-
1
-
-
9244243061
-
Small-molecule natural products: New structures, new activities
-
Baker, D.D. and Alvi, K.A., Small-molecule natural products: new structures, new activities, Curr. Opin. Biotechnol., 15, 576, 2004.
-
(2004)
Curr. Opin. Biotechnol.
, vol.15
, pp. 576
-
-
Baker, D.D.1
Alvi, K.A.2
-
2
-
-
0345118205
-
Novel biologically active natural and unnatural products
-
Myles, D.C., Novel biologically active natural and unnatural products, Curr. Opin. Biotechnol., 14, 627, 2003.
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 627
-
-
Myles, D.C.1
-
4
-
-
0035695659
-
Medicinals for the millennia: The historical record
-
Cragg, G.M. and Newman, D.J., Medicinals for the millennia: the historical record, Ann. N.Y. Acad. Sci., 953, 3, 2001.
-
(2001)
Ann. N.Y. Acad. Sci.
, vol.953
, pp. 3
-
-
Cragg, G.M.1
Newman, D.J.2
-
5
-
-
0034082239
-
The influence of natural products upon drug discovery
-
Newman, D.J., Cragg, G.M., and Snader, K.M., The influence of natural products upon drug discovery, Nat. Prod. Rep., 17, 215, 2000.
-
(2000)
Nat. Prod. Rep.
, vol.17
, pp. 215
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
6
-
-
0030706057
-
The role of plant-derived drugs and herbal medicines in healthcare
-
DeSmet, P.A.G.M., The role of plant-derived drugs and herbal medicines in healthcare, Drugs, 54, 801, 1997.
-
(1997)
Drugs
, vol.54
, pp. 801
-
-
DeSmet, P.A.G.M.1
-
7
-
-
44949283098
-
-
Hamburger, M. and Hostettmann, K., Phytochemistry, 30, 3864, 1991.
-
(1991)
Phytochemistry
, vol.30
, pp. 3864
-
-
Hamburger, M.1
Hostettmann, K.2
-
8
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drews, J., Drug discovery: a historical perspective, Science, 287, 1960, 2000.
-
(2000)
Science
, vol.287
, pp. 1960
-
-
Drews, J.1
-
9
-
-
11344264363
-
-
6th ed., Abraham, D.J., Ed, Drug Discovery, John Wiley & Sons, New York
-
Buss, A.D., Cox, B., and Waigh, R.D., in Burger’s Medicinal Chemistry and Drug Discovery, 6th ed., Abraham, D.J., Ed., Vol. 1: Drug Discovery, John Wiley & Sons, New York, 2003, pp. 847-900.
-
(2003)
Burger’s Medicinal Chemistry and Drug Discovery
, vol.1
, pp. 847-900
-
-
Buss, A.D.1
Cox, B.2
Waigh, R.D.3
-
10
-
-
0037506132
-
Natural products for lead identification: Nature is a valuable resource for providing tools
-
Hillisch, A. and Hilgenfeld, R., Eds
-
Grabley, S. and Sattler, I., Natural products for lead identification: nature is a valuable resource for providing tools, in Modern Methods of Drug Discovery, Hillisch, A. and Hilgenfeld, R., Eds., 2003, pp. 87-107.
-
(2003)
Modern Methods of Drug Discovery
, pp. 87-107
-
-
Grabley, S.1
Sattler, I.2
-
11
-
-
11344292132
-
The role of natural product chemistry in drug discovery
-
Butler, M.S., The role of natural product chemistry in drug discovery, J. Nat. Prod., 67, 2141, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 2141
-
-
Butler, M.S.1
-
12
-
-
17844399025
-
Natural products to drugs: Natural product derived compounds in clinical trials
-
Butler, M.S., Natural products to drugs: natural product derived compounds in clinical trials, Nat. Prod. Rep., 22, 162, 2005.
-
(2005)
Nat. Prod. Rep.
, vol.22
, pp. 162
-
-
Butler, M.S.1
-
13
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials
-
Newman, D.J. and Cragg, G.M., Marine natural products and related compounds in clinical and advanced preclinical trials, J. Nat. Prod., 67, 1216, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1216
-
-
Newman, D.J.1
Cragg, G.M.2
-
14
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
Newman, D.J., Cragg, G.M., and Snader, K.M., Natural products as sources of new drugs over the period 1981-2002, J. Nat. Prod., 66, 1022, 2003.
-
(2003)
J. Nat. Prod.
, vol.66
, pp. 1022
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
15
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn, F.E. and Carter, G.T., The evolving role of natural products in drug discovery, Nat. Rev. Drug Discovery, 4, 206, 2005.
-
(2005)
Nat. Rev. Drug Discovery
, vol.4
, pp. 206
-
-
Koehn, F.E.1
Carter, G.T.2
-
16
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A. et al., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Delivery Rev., 23, 3, 1997.
-
(1997)
Adv. Drug Delivery Rev.
, vol.23
, pp. 3
-
-
Lipinski, C.A.1
-
17
-
-
11144311139
-
Lessons from natural molecules
-
Clardy, J. and Walsh, C., Lessons from natural molecules, Nature, 432, 829, 2004.
-
(2004)
Nature
, vol.432
, pp. 829
-
-
Clardy, J.1
Walsh, C.2
-
18
-
-
7044263277
-
Synthesis and applications of small molecule libraries
-
Thompson, L.A. and Ellman, J.A., Synthesis and applications of small molecule libraries, Chem. Rev., 96, 555, 1996.
-
(1996)
Chem. Rev.
, vol.96
, pp. 555
-
-
Thompson, L.A.1
Ellman, J.A.2
-
19
-
-
0028243847
-
Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
-
Gallop, M.A. et al., Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries, J. Med. Chem., 37, 1233, 1994.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1233
-
-
Gallop, M.A.1
-
20
-
-
0028318863
-
Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions
-
Gordon, E.M. et al., Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions, J. Med. Chem., 37, 1385, 1994.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1385
-
-
Gordon, E.M.1
-
21
-
-
85056028936
-
A system for the development and production of small-molecule libraries
-
Yan, B. and Czarnik, A.W., Eds., Marcel Dekker: New York
-
Boldi, A.M. and Johnson, C.R., A system for the development and production of small-molecule libraries, in Optimization of Solid-Phase Combinatorial Synthesis, Yan, B. and Czarnik, A.W., Eds., Marcel Dekker: New York, 2001, pp. 1-27.
-
(2001)
Optimization of Solid-Phase Combinatorial Synthesis
, pp. 1-27
-
-
Boldi, A.M.1
Johnson, C.R.2
-
23
-
-
77956769873
-
Application of combinatorial and parallel synthesis to medicinal chemistry
-
Doherty, A., Ed., Academic Press, San Diego, CA, chap. 27
-
Bunin, B.A., Dener, J.M., and Livingston, D.A., Application of combinatorial and parallel synthesis to medicinal chemistry, in Annual Reports in Medicinal Chemistry, Doherty, A., Ed., Vol. 34, Academic Press, San Diego, CA, 1999, pp. 267-286, chap. 27.
-
(1999)
Annual Reports in Medicinal Chemistry
, vol.34
, pp. 267-286
-
-
Bunin, B.A.1
Dener, J.M.2
Livingston, D.A.3
-
25
-
-
7044263277
-
-
Thompson, L.A. and Ellman, J.A., Chem. Rev., 96, 555, 1996.
-
(1996)
Chem. Rev.
, vol.96
, pp. 555
-
-
Thompson, L.A.1
Ellman, J.A.2
-
26
-
-
0037019535
-
Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis
-
Zhang, W. et al., Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis, J. Am. Chem. Soc., 124, 10443, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 10443
-
-
Zhang, W.1
-
27
-
-
0034321912
-
Solution phase synthesis of libraries of polycyclic natural product analogues by cascade radical annulation: Synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues
-
de Frutos, O. and Curran, D.P., Solution phase synthesis of libraries of polycyclic natural product analogues by cascade radical annulation: synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues, J. Comb. Chem., 2, 639, 2000.
