Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 21, 2008, Pages 7534-7539

  Jang, Saebyeol ^a   Kelley, Keith W ^a   Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Brain; Cytokines; Flavonoids; MAPK; Neuroinflammation

Indexed keywords

CYTOKINE; FLAVONOID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE 14; TRANSCRIPTION FACTOR AP 1; CHUK PROTEIN, MOUSE; DNA; I KAPPA B KINASE; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CYTOKINE PRODUCTION; DNA BINDING; ENCEPHALITIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLUID INTAKE; GEL MOBILITY SHIFT ASSAY; GENE INDUCTION; HIPPOCAMPUS; IMMUNE RESPONSE; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN LOCALIZATION; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BRAIN; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PROMOTER REGION;

APIUM GRAVEOLENS VAR. DULCE; MURINAE; MUS;

ANIMALS; BRAIN; CELLS, CULTURED; DNA; ENCEPHALITIS; I-KAPPA B KINASE; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LUTEOLIN; MALE; MICE; MICE, INBRED BALB C; MICROGLIA; NF-KAPPA B; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

EID: 44949125522     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802865105     Document Type: Article

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