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Volumn 101, Issue 6, 2009, Pages 886-894

Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: Randomized controlled trial

Author keywords

Blood pressure; Cardiovascular disease; Catechin; Obesity; Type 2 diabetes

Indexed keywords

EPIGALLOCATECHIN GALLATE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LACTOSE; LOW DENSITY LIPOPROTEIN; PLACEBO;

EID: 67649422274     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508047727     Document Type: Article
Times cited : (216)

References (55)
  • 1
    • 33645474277 scopus 로고    scopus 로고
    • Insulin resistance - a common link between type 2 diabetes and cardiovascular disease
    • Lebovitz HE (2006) Insulin resistance - a common link between type 2 diabetes and cardiovascular disease. Diabetes Obes Metab 8, 237-249.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 237-249
    • Lebovitz, H.E.1
  • 2
    • 34547679576 scopus 로고    scopus 로고
    • Tea polyphenols for health promotion
    • Kahn N & Mukhtar H (2007) Tea polyphenols for health promotion. Life Sci 81, 519-533.
    • (2007) Life Sci , vol.81 , pp. 519-533
    • Kahn, N.1    Mukhtar, H.2
  • 4
    • 0036866660 scopus 로고    scopus 로고
    • Beneficial effects of tea catechins on diet-induced obesity: Stimulation of lipid catabolism in the liver
    • Murase T, Nagasawa A, Suzuki J, Hase T & Tokimitsu I (2002) Beneficial effects of tea catechins on diet-induced obesity: Stimulation of lipid catabolism in the liver. Int J Obes 26, 1459-1464.
    • (2002) Int J Obes , vol.26 , pp. 1459-1464
    • Murase, T.1    Nagasawa, A.2    Suzuki, J.3    Hase, T.4    Tokimitsu, I.5
  • 5
    • 2442686532 scopus 로고    scopus 로고
    • Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model
    • Wu LY, Juan CC, Hwang LS, Hsu YP, Ho PH & Ho LT (2004) Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr 43, 116-124.
    • (2004) Eur J Nutr , vol.43 , pp. 116-124
    • Wu, L.Y.1    Juan, C.C.2    Hwang, L.S.3    Hsu, Y.P.4    Ho, P.H.5    Ho, L.T.6
  • 6
    • 0842284665 scopus 로고    scopus 로고
    • Effect of green tea supplementation on insulin sensitivity in SpragueDawley rats
    • Wu LY, Juan CC, Ho LT, Hsu YP & Hwang LS (2004) Effect of green tea supplementation on insulin sensitivity in SpragueDawley rats. J Agric Food Chem 52, 643-648.
    • (2004) J Agric Food Chem , vol.52 , pp. 643-648
    • Wu, L.Y.1    Juan, C.C.2    Ho, L.T.3    Hsu, Y.P.4    Hwang, L.S.5
  • 8
    • 12944291304 scopus 로고    scopus 로고
    • Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans
    • Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T & Kimura I (2004) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol 4, 18.
    • (2004) BMC Pharmacol , vol.4 , pp. 18
    • Tsuneki, H.1    Ishizuka, M.2    Terasawa, M.3    Wu, J.B.4    Sasaoka, T.5    Kimura, I.6
  • 9
    • 0034117424 scopus 로고    scopus 로고
    • Insulinlike biological activity of culinary and medicinal plant aqueous extracts in vitro
    • Broadhurst CL, Polansky MM & Anderson RA (2000) Insulinlike biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 48, 849-852.
    • (2000) J Agric Food Chem , vol.48 , pp. 849-852
    • Broadhurst, C.L.1    Polansky, M.M.2    Anderson, R.A.3
  • 13
    • 0036779369 scopus 로고    scopus 로고
    • A green tea-derived polyphenol, epigallocatechin- 3-gallate, inhibits I kappa B kinase activation and IL-8 gene expression in respiratory epithelium
    • Chen PC, Wheeler DS, Malhotra V, Odoms K, Denenberg AG & Wong HR (2002) A green tea-derived polyphenol, epigallocatechin- 3-gallate, inhibits I kappa B kinase activation and IL-8 gene expression in respiratory epithelium. Inflammation 26, 233-241.
