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Volumn 243, Issue 1-2, 2003, Pages 153-160

Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage

Author keywords

Anti inflammation; LPS; MAP kinases; NF B; Quercetin

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BETA ACTIN; CYTOKINE; FLAVONOID; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUERCETIN; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0037281331     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021624520740     Document Type: Article
Times cited : (305)

References (40)
  • 1
    • 0032484218 scopus 로고    scopus 로고
    • Protein kinase C-α modulates LPS-induced functions in a murine macrophage cell line
    • Anik ST, Frederic C, Pierre T, Yves SP, Albert D: Protein kinase C-α modulates LPS-induced functions in a murine macrophage cell line. J Biol Chem 273: 32787-32792, 1998
    • (1998) J. Biol. Chem. , vol.273 , pp. 32787-32792
    • Anik, S.T.1    Frederic, C.2    Pierre, T.3    Yves, S.P.4    Albert, D.5
  • 2
    • 0033136947 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in IL-1β transcription
    • Baldassare JJ, Bi Y, Bellone CJ: The role of p38 mitogen-activated protein kinase in IL-1β transcription. J Immunol 162: 5367-5373, 1999
    • (1999) J. Immunol. , vol.162 , pp. 5367-5373
    • Baldassare, J.J.1    Bi, Y.2    Bellone, C.J.3
  • 3
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433, 1990
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 4
    • 0037070047 scopus 로고    scopus 로고
    • Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-γ-activated RAW 264.7 macrophages
    • Wang J, Mazza G: Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-γ-activated RAW 264.7 macrophages. J Agric Food Chem 50: 850-857, 2002
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 850-857
    • Wang, J.1    Mazza, G.2
  • 5
    • 0028244816 scopus 로고
    • Tumor necrosis factor: A pleiotropic cytokine and therapeutic target
    • Tracey KJ, Cerami A: Tumor necrosis factor: A pleiotropic cytokine and therapeutic target. Annu Rev Med 45: 491-503, 1994
    • (1994) Annu. Rev. Med. , vol.45 , pp. 491-503
    • Tracey, K.J.1    Cerami, A.2
  • 6
    • 0034306061 scopus 로고    scopus 로고
    • Effect of bioflavonoids extracted from the bark of Pins maritima on proinflammatory cytokine IL-1 production in LPS-stimulated RAW 264.7
    • Cho KJ, Yun CH, Yoon DY, Cho YS, Rimbach G, Packer L, Chung AS: Effect of bioflavonoids extracted from the bark of Pins maritima on proinflammatory cytokine IL-1 production in LPS-stimulated RAW 264.7. Toxicol Appl Pharmacol 168: 64-71, 2000
    • (2000) Toxicol. Appl. Pharmacol. , vol.168 , pp. 64-71
    • Cho, K.J.1    Yun, C.H.2    Yoon, D.Y.3    Cho, Y.S.4    Rimbach, G.5    Packer, L.6    Chung, A.S.7
  • 7
  • 8
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls and controls
    • Nathan C, Xie QW: Nitric oxide synthases: Roles, tolls and controls. Cell 78: 915-918, 1994
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 9
    • 0023912670 scopus 로고    scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginin
    • Palmer RM, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginin. Nature (Lond) 333: 664-666, 1998
    • (1998) Nature (Lond) , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 10
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginin deaminase and imino nitrogen oxidation to nitrate
    • Hibbs JB, Taintor RR, Vavrin Z: Macrophage cytotoxicity: Role for L-arginin deaminase and imino nitrogen oxidation to nitrate. Science 235: 473-476, 1987
    • (1987) Science , vol.235 , pp. 473-476