-
(2000)
J. Comb. Chem.
, vol.2
, pp. 639
-
-
de Frutos, O.1
Curran, D.P.2
-
28
-
-
4944221253
-
Comprehensive survey of combinatorial library synthesis: 2003
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 2003, J. Comb. Chem., 6, 623, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 623
-
-
Dolle, R.E.1
-
29
-
-
0345550453
-
Comprehensive survey of combinatorial library synthesis: 2002
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 2002, J. Comb. Chem., 5, 693, 2003.
-
(2003)
J. Comb. Chem.
, vol.5
, pp. 693
-
-
Dolle, R.E.1
-
30
-
-
0000669419
-
Comprehensive survey of combinatorial library synthesis: 2001
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 2001, J. Comb. Chem., 4, 369, 2002.
-
(2002)
J. Comb. Chem.
, vol.4
, pp. 369
-
-
Dolle, R.E.1
-
31
-
-
0035513630
-
Comprehensive survey of combinatorial library synthesis: 2000
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 2000, J. Comb. Chem., 3, 477, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 477
-
-
Dolle, R.E.1
-
32
-
-
0034265578
-
Comprehensive survey of combinatorial library synthesis: 1999
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 1999, J. Comb. Chem., 2, 383, 2000.
-
(2000)
J. Comb. Chem.
, vol.2
, pp. 383
-
-
Dolle, R.E.1
-
33
-
-
0033156688
-
Comprehensive survey of combinatorial library synthesis: 1998
-
Dolle, R.E., Comprehensive survey of combinatorial library synthesis: 1998, J. Comb. Chem., 1, 235, 1999.
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 235
-
-
Dolle, R.E.1
-
35
-
-
0033576601
-
The design of lead-like combinatorial libraries
-
Teague, S.J. et al., The design of lead-like combinatorial libraries, Angew. Chem., Int. Ed. Engl., 38, 3743, 1999.
-
(1999)
Angew. Chem., Int. Ed. Engl.
, vol.38
, pp. 3743
-
-
Teague, S.J.1
-
36
-
-
7444242717
-
A synthesis strategy yielding skeletally diverse small molecules combinatorially
-
Burke, M.D., Berger, E.M., and Schreiber, S.L., A synthesis strategy yielding skeletally diverse small molecules combinatorially, J. Am. Chem. Soc., 126, 14095, 2004.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 14095
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
37
-
-
3042799070
-
A planning strategy for diversity-oriented synthesis
-
Burke, M.D. and Schreiber, S.L., A planning strategy for diversity-oriented synthesis, Angew. Chem., Int. Ed. Engl., 43, 46, 2004.
-
(2004)
Angew. Chem., Int. Ed. Engl.
, vol.43
, pp. 46
-
-
Burke, M.D.1
Schreiber, S.L.2
-
38
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber, S.L., Target-oriented and diversity-oriented organic synthesis in drug discovery, Science, 287, 1964, 2000.
-
(2000)
Science
, vol.287
, pp. 1964
-
-
Schreiber, S.L.1
-
39
-
-
0035910436
-
Diversity-based organic synthesis in the era of genomics and proteomics
-
Arya, P., Chou, D.T.H., and Baek, M.-G., Diversity-based organic synthesis in the era of genomics and proteomics, Angew. Chem., Int. Ed. Engl., 40, 339, 2001.
-
(2001)
Angew. Chem., Int. Ed. Engl.
, vol.40
, pp. 339
-
-
Arya, P.1
Chou, D.T.H.2
Baek, M.-G.3
-
40
-
-
0142147275
-
Generating diverse skeletons of small molecules combinatorially
-
Burke, M.D., Berger, E.M., and Schreiber, S.L., Generating diverse skeletons of small molecules combinatorially, Science, 302, 613, 2003.
-
(2003)
Science
, vol.302
, pp. 613
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
41
-
-
33644839988
-
Diversity-oriented synthesis: Exploring the intersections between chemistry and biology
-
Tan, D.S., Diversity-oriented synthesis: exploring the intersections between chemistry and biology, Nat. Chem. Biol., 1, 74, 2005.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 74
-
-
Tan, D.S.1
-
42
-
-
20444410443
-
Advanced chemistry and biology through diversity-oriented synthesis of natural product-like libraries
-
Shang, S. and Tan, D.S., Advanced chemistry and biology through diversity-oriented synthesis of natural product-like libraries, Curr. Opin. Chem. Biol., 9, 248, 2005.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 248
-
-
Shang, S.1
Tan, D.S.2
-
43
-
-
5644294669
-
Current progress in natural product-like libraries for discovery screening
-
Tan, D.S., Current progress in natural product-like libraries for discovery screening, Comb. Chem. High Throughput Screen., 7, 631, 2004.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 631
-
-
Tan, D.S.1
-
44
-
-
6344226681
-
Rescuing combichem
-
Borman, S., Rescuing combichem, Chem. Eng. News, 82, 32, 2004.
-
(2004)
Chem. Eng. News
, vol.82
, pp. 32
-
-
Borman, S.1
-
45
-
-
0035358567
-
Lead compounds discovered from libraries
-
Golebiowski, A., Klopfenstein, S.R., and Portlock, D.E., Lead compounds discovered from libraries, Curr. Opin. Chem. Biol., 5, 273, 2001.
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 273
-
-
Golebiowski, A.1
Klopfenstein, S.R.2
Portlock, D.E.3
-
46
-
-
0042029627
-
The impact of combinatorial chemistry on drug discovery
-
Lee, A. and Breitenbucher, J.G., The impact of combinatorial chemistry on drug discovery, Curr. Opin. Drug Discovery Dev., 6, 494, 2003.
-
(2003)
Curr. Opin. Drug Discovery Dev.
, vol.6
, pp. 494
-
-
Lee, A.1
Breitenbucher, J.G.2
-
47
-
-
0142228822
-
Rediscovering natural products
-
Rouhi, A.M., Rediscovering natural products, Chem. Eng. News, 81, 77, 2003.
-
(2003)
Chem. Eng. News
, vol.81
, pp. 77
-
-
Rouhi, A.M.1
-
48
-
-
2942565810
-
Natural products and combinatorial chemistry: Back to the future
-
Ortholand, Y.-Y. and Ganesan, A., Natural products and combinatorial chemistry: back to the future, Curr. Opin. Chem. Biol., 8, 271, 2004.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 271
-
-
Ortholand, Y.-Y.1
Ganesan, A.2
-
49
-
-
0035743183
-
Integrating natural product synthesis and combinatorial chemistry
-
Ganesan, A., Integrating natural product synthesis and combinatorial chemistry, Pure Appl. Chem., 73, 1033, 2001.
-
(2001)
Pure Appl. Chem.
, vol.73
, pp. 1033
-
-
Ganesan, A.1
-
50
-
-
0142259831
-
Moving beyond natural products
-
Rouhi, A.M., Moving beyond natural products, Chem. Eng. News., 81, 104, 2003.
-
(2003)
Chem. Eng. News.
, vol.81
, pp. 104
-
-
Rouhi, A.M.1
-
51
-
-
0040685387
-
Strategy and tactics in combinatorial organic synthesis: Applications to drug discovery
-
Gordon, E.M. et al., Strategy and tactics in combinatorial organic synthesis: applications to drug discovery, Chimia, 51, 821, 1997.
-
(1997)
Chimia
, vol.51
, pp. 821
-
-
Gordon, E.M.1
-
52
-
-
0033446638
-
Combinatorial chemistry: The impact of natural products
-
Paululat, T. et al., Combinatorial chemistry: the impact of natural products, Chimica Oggi, 17, 52, 1999.