    • (2002) Inflammation , vol.26 , pp. 233-241
    • Chen, P.C.1    Wheeler, D.S.2    Malhotra, V.3    Odoms, K.4    Denenberg, A.G.5    Wong, H.R.6
  • 14
    • 0033976073 scopus 로고    scopus 로고
    • Suppression of lipopolysaccharide-induced nuclear factor-kappa B activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of I kappa B kinase activity in macrophages
    • Pan MH, Lin-Shiau SY, Ho CT, Lin JH & Lin JK (2000) Suppression of lipopolysaccharide-induced nuclear factor-kappa B activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of I kappa B kinase activity in macrophages. Biochem Pharmacol 59, 357-367.
    • (2000) Biochem Pharmacol , vol.59 , pp. 357-367
    • Pan, M.H.1    Lin-Shiau, S.Y.2    Ho, C.T.3    Lin, J.H.4    Lin, J.K.5
  • 15
    • 0034859081 scopus 로고    scopus 로고
    • The green tea polyphenol (-)-epigallocatechin- 3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
    • Yang FJ, Oz HS, Barve S, De Villiers WJS, McClain CJ & Varilek GW (2001) The green tea polyphenol (-)-epigallocatechin- 3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60, 528-533.
    • (2001) Mol Pharmacol , vol.60 , pp. 528-533
    • Yang, F.J.1    Oz, H.S.2    Barve, S.3    De Villiers, W.J.S.4    McClain, C.J.5    Varilek, G.W.6
  • 16
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and dietinduced insulin resistance
    • Shoelson SE, Lee J & Yuan M (2003) Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and dietinduced insulin resistance. Int J Obes 27, S49-S52.
    • (2003) Int J Obes , vol.27
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 17
    • 33845947091 scopus 로고    scopus 로고
    • Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappa B in db/ db mice
    • Tamura Y, Ogihara T, Uchida T, et al. (2007) Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappa B in db/ db mice. Diabetologia 50, 131-141.
    • (2007) Diabetologia , vol.50 , pp. 131-141
    • Tamura, Y.1    Ogihara, T.2    Uchida, T.3
  • 18
    • 32044438645 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain
    • Adachi N, Tomonaga S, Tachibana T, Denbow DM & Furuse M (2006) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain. Eur J Pharmacol 531, 171-175.
    • (2006) Eur J Pharmacol , vol.531 , pp. 171-175
    • Adachi, N.1    Tomonaga, S.2    Tachibana, T.3    Denbow, D.M.4    Furuse, M.5
  • 20
    • 0021813187 scopus 로고
    • Homeostasis model assessment - insulin resistance and beta-cell function from fasting plasma-glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC (1985) Homeostasis model assessment - insulin resistance and beta-cell function from fasting plasma-glucose and insulin concentrations in man. Diabetologia 28, 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 21
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing - comparison with the euglycemic insulin clamp
    • Matsuda M & DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing - comparison with the euglycemic insulin clamp. Diabetes Care 22, 1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 22
    • 0028204065 scopus 로고
    • Understanding oral glucose-tolerance - comparison of glucose or insulin measurements during the oral glucose-tolerance test with specific measurements of insulin-resistance and insulin-secretion
    • Phillips DIW, Clark PM, Hales CN & Osmond C (1994) Understanding oral glucose-tolerance - comparison of glucose or insulin measurements during the oral glucose-tolerance test with specific measurements of insulin-resistance and insulin-secretion. Diabetes Med 11, 286-292.