    • Hibbs, J.B.1    Taintor, R.R.2    Vavrin, Z.3
  • 11
    • 0035119296 scopus 로고    scopus 로고
    • Inhibition of caspase 3 abrogates LPS-induced NO production by preventing activation of NF-κB and JNK/SAPK in RAW 264.7 murine macrophage cells
    • Chakravorty D, Kato Y, Sugiyama T, Koide N, Mu MM, Yoshida T, Yokochi T: Inhibition of caspase 3 abrogates LPS-induced NO production by preventing activation of NF-κB and JNK/SAPK in RAW 264.7 murine macrophage cells. Infect Immun 69: 1315-1321, 2001
    • (2001) Infect. Immun. , vol.69 , pp. 1315-1321
    • Chakravorty, D.1    Kato, Y.2    Sugiyama, T.3    Koide, N.4    Mu, M.M.5    Yoshida, T.6    Yokochi, T.7
  • 12
    • 0029054963 scopus 로고
    • Activation of Raf-1 and MAP kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events
    • Hambleton J, McMahon M, Defranco AL: Activation of Raf-1 and MAP kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med 182: 147-154, 1995
    • (1995) J. Exp. Med. , vol.182 , pp. 147-154
    • Hambleton, J.1    McMahon, M.2    Defranco, A.L.3
  • 14
    • 0034522674 scopus 로고    scopus 로고
    • LPS directly stimulates the intrapituitary IL-6 production by folliculostellate cells via specific receptors and the p38α MAPK/NF-κB pathway
    • Lohrer P, Gloddek J, Nagashima AC, Korali Z, Hopfner U, Pereda MP, Arzt E, Stalla GK, Renner U: LPS directly stimulates the intrapituitary IL-6 production by folliculostellate cells via specific receptors and the p38α MAPK/NF-κB pathway. Endocrinology 141: 4457-4465, 2000
    • (2000) Endocrinology , vol.141 , pp. 4457-4465
    • Lohrer, P.1    Gloddek, J.2    Nagashima, A.C.3    Korali, Z.4    Hopfner, U.5    Pereda, M.P.6    Arzt, E.7    Stalla, G.K.8    Renner, U.9
  • 15
    • 0034810663 scopus 로고    scopus 로고
    • Involvement of p38 MAP kinase in the inhibitory effects of phosphatidylserine liposomes on NO production form macrophages stimulated with LPS
    • Aramaki Y, Matsuno R, Tsuchiya S: Involvement of p38 MAP kinase in the inhibitory effects of phosphatidylserine liposomes on NO production form macrophages stimulated with LPS. Biochem Biophys Res Commun 280: 982-987, 2001
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 982-987
    • Aramaki, Y.1    Matsuno, R.2    Tsuchiya, S.3
  • 16
    • 0032712331 scopus 로고    scopus 로고
    • Role of oxidant stress in cytokine-induced activation of NF-κB in human aortic smooth muscle cells
    • Hoare GS, Marczin N, Chester AH, Yacoub MH: Role of oxidant stress in cytokine-induced activation of NF-κB in human aortic smooth muscle cells. Am J Physiol 277: 1975-1984, 1999
    • (1999) Am. J. Physiol. , vol.277 , pp. 1975-1984
    • Hoare, G.S.1    Marczin, N.2    Chester, A.H.3    Yacoub, M.H.4
  • 17
    • 0035193217 scopus 로고    scopus 로고
    • Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages
    • Angeliki X, Andreas P, Antinis M, Michalis E, Theodore F, Charis R: Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 296: 181-187, 2001
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 181-187
    • Angeliki, X.1    Andreas, P.2    Antinis, M.3    Michalis, E.4    Theodore, F.5    Charis, R.6
  • 18
    • 0034578521 scopus 로고    scopus 로고
    • Comparative studies on the suppression of NO synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NF-κB activation in macrophages
    • Pan MH, Shiau SY, Lin JK: Comparative studies on the suppression of NO synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NF-κB activation in macrophages. Biochem Pharmacol 60: 1665-1676, 2000
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1665-1676
    • Pan, M.H.1    Shiau, S.Y.2    Lin, J.K.3
  • 19
