.Q. Ma, et al. Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3.Chin Med J (Engl). 2006; 20: 119(8):640-648.
32. Nakamura Y., Ghaffar O., Olivenstein R., Taha R.A., Soussi-Gounni A., Zhang D.H., et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol 103 (1999) 215-222
33. Parronchi P., de Carli M., Manetti R., Simonelli C., Sampognaro S., Piccinni M.P., et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on development of cytolytic potential by Th1 or Th2 human T cell clones. J Immunol 149 (1992) 2977-2983
34. Montefort S., and Holgate S.T. Adhesion molecules and their role in inflammation. Respir Med 85 2 (1991) 91-99
35. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
36. Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., Glimcher L.H., et al. Distinct effects of T-bet in Th1 lineage commitment and IFN- production in CD4 and CD8 T cells. Science 295 (2002) 338-342
37. Afkarian M., Sedy J.R., Yang J., Jacobson N.G., Cereb N., Yang S.Y., et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3 (2002) 549-557
38. Mullen A.C., High F.A., Hutchins A.S., Lee H.W., Villarino A.V., Livingston D.W., et al. Role of T-bet in commitment of Th1 cells before IL-12-dependent selection. Science 292 (2001) 1907-1910
39. Gavett S.H., O'Hearn D.J., Li X., Huang S.K., Finkelman F.D., and Wills-Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 182 (1995) 1527-1536
40. Li X.M., Chopra R.K., Chou T.Y., Schofield B.H., Wills-Karp M., and Huang S.K. Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol 157 (1996) 3216-3219
41. Orkin S.H. Hematopoiesis: how does it happen?. Curr Opin Cell Biol 7 (1995) 870-877
42. Ouyang W., Ranganath S.H., Weindel K., Bhattacharya D., Murphy T.L., Sha W.C., et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9 (1998) 745-755