    • (1994) Diabetes Med , vol.11 , pp. 286-292
    • Phillips, D.I.W.1    Clark, P.M.2    Hales, C.N.3    Osmond, C.4
  • 23
    • 0029549344 scopus 로고
    • Measurement of diet in a large national survey: Comparison of computerised and manual coding in household measures
    • Price GM, Paul AA, Key FB, Harter AC, Cole TJ, Day KC & Wadsworth MEJ (1995) Measurement of diet in a large national survey: Comparison of computerised and manual coding in household measures. J Hum Nutr Diet 8, 417-428.
    • (1995) J Hum Nutr Diet , vol.8 , pp. 417-428
    • Price, G.M.1    Paul, A.A.2    Key, F.B.3    Harter, A.C.4    Cole, T.J.5    Day, K.C.6    Wadsworth, M.E.J.7
  • 24
    • 0006016803 scopus 로고    scopus 로고
    • Foods Standards Agency , 6th ed. Cambridge: Royal Society of Chemistry
    • Foods Standards Agency (2002) McCance and Widdowson's The Composition of Food, 6th ed. Cambridge: Royal Society of Chemistry.
    • (2002) McCance and Widdowson's The Composition of Food
  • 25
    • 85004720978 scopus 로고
    • Refining the measurement of mood - the UWIST mood adjective checklist
    • Matthews G, Jones DM & Chamberlain AG (1990) Refining the measurement of mood - the UWIST mood adjective checklist. Br J Psychol 81, 17-42.
    • (1990) Br J Psychol , vol.81 , pp. 17-42
    • Matthews, G.1    Jones, D.M.2    Chamberlain, A.G.3
  • 26
    • 0023832668 scopus 로고
    • GSRS - a clinical rating-scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic-ulcer disease
    • Svedlund J, Sjodin I & Dotevall G (1988) GSRS - a clinical rating-scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic-ulcer disease. Digest Dis Sci 33, 129-134.
    • (1988) Digest Dis Sci , vol.33 , pp. 129-134
    • Svedlund, J.1    Sjodin, I.2    Dotevall, G.3
  • 27
    • 0027180608 scopus 로고
    • How good a marker is insulin level for insulin-resistance
    • Laakso M (1993) How good a marker is insulin level for insulin-resistance. Am J Epidemiol 137, 959-965.
    • (1993) Am J Epidemiol , vol.137 , pp. 959-965
    • Laakso, M.1
  • 28
    • 0242300698 scopus 로고    scopus 로고
    • Follow-up report on the diagnosis of diabetes mellitus
    • Genuth S, Alberti KGMM, Bennett P, et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26, 3160-3167.
    • (2003) Diabetes Care , vol.26 , pp. 3160-3167
    • Genuth, S.1    Alberti, K.G.M.M.2    Bennett, P.3
  • 29
    • 0037196138 scopus 로고    scopus 로고
    • Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom
    • Khokhar S & Magnusdottir SGM (2002) Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom. J Agric Food Chem 50, 565-570.
    • (2002) J Agric Food Chem , vol.50 , pp. 565-570
    • Khokhar, S.1    Magnusdottir, S.G.M.2
  • 30
    • 28444478321 scopus 로고    scopus 로고
    • Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers
    • Fukino Y, Shimbo M, Aoki N, Okubo T & Iso H (2005) Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol 51, 335-342.
    • (2005) J Nutr Sci Vitaminol , vol.51 , pp. 335-342
    • Fukino, Y.1    Shimbo, M.2    Aoki, N.3    Okubo, T.4    Iso, H.5
  • 31
    • 67649426376 scopus 로고    scopus 로고
    • Fukino, Y, Ikeda A, Maruyama K, Aoki N, Okubo T & Iso H (2007) Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur J Clin Nutr (Epublication ahead of print version 6 June 2007).
    • Fukino, Y, Ikeda A, Maruyama K, Aoki N, Okubo T & Iso H (2007) Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur J Clin Nutr (Epublication ahead of print version 6 June 2007).