-
(1999)
Chimica Oggi
, vol.17
, pp. 52
-
-
Paululat, T.1
-
53
-
-
0033549539
-
Polymer-supported synthesis of non-oligomeric natural products
-
Watson, C., Polymer-supported synthesis of non-oligomeric natural products, Angew. Chem., Int. Ed. Engl., 38, 1903, 1999.
-
(1999)
Angew. Chem., Int. Ed. Engl.
, vol.38
, pp. 1903
-
-
Watson, C.1
-
54
-
-
2942590399
-
Libraries from natural product-like scaffolds
-
Boldi, A.M., Libraries from natural product-like scaffolds, Curr. Opin. Chem. Biol., 8, 281, 2004.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 281
-
-
Boldi, A.M.1
-
55
-
-
0242690225
-
Natural product-like combinatorial libraries
-
Abreu, P.M. and Branco, P.S., Natural product-like combinatorial libraries, J. Braz. Chem. Soc., 14, 675, 2003.
-
(2003)
J. Braz. Chem. Soc.
, vol.14
, pp. 675
-
-
Abreu, P.M.1
Branco, P.S.2
-
56
-
-
0035293182
-
Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: A comprehensive survey
-
Hall, D.G., Manku, S., and Wang, F., Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: a comprehensive survey, J. Comb. Chem., 3, 125, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 125
-
-
Hall, D.G.1
Manku, S.2
Wang, F.3
-
57
-
-
0036603591
-
Combinatorial synthesis of natural products
-
Nielsen, J., Combinatorial synthesis of natural products, Curr. Opin. Chem. Biol., 6, 297, 2002.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 297
-
-
Nielsen, J.1
-
58
-
-
0034032705
-
Synthesis of natural product-based compound libraries
-
Wessjohann, L.A., Synthesis of natural product-based compound libraries, Curr. Opin. Chem. Biol., 4, 303, 2000.
-
(2000)
Curr. Opin. Chem. Biol.
, vol.4
, pp. 303
-
-
Wessjohann, L.A.1
-
59
-
-
0035743183
-
Integrating natural product synthesis and combinatorial chemistry
-
Ganesan, A., Integrating natural product synthesis and combinatorial chemistry, Pure Appl. Chem., 73, 1033, 2001.
-
(2001)
Pure Appl. Chem.
, vol.73
, pp. 1033
-
-
Ganesan, A.1
-
60
-
-
0036664004
-
Synthetic aspects of combinatorial chemistry
-
Wipf, P., Synthetic aspects of combinatorial chemistry, Pharmaceutical News, 9, 157, 2002.
-
(2002)
Pharmaceutical News
, vol.9
, pp. 157
-
-
Wipf, P.1
-
61
-
-
0036679630
-
Modern methods to produce natural-product libraries
-
Abel, U. et al., Modern methods to produce natural-product libraries, Curr. Opin. Chem. Biol., 6, 453, 2002.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 453
-
-
Abel, U.1
-
62
-
-
0000172482
-
Recent advances in the solid-phase synthesis of natural products
-
Burgess, K., Ed., John Wiley & Sons, New York
-
Wilson, L.J., Recent advances in the solid-phase synthesis of natural products, in Solid-Phase Organic Synthesis, Burgess, K., Ed., John Wiley & Sons, New York, 2000, pp. 247-267.
-
(2000)
Solid-Phase Organic Synthesis
, pp. 247-267
-
-
Wilson, L.J.1
-
63
-
-
0346251241
-
Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era
-
Knepper, K., Gil, C., and Bräse, S., Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era, Comb. Chem. High Throughput Screen., 6, 673, 2003.
-
(2003)
Comb. Chem. High Throughput Screen.
, vol.6
, pp. 673
-
-
Knepper, K.1
Gil, C.2
Bräse, S.3
-
64
-
-
9244238653
-
Natural products as a hunting ground for combinatorial chemistry
-
Ganesan, A., Natural products as a hunting ground for combinatorial chemistry, Curr. Opin. Biotechnol., 15, 584, 2004.
-
(2004)
Curr. Opin. Biotechnol.
, vol.15
, pp. 584
-
-
Ganesan, A.1
-
65
-
-
0037861156
-
Computational design strategies for combinatorial libraries
-
Rose, S. and Stevens, A., Computational design strategies for combinatorial libraries, Curr. Opin. Chem. Biol., 7, 331, 2003.
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 331
-
-
Rose, S.1
Stevens, A.2
-
66
-
-
20144385483
-
Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery
-
Samiulla, D.S. et al., Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery, Mol. Diversity, 9, 131, 2005.
-
(2005)
Mol. Diversity
, vol.9
, pp. 131
-
-
Samiulla, D.S.1
-
67
-
-
0037208308
-
Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry
-
Feher, M. and Schmidt, J.M., Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry, J. Chem. Inf. Comput. Sci., 43, 218, 2003.
-
(2003)
J. Chem. Inf. Comput. Sci.
, vol.43
, pp. 218
-
-
Feher, M.1
Schmidt, J.M.2
-
68
-
-
0033104653
-
Statistical investigation into the structural complementarity of natural products and synthetic compounds
-
Henkel, T. et al., Statistical investigation into the structural complementarity of natural products and synthetic compounds, Angew. Chem., Int. Ed. Engl., 38, 643, 1999.
-
(1999)
Angew. Chem., Int. Ed. Engl.
, vol.38
, pp. 643
-
-
Henkel, T.1
-
69
-
-
0035347869
-
Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
-
Lee, M.-L. and Schneider, G., Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries, J. Comb. Chem., 3, 284, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 284
-
-
Lee, M.-L.1
Schneider, G.2
-
70
-
-
0036589465
-
Chemoinformatics methods for systematic comparison of molecules from natural and synthetic sources and design of hybrid libraries
-
Bajorath, J., Chemoinformatics methods for systematic comparison of molecules from natural and synthetic sources and design of hybrid libraries, J. Comp. Aided Mol. Design, 16, 431, 2002.
-
(2002)
J. Comp. Aided Mol. Design
, vol.16
, pp. 431
-
-
Bajorath, J.1
-
71
-
-
0345390176
-
Generating new molecular function: A lesson from nature
-
Liu, D.R. and Schultz, P.G., Generating new molecular function: a lesson from nature, Angew. Chem., Int. Ed. Engl., 38, 36, 1999.
-
(1999)
Angew. Chem., Int. Ed. Engl.
, vol.38
, pp. 36
-
-
Liu, D.R.1
Schultz, P.G.2
-
72
-
-
0035471140
-
Protein design and phage display
-
Hoess, R.H., Protein design and phage display, Chem. Rev., 101, 3205, 2001.
-
(2001)
Chem. Rev.
, vol.101
, pp. 3205
-
-
Hoess, R.H.1
-
73
-
-
0035813878
-
Directed evolution and biocatalysis
-
Powell, K.A. et al., Directed evolution and biocatalysis, Angew. Chem., Int. Ed. Engl., 40, 3948, 2001.
-
(2001)
Angew. Chem., Int. Ed. Engl.
, vol.40
, pp. 3948
-
-
Powell, K.A.1
-
74
-
-
0036669389
-
Towards novel processes for the fine-chemical and pharmaceutical industries
-
Huisman, G.W. and Gray, D., Towards novel processes for the fine-chemical and pharmaceutical industries, Curr. Opin. Biotech., 13, 352, 2002.
-
(2002)
Curr. Opin. Biotech.
, vol.13
, pp. 352
-
-
Huisman, G.W.1
Gray, D.2
-
75
-
-
0041430618
-
-
Huisman, G. and Sligar, S.G., Curr. Opin. Biotech., 14, 357, 2003.
-
(2003)
Curr. Opin. Biotech.