    • 0034694870 scopus 로고    scopus 로고
    • Bioflavonoid quercetin inhibit mitosis and apoptosis of glomerular cells in vitro and vivo
    • Yoshihisa I, Kitamura M: Bioflavonoid quercetin inhibit mitosis and apoptosis of glomerular cells in vitro and vivo. Biochem Biophys Res Commun 297: 629-634, 2000
    • (2000) Biochem. Biophys. Res. Commun. , vol.297 , pp. 629-634
    • Yoshihisa, I.1    Kitamura, M.2
  • 20
    • 0031969571 scopus 로고    scopus 로고
    • Effect of antioxidants, resversatol, quercetin, and n-actetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupper cells
    • Kawada N, Seki S, Inoue M, Kuroki T: Effect of antioxidants, resversatol, quercetin, and n-actetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupper cells. Hepatology 27: 1256-1274, 1998
    • (1998) Hepatology , vol.27 , pp. 1256-1274
    • Kawada, N.1    Seki, S.2    Inoue, M.3    Kuroki, T.4
  • 22
    • 0031003969 scopus 로고    scopus 로고
    • Ginko biloba extract (Egb 761): Inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7
    • Kobuchi H, Droy-Lefaix MT, Christen Y, Packer L: Ginko biloba extract (Egb 761): Inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7. Biochem Pharmacol 53: 897-903, 1997
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 897-903
    • Kobuchi, H.1    Droy-Lefaix, M.T.2    Christen, Y.3    Packer, L.4
  • 23
    • 0023897154 scopus 로고    scopus 로고
    • Differential effects of flavonoids as inhibitors of tyrosine protein kinase and serine/threonine protein kinases
    • Hagiwara M, Inoue S, Tanada T, Nunoki K, Ito M, Hidaka H: Differential effects of flavonoids as inhibitors of tyrosine protein kinase and serine/threonine protein kinases. Biochem Pharmacol 37:2987-2992, 1998
    • (1998) Biochem. Pharmacol. , vol.37 , pp. 2987-2992
    • Hagiwara, M.1    Inoue, S.2    Tanada, T.3    Nunoki, K.4    Ito, M.5    Hidaka, H.6
  • 24
    • 0030945675 scopus 로고    scopus 로고
    • Molecular mechanisms in the antiproliferative action of quercetin
    • Csokay B, Prajda N, Weber G, Olah E: Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60: 2157-2163, 1997
    • (1997) Life Sci. , vol.60 , pp. 2157-2163
    • Csokay, B.1    Prajda, N.2    Weber, G.3    Olah, E.4
  • 25
    • 0030800625 scopus 로고    scopus 로고
    • Effects of tryphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase
    • Ruetten H, Thiemermann C: Effects of tryphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase. Br J Pharmacol 122: 59-70, 1997
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 59-70
    • Ruetten, H.1    Thiemermann, C.2
  • 28
    • 0030770782 scopus 로고    scopus 로고
    • Unexpected protection of glomerular mesangial cells from oxidant-triggered apoptosis by bioflavonoid quercetin
    • Yokoo T, Kitamura M: Unexpected protection of glomerular mesangial cells from oxidant-triggered apoptosis by bioflavonoid quercetin. Am J Physiol 273: 206-212, 1997
    • (1997) Am. J. Physiol. , vol.273 , pp. 206-212
    • Yokoo, T.1    Kitamura, M.2
  • 29
    • 0028786336 scopus 로고
    • Transcriptional regulation by MAP kinase
    • Davis RJ: Transcriptional regulation by MAP kinase. Mol Reprod Dev 42: 459-472, 1995
    • (1995) Mol. Reprod. Dev. , vol.42 , pp. 459-472
    • Davis, R.J.1
  • 30
    • 0029664650 scopus 로고    scopus 로고
    • Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms
    • Lee JC, Young PR: Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J Leuk Biol 59: 152-157, 1996
    • (1996) J. Leuk. Biol. , vol.59 , pp. 152-157
    • Lee, J.C.1    Young, P.R.2
  • 31
    • 0033136947 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in IL-1β transcription