  • 32
    • 29344455268 scopus 로고    scopus 로고
    • Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome - a randomized placebo-controlled trial
    • Chan CCW, Koo MWL, Ng EHY, Tang OS, Yeung WSB & Ho PC (2006) Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome - a randomized placebo-controlled trial. J Soc Gynecol Invest 13, 63-68.
    • (2006) J Soc Gynecol Invest , vol.13 , pp. 63-68
    • Chan, C.C.W.1    Koo, M.W.L.2    Ng, E.H.Y.3    Tang, O.S.4    Yeung, W.S.B.5    Ho, P.C.6
  • 34
    • 33749446855 scopus 로고    scopus 로고
    • Metabolism of green tea catechins: An overview
    • Feng WY (2006) Metabolism of green tea catechins: An overview. Curr Drug Metab 7, 755-809.
    • (2006) Curr Drug Metab , vol.7 , pp. 755-809
    • Feng, W.Y.1
  • 35
    • 0037144406 scopus 로고    scopus 로고
    • Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production
    • Waltner-Law ME, Wang XHL, Law BK, Hall RK, Nawano M & Granner DK (2002) Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 277, 34933-34940.
    • (2002) J Biol Chem , vol.277 , pp. 34933-34940
    • Waltner-Law, M.E.1    Wang, X.H.L.2    Law, B.K.3    Hall, R.K.4    Nawano, M.5    Granner, D.K.6
  • 36
    • 0028927046 scopus 로고
    • Implications of small reductions in diastolic blood-pressure for primary prevention
    • Cook NR, Cohen J, Hebert PR, Taylor JO & Hennekens CH (1995) Implications of small reductions in diastolic blood-pressure for primary prevention. Arch Intern Med 155, 701-709.
    • (1995) Arch Intern Med , vol.155 , pp. 701-709
    • Cook, N.R.1    Cohen, J.2    Hebert, P.R.3    Taylor, J.O.4    Hennekens, C.H.5
  • 37
    • 3242784737 scopus 로고    scopus 로고
    • The protective effect of habitual tea consumption on hypertension
    • Yang YC, Lu FH, Wu JS, Wu CH & Chang CJ (2004) The protective effect of habitual tea consumption on hypertension. Arch Intern Med 164 1534-1540.
    • (2004) Arch Intern Med , vol.164 , pp. 1534-1540
    • Yang, Y.C.1    Lu, F.H.2    Wu, J.S.3    Wu, C.H.4    Chang, C.J.5
  • 38
    • 0021262815 scopus 로고
    • Reduction of chronic psychosocial hypertension in mice by decaffeinated tea
    • Henry JP & Stephenslarson P (1984) Reduction of chronic psychosocial hypertension in mice by decaffeinated tea. Hypertension 6, 437-444.
    • (1984) Hypertension , vol.6 , pp. 437-444
    • Henry, J.P.1    Stephenslarson, P.2
  • 39
    • 0346726183 scopus 로고    scopus 로고
    • Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats
    • Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y & Yamori Y (2004) Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 134, 38-42.
    • (2004) J Nutr , vol.134 , pp. 38-42
    • Negishi, H.1    Xu, J.W.2    Ikeda, K.3    Njelekela, M.4    Nara, Y.5    Yamori, Y.6
  • 40
    • 1242294387 scopus 로고    scopus 로고
    • A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation
    • Lorenz M, Wessler S, Follmann E, Michaelis W, Dusterhoft T, Baumann G, Stangl K & Stangl V (2004) A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 279, 6190-6195.
    • (2004) J Biol Chem , vol.279 , pp. 6190-6195
    • Lorenz, M.1    Wessler, S.2    Follmann, E.3    Michaelis, W.4    Dusterhoft, T.5    Baumann, G.6    Stangl, K.7    Stangl, V.8
  • 41
    • 33747061585 scopus 로고    scopus 로고
    • Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells
    • Persson IA, Josefsson M, Persson K & Andersson RG (2006) Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells. J Pharm Pharmacol 58, 1139-1144.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1139-1144
    • Persson, I.A.1    Josefsson, M.2    Persson, K.3    Andersson, R.G.4
  • 42
    • 34250174411 scopus 로고    scopus 로고
    • Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn
    • Kim JA, Formoso G, Li YH, Potenza MA, Marasciulo FL, Montagnani M & Quon MJ (2007) Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 282, 13736-13745.