, vol.14
, pp. 357
-
-
Huisman, G.1
Sligar, S.G.2
-
76
-
-
0034552096
-
Natural product biosynthesis: A new interface between enzymology and medicine
-
Khosla, C., Natural product biosynthesis: a new interface between enzymology and medicine, J. Org. Chem., 65, 8127, 2000.
-
(2000)
J. Org. Chem.
, vol.65
, pp. 8127
-
-
Khosla, C.1
-
77
-
-
0035533265
-
A natural approach to combinatorial chemistry
-
Coffen, D.L. and Xiao, X.-Y., A natural approach to combinatorial chemistry, Chemistry Today, 9-11, 2001.
-
(2001)
Chemistry Today
, pp. 9-11
-
-
Coffen, D.L.1
Xiao, X.-Y.2
-
78
-
-
0030805336
-
Design and synthesis of a taxoid library using radiofrequency encoded combinatorial chemistry
-
Xiao, X.-Y., Parandoosh, Z., and Nova, M.P., Design and synthesis of a taxoid library using radiofrequency encoded combinatorial chemistry, J. Org. Chem., 62, 6029, 1997.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 6029
-
-
Xiao, X.-Y.1
Parandoosh, Z.2
Nova, M.P.3
-
79
-
-
0033949965
-
Solid-phase combinatorial synthesis using microkan reactors, Rf tagging, and directed sorting
-
Xiao, X.-Y. et al., Solid-phase combinatorial synthesis using microkan reactors, Rf tagging, and directed sorting, Biotechnol. Bioeng., 71, 44, 2000.
-
(2000)
Biotechnol. Bioeng.
, vol.71
, pp. 44
-
-
Xiao, X.-Y.1
-
80
-
-
2942608296
-
Natural products and combinatorial chemistry - the comeback of nature in drug discovery
-
Frormann, S. and Jas, G., Natural products and combinatorial chemistry - the comeback of nature in drug discovery, Bus. Briefing: Future Drug Discovery, 84, 2002.
-
(2002)
Bus. Briefing: Future Drug Discovery
, pp. 84
-
-
Frormann, S.1
Jas, G.2
-
82
-
-
85056065757
-
Building discovery libraries from natural products
-
Leesburg, VA, September 21-24
-
Boldi, A.M., Building discovery libraries from natural products, ACS Prospectives Conference on Combinatorial Chemistry: New Methods, New Discoveries, Leesburg, VA, September 21-24, 2003.
-
(2003)
ACS Prospectives Conference on Combinatorial Chemistry: New Methods, New Discoveries
-
-
Boldi, A.M.1
-
83
-
-
0141427680
-
Natural product hybrids as new leads for drug discovery
-
Tietze, L.F., Bell, H.P., and Chandrasekhar, S., Natural product hybrids as new leads for drug discovery, Angew. Chem., Int. Ed. Engl., 42, 3996, 2003.
-
(2003)
Angew. Chem., Int. Ed. Engl.
, vol.42
, pp. 3996
-
-
Tietze, L.F.1
Bell, H.P.2
Chandrasekhar, S.3
-
84
-
-
17644400733
-
Convergent diversity-oriented synthesis of small-molecule hybrids
-
Chen, C. et al., Convergent diversity-oriented synthesis of small-molecule hybrids, Angew. Chem., Int. Ed. Engl., 44, 2249, 2005.
-
(2005)
Angew. Chem., Int. Ed. Engl.
, vol.44
, pp. 2249
-
-
Chen, C.1
-
85
-
-
20444401576
-
Wanted: New multicomponent reactions for generating libraries of polycyclic natural products
-
Ulaczyk-Lesanko, A. and Hall, D.G., Wanted: new multicomponent reactions for generating libraries of polycyclic natural products, Curr. Opin. Chem. Biol., 9, 266, 2005.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 266
-
-
Ulaczyk-Lesanko, A.1
Hall, D.G.2
-
86
-
-
0037025958
-
Multicomponent domino process to oxa-bridged polyheterocycles and pyrrolopyridines, structural diversity derived from work-up procedure
-
Gámez-Montaño, R. et al., Multicomponent domino process to oxa-bridged polyheterocycles and pyrrolopyridines, structural diversity derived from work-up procedure, Tetrahedron, 58, 6351, 2002.
-
(2002)
Tetrahedron
, vol.58
, pp. 6351
-
-
Gámez-Montaño, R.1
-
87
-
-
0037020334
-
Synthesis of furoquinolines by a multicomponent domino process
-
Fayol, A. and Zhu, J., Synthesis of furoquinolines by a multicomponent domino process, Angew. Chem., Int. Ed. Engl., 41, 3633, 2002.
-
(2002)
Angew. Chem., Int. Ed. Engl.
, vol.41
, pp. 3633
-
-
Fayol, A.1
Zhu, J.2
-
88
-
-
0037529208
-
Dihydropyridine-based multicomponent reactions. Efficient entry into new tetrahydroquinoline systems through Lewis acid-catalyzed formal [4+2] cycloadditions
-
Lavilla, R. et al., Dihydropyridine-based multicomponent reactions. Efficient entry into new tetrahydroquinoline systems through Lewis acid-catalyzed formal [4+2] cycloadditions, Org. Lett., 5, 717, 2003.
-
(2003)
Org. Lett.
, vol.5
, pp. 717
-
-
Lavilla, R.1
-
89
-
-
0000418347
-
Tandem aza[4+2]/allylboration: A novel multicomponent reaction for the stereocontrolled synthesis of a a-hydroxyalkyl piperidine derivatives
-
Tailor, J. and Hall, D.G., Tandem aza[4+2]/allylboration: a novel multicomponent reaction for the stereocontrolled synthesis of a a-hydroxyalkyl piperidine derivatives, Org. Lett., 2, 3715, 2002.
-
(2002)
Org. Lett.
, vol.2
, pp. 3715
-
-
Tailor, J.1
Hall, D.G.2
-
90
-
-
0037455241
-
A three-component reaction for diversity-oriented synthesis of polysubstituted piperidines: Solution and solid-phase optimization of the first tandem aza[4+2]/allylboration
-
Toure, B.B., Hoveyda, H.R., Tailor, J., Ulaczyk-Lesanko, A., and Hall, D.G., A three-component reaction for diversity-oriented synthesis of polysubstituted piperidines: solution and solid-phase optimization of the first tandem aza[4+2]/allylboration, Chemistry, 9, 466, 2003.
-
(2003)
Chemistry
, vol.9
, pp. 466
-
-
Toure, B.B.1
Hoveyda, H.R.2
Tailor, J.3
Ulaczyk-Lesanko, A.4
Hall, D.G.5
-
91
-
-
10344242467
-
A library of spirooxindoles based on a stereoselective three-component coupling reaction
-
Lo, M.M.-C. et al., A library of spirooxindoles based on a stereoselective three-component coupling reaction, J. Am. Chem. Soc., 126, 16077, 2004.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 16077
-
-
Lo, M.M.-C.1
-
92
-
-
20444400874
-
Natural product-like libraries based on non-aromatics, polycyclic motifs
-
Messer, R., Fuhrer, C.A., and Häner, R, Natural product-like libraries based on non-aromatics, polycyclic motifs, Curr. Opin. Curr. Biol., 9, 259, 2005.
-
(2005)
Curr. Opin. Curr. Biol.
, vol.9
, pp. 259
-
-
Messer, R.1
Fuhrer, C.A.2
Häner, R.3
-
93
-
-
1642282627
-
Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via a stereoselective Mannich reaction
-
Fujita, T. et al., Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via a stereoselective Mannich reaction, Org. Lett., 6, 827, 2004.
-
(2004)
Org. Lett.
