Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: Structure-activity relationships

Molecular Pharmacology

Volumn 66, Issue 3, 2004, Pages 683-693

  Chen, Ching Chow ^a   Chow, Man Ping ^a   Huang, Wei Chien ^a   Lin, Yi Chu ^a   Chang, Ya Jen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; BAICALEIN; BAICALIN; CHRYSIN; FLAVONOID; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; KAEMPFEROL; LUCIFERASE; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYRICETIN; PROTEIN C FOS; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CONCENTRATION RESPONSE; DNA PROTEIN COMPLEX; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; STRUCTURE ACTIVITY RELATION; UPREGULATION;

APIGENIN; DRUG INTERACTIONS; EPITHELIAL CELLS; FLAVONOIDS; FLAVONOLS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KAEMPFEROLS; LUTEOLIN; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-FOS; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; UP-REGULATION;

EID: 4944228697     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Albelda SM, Smith CW, and Ward PA (1994) Adhesion molecules and inflammatory injury. FASEB J 8:504-512.
2. Avila MA, Velasco JA, Cansado J, and Notario V (1994) Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 54:2424-2428.
3. Baldwin AS (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14:649-683.
4. Barnes PJ (1994) Cytokines as mediators of chronic asthma. Am J Respir Crit Care Med 150:842-849.
5. Barton RW, Rothlein R, Ksiazek J, and Kennedy C (1989) The effect of anti-ICAM-1 on phorbol-ester-induced rabbit lung inflammation. J Immunol 143:1278-1282.
6. Bassi V, Vitale M, Feliciello A, De Riu S, Rossi G, and Fenzi G (1995) Retinoic acid induces ICAM-1 hyperexpression in human thyroid carcinoma cell lines. J Clin Endocrinol Metab 80:1129-1135.
7. Beutler B (1995) TNF, immunity and inflammatory disease: lessons of the past decade. J Investis Med 43:227-235.
8. Chang YJ, Holtzman MJ, and Chen CC (2002) IFN-γ-induced epithelial ICAM-1 expression and monocyte adhesion. Involement of PKC-dependent c-Src typosine kinase activation pathway. J Biol Chem 277:7118-7126.
9. Chang YJ, Holtzman MJ, and Chen CC (2004) Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase C-γ, c-Src, and STAT1. Mol Pharmacol 65:589-598.
10. Chen CC, Chen JJ, and Chou CY (2000) PKCα but not p44/42 MAPK, p38, JNK is required for ICAM-1 expression mediated by IL-1β: involvement of sequential activation of tyrosine kinase, NIK, and IKK2. Mol Pharmacol 58:1479-1489.
11. Chen C, Chou C, Sun Y, and Huang W (2001) TNF-α-induced activation of downstream NF-κB site of the promoter mediates epithelial expression and monocyte adhesion: involvement of PKCα, tyrosine kinase and IKK2 but not MAPKs, pathway. Cell Signal 13:543-553.
12. Chinenov Y and Kerppola TK (2001) Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 20:2438-2452.
13. Colletti LM, Cortis A, Lukacs N, Kunkel SL, Green M, and Strieter RM (1998) TNF up-regulates ICAM-1 which is important in the neutrophil-dependent lung and liver injury associated with hepatic ischemia and reperfusion in the rat. Shock 10:182-191.
14. Cornelius LA, Taylor JT, Degitz K, Li LJ, Lawley TJ, and Caughman SW (1993) A 5′-portion of the ICAM-1 gene confers tissue-specific differential expression levels and cytokine responsiveness. J Investig Dermatol 100:753-758.
15. Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, and Perry CA (1995) Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 147:278-292.
16. Gomez del Arco P, Martinez-Martinez S, Calvo V, Armesilla AL, and Redondo JM (1997) Antioxidants and AP-1 activation: a brief overview. Immunobiology 198:273-278.
17. Huang WC, Chan ST, Yang TL, Tzeng CC, and Chen CC (2004) Inhibition of ICAM-1 gene expression, monocyte adhesion, and cancer cell invasion by targeting IKK complex: molecular and functional study of novel α-methylene-γ- butyrolactone derivatives. Carcinogenesis, in press.
18. Huang WC, Chen JJ, and Chen CC (2003) c-Src-dependent tyrosine phosphorylation of IKKβ is involved in TNF-α-induced ICAM-1 expression. J Biol Chem 278:9944-9952.
19. Kacimi R, Karliner JS, Koudssi F, and Long CS (1998) Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia. Circ Res 82:576-586.
20. Karin M (1995) The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486.
21. Karin M (1999) The beginning of the end: IκB kinase (IKK) and NF-κB activation. J Biol Chem 274:27339-27432.
22. Kobuchi H, Roy S, Sen CK, Nguyen HG, and Packer L (1999) Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am J Physiol 277:C403-C411.
23. Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, and Lin JK (1999) Supression of inducible COX and iNOS by apigenin and related flavonoids in mouse macrophage. Carcinogenesis 20:1945-1952.
24. Rice-Evans C, Miller N, and Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20:933-956.
25. Roebuck KA, Rahman A, Lakshminarayanan V, Janakidevi K, and Malik AB (1995) H2O2 and TNF-α activate ICAM-1 gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter. J Biol Chem 270:18966-19874.
26. Sampath D, Castro M, Look DC, and Holtzman MJ (1979) Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Investis 103:1353-1361.
27. Stanciu LA and Djukanovic R (1998) The role of ICAM-1 on T-cells in the pathogenesis of asthma. Eur Respir J 11:949-957.
28. van de Stolpe A and van der Saag PT (1996) Intercellular adhesion molecule-1. J Mol Med 74:13-33.
29. Voraberger G, Schafer R, and Stratowa C (1991) Cloning of the human gene for ICAM-1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester. J Immunol 147:2770-2786.
30. Wadsworth TL and Koop DR (1999) Effects of the wine polyphenolic quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem Pharmacol 57:941-949.
31. Welty SE, Rivera JL, Elliston JF, Smith CV, Zeb T, Ballantyne CM, Montgomery CA, and Hansen TN (1993) Increases in lung tissue expression of ICAM-1 are associated with hypertoxic lung injury and inflammation in mice. Am J Respir Cell Mol Biol 9:393-400.
32. Whitmarsh AJ and Davis RJ (1996) Transcription factor AP-1 regulation by MAPK signal transduction pathways. J Mol Med 74:589-607.
33. Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, and Roussos C (2001) Luteolin inhibits endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 296:181-187.
34. Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, and Varilek GW (2001) The green tea polyphenol (-)-Epigallocatechin-3-galate blocks NF-κB activation by inhibiting IKK activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60:528-533.
35. Zuckerman LA, Pullen L, and Miller J (1998) Functional consequences of costimulation by ICAM-1 on IL-2 gene expression and T cell activation. J Immunol 160:3259-3268.