A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IκB kinase activation and IL-8 gene expression in respiratory epithelium

Inflammation

Volumn 26, Issue 5, 2002, Pages 233-241

  Chen, Philip C ^a   Wheeler, Derek S ^a   Malhotra, Vivek ^a   Odoms, Kelli ^a   Denenberg, Alvin G ^a   Wong, Hector R ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Inflammation; I B ; Nuclear factor B; Signal transduction; Tumor necrosis factor

Indexed keywords

EPIGALLOCATECHIN GALLATE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; POLYPHENOL; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; CATECHIN; CHUK PROTEIN, HUMAN; DRUG DERIVATIVE; FLAVONOID; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; MESSENGER RNA; PHENOL DERIVATIVE; POLYMER; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG INJURY; NORTHERN BLOTTING; PATHOPHYSIOLOGY; PROMOTER REGION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; TEA; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; RESPIRATORY TRACT MUCOSA;

ANTIOXIDANTS; CATECHIN; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-8; NF-KAPPA B; PHENOLS; POLYMERS; PROTEIN-SERINE-THREONINE KINASES; RESPIRATORY MUCOSA; RNA, MESSENGER; TEA; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036779369     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019718718977     Document Type: Article

References (44)

1. Green tea and cancer in humans: A review of the literature
2. Japanese green tea as a cancer preventive in humans
3. Tea consumption and cancer
4. Tea and cancer
5. Green tea suppresses lipopolysaccharide-induced liver injury in d-galactosamine-sensitized rats
6. Antimutagenic and anticarcinogenic activity of tea polyphenols
7. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats
8. Polyphenolic flavenols as scavengers of aqueous phase radicals and as chain-breaking antioxidants
9. Antioxidants in tea
10. Anti-oxidative effect of polyphenol extract prepared from various Chinese teas
11. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor production in 7, 12-dimethylbenz(a)anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea
12. Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation
13. Suppression of azoxymethane-induced preneoplastic lesions and inhibition of cyclooxygenase-2 activity in the colonic mucosa of rats drinking a crude green tea extract
14. Modulation of the UVA activation of heme oxygenase, collagenase, and cyclooxygenase gene expression by epigallocatechin in human skin cells
15. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea
16. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-κB
17. Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression
18. Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis)
19. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor κB activation by inhibiting IκB kinase activity in the intestinal epithelial cell line IEC-6
20. The NF-κB and IκB proteins: New discoveries and insights
21. The role of nuclear factor-κB in cytokine gene regulation
22. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
23. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
24. Phosphorylation meets ubiquitination: The control of NF-κB activity
25. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
26. Molecular mechanisms of interleukin-8 gene expression
27. Ester bond-containing tea polyphenols potently inhibit proteosome activity in vitro and in vivo
28. Hyperoxia synergistically increases TNF-α-induced interleukin-8 gene expression in A549 cells
29. Geldanamycin inhibits NF-κB activation and interleukin-8 gene expression in cultured human respiratory epithelium
30. Increased expression of heat shock protein-70 protects human respiratory epithelium against hyperoxia
31. Chemotactic cytokines that mediate inflammation
32. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS
33. Interleukin-8 gene expression by a pulmonary epithelial cell line, a model for cytokine networks in the lung
34. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome
35. Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury
36. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome
37. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality
38. Regulation of interleukin-8 gene expression
39. A promoter recruitment mechanism for tumor necrosis factor α-induced interleukin-8 transcription in type II pulmonary epithelial cells: Dependence on nuclear abundance of Rel A, NF-B1, and c-Rel transcription factors
40. Suppression of lipopolysaccharide-induced nuclear factor-κB activity by theaflavin-3, 3′-digallate from black tea and other polyphenols through down-regulation of IκB kinase activity in macrophages
41. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways
42. Requirement of a novel upstream response element in respiratory syncytial virus-induced IL-8 gene expression
43. Tea polyphenols: Prevention of cancer and optimizing health
44. Tea consumption and mortality after acute myocardial infarction