    • Joseph JB, Yanhua B, Clifford JB: The role of p38 mitogen-activated protein kinase in IL-1β transcription. J Immunol 162: 5367-5373, 1999
    • (1999) J. Immunol. , vol.162 , pp. 5367-5373
    • Joseph, J.B.1    Yanhua, B.2    Clifford, J.B.3
  • 32
    • 0027325770 scopus 로고
    • Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages
    • Dong Z, Qi X, Fidler IJ: Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J Immunol 151: 2717-2724, 1993
    • (1993) J. Immunol. , vol.151 , pp. 2717-2724
    • Dong, Z.1    Qi, X.2    Fidler, I.J.3
  • 33
    • 0034660627 scopus 로고    scopus 로고
    • Regulation of TNF expression by multiple mitogen-activated protein kinase pathway
    • Wei Z, Jocelyn SD, Jun G, Franco DP, Hermann G, Jiahuai H: Regulation of TNF expression by multiple mitogen-activated protein kinase pathway. J Immunol 163: 6349-6358, 2000
    • (2000) J. Immunol. , vol.163 , pp. 6349-6358
    • Wei, Z.1    Jocelyn, S.D.2    Jun, G.3    Franco, D.P.4    Hermann, G.5    Jiahuai, H.6
  • 34
    • 0029983730 scopus 로고    scopus 로고
    • The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
    • Beyaert R, Cuenda A, Vanden BW, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W: The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 15: 1914-1923, 1996
    • (1996) EMBO. J. , vol.15 , pp. 1914-1923
    • Beyaert, R.1    Cuenda, A.2    Vanden, B.W.3    Plaisance, S.4    Lee, J.C.5    Haegeman, G.6    Cohen, P.7    Fiers, W.8
  • 35
    • 0031985903 scopus 로고    scopus 로고
    • Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/44 mitogen-activated protein kinases
    • Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BM, Brennan FM: Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 160: 920-928, 1998
    • (1998) J. Immunol. , vol.160 , pp. 920-928
    • Foey, A.D.1    Parry, S.L.2    Williams, L.M.3    Feldmann, M.4    Foxwell, B.M.5    Brennan, F.M.6
  • 36
    • 0034629364 scopus 로고    scopus 로고
    • The differential time-course of ERK activity correlates with macrophage response toward proliferation or activation
    • Annabel FV, Monica C, Jordi X, Antonio C: The differential time-course of ERK activity correlates with macrophage response toward proliferation or activation. J Biol Chem 275: 7403-7409, 2000
    • (2000) J. Biol. Chem. , vol.275 , pp. 7403-7409
    • Annabel, F.V.1    Monica, C.2    Jordi, X.3    Antonio, C.4
  • 38
    • 0029090620 scopus 로고
    • Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor α
    • Prichett W, Hand A, Sheilds J, Dunnington D: Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor α. J Inflamm 45: 97-105, 1995
    • (1995) J. Inflamm. , vol.45 , pp. 97-105
    • Prichett, W.1    Hand, A.2    Sheilds, J.3    Dunnington, D.4
  • 39
    • 0033561579 scopus 로고    scopus 로고
    • Effect of the wine polyphenolics quercetin and resversatol on proinflammatory cytokine expression in RAW 264.7 macrophage
    • Teri LW, Dennis RK: Effect of the wine polyphenolics quercetin and resversatol on proinflammatory cytokine expression in RAW 264.7 macrophage. Biochem Pharmacol 57: 941-949, 1999
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 941-949
    • Teri, L.W.1    Dennis, R.K.2
  • 40
    • 0032411659 scopus 로고    scopus 로고
    • Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model
    • Yang F, Villiers WJ, McClain CJ, Varilek GW: Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model. J Nutr 128: 2334-2340, 1998
    • (1998) J. Nutr. , vol.128 , pp. 2334-2340
    • Yang, F.1    Villiers, W.J.2    McClain, C.J.3    Varilek, G.W.4


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