, vol.6
, pp. 827
-
-
Fujita, T.1
-
94
-
-
4944234665
-
A parallel solution-phase synthesis of substituted 3,7-diazabicyclo[ 3.3.1]nonanes
-
Ivachtchenko, A.V. et al., A parallel solution-phase synthesis of substituted 3,7-diazabicyclo[ 3.3.1]nonanes, J. Comb. Chem., 6, 828, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 828
-
-
Ivachtchenko, A.V.1
-
95
-
-
13544273419
-
Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2+2+1] cycloaddition of alkynyl allenes
-
Manku, S. and Curran, D.P., Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2+2+1] cycloaddition of alkynyl allenes, J. Comb. Chem., 7, 63, 2005.
-
(2005)
J. Comb. Chem.
, vol.7
, pp. 63
-
-
Manku, S.1
Curran, D.P.2
-
96
-
-
0041851110
-
Modular, parallel synthesis of an illudinoid combinatorial library
-
Pirrung, M.C. and Liu, H., Modular, parallel synthesis of an illudinoid combinatorial library, Org. Lett., 5, 1983, 2003.
-
(2003)
Org. Lett.
, vol.5
, pp. 1983
-
-
Pirrung, M.C.1
Liu, H.2
-
97
-
-
0036008841
-
Toward high-throughput synthesis of complex natural productlike compounds in the genomics and proteomics age
-
Arya, P., Joseph, R., and Chou, D.T.H., Toward high-throughput synthesis of complex natural productlike compounds in the genomics and proteomics age, Chem. Biol., 9, 145, 2002.
-
(2002)
Chem. Biol.
, vol.9
, pp. 145
-
-
Arya, P.1
Joseph, R.2
Chou, D.T.H.3
-
98
-
-
0036423173
-
Natural product guided compound library development
-
Breinbauer, R. et al., Natural product guided compound library development. Curr. Med. Chem., 9, 2129, 2002.
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 2129
-
-
Breinbauer, R.1
-
99
-
-
0027068161
-
A general and expedient method for the solid-phase synthesis of 1,4-Benzodiazepine derivatives
-
Bunin, B.A. and Ellman, J.A., A general and expedient method for the solid-phase synthesis of 1,4-Benzodiazepine derivatives, J. Am. Chem. Soc., 114, 10997, 1992.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10997
-
-
Bunin, B.A.1
Ellman, J.A.2
-
100
-
-
0024239320
-
Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists
-
Evans, B.E. et al., Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists, J. Med. Chem., 31, 2235, 1988.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 2235
-
-
Evans, B.E.1
-
101
-
-
0029561554
-
A new 1,4-benzodiazepine atropisomer
-
Sun, H.H., Barrow, C.J., and Cooper, R., Benzomalvin D, a new 1,4-benzodiazepine atropisomer, J. Nat. Prod., 58, 1575, 1995.
-
(1995)
J. Nat. Prod.
, vol.58
, pp. 1575
-
-
Sun, H.H.1
Barrow, C.J.2
Cooper, R.3
Benzomalvin, D.4
-
102
-
-
0032948888
-
Sclerotigenin: A new antiinsectan benzodiazepine from the sclerotia of Penicillium sclerotigenum
-
Joshi, B.K. et al., Sclerotigenin: a new antiinsectan benzodiazepine from the sclerotia of Penicillium sclerotigenum, J. Nat. Prod., 62, 650, 1999.
-
(1999)
J. Nat. Prod.
, vol.62
, pp. 650
-
-
Joshi, B.K.1
-
103
-
-
0018329376
-
The benzodiazepine story
-
Sternbach, L.H., The benzodiazepine story, J. Med. Chem., 22, 1, 1979.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 1
-
-
Sternbach, L.H.1
-
104
-
-
0028555379
-
Simultaneous solid-phase synthesis of β-turn mimetics incorporating side-chain functionality
-
Virgilio, A.A. and Ellman, J.A., Simultaneous solid-phase synthesis of β-turn mimetics incorporating side-chain functionality, J. Am. Chem. Soc., 116, 11580, 1994.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 11580
-
-
Virgilio, A.A.1
Ellman, J.A.2
-
105
-
-
12044258141
-
Synthesis of therapeutically useful prostaglandin and prostacyclin analogs
-
Collins, P.W. and Djuric, S.W., Synthesis of therapeutically useful prostaglandin and prostacyclin analogs, Chem. Rev., 93, 1533, 1993.
-
(1993)
Chem. Rev.
, vol.93
, pp. 1533
-
-
Collins, P.W.1
Djuric, S.W.2
-
106
-
-
0030883333
-
Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries
-
Chen, S. and Janda, K.D., Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries, J. Am. Chem. Soc., 119, 8724, 1997.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 8724
-
-
Chen, S.1
Janda, K.D.2
-
107
-
-
0024987706
-
Three-component coupling synthesis of prostaglandins. A simplified, general procedure
-
Suzuki, M. et al., Three-component coupling synthesis of prostaglandins. A simplified, general procedure, Tetrahedron, 46, 4809, 1990.
-
(1990)
Tetrahedron
, vol.46
, pp. 4809
-
-
Suzuki, M.1
-
108
-
-
0033518061
-
Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity
-
Lee, K.J. et al., Soluble-polymer supported synthesis of a prostanoid library: identification of antiviral activity, Org. Lett., 1, 1859, 1999.
-
(1999)
Org. Lett.
, vol.1
, pp. 1859
-
-
Lee, K.J.1
-
109
-
-
0032478678
-
Solid-phase synthesis of diverse E- and F-Series prostaglandins
-
Thompson, L.A. et al., Solid-phase synthesis of diverse E- and F-Series prostaglandins, J. Org. Chem., 63, 2066, 1998.
-
(1998)
J. Org. Chem.
, vol.63
, pp. 2066
-
-
Thompson, L.A.1
-
110
-
-
0033223066
-
Parallel synthesis of prostaglandin E1 analogues
-
Dragoli, D.R. et al., Parallel synthesis of prostaglandin E1 analogues, J. Comb. Chem., 1, 534, 1999.
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 534
-
-
Dragoli, D.R.1
-
111
-
-
0001302995
-
-
Johnson, C.R. and Braun, M.P., A two-step, three-component synthesis of PGE1: utilization of - iodoenones in Pd(0)-catalyzed cross-couplings of organoboranes, J. Am. Chem. Soc., 115, 11014, 1993.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 11014
-
-
Johnson, C.R.1
Braun, M.P.2
-
115
-
-
0033516914
-
Chemistry, biology, and medicine of the glycopeptide antibiotics
-
Nicolaou, K.C., Boddy, C.N.C., Bräse, S., and Winssinger, N., Chemistry, biology, and medicine of the glycopeptide antibiotics, Angew. Chem. Int. Ed. Engl., 38, 2096, 1999.
-
(1999)
Angew. Chem. Int. Ed. Engl.
, vol.38
, pp. 2096
-
-
Nicolaou, K.C.1
Boddy, C.N.C.2
Bräse, S.3
Winssinger, N.4
-
116
-
-
0033606246
-
Combinatorial library approach for the identification of synthetic receptors targeting vancomycin-resistant bacteria
-
Xu, R. et al., Combinatorial library approach for the identification of synthetic receptors targeting vancomycin-resistant bacteria, J. Am. Chem. Soc., 121, 4898, 1999.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 4898
-
-
Xu, R.1
-
117
-
-
3543056384
-
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
-
Nicolaou, K.C. et al., Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria, Chem. Eur. J., 7, 3798, 2001.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 3798
-
-
Nicolaou, K.C.1
-
118
-
-
0037622609
-
D-Ala-D-Lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant Enterococci
-
references cited therein
-
Jain, R.K., Trias, J., and Ellman, J.A., D-Ala-D-Lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant Enterococci, J. Am. Chem. Soc., 125, 8740, 2003 and references cited therein.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8740
-
-
Jain, R.K.1
Trias, J.2
Ellman, J.A.3
-
119
-
-
17844373179
-
Solid-phase synthesis of natural products and natural productlike libraries
-
Nicolaou, K.C., Hanko, R. and Hartwig, W., Eds., Wiley, Weinhaim, Germany
-
Nicolaou, K.C. and Pfefferkorn, J.A., Solid-phase synthesis of natural products and natural productlike libraries, in Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials, Nicolaou, K.C., Hanko, R. and Hartwig, W., Eds., Wiley, Weinhaim, Germany, 2002, 613-642.
