SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 43, Issue 1, 2004, Pages 46-58

A Planning Strategy for Diversity-Oriented Synthesis

(2) Burke, Martin D a Schreiber, Stuart L a

a HARVARD UNIVERSITY (United States)

Author keywords

Diversity oriented synthesis; Drug design; Retro reactions; Small molecules; Synthesis design

Indexed keywords

DIVERSITY ORIENTED SYNTHESIS (DOS);

MOLECULAR STRUCTURE; STEREOCHEMISTRY; SURFACE CHEMISTRY;

SYNTHESIS (CHEMICAL);

CHEMICAL REACTION; COMBINATORIAL CHEMISTRY; DIVERSITY ORIENTED SYNTHESIS; DRUG DESIGN; PLANNING; REVIEW; STEREOCHEMISTRY; SYNTHESIS;

EID: 3042799070 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200300626 Document Type: Review

Times cited : (1324)

References (95)

1
- 0347688058
- note
- Chemistry space is multidimensional, with each dimension defined by a value of a descriptor; descriptors can be of a biological or chemical nature and are either computed or measured.

2
- 0034678033
- S. L. Schreiber, Science 2000, 287, 1964; S. L. Schreiber, Chem. Eng. News 2003, 81(9), 51.
- (2000) Science , vol.287 , pp. 1964
- Schreiber, S.L.¹

3
- 0037416141
- S. L. Schreiber, Science 2000, 287, 1964; S. L. Schreiber, Chem. Eng. News 2003, 81(9), 51.
- (2003) Chem. Eng. News , vol.81 , Issue.9 , pp. 51
- Schreiber, S.L.¹

4
- 0004114335
- Wiley, New York
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1995) The Logic of Chemical Synthesis
- Corey, E.J.¹ Cheng, X.-M.²

5
- 0000080313
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1991) Angew. Chem. , vol.103 , pp. 469
- Corey, E.J.¹

6
- 0025911415
- Nobel Lecture
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1991) Angew. Chem. Int. Ed. Engl. , vol.30 , pp. 455

7
- 0011362257
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1967) Pure. Appl. Chem. , vol.14 , pp. 19
- Corey, E.J.¹

8
- 37049231053
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1969) Science , vol.166 , pp. 178
- Corey, E.J.¹ Wipke, W.T.²

9
- 0007316055
- E.J. Corey, X.-M. Cheng, The Logic of Chemical Synthesis, Wiley, New York, 1995; E. J. Corey, Angew. Chem. 1991, 103, 469; Angew. Chem. Int. Ed. Engl. 1991, 30, 455 (Nobel Lecture); E. J. Corey, Pure. Appl. Chem. 1967, 14, 19; E. J. Corey, W. T. Wipke, Science 1969, 166, 178; E. J. Corey, Q. Rev. Chem. Soc. 1971, 25, 455.
- (1971) Q. Rev. Chem. Soc , vol.25 , pp. 455
- Corey, E.J.¹

10
- 0031152053
- M. R. Spaller, M. T. Burger, M. Fardis, P. A. Bartlett, Curr. Opin. Chem. Biol. 1997, 1, 47.
- (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 47
- Spaller, M.R.¹ Burger, M.T.² Fardis, M.³ Bartlett, P.A.⁴

11
- 0345796200
- http://chembank.med.harvard.edu/.

12
- 0347688057
- Cascade Reactions
- (Ed.: R. Grigg), Elsevier, New York
- For reviews, see "Cascade Reactions": Tetrahedron Symposium in Print, No. 62 (Ed.: R. Grigg), Elsevier, New York, 1996; F. E. Ziegler in Comprehensive Organic Synthesis, Combining C-C π-Bonds, Vol. 5 (Ed.: L. A. Paquette), Permagon, Oxford, 1991, chap. 7.3; T.-L. Ho, Tandem Organic Reactions, Wiley, New York, 1992.
- (1996) Tetrahedron Symposium in Print , vol.62

13
- 0003417469
- (Ed.: L. A. Paquette), Permagon, Oxford, chap 73
- For reviews, see "Cascade Reactions": Tetrahedron Symposium in Print, No. 62 (Ed.: R. Grigg), Elsevier, New York, 1996; F. E. Ziegler in Comprehensive Organic Synthesis, Combining C-C π-Bonds, Vol. 5 (Ed.: L. A. Paquette), Permagon, Oxford, 1991, chap. 7.3; T.-L. Ho, Tandem Organic Reactions, Wiley, New York, 1992.
- (1991) Comprehensive Organic Synthesis, Combining C-C π-Bonds , vol.5
- Ziegler, F.E.¹

14
- 0004198491
- Wiley, New York
- For reviews, see "Cascade Reactions": Tetrahedron Symposium in Print, No. 62 (Ed.: R. Grigg), Elsevier, New York, 1996; F. E. Ziegler in Comprehensive Organic Synthesis, Combining C-C π-Bonds, Vol. 5 (Ed.: L. A. Paquette), Permagon, Oxford, 1991, chap. 7.3; T.-L. Ho, Tandem Organic Reactions, Wiley, New York, 1992.
- (1992) Tandem Organic Reactions
- Ho, T.-L.¹

