Polyphenols as potential therapeutical agents against cardiovascular diseases

Pharmacological Reports

Volumn 57, Issue SUPPL., 2005, Pages 97-107

  Curin, Yann ^a,b   Andriantsitohaina, Ramaroson ^a  

^a CNRS   (France)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Antioxidant; Cardiovascular diseases; Endothelial function; NO; Polyphenols

Indexed keywords

ALPHA TOCOPHEROL; ANTHOCYANIN; ASCORBIC ACID; CAROTENOID; CATECHIN; CURCUMIN; DELPHINIDIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FLAVANOL DERIVATIVE; FLAVONOID; FLAVONOID GLYCOSIDE; FLAVONOL DERIVATIVE; FREE RADICAL; HYDROGEN PEROXIDE; KAEMPFEROL; LOW DENSITY LIPOPROTEIN; MYRICETIN; NITRIC OXIDE; PHENOL DERIVATIVE; POLYPHENOL DERIVATIVE; PROCYANIDIN DERIVATIVE; QUERCETIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SCAVENGER; SUPEROXIDE DISMUTASE; UNINDEXED DRUG; XANTHINE OXIDASE;

ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; BLOOD VESSEL TONE; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CELL ADHESION; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CEREBROVASCULAR ACCIDENT; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HOMEOSTASIS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; LIPID OXIDATION; LIPID PEROXIDATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REVIEW; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM;

EID: 33645702096     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Review

References (107)

