Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting

Biotechnology and Bioengineering

Volumn 71, Issue 1, 2000, Pages 44-50

  Xiao, Xiao Yi ^a   Li, Rongshi ^a   Zhuang, Hui ^a   Ewing, Bill ^a   Karunaratne, K ^a   Lillig, John ^a   Brown, Rick ^a   Nicolaou, K C ^b,c  

^a Discov Ptnrs International Company   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Directed sorting; MicroKan reactor; Parallel synthesis; Radiofrequency tagging; Solid phase synthesis; Split and pool

Indexed keywords

BIOREACTORS; SORTING;

MICROKAN REACTORS; RADIOFREQUENCY TAGGING;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; CARBOHYDRATE DERIVATIVE; EPOTHILONE DERIVATIVE; MONOSACCHARIDE; PACLITAXEL DERIVATIVE; POLYPROPYLENE; RESIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; PHARMACOPHORE; PRODUCTIVITY; RADIOFREQUENCY; REACTOR; RELIABILITY; ROBOTICS; SOLID STATE;

CHEMISTRY, ORGANIC; DATABASES; DRUG DESIGN; INDICATORS AND REAGENTS; ORGANIC CHEMICALS; PACLITAXEL; RADIO WAVES; RESINS, PLANT;

EID: 0033949965     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(200024)71:1<44::AID-BIT7>3.0.CO;2-J     Document Type: Article

References (27)

1. Porco, J.A.Jr.; Deegan, T.L.; Devonport, W.; Gooding, O.W.; Labadie, J.W.; MacDonald, A.A.; Newcomb, W.S.; Van Eikeren, P. Drug Future 1998, 23, 71-78.
2. Brennan, T.; Biddison, G.; Frauendorf, A.; Schwarcz, L.; Keen, B.; Ecker, D.J.; Davis, P.W.; Tinder, R.; Swayze, E.E. Biotechnol Bioeng (Comb Chem) 1998, 61, 33-45.
3. DeWitt, S.H. Ann. Rep. Comb. Chem. Mol. Diversity 1997, 1, 69-77.
4. Lam, K.S.; Salmon, S.E.; Hersh, E.M.; Hruby, V.J.; Kazmierski, W.M.; Knapp, R.J. Nature 1991, 354, 82-84.
5. Lam, K.S.; Hruby, V.J.; Lebl, M; Knapp, R.J.; Kazmierski, W.M.; Hersh, E.M., Salmon, S.E. Bioorg Med Chem Lett 1993, 3, 419-425.
6. Furka, Á.; Sevestyén, F.; Asgedom, M.; Dibó, G. Int J Pep Res 1991, 37, 487-491.
7. Houghten, R.A. Proc Natl Acad Sci USA 1985, 82, 5131-5135.
8. Nicolaou, K.C.; Xiao, X.-Y.; Parandoosh, Z.; Senyei, A.; Nova, M.P. Angew. Chem. Int Ed Engl 1995, 34, 2289-2291.
9. Moran, E.J.; Sarshar, S.; Cargill, J.F.; Shahbaz, M.J.M.; Lio, A.; Mjalli, A.M.; Armstrong, R.W. J.Am Chem Soc 1995, 117, 10787-10788.
10. Xiao, X.Y.; Zhao, C.; Potash, H.; Nova, M.P. Angew Chem Int Ed Engl 1997, 36, 780-782.
11. Hunn, B.A.; Howell, E.N. U.S. Patent 3671721, 1972.
12. Burgess, K.; Liaw, A.I.; Wang, N. J. Med. Chem. 1994, 37, 2985-2988.
13. Nicolaou, K.C.; Dai, W.-M.; Guy, R.K. Angew Chem Int Ed Engl 1994, 33, 15-44.
14. Schiff, P.B.; Fant, J.; Horwitz, S.B. Nature 1979, 277, 665-667.
15. Schiff, P.B.; Horwitz, S.B. Proc Natl Acad Sci USA 1980, 77, 1561-1565.
16. Xiao, X.Y.; Parandoosh, Z.; Nova, M.P. J Org Chem 1997, 62, 6029-6033.
17. Nicolaou, K.C.; Vourloumis, D.; Li, T.; Pastor, J.; Winssinger, N.; He, Y.; Ninkovic, S.; Sarabia, F.; Vallberg, H.; Roschangar, F.; King, N.P.; Finlay, M.R.V.; Giannakakou, P.; Verdier-Pinard, P.; Hamel, E. Angew Chem Int Ed Engl 1997, 36, 2097-2103.
18. Nicolaou, K.C.; Winssinger, N.; Pastor, J.; Ninkoivc, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. Nature 1997, 387, 268-239.
19. Kowalski, R.J.; Giannakakou, P.; Hamel, E. J Biol Chem 1997, 272, 2534-2541.
20. Hirschmann, R.; Nicolaou, K.C.; Pietranico, S.; Leahy, E.M.; Salvino, J.; Arison, B.; Cichy, M.A.; Spoors, P.G.; Shakespear, W.C.; Sprengeler, P.A.; Hamley, P.; Smith, A.B., III; Reisine, T.; Raynor, K.; Maechler, L.; Donaldson, C.; Vale, W.; Freidinger, R.M.; Cascieri, M.R.; Strader, C.D. J Am Chem Soc 1993, 115, 12550-12568.
21. Sofia, M.J.; Hunter, R.; Chan, T.Y.; Vaughan, A.; Dulina, R.; Wang, H.; Gange, D. J Org Chem 1998, 63, 2802-2803.
22. Li, R.; Xiao, X.-Y.; Czarnik, A.W. Tetrahedron Lett 1998, 39, 8581-8584.
23. Zhao, C.; Shi, S.; Mir, D.; Hurst, D.; Li, R.; Xiao, X.-Y.; Lillig, J.; Czarnik, A.W. J Comb Chem 1999, 1, 91-95.
24. Shi, S.; Xiao, X.-Y.; Czarnik, A.W. Biotechnol Bioeng (Comb Chem), 1998, 61, 7-12.
25. Li, R.; Xiao, X.-Y.; Nicolaou, K.C. In: High Throughput Organic Synthesis, 1st ed.; Suchleiki, I., Ed.; Marcel Dekker: New York, 1999, in press.
26. Nicolaou, K.C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J.-Y.; Li, T. J Am Chem Soc 1998, 120, 10814-10826.
27. Andres, C.J.; Swann, R.T.; Grant-Young, K.; D'Andrea, S.V.; Deshpande, M.S. Comb Chem & HTS, 1999, 2, 29-32.