15
- 20744456789
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1963) J. Am. Chem. Soc. , vol.85 , pp. 2149
- Merrifield, R.B.¹

16
- 0001497178
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1972) Can. J. Chem. , vol.50 , pp. 2892
- Leznoff, C.C.¹ Wong, J.Y.²

17
- 0006146992
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1971) Tetrahedron Lett. , vol.12 , pp. 1713
- Camps, F.¹ Castells, J.² Ferrando, M.J.³ Font, J.⁴

18
- 0000303445
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1974) An. Quim. , vol.70 , pp. 848
- Camps, F.¹ Castells, J.² Pi, J.³

19
- 0041016967
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1970) J. Am. Chem. Soc. , vol.92 , pp. 7857
- Patchornik, A.¹ Kraus, M.A.²

20
- 33947296610
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1970) J. Am. Chem. Soc. , vol.92 , pp. 6363
- Crowley, J.I.¹ Rapoport, H.²

21
- 0000021185
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1980) Can. J. Chem. , vol.58 , pp. 1140
- Yedida, V.¹ Lexnoff, C.C.²

22
- 33847797467
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1976) J. Org. Chem. , vol.41 , pp. 3877
- Farrall, M.J.¹ Fréchet, J.M.J.²

23
- 0000975204
- R. B. Merrifield, J. Am. Chem. Soc. 1963, 85, 2149; C. C. Leznoff, J. Y. Wong, Can. J. Chem. 1972, 50, 2892; F. Camps, J. Castells, M. J. Ferrando, J. Font, Tetrahedron Lett. 1971, 12, 1713; F. Camps, J. Castells, J. Pi, An. Quim. 1974, 70, 848; A. Patchornik, M. A. Kraus, J. Am. Chem. Soc. 1970, 92, 7857; J. I. Crowley, H. Rapoport, J. Am. Chem. Soc. 1970, 92, 6363; V. Yedida, C. C. Lexnoff, Can. J. Chem. 1980, 58, 1140; M. J. Farrall, J. M. J. Fréchet, J. Org. Chem. 1976, 41, 3877; J. M. J. Fréchet, Tetrahedron 1981, 37, 663.
- (1981) Tetrahedron , vol.37 , pp. 663
- Fréchet, J.M.J.¹

24
- 0027068161
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1992) J. Am. Chem. Soc. , vol.114 , pp. 10997
- Bunin, B.A.¹ Ellman, J.A.²

25
- 0026726041
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 9367
- Simon, R.J.¹ Kania, K.S.² Zuckermann, R.N.³ Huebner, V.D.⁴ Jewell, D.A.⁵ Banville, S.⁶ Ng, S.⁷ Wang, L.⁸ Rosenberg, S.⁹ Marlowe, C.K.¹⁰ Spellmeyer, D.C.¹¹ Tan, R.¹² Frankel, A.D.¹³ Santi, D.V.¹⁴ Cohen, F.E.¹⁵ Bartlett, P.A.¹⁶

26
- 0027202613
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6909
- Dewitt, S.H.¹ Kiely, J.S.² Stankovic, C.J.³ Schroeder, M.C.⁴ Cody, D.M.R.⁵ Pavia, M.R.⁶

27
- 0029930278
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1996) Tetrahedron , vol.52 , pp. 4527
- Hermkens, P.H.H.¹ Ottenheijm, H.C.J.² Rees, D.³

28
- 0031001699
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1997) Tetrahedron , vol.53 , pp. 5643
- Hermkens, P.H.H.¹ Ottenheijm, H.C.J.² Rees, D.³

29
- 0033156688
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (1999) J. Comb. Chem. , vol.1 , pp. 235
- Dolle, R.E.¹ Nelson Jr., K.H.²

30
- 0034265578
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (2000) J. Comb. Chem. , vol.2 , pp. 383
- Dolle, R.E.¹

31
- 0035513630
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (2001) J. Comb. Chem. , vol.3 , pp. 477
- Dolle, R.E.¹

32
- 0026726041
- B. A. Bunin, J. A. Ellman, J. Am. Chem. Soc. 1992, 114, 10997; R. J. Simon, K. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9367; S. H. Dewitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. M. R. Cody, M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 6909; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1996, 52, 4527; P. H. H. Hermkens, H. C. J. Ottenheijm, D. Rees, Tetrahedron 1997, 53, 5643; R. E. Dolle, K. H. Nelson, Jr., J. Comb. Chem. 1999, 1, 235; R. E. Dolle, J. Comb. Chem. 2000, 2, 383; R. E. Dolle, J. Comb. Chem. 2001, 3, 477; R. E. Dolle, J. Comb. Chem. 2002, 4, 369.
- (2002) J. Comb. Chem. , vol.4 , pp. 369
- Dolle, R.E.¹

33
- 0001939