    • (2007) J Biol Chem , vol.282 , pp. 13736-13745
    • Kim, J.A.1    Formoso, G.2    Li, Y.H.3    Potenza, M.A.4    Marasciulo, F.L.5    Montagnani, M.6    Quon, M.J.7
  • 44
    • 20944436777 scopus 로고    scopus 로고
    • Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKK beta
    • Kim F, Tysseling KA, Rice J, et al. (2005) Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKK beta. Arterioscler Thromb Vasc Biol 25, 989-994.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 989-994
    • Kim, F.1    Tysseling, K.A.2    Rice, J.3
  • 45
    • 0033976073 scopus 로고    scopus 로고
    • Suppression of lipopolysaccharide-induced nuclear factor-kappa B activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of I kappa B kinase activity in macrophages
    • Pan MH, Lin-Shiau SY, Ho CT, Lin JH & Lin JK (2000) Suppression of lipopolysaccharide-induced nuclear factor-kappa B activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of I kappa B kinase activity in macrophages. Biochem Pharmacol 59, 357-367.
    • (2000) Biochem Pharmacol , vol.59 , pp. 357-367
    • Pan, M.H.1    Lin-Shiau, S.Y.2    Ho, C.T.3    Lin, J.H.4    Lin, J.K.5
  • 46
    • 33745133405 scopus 로고    scopus 로고
    • Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level
    • Tang WJ, Hu CP, Chen MF, Deng PY & Li YJ (2006) Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level. Can J Physiol Pharm 84, 163-171.
    • (2006) Can J Physiol Pharm , vol.84 , pp. 163-171
    • Tang, W.J.1    Hu, C.P.2    Chen, M.F.3    Deng, P.Y.4    Li, Y.J.5
  • 48
    • 67649453765 scopus 로고    scopus 로고
    • The effect of green tea on endothelial dysfunction and circulating endothelial progenitor cells in the chronic smoker
    • Kim W, Jeong MH, Hong YJ, Ahn YK, Kim JH, Cho JG & Kang JC (2006) The effect of green tea on endothelial dysfunction and circulating endothelial progenitor cells in the chronic smoker. Am J Cardiol 97, 60D.
    • (2006) Am J Cardiol , vol.97
    • Kim, W.1    Jeong, M.H.2    Hong, Y.J.3    Ahn, Y.K.4    Kim, J.H.5    Cho, J.G.6    Kang, J.C.7
  • 51
    • 0031595920 scopus 로고    scopus 로고
    • Wide distribution of [H-3](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
    • Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H & Fujiki H (1998) Wide distribution of [H-3](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 19, 1771-1776.
    • (1998) Carcinogenesis , vol.19 , pp. 1771-1776
    • Suganuma, M.1    Okabe, S.2    Oniyama, M.3    Tada, Y.4    Ito, H.5    Fujiki, H.6
  • 52
    • 0033029485 scopus 로고    scopus 로고
    • Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds
    • Paladini AC, Marder M, Viola H, Wolfman C, Wasowski C & Medina JH (1999) Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol 51, 519-526.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 519-526
    • Paladini, A.C.1    Marder, M.2    Viola, H.3    Wolfman, C.4    Wasowski, C.5    Medina, J.H.6
  • 54
    • 15744388677 scopus 로고    scopus 로고
    • Short administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    • Grassi D, Lippi C, Necozione S, Desideri G & Ferri C (2007) Short administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 81, 611-614.
    • (2007) Am J Clin Nutr , vol.81 , pp. 611-614
    • Grassi, D.1    Lippi, C.2    Necozione, S.3    Desideri, G.4    Ferri, C.5


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