-
(2002)
Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials
, pp. 613-642
-
-
Nicolaou, K.C.1
Pfefferkorn, J.A.2
-
120
-
-
0035688790
-
Solid-phase synthesis of complex natural products and libraries thereof
-
Nicolaou, K.C. and Pfefferkorn, J.A., Solid-phase synthesis of complex natural products and libraries thereof, Biopolymers, 60, 171, 2001.
-
(2001)
Biopolymers
, vol.60
, pp. 171
-
-
Nicolaou, K.C.1
Pfefferkorn, J.A.2
-
121
-
-
0032862624
-
Total synthesis and chemical biology of the sarcodictyins
-
Nicolaou, K.C. et al., Total synthesis and chemical biology of the sarcodictyins, Chem. Pharm. Bull., 47, 1199, 1999.
-
(1999)
Chem. Pharm. Bull.
, vol.47
, pp. 1199
-
-
Nicolaou, K.C.1
-
122
-
-
0032576190
-
Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictyin libraries
-
Nicolaou, K.C. et al., Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictyin libraries, J. Am. Chem. Soc., 120, 10814, 1998.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 10814
-
-
Nicolaou, K.C.1
-
123
-
-
17744405184
-
Synthesis of epothiolones A and B in solid and solution phase
-
Nicolaou, K.C. et al., Synthesis of epothiolones A and B in solid and solution phase, Nature, 387, 268, 1997.
-
(1997)
Nature
, vol.387
, pp. 268
-
-
Nicolaou, K.C.1
-
124
-
-
3543056384
-
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
-
Nicolaou, K.C. et al., Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria, Chem. Eur. J., 7, 3798, 2001.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 3798
-
-
Nicolaou, K.C.1
-
125
-
-
0034602053
-
Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria
-
Nicolaou, K.C. et al., Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria, Angew. Chem., Int. Ed. Engl., 39, 3823, 2000.
-
(2000)
Angew. Chem., Int. Ed. Engl.
, vol.39
, pp. 3823
-
-
Nicolaou, K.C.1
-
126
-
-
0032572123
-
Solid phase synthesis of macrocycles by an intramolecular ketophosphonate reaction: Synthesis of a (DL)-muscone library
-
Nicolaou, K.C. et al., Solid phase synthesis of macrocycles by an intramolecular ketophosphonate reaction: synthesis of a (DL)-muscone library, J. Am. Chem. Soc., 120, 5132, 1998.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 5132
-
-
Nicolaou, K.C.1
-
127
-
-
0035477106
-
Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin a type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)
-
Nicolaou, K.C. et al., Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin a type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA), Chem. Eur. J., 7, 4280, 2001.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 4280
-
-
Nicolaou, K.C.1
-
128
-
-
0035477708
-
Optimization and mechanistic studies of psammaplin a type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)
-
Nicolaou, K.C. et al., Optimization and mechanistic studies of psammaplin a type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA), Chem. Eur. J., 7, 4296, 2001.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 4296
-
-
Nicolaou, K.C.1
-
130
-
-
85056049182
-
General principles and solid-phase synthesis of benzopyrans
-
General principles and solid-phase synthesis of benzopyrans, J. Am. Chem. Soc., 122, 9939, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9939
-
-
-
132
-
-
0034684225
-
Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding
-
Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding, J. Am. Chem. Soc., 122, 9954, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9954
-
-
-
134
-
-
85056046637
-
The “libraries from libraries” principle for diversity enhancement of benzopyran libraries
-
The “libraries from libraries” principle for diversity enhancement of benzopyran libraries, J. Am. Chem. Soc., 122, 9968, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9968
-
-
-
135
-
-
0037366605
-
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
-
Horton, D.A., Bourne, G.T., and Smythe, M.L., The combinatorial synthesis of bicyclic privileged structures or privileged substructures, Chem. Rev., 103, 893, 2003.
-
(2003)
Chem. Rev.
, vol.103
, pp. 893
-
-
Horton, D.A.1
Bourne, G.T.2
Smythe, M.L.3
-
136
-
-
0034526302
-
Combinatorial synthesis of novel and potent inhibitors of NADH: Ubiquninone oxidoreductase
-
Nicolaou, K.C. et al., Combinatorial synthesis of novel and potent inhibitors of NADH: ubiquninone oxidoreductase, Chem. Biol., 7, 979, 2000.
-
(2000)
Chem. Biol.
, vol.7
, pp. 979
-
-
Nicolaou, K.C.1
-
137
-
-
0000754115
-
Use of combinatorial and multiple parallel synthesis methodologies for the development of anti-infective natural products
-
Fecik, R.A. et al., Use of combinatorial and multiple parallel synthesis methodologies for the development of anti-infective natural products, Pure Appl. Chem., 71, 559, 1999.
-
(1999)
Pure Appl. Chem.
, vol.71
, pp. 559
-
-
Fecik, R.A.1
-
138
-
-
0035382954
-
Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries
-
Nicolaou, K.C. et al., Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries, Chembiochem, 460, 2001.
-
(2001)
Chembiochem
, pp. 460
-
-
Nicolaou, K.C.1
-
139
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
Downes, M. et al., A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR, Mol. Cell, 11, 1079, 2003.
-
(2003)
Mol. Cell
, vol.11
, pp. 1079
-
-
Downes, M.1
-
140
-
-
0038274333
-
Discovery and optimization of non-steroidal FXR agonists from natural productlike libraries
-
Nicolaou, K.C. et al., Discovery and optimization of non-steroidal FXR agonists from natural productlike libraries, Org. Biomol. Chem., 1, 908, 2003.
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 908
-
-
Nicolaou, K.C.1
-
141
-
-
0142147275
-
Generating diverse skeletons of small molecules combinatorially
-
Burke, M.D., Berger, E.M., and Schreiber, S.L., Generating diverse skeletons of small molecules combinatorially, Science, 302, 613, 2003.
-
(2003)
Science
, vol.302
, pp. 613
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
142
-
-
0031710509
-
Chemical genetics resulting from a passion for synthetic organic chemistry
-
Schreiber, S.L., Chemical genetics resulting from a passion for synthetic organic chemistry, Bioorg. Med. Chem., 6, 1127, 1998.
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1127
-
-
Schreiber, S.L.1
-
143
-
-
4644273636
-
Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes
-
Wong, J.C. et al., Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes, Chem. Biol., 11, 1279, 2004.
-
(2004)
Chem. Biol.
, vol.11
, pp. 1279
-
-
Wong, J.C.1
-
144
-
-
1842454311
-
Macrolactones in diversity-oriented synthesis: Preparation of a pilot library and exploration of factors controlling macrocyclization
-
Schmidt, D.R., Kwon, O., and Schreiber, S.L., Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization, J. Comb. Chem., 6, 286, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 286
-
-
Schmidt, D.R.1
Kwon, O.2
Schreiber, S.L.3
-
145
-
-
8744290775
-
Syntheses of stereochemically diverse nine-membered ring-containing biaryls
-
Krishnan, S. and Schreiber, S.L., Syntheses of stereochemically diverse nine-membered ring-containing biaryls, Org. Lett., 6, 4021, 2004.
-
(2004)
Org. Lett.
