Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin

Journal of Cellular Biochemistry

Volumn 67, Issue SUPPL. 28/29, 1997, Pages 39-48

  Lin, Jen Kun ^a   Chen, Yen Chou ^a   Huang, Ying Tang ^a   Lin Shiau, Shoei Yn ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apigenin; C fos; C jun; Curcumin; Genistein; Kaempferol; PKC; PTK

Indexed keywords

8 HYDROXYGUANINE; ADENOSINE TRIPHOSPHATE; APIGENIN; CURCUMIN; FLAVONOID; GENISTEIN; KAEMPFEROL; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLSERINE; POLYPHENOL DERIVATIVE; PROTEIN C FOS; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; XANTHINE OXIDASE; ANTINEOPLASTIC AGENT; CHAMOMILE; ENZYME INHIBITOR; ESSENTIAL OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CELL NUCLEUS; CELL STRAIN 3T3; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; MEDICINAL PLANT; METABOLISM; ONCOGENE; REVIEW;

ANIMALS; ANTICARCINOGENIC AGENTS; CELL NUCLEUS; CHAMOMILE; CURCUMIN; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION; MICE; OILS, VOLATILE; ONCOGENES; PLANTS, MEDICINAL; PROTEIN KINASE C;

EID: 0031394645     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(1997)28/29+<39::AID-JCB5>3.0.CO;2-X     Document Type: Article

References (35)

1. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Sigman CC (1994): Chemopreventive drug development: Perspectives and progress. Cancer Epidemiol Biomark Prev 3:85-98.
2. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T, Lou Y-R, Mitchell JM, Laskin JD, Newmark H, Yang CS, Conney AH (1992): Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13:947-954.
3. Czeczot H, Tudek B, Kusztelak (1990): Isolation and studies of the mutagenic activity in the Ames test of flavonoids nautili occurring in medical herbs. Mutat Res 240:209-216.
4. Kuo ML, Lee KC, Lin JK (1992): Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid, and indole-3-carbinol in the Salmonella and CHO systems. Mutat Res 270:87-95.
5. Hertog MGL, Hollman PCH, Katan MB, Kromhout D (1993): Intake of potentially anticarcinogenic flavonoids and their determinants in adducts in Netherlands. Nutr Cancer 20:21-29.
6. Geahlen RL, Koonchanok NM, McLaughlin JL (1989): Inhibition of protein tyrosine kinase activity by polyphenoids and related compounds. J Nat Prod 52:982-986.
7. Hirano J, Oka K, Akika M (1989): Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line. ZR-75-1. Res Commun Chem Pathol Pharmacol 64:69-78.
8. Chaumontent C, Bex V, Gallard-Sanchez I, Seillan-Heberden C, Suschetet M, Martel P (1994): Apigenin and tangeretin enhance gap junction intracellular communication in rat liver epithelial cells. Carcinogenesis 15:2325-2330.
9. Kuo ML, Lin JK, Huang TS, Yang NC (1994): Reversion of the transformed phenotypes of v-Ha-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett 87:91-97.
10. Sato F, Matsukawa Y, Matsumoto K, Nishino H, Sakai T (1994): Apigenin induced morphological differentiation & G2-M arrest in rat neuronal cells. Biochem Biophys Res Commun 204:578-584.
11. Birt DF, Walker B, Tibbels MG, Bresnick E (1986): Anti-mutagenesis and anti-promotion by apigenin, robinetin, and indo-3-carbinol. Carcinogenesis 7:959-963.
12. Chae YH, Ho DK, Cassady JM, Cook VM, Marcus CB, Baird WM (1992): Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo [a]pyrene in hamster embryo cell cultures. Chem Biol Interaction 82:181-193.
13. Wei H, Tye L, Bresnick E, Birt DF (1996): Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res 50:499-502.
14. Huang YT, Kuo ML, Liu JY, Huang SY, Lin JK (1996): Inhibition of protein kinase C and proto-oncogene expressions in NIH3T3 cells by apigenin. Eur J Cancer 32A:146-151.
15. Akiyama T, Ishida J, Nakagawa S, Ogawra H, Watanabe S-I, Hoh H, Shibuya M, Fukami Y (1987): Genistein, a specific inhibitor of tyrosine specific protein kinases. J Biol Chem 262:5592-5595.
16. Huang RS, Lee SC, Lin JK (1991): Suppression of c-jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc Natl Acad Sci USA 88:5292-5296.
17. Lin JK, Huang TS, Shih CA, Lin JY (1994): Molecular mechanism of action of curcumin. In Ho CT, Dsama T, Huang MT, Rosen RT (eds): "Food Phytochemicals for Cancer Prevention, II. Teas, Spices and Herbs. Washington, DC: American Chemical Society, pp 196-203.
18. Huang MT, Smart RC, Wong CQ, Conney AH (1988): Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferilic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 48:5941-5946.
19. Nagabhushan M, Bhide SV (1992): Curcumin as an inhibitor of cancer. J Am Coll Nutr 11:192-198.
20. Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH (1994): Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res 54:5841-5847.
21. Mehta RG, Moon RC (1991): Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol. Anti-Cancer Res 11:593-596.
22. Rao CV, Simi B, Reddy BS (1993): Inhibition effect of dietary curcumin by azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism, and aberrant crypt foci formation in the rat colon. Carcinogenesis 14:2219-2215.
23. Huang MT, Wang ZY, Georgiadis CA, Laskin JD, Conney AH (1992): Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenzy-[a]anthracene. Carcinogenesis 13:2183-2186.
24. Mukundan MA, Chacko MC, Annapurna W, Krishnaswamy K (1993): Effect of turmeric and curcumin on BP-DNA adducts. Carcinogenesis 14:493-496.
25. Azyine MA, Bhide SV (1992): Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr Cancer 17:77-83.
26. Kunchandy E, Rao MNA (1990): Oxygen radical scavenging activity of curcumin. Int J Pharm 58:237-240.
27. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH (1991): Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res 51:813-819.
28. Liu JY, Lin SJ, Lin JK (1993): Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl phorbol-13-acetate in NIH3T3 cells. Carcinogenesis 14:857-861.
29. Lin JK, Shih CA (1994): Inhibitory effect of curcumin in xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells. Carcinogenesis 15:1717-1721.
30. Shih CA, Lin JK (1993): Inhibition of 8-hydroxydeoxy-guanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis 14:709-712.
31. Kuo ML, Lin JK, Huang TS, Yang NC (1994): Reversion of the transformed phenotypes of v-Ha-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett 87:91-97.
32. Jiang MC, Yang-Yen HF, Yen JJ, Lin JK (1996): Curcumin induces apoptosis in immortalized NIH3T3 and malignant cancer cell lines. Nutr Cancer 26:111-120.
33. Weinstein IB (1988): Strategies for inhibiting multistage carcinogenesis based on signal transduction pathways. Mutat Res 202:413-420.
34. Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN (1991): Selective inhibition of isoprenylation of 21-26 kDa proteins by the anti-carcinogen d-limonene and its metabolites. J Biol Chem 266:17679-17685.
35. Lepley DM, Pelling JC (1997): Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin. Mol Carcinog 19:74-82.