Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries

Organic and Biomolecular Chemistry

Volumn 1, Issue 6, 2003, Pages 908-920

  Nicolaou, K C ^a,b   Evans, Ronald M ^c   Roecker, A J ^a   Hughes, Robert ^a   Downes, Michael ^c   Pfefferkorn, Jeffery A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; BIOSYNTHESIS; DISEASES; DRUG PRODUCTS; LIPIDS; METABOLISM; MOLECULAR STRUCTURE; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

FARNESOID X RECEPTOR; LIPID HOMEOSTASIS; SOLUTION-PHASE SYNTHESIS;

CHOLESTEROL;

BENZOPYRAN DERIVATIVE; BILE ACID; BIOLOGICAL FACTOR; CELL RECEPTOR; CHOLESTEROL; DNA BINDING PROTEIN; FARNESOID X RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; LIGAND; TRANSCRIPTION FACTOR;

ARTICLE; BILE; CHEMICAL STRUCTURE; DRUG POTENTIATION; DRUG SCREENING; METABOLISM; METHODOLOGY; PHYSIOLOGY; SYNTHESIS;

BENZOPYRANS; BILE; BILE ACIDS AND SALTS; BIOLOGICAL FACTORS; CHOLESTEROL; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; LIGANDS; MOLECULAR STRUCTURE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0038274333     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b300525a     Document Type: Article

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