, vol.6
, pp. 4021
-
-
Krishnan, S.1
Schreiber, S.L.2
-
146
-
-
0037138650
-
Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform
-
Spring, D.R. et al., Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform, J. Am. Chem. Soc., 124, 1354, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 1354
-
-
Spring, D.R.1
-
147
-
-
4544326369
-
Synthetic strategy toward skeletal diversity via solidsupported, otherwise unstable reactive intermediates
-
Taylor, S.J., Taylor, A.M., and Schreiber, S.L., Synthetic strategy toward skeletal diversity via solidsupported, otherwise unstable reactive intermediates, Angew. Chem., Int. Ed. Engl., 43, 1681, 2004.
-
(2004)
Angew. Chem., Int. Ed. Engl.
, vol.43
, pp. 1681
-
-
Taylor, S.J.1
Taylor, A.M.2
Schreiber, S.L.3
-
148
-
-
0344514145
-
Stereochemical control of skeletal diversity
-
Sello, J.K. et al., Stereochemical control of skeletal diversity, Org. Lett., 5, 4125, 2003.
-
(2003)
Org. Lett.
, vol.5
, pp. 4125
-
-
Sello, J.K.1
-
149
-
-
0036008853
-
Pathway development and pilot library realization in diversity-oriented synthesis:Exploring Ferrier and Pauson-Khand reactions on a glycal template
-
Kubota, H. et al., Pathway development and pilot library realization in diversity-oriented synthesis:exploring Ferrier and Pauson-Khand reactions on a glycal template, Chem. Biol., 9, 265, 2002.
-
(2002)
Chem. Biol.
, vol.9
, pp. 265
-
-
Kubota, H.1
-
152
-
-
20444404268
-
Synthetic approaches towards structurally diverse g-butyrolactone natural product-like compounds
-
Seitz, M. and Reiser, O., Synthetic approaches towards structurally diverse g-butyrolactone natural product-like compounds, Curr. Opin. Chem. Biol., 9, 285, 2005.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 285
-
-
Seitz, M.1
Reiser, O.2
-
153
-
-
12344293904
-
Skeletal diversity via a folding pathway: Synthesis of indole alkaloidlike skeletons
-
Oguri, H. and Schreiber, S.L., Skeletal diversity via a folding pathway: synthesis of indole alkaloidlike skeletons, Org. Lett., 7, 47, 2005.
-
(2005)
Org. Lett.
, vol.7
, pp. 47
-
-
Oguri, H.1
Schreiber, S.L.2
-
154
-
-
29844455070
-
Small-molecule diversity using a skeletal transformation strategy
-
Kumar, N. et al., Small-molecule diversity using a skeletal transformation strategy, Org. Lett., 7, 2535, 2005.
-
(2005)
Org. Lett.
, vol.7
, pp. 2535
-
-
Kumar, N.1
-
155
-
-
20444420189
-
Natural product-like chemical space: Search for chemical dissectors of macromolecular interactions
-
Reayi, A. and Arya, P., Natural product-like chemical space: search for chemical dissectors of macromolecular interactions, Curr. Opin. Chem. Biol., 9, 240, 2005.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 240
-
-
Reayi, A.1
Arya, P.2
-
156
-
-
14144251136
-
Exploring new chemical space by stereocontrolled diversity-oriented synthesis
-
Arya, P. et al., Exploring new chemical space by stereocontrolled diversity-oriented synthesis, Chem. Biol., 12, 163, 2005.
-
(2005)
Chem. Biol.
, vol.12
, pp. 163
-
-
Arya, P.1
-
157
-
-
20044379929
-
Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis
-
Arya, P. et al., Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis, Pure Appl. Chem., 77, 163, 2005.
-
(2005)
Pure Appl. Chem.
, vol.77
, pp. 163
-
-
Arya, P.1
-
158
-
-
0942289837
-
A solid-phase, library synthesis of natural product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold
-
Couve-Bonnaire, S. et al., A solid-phase, library synthesis of natural product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold, J. Comb. Chem., 6, 73, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 73
-
-
Couve-Bonnaire, S.1
-
159
-
-
4143121319
-
Solid-phase synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives employing support- bound tyrosine esters in the Pictet-Spengler reaction
-
Kane, T.R. et al., Solid-phase synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives employing support- bound tyrosine esters in the Pictet-Spengler reaction, J. Comb. Chem., 6, 564, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 564
-
-
Kane, T.R.1
-
160
-
-
0942289842
-
Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline- based polycyclic derivatives
-
Arya, P. et al., Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline- based polycyclic derivatives, J. Comb. Chem., 6, 54, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 54
-
-
Arya, P.1
-
161
-
-
4944243450
-
A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ring
-
Khadem, S. et al., A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ring, J. Comb. Chem., 6, 724, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 724
-
-
Khadem, S.1
-
162
-
-
4944223351
-
Solution- and solid-phase synthesis of natural product-like tetrahydroquinoline-based polycyclics having a medium size ring
-
Arya, P. et al., Solution- and solid-phase synthesis of natural product-like tetrahydroquinoline-based polycyclics having a medium size ring, J. Comb. Chem., 6, 735, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 735
-
-
Arya, P.1
-
163
-
-
0942289835
-
A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by Mitsunobu approach
-
Arya, P. et al., A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by Mitsunobu approach, J. Comb. Chem., 6, 65, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 65
-
-
Arya, P.1
-
164
-
-
85056032383
-
Stereocontrolled solid-phase synthesis of a 90-member library of indoline-alkaloid-like polycyclics from an enantiorich aminoindoline scaffold
-
Gan, Z. et al., Stereocontrolled solid-phase synthesis of a 90-member library of indoline-alkaloid-like polycyclics from an enantiorich aminoindoline scaffold, Angew. Chem., Int. Ed. Engl., 44, 2, 2005.
-
(2005)
Angew. Chem., Int. Ed. Engl.
, vol.44
, pp. 2
-
-
Gan, Z.1
-
165
-
-
17044421362
-
Protein structure similarity clustering and natural product structure as guiding principles in drug discovery
-
Koch, M.A. and Waldmann, H., Protein structure similarity clustering and natural product structure as guiding principles in drug discovery, Drug Discovery Today, 10, 471, 2005.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 471
-
-
Koch, M.A.1
Waldmann, H.2
-
166
-
-
20444409179
-
Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics
-
Dekker, F.J., Koch, M.A., and Waldmann, H., Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics, Curr. Opin. Chem. Biol., 9, 232, 2005.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 232
-
-
Dekker, F.J.1
Koch, M.A.2
Waldmann, H.3
-
167
-
-
0037119336
-
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries
-
Breinbauer, R., Vetter, I.R., and Waldmann, H., From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries, Angew. Chem., Int. Ed. Engl., 41, 2879, 2002.
-
(2002)
Angew. Chem., Int. Ed. Engl.
, vol.41
, pp. 2879
-
-
Breinbauer, R.1
Vetter, I.R.2
Waldmann, H.3
-
168
-
-
0036423173
-
Natural product guided compound library development
-
Breinbauer, R. et al., Natural product guided compound library development, Curr. Med. Chem., 9, 2129, 2002.
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 2129
-
-
Breinbauer, R.1
-
169
-
-
0037032265
-
Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors
-
Brohm, D. et al., Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors, J. Am. Chem. Soc., 124, 13171, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 13171
-
-
Brohm, D.1
-
170
-
-
0037126836
-
Natural products are biologically validated starting points in structural space for compound library development: Solid-phase synthesis of dysidiolide- derived phosphatase inhibitors
-
Brohm, D. et al., Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide- derived phosphatase inhibitors, Angew. Chem., Int. Ed. Engl., 41, 307, 2002.
-
(2002)
Angew. Chem., Int. Ed. Engl.
