Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine

Molecular Cell

Volumn 6, Issue 4, 2000, Pages 909-919

  Walker, Edward H ^a   Pacold, Michael E ^a   Perisic, Olga ^a   Stephens, Len ^b   Hawkins, Philip T ^b   Wymann, Matthias P ^c   Williams, Roger L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; MYRICETIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; QUERCETIN; STAUROSPORINE; WORTMANNIN;

ARTICLE; CANCER; CATALYSIS; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MUTAGENESIS; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EID: 0033634827     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00089-4     Document Type: Article

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