Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation: Implication for neurodegenerative disorders

Journal of Neurochemistry

Volumn 85, Issue 2, 2003, Pages 306-317

  Chiarugi, Alberto ^a,b   Moskowitz, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Amyloid; IL 1 ; iNOS; Microglia; Neurodegeneration; PARP 1

Indexed keywords

6(5H) PHENANTHRIDINONE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BENZAMIDE; BENZOIC ACID; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; NOVOBIOCIN; PHENANTHRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; DEGENERATIVE DISEASE; DNA BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; IN VITRO STUDY; INHIBITION KINETICS; MICROGLIA; NERVE CELL; NEUROIMMUNOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0037387772     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01684.x     Document Type: Article

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