, vol.41
, pp. 307
-
-
Brohm, D.1
-
171
-
-
10044253102
-
Compound library development guided by protein structure similarity clustering and natural product structure
-
Koch, M.A. et al., Compound library development guided by protein structure similarity clustering and natural product structure, Proc. Natl. Acad. Sci. U.S.A., 101, 16721, 2004.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 16721
-
-
Koch, M.A.1
-
172
-
-
0035407227
-
Solid-phase library synthesis of alkoxyprolines
-
Boldi, A.M., Dener, J.M., and Hopkins, T.P., Solid-phase library synthesis of alkoxyprolines, J. Comb. Chem., 3, 367, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 367
-
-
Boldi, A.M.1
Dener, J.M.2
Hopkins, T.P.3
-
174
-
-
11144355895
-
High-throughput purification of combinatorial libraries I: A high-throughput purification system using an accelerated retention window approach
-
Yan, B. et al., High-throughput purification of combinatorial libraries I: A high-throughput purification system using an accelerated retention window approach, J. Comb. Chem., 6, 255, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 255
-
-
Yan, B.1
-
175
-
-
4143082527
-
High-throughput purification of combinatorial libraries II: Automated separation of single diastereomers from a 4-amido-pyrrolidone library containing intentional diastereomer pairs
-
Irving, M. et al., High-throughput purification of combinatorial libraries II: Automated separation of single diastereomers from a 4-amido-pyrrolidone library containing intentional diastereomer pairs, J. Comb. Chem., 6, 478, 2004.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 478
-
-
Irving, M.1
-
176
-
-
85056025970
-
-
Chemistry, Structures, & 3D Molecules @ 3Dchem.com, accessed Feb
-
Chemistry, Structures, & 3D Molecules @ 3Dchem.com. http//www.3dchem.com (accessed Feb 2006).
-
(2006)
-
-
-
177
-
-
85056030593
-
Synthesis of cis-4a(S),8a(R)-perhydro-6(2H)-isoquinolines from quinine
-
Hutchison, D.R. et al., Synthesis of cis-4a(S),8a(R)-perhydro-6(2H)-isoquinolines from quinine, Org. Synth., 75, 223, 1997.
-
(1997)
Org. Synth.
, vol.75
, pp. 223
-
-
Hutchison, D.R.1
-
178
-
-
13744263775
-
The quest for quinine: Those who won the battles and those who won the war
-
Kaufman, T.S. and Rúveda, E.A., The quest for quinine: Those who won the battles and those who won the war, Angew. Chem. Int. Ed. Engl., 44, 854, 2005.
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 854
-
-
Kaufman, T.S.1
Rúveda, E.A.2
-
179
-
-
33947294569
-
Modified support for solid-phase peptide synthesis which permits the synthesis of protected peptide fragments
-
Marshall, D.L. and Liener, I.E., Modified support for solid-phase peptide synthesis which permits the synthesis of protected peptide fragments, J. Org. Chem., 35, 867, 1970.
-
(1970)
J. Org. Chem.
, vol.35
, pp. 867
-
-
Marshall, D.L.1
Liener, I.E.2
-
180
-
-
84982443772
-
Intramolecular 1,3-dipolar cycloaddition reactions
-
Padwa, A., Intramolecular 1,3-dipolar cycloaddition reactions, Angew. Chem., Int. Ed. Engl., 15, 123, 1976.
-
(1976)
Angew. Chem., Int. Ed. Engl.
, vol.15
, pp. 123
-
-
Padwa, A.1
-
181
-
-
0030200350
-
Solid phase reductive alkylation of secondary amines
-
Khan, N.M., Arumugam, V., and Balasubramanian S., Solid phase reductive alkylation of secondary amines, Tetrahedron Lett., 37, 4819, 1996.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 4819
-
-
Khan, N.M.1
Arumugam, V.2
Balasubramanian, S.3
-
182
-
-
0032537007
-
Libraries of N-alkylaminoheterocycles from nucleophilic aromatic substitution with purification by solid-supported liquid extraction
-
Johnson, C.R. et al., Libraries of N-alkylaminoheterocycles from nucleophilic aromatic substitution with purification by solid-supported liquid extraction, Tetrahedron, 54, 4097, 1998.
-
(1998)
Tetrahedron
, vol.54
, pp. 4097
-
-
Johnson, C.R.1
-
183
-
-
0001355923
-
Scope and limitations of solid-supported liquid-liquid extraction for the high-throughput purification of compound libraries
-
Breitenbucher, J.G., Arienti, K.L., and McClure, K.J., Scope and limitations of solid-supported liquid-liquid extraction for the high-throughput purification of compound libraries, J. Comb. Chem., 3, 528, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 528
-
-
Breitenbucher, J.G.1
Arienti, K.L.2
McClure, K.J.3
-
184
-
-
0003422388
-
-
W.H. Freeman and Co., New York
-
Darnell, J., Lodish, H., and Baltimore, D., Molecular Cell Biology, W.H. Freeman and Co., New York, 1990.
-
(1990)
Molecular Cell Biology
-
-
Darnell, J.1
Lodish, H.2
Baltimore, D.3
-
186
-
-
0001510424
-
A convenient procedure for esterification of carboxylic acids
-
Ono, N. et al., A convenient procedure for esterification of carboxylic acids, Bull. Chem. Soc. Jpn., 51, 2401, 1978.
-
(1978)
Bull. Chem. Soc. Jpn.
, vol.51
, pp. 2401
-
-
Ono, N.1
-
187
-
-
84943845170
-
A new rapid esterification procedure utilizing exceptionally mild reaction conditions
-
Rao, C.G., A new rapid esterification procedure utilizing exceptionally mild reaction conditions, Org. Prep. Procedures Int., 12, 225, 1980.
-
(1980)
Org. Prep. Procedures Int.
, vol.12
, pp. 225
-
-
Rao, C.G.1
-
188
-
-
0001139490
-
Pyridinium dichromate oxidation:Modifications enhancing its synthetic utility
-
Czernecki, S. et al., Pyridinium dichromate oxidation:modifications enhancing its synthetic utility, Tetrahedron Lett., 26, 1699, 1985.
-
(1985)
Tetrahedron Lett.
, vol.26
, pp. 1699
-
-
Czernecki, S.1
-
189
-
-
0037859750
-
Kinetics study of amine cleavage reactions of various resin-bound thiophenol esters from Marshall linker
-
Fang, L. et al., Kinetics study of amine cleavage reactions of various resin-bound thiophenol esters from Marshall linker, J. Comb. Chem., 4, 362, 2002.
-
(2002)
J. Comb. Chem.
, vol.4
, pp. 362
-
-
Fang, L.1
-
190
-
-
0035461675
-
Repeated use of solid supports in combinatorial synthesis: The case of Marshall resin recycling
-
Irving, M.M. et al., Repeated use of solid supports in combinatorial synthesis: the case of Marshall resin recycling, J. Comb. Chem., 3, 407, 2001.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 407
-
-
Irving, M.M.1
-
191
-
-
85056025402
-
Chemogenomic approaches to drug discovery
-
Caron, P.R. et al., Chemogenomic approaches to drug discovery, Curr. Opin. Chem. Biol., 5, 464, 2001.
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 464
-
-
Caron, P.R.1
-
192
-
-
5644255983
-
Quality, not quantity: The role of natural products and chemical proteomics in modern drug discovery
-
Piggott, A.M. and Karuso, P., Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery, Comb. Chem. High Throughput Screen., 7, 607, 2004.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 607
-
-
Piggott, A.M.1
Karuso, P.2
-
193
-
-
33644846857
-
Small molecules: The missing link in the central dogma
-
Schreiber, S.L., Small molecules: the missing link in the central dogma, Nat. Chem. Biol., 1, 64, 2005.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 64
-
-
Schreiber, S.L.1
|