Inhibitions of Protein Kinase C and Proto-oncogene Expressions in NIH 3T3 Cells by Apigenin

European Journal of Cancer

Volumn 32, Issue 1, 1996, Pages 146-151

  Huang, Ying Tang ^a   Kuo, Min Liang ^b   Liu, Jer Yuh ^a   Huang, Su Yu ^b   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apigenin; C FOS; C JUN; Protein kinase C; Protein tyrosine kinases; TPA

Indexed keywords

APIGENIN; FIBROBLAST GROWTH FACTOR RECEPTOR; FLAVANOID; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL STRAIN 3T3; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTO ONCOGENE;

3T3 CELLS; ANIMALS; BLOTTING, NORTHERN; CELL DIVISION; CHAMOMILE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GENE EXPRESSION; MICE; OILS, VOLATILE; PHOSPHORYLATION; PLANTS, MEDICINAL; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE;

EID: 0029912466     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00540-4     Document Type: Article

References (58)

1. Slaga TJ. Overview of tumor promotion in animals. Environ Health Perspect 1983, 50, 3-14.
2. Blumber PM. Protein kinase C as the receptor the phorbol ester tumor promoter. Cancer Res 1988, 48, 1-8.
3. Fujiki H, Tanaka Y, Miyake R, Kikkawa U, Nishizuka Y, Sugimura T. Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin. Biochem Biophys Res Commun 1984, 120, 339-343.
4. Birt DF, Walker B, Tibbels MG, Bresnick E. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis 1986, 7, 959-963.
5. Wu W-S, Lin J-K, Wu FY-H. Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro. Oncogene 1992, 7, 2287-2294.
6. Grausz JD, Fradelizi D, Dautry F, Monier R, Lehn P. Modulation of c-fos and c-myc mRNA levels in normal human lymphocytes by calcium ionophore A23187 and phorbol ester. Eur J Immunol 1986, 16, 1217-1221.
7. Rodriguez-Pena A, Rozengurt E. Phosphorylation of an acidic mol. wt. 80,000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity. EMBO J 1986, 5, 77-83.
8. Blackshear P, Wen L, Glynn BP, Witters LA. Protein kinase C stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol ester and growth factors in intact fibroblasts. J Biol Chem 1986, 261, 1459-1469.
9. Frenkel K. Oxidation of DNA bases by tumor promoter-activated processes. Environ Health Perspect 1986, 81, 45-54.
10. Shih C-A, Lin JK. Inhibition of 8-hydroxydeoxyguanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis 1993, 14, 709-712.
11. Floyd RA. Role of oxygen free radical in carcinogenesis and brain ischemia. FASEB J 1990, 4, 2587-2597.
12. Nishizuka, Y. The family of protein kinase C for signal transduction. JAMA 1989, 262, 1826-1833.
13. Kuhnau J. The flavonoids: a class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 1976, 24, 117-120.
14. Czeczot H, Tudek B, Kusztelak T, et al. Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs. Mutat Res 1990, 240, 209-216.
15. Kuo ML, Lee KC, Lin J-K. Genotoxicity of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems. Mutat Res 1992, 270, 87-95.
16. Hertog MGL, Hollman PCH, Katan MB, Kromhout D. Estimation of daily intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 1993, 20, 21-29.
17. Geahlen RL, Koonchanok NM, McLaughlin JL. Inhibition of protein-tyrosine kinase activity by flavonoids and related compounds. J Nat Prod 1989, 52, 982-986.
18. Akiyama T, Ishida J, Nakagawa S, et al. Genistenin, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987, 262, 5592-5595.
19. Hirano T, Oka K, Akiba M. Antiproliferative effects of synthetic and naturally occuring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Res Commun Chem Pathol Pharmacol 1989, 64, 69-78.
20. Sato F, Matsukawa Y, Matsumoto K, Nishino H, Sakai T. Apigenin induced morphological differentiation and G2-M arrest in rat neuronal cells. Biochem Biophys Res Commun 1994, 204, 578-584.
21. Kuo ML, Lin JK, Huang TS, Yang NC. Reversion of the transformed phenotypes of v-Ha-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett 1994, 87, 91-97.
22. Chaumontent C, Bex V, Gallard-Sanchez I, Seillan-Heberden C, Suschetet M, Martel P. Apigenin and tangeretin enhance gap junction intercellular communication in rat liver cells. Carcinogenesis 1994, 15, 2325-2330.
23. Edenharder R, von Petersdorff I, Rauscher R. Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food. Mutat Res 1993, 287, 261-274.
24. Chae YH, Ho DK, Cassady JM, Cook VM, Marcus CB, Baird WM. Effective of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell cultures. Chem Biol Interactions 1992, 82, 181-193.
25. Wei H, Tye L, Bresnick E, Brit DF. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res 1990, 50, 499-502.
26. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1974, 227, 680-685.
27. Curran T, Peter G, Beveren CV, Teich NM, Verma IM. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active provial DNA. J Virol 1982, 44, 674-682.
28. Bohmann D, Bos TT, Admon A, Nishimura T, Vogt PK, Tjian R. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 1987, 238, 1386-1392.
29. Tso JY, Sun X-H, Kao T-H, S. Reece K, Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res 1983, 13, 2485-2502.
30. Chomcynsk P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt Biochem 1987, 162, 156-159.
31. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning: a Laboratory Manual. New York, Cold Spring Harbor Laboratory Press, 1989.
32. Liu J-Y, Lin S-J, Lin J-K. Inhibitory effect of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-13-acetate in NIH 3T3 cells. Carcinogenesis 1993, 14, 857-861.
33. Masmoudi A, Labourdette G, Mesel M, et al. Protein kinase C located in rat liver nuclei. J Biol Chem 1989, 264, 1172-1179.
34. Kumar R, Atlas I. Interferon α induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation. Proc Natl Acad Sci USA 1992, 89, 6599-6603.
35. Chao CC-K, Huang YT, Ma CM, Chou WY, Lin-Chao S. Overexpression of glutathione S-transferase and elevation of thiol pool in a multidrug-resistant human colon cancer cell line. Mol Pharmacol 1992, 41, 69-75.
36. Shisheva A, Lietner O, Shechter Y. A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine. J Biochem Biophys Meth 1991, 23, 307-314.
37. Fujita-Yamaguchi Y, Sahal D. Protein kinase assay by paper trichloroacetic acid method: high performance using phosphocellulose paper and washing an ensemble of samples on flat sheets. Analyt Biochem 1987, 167, 23-30.
38. Epand RM, Lester DS. The role of membrane biophysical properties in regulation of protein kinase C activity. Trends Pharmacol Sci 1990, 11, 317-320.
39. Huang T-S, Lee S-C, Lin J-K. Suppression of c-jun/Ap-1 activation by an inhibitory of tumor promotion in mouse fibroblast cells. Proc Natl Acad Sci USA 1991, 88, 5292-5296.
40. Weinstein IB. The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment - twenty-seventh G.H.A. Clowes Memorial Award Lecture. Cancer Res 1988, 48, 4135-4143.
41. lck in T cells. Oncogene 1993, 8, 3133-3139.
42. Brawn MK, Chiou WJ, Leach KL. Oxidant-induced activation of protein kinase C in UC11MG cells. Free Rad Res 1995, 22, 23-37.
43. Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anion. Biochem Pharmacol 1988, 37, 83-88.
44. Husain SR, Cillard P. Hydroxy radicals scavenging activity of flavonoids. Photochemistry 1987, 26, 2489-2492.
45. Carter TH. Mechanism of Environmental Carcinogenesis. Boca Raton, CRC Press, 1987, 47-80.
46. Lerman MI, Colburn NH. Tumor Promotion: Biological Approaches for Mechanistic Studies and Assay Systems. New York, Raven Press, 1987, 357-385.
47. Lau LF, Nathans D. Expression of a set of growth-related immediate early genes in BALB/c 3T3: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 1987, 84, 1182-1186.
48. Ryder K, Nathans D. Induction of protooncogene c-jun by serum growth factors. Proc Natl Acad Sci USA 1988, 85, 9464-8467.
49. Ryseck R-P, Hirai SI, Yaniv M, Bravo R. Transcription activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature 1988, 334, 535-537.
50. Castellazzi M, Dangy J-P, Mechta F, et al. Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype. Oncogene 1990, 5, 1541-1547.
51. Boyle WJ, Smeal T, Defize LHK, et al. Activation of protein kinase C decreases phosphorylation of c-JUN at sites that negatively regulate its DNA-binding activity. Cell 1991, 64, 573-584.
52. Ransone LJ, Verma IM. Nuclear proto-oncogene fos and jun. Annu Rev Cell Biol 1990, 6, 539-557.
53. Nose K, Shibanuma M, Kikuchi K, Kageyama H, Sakiyama S, Kuroki T. Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem 1991, 201, 99-106.
54. Devary Y, Gottlieb RA, Lau LF, Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 1991, 11, 2804-2811.
55. Amstad PA, Krupitza G, Cerutti PA. Mechanism of c-fos induction by active oxygen. Cancer Res 1992, 52, 3952-3960.
56. Witz G. Active oxygen species as factors in multistage carcinogenesis. Proc Soc Exp Biol Med 1991, 198, 675-682.
57. Perchellet JP, Perchell EM. Antioxidant and multistage carcinogenesis in mouse skin. Free Rad Biol Med 1989, 7, 377-408.
58. Semba M, Inui N. Inhibitory effects of radical scavengers on diacylglycerol-promoted transformation in BALB/3T3 cells. Toxicol Lett 1991, 56, 299-303.