1. Abu-Amsha R, Croft KD, Puddey IB, Proudfoot JM, Beilin LJ: Phenolic content of various beverages determines the extent of inhibition of human serum and low-density lipoprotein oxidation in vitro: identification and mechanism of action of some cinnamic acid derivatives from red wine. Clin Sci (Lond), 1996, 91, 449-458.
2. Akimoto S, Mitsumata M, Sasaguri T, Yoshida Y: Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/Waf1). Circ Res, 2000, 86, 185-190.
3. Andriambeloson E, Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R: Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol, 1997, 120, 1053-1058.
4. Andriambeloson E, Stoclet JC and Andriantsitohaina R: Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol, 1999, 33, 248-254.
5. Aviram M, Rosenblat M: Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor. J Lipid Res, 1994, 35, 385-398.
6. Badia E, Sacanella E, Fernandez-Sola J, Nicolas JM, Antunez E, Rotilio D, de Gaetano G et al.: Decreased tumor necrosis factor-induced adhesion of human monocytes to endothelial cells after moderate alcohol consumption. Am J Clin Nutr, 2004, 80, 225-230.
7. Balentine DA, Wiseman SA, Bouwens LC: The chemistry of tea flavonoids. Crit Rev Food Sci Nutr, 1997, 37, 693-704.
8. Bazzoni G and Dejana E: Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev, 2004, 84, 869-901.
9. Becker BF, Heindl B, Kupatt C, Zahler S: Endothelial function and hemostasis. Z Kardiol, 2000, 89, 160-167.
10. Beretz A, Anton R, Cazenave JP: The effects of flavonoids on cyclic nucleotide phosphodiesterases. Prog Clin Biol Res, 1986, 213, 281-296.
11. Beretz A, Briancon-Scheid F, Stierle A, Corre G, Anton R, Cazenave JP: Inhibition of human platelet cyclic AMP phosphodiesterase and of platelet aggregation by a hemisynthetic flavonoid, amentoflavone hexaacetate. Biochem Pharmacol, 1986, 35, 257-262.
12. Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R: Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol, 2002, 282, H942-948.
13. Binsack R, Boersma BJ, Patel RP, Kirk M, White CR, Darley-Usmar V, Barnes S et al.: Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acid. Alcohol Clin Exp Res, 2001, 25, 434-443.
14. Bogatcheva NV, Garcia JG, Verin AD: Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc), 2002, 67, 75-84.
15. Brookes PS, Digerness SB, Parks DA, Darley-Usmar V: Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radic Biol Med, 2002, 32, 1220-1228.
16. Brown AA, Hu FB: Dietary modulation of endothelial function: implications for cardiovascular disease. Am J Clin Nutr, 2001, 73, 673-686.
17. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS et al.: Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood, 1998, 91, 3527-3561.
18. Cordova AC, Jackson LS, Berke-Schlessel DW, Sumpio BE: The cardiovascular protective effect of red wine. J Am Coll Surg, 2005, 200, 428-439.
19. Cotelle N, Bernier JL, Catteau JP, Pommery J, Wallet JC, Gaydou EM: Antioxidant properties of hydroxy-flavones. Free Radic Biol Med, 1996, 20, 35-43.
20. Cui J, Cordis GA, Tosaki A, Maulik N, Das DK: Reduction of myocardial ischemia reperfusion injury with regular consumption of grapes. Ann N Y Acad Sci, 2002, 957, 302-307.
21. Curin Y, Ratajczak P, Dupont A, Ritz M-F, Mendelowitsch A, Pinet F, Andriantsitohaina R: Identification par analyse protéomique des dţerminants moléculaires de la neuroprotection induite par les polyphenols dands l'ischémie cérébrale. Arch Mal Coeur Vaiss, 2005, 98, 392.
22. Curin Y, Ritz M-F, Cam E, Andriantsitohaina R, Mendelowitsch A: Chronic treatment witn Red Wine Polyphenolic Compounds protects against vascular and neuronal excito-toxicity in response to focal cerebral ischemia in male rats. Arch Mal Coeur Vaiss, 2004, 97, 417.
23. de Gaetano G, De Curtis A, di Castelnuovo A, Donati MB, Iacoviello L, Rotondo S: Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption. Ann N Y Acad Sci, 2002, 957, 174-188.
24. de Lorgeril M, Salen P, Martin JL, Boucher F, Paillard F, de Leiris J: Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction. Circulation, 2002, 106, 1465-1469.
25. de Rijke YB, Demacker PN, Assen NA, Sloots LM, Katan MB, Stalenhoef AF: Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. Am J Clin Nutr, 1996, 63, 329-334.
26. Dell'Agli M, Galli GV, Vrhovsek U, Mattivi F, Bosisio E: In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes. J Agric Food Chem, 2005, 53, 1960-1965.
27. Demrow HS, Slane PR, Folts JD: Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation, 1995, 91, 1182-1188.
28. Diebolt M, Bucher B, Andriantsitohaina R: Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension, 2001, 38, 159-165.
29. Dimmeler S, Haendeler J, Galle J, Zeiher AM: Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation, 1997, 95, 1760-1763.
30. Dreosti IE: Bioactive ingredients: antioxidants and polyphenols in tea. Nutr Rev, 1996, 54, S51-58.
31. Duarte J, Andriambeloson E, Diebolt M, Andriantsitohaina R: Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol Res, 2004, 53, 595-602.
32. Elbaz M, Roul G, Alvčs A, Andriantsitohaina R: Provinols, a polyphenolic extract of red wine inhibits in-stent neointimal growth in cholesterol-fed rabbit. Arch Mal Coeur Vaiss, 2005, 98, 406.
33. Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G: Effects of resveratrol on human immune cell function. Life Sci, 2001, 70, 81-96.
34. Feletou M, Vanhoutte PM: Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol, 1988, 93, 515-524.
35. Feng AN, Chen YL, Chen YT, Ding YZ, Lin SJ: Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits. Circulation, 1999, 100, 2254-2259.
36. Ferrandiz ML, Alcaraz MJ: Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions, 1991, 32, 283-288.
37. Ferrara LA, Raimondi AS, d'Episcopo L, Guida L, Dello Russo A, Marotta T: Olive oil and reduced need for antihypertensive medications. Arch Intern Med, 2000, 160, 837-842.
38. Fitzpatrick DF, Hirschfield SL, Coffey RG: Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol, 1993, 265, H774-778.
39. Frankel EN, Waterhouse AL, Kinsella JE: Inhibition of human LDL oxidation by resveratrol. Lancet, 1993, 341, 1103-1104.
40. Fuhrman B, Aviram M: Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol, 2001, 12, 41-48.
41. Fuhrman B, Lavy A, Aviram M: Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr, 1995, 61, 549-554.
42. Fuhrman B, Volkova N, Suraski A, Aviram M: White wine with red wine-like properties: increased extraction of grape skin polyphenols improves the antioxidant capacity of the derived white wine. J Agric Food Chem, 2001, 49, 3164-3168.
43. Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 1980, 288, 373-376.
44. Geleijnse JM, Launer LJ, Van der Kuip DA, Hofman A, Witteman JC: Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr, 2002, 75, 880-886.
45. Hertog MG, Hollman PC, Katan MB, Kromhout D: Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer, 1993, 20, 21-29.
46. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA, 1987, 84, 9265-9269.
47. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB: Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol, 1999, 163, 3474-3483.
48. Justesen U, Knuthsen P, Leth T: Determination of plant polyphenols in Danish foodstuffs by HPLC-UV and LC-MS detection. Cancer Lett, 1997, 114, 165-167.
49. Kim HP, Mani I, Iversen L, Ziboh VA: Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins Leukot Essent Fatty Acids, 1998, 58, 17-24.
50. Korkina LG, Afanas'ev IB: Antioxidant and chelating properties of flavonoids. Adv Pharmacol, 1997, 38, 151-163.
51. Krinsky NI: Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med, 1992, 200, 248-254.
52. Kuhnau J: The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet, 1976, 24, 117-191.
53. Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B: Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol, 1991, 42, 1673-1681.
54. Leikert JF, Rathel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM: Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation, 2002, 106, 1614-1617.
55. Li HF, Chen SA, Wu SN: Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells. Cardiovasc Res, 2000, 45, 1035-1045.
56. Lugnier C, Schini VB: Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells. Biochem Pharmacol, 1990, 39, 75-84.
57. Luscher TF, Barton M: Biology of the endothelium. Clin Cardiol, 1997, 20, II-3-10.
58. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr, 2004, 79, 727-747.
59. Martin S, Andriambeloson E, Takeda K, Andriantsitohaina R: Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br J Pharmacol, 2002, 135, 1579-1587.
60. Martin S, Giannone G, Andriantsitohaina R, Martinez MC: Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br J Pharmacol, 2003, 139, 1095-1102.
61. Martinez J, Moreno JJ: Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem Pharmacol, 2000, 59, 865-70.
62. Matsuo S, Nakamura Y, Takahashi M, Ouchi Y, Hosoda K, Nozawa M, Kinoshita M: Effect of red wine and ethanol on production of nitric oxide in healthy subjects. Am J Cardiol, 2001, 87, 1029-1031, A6.
63. Matz R, Andriantsitohaina R: Age-related endothelial dysfunction: potential implications for pharmacotherapy. Drugs Aging, 2003, 20, 527-550.
64. 2+ ATPase by quercetin. J Biol Chem, 1996, 271, 24517-24525.
65. Middleton E Jr, Kandaswami C, Theoharides TC: The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev, 2000, 52, 673-751.
66. Moncada S, Vane JR: Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev, 1978, 30, 293-331.
67. Naissides M, Mamo JC, James AP, Pal S: The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women. Atherosclerosis, 2005 (in press).
68. Nam S, Smith DM, Dou QP: Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis. Cancer Epidemiol Biomarkers Prev, 2001, 10, 1083-1088.
69. Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB: Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. Faseb J, 2005, 19, 455-457.
70. Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA: Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr, 2001, 74, 418-425.
71. Ning XH, Ding X, Childs KF, Bolling SF, Gallagher KP: Flavone improves functional recovery after ischemia in isolated reperfused rabbit hearts. J Thorac Cardiovasc Surg, 1993, 105, 541-549.
72. O'Reilly JD, Mallet AI, McAnlis GT, Young IS, Halliwell B, Sanders TA, Wiseman H: Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am J Clin Nutr, 2001, 73, 1040-1044.
73. Orallo F, Alvarez E, Camina M, Leiro JM, Gomez E, Fernandez P: The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol, 2002, 61, 294-302.
74. Ou HC, Chou FP, Sheen HM, Lin TM, Yang CH, Huey-Herng Sheu W: Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells. Clin Chim Acta, 2005 (in press).
75. Pan MH, Liang YC, Lin-Shiau SY, Zhu NQ, Ho CT, Lin JK: Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. J Agric Food Chem, 2000, 48, 6337-6346.
76. Pannala AS, Rice-Evans CA, Halliwell B, Singh S: Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols. Biochem Biophys Res Commun, 1997, 232, 164-168.
77. Parthasarathy S, Printz DJ, Boyd D, Joy L, Steinberg D: Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis, 1986, 6, 505-510.
78. Patel KD, Cuvelier SL, Wiehler S: Selectins: critical mediators of leukocyte recruitment. Semin Immunol, 2002, 14, 73-81.
79. Pearson JD: Endothelial cell function and thrombosis. Baillieres Best Pract Res Clin Haematol, 1999, 12, 329-341.
80. Pechanova O, Bernatova II, Babal P, Martinez MC, Kysela S, Stvrtina S, Andriantsitohaina R: Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens, 2004, 22, 1551-1559.
81. Preissner KT, Nawroth PP, Kanse SM: Vascular protease receptors: integrating haemostasis and endothelial cell functions. J Pathol, 2000, 190, 360-372.
82. Pries AR, Secomb TW, Gaehtgens P: The endothelial surface layer. Pflugers Arch, 2000, 440, 653-666.
83. Ranaivo HR, Diebolt M, Andriantsitohaina R: Wine polyphenols induce hypotension, and decrease cardiac reactivity and infarct size in rats: involvement of nitric oxide. Br J Pharmacol, 2004, 142, 671-678.
84. Raza H, John A: Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol Appl Pharmacol, 2005, 207, 212-220.
85. Rechner AR, Kroner C: Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function. Thromb Res, 2005, 116, 327-234.
86. Rein D, Paglieroni TG, Pearson DA, Wun T, Schmitz HH, Gosselin R, Keen CL: Cocoa and wine polyphenols modulate platelet activation and function. J Nutr, 2000, 130, 2120S-2126S.
87. Rice-Evans CA, Miller NJ, Structure-antioxidant activity relationships of flavonoids and isoflavonoids. In: Flavonoids in Health and Disease. Marcell Dekker, Inc., New York, 1998, 199-238.
88. Rice-Evans CA, Miller NJ, Paganga G: Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med, 1996, 20, 933-956.
89. Rubio AR, Morales-Segura MA: Nitric oxide, an iceberg in cardiovascular physiology: far beyond vessel tone control. Arch Med Res, 2004, 35, 1-11.
90. usso P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C: Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation. Nutr Metab Cardiovasc Dis, 2001, 11, 25-29.
91. Sato M, Ray PS, Maulik G, Maulik N, Engelman RM, Bertelli AA, Bertelli A, Das DK: Myocardial protection with red wine extract. J Cardiovasc Pharmacol, 2000, 35, 263-268.
92. Shutenko Z, Henry Y, Pinard E, Seylaz J, Potier P, Berthet F, Girard P, Sercombe R: Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion. Biochem Pharmacol, 1999, 57, 199-208.
93. Sies H: Oxidative stress: from basic research to clinical application. Am J Med, 1991, 91, 31S-38S.
94. Simonyi A, Wang Q, Miller RL, Yusof M, Shelat PB, Sun AY, Sun GY: Polyphenols in cerebral ischemia: novel targets for neuroprotection. Mol Neurobiol, 2005, 31, 135-148.
95. Spencer JP, Schroeter H, Kuhnle G, Srai SK, Tyrrell RM, Hahn U, Rice-Evans C: Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation. Biochem J, 2001, 354, 493-500.
96. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD: Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation, 1999, 100, 1050-1055.
97. Szende B, Tyihak E, Kiraly-Veghely Z: Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Exp Mol Med, 2000, 32, 88-92.
98. Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, Kofler R et al.: Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. Faseb J, 2001, 15, 1613-1615.
99. Toborek M, Kaiser S: Endothelial cell functions. Relationship to atherogenesis. Basic Res Cardiol, 1999, 94, 295-314.
100. Ulbricht TL, Southgate DA: Coronary heart disease: seven dietary factors. Lancet, 1991, 338, 985-992.
101. Vieira O, Escargueil-Blanc I, Meilhac O, Basile JP, Laranjinha J, Almeida L, Salvayre R, Negre-Salvayre A: Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL. Br J Pharmacol, 1998, 123, 565-573.
102. Vinson JA, Teufel K, Wu N: Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis, 2001, 156, 67-72.
103. Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, Forstermann U: Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation, 2002, 106, 1652-1658.
104. Wang Q, Simonyi A, Li W, Sisk BA, Miller RL, Macdonald RS, Lubahn DE et al.: Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbils. Mol Nutr Food Res, 2005 (in press).
105. Zenebe W, Pechanova O, Andriantsitohaina R: Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity. Physiol Res, 2003, 52, 425-432.
106. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML: Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr, 2005, 135, 1911-1917.
107. Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, Ledda F: Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest, 1994, 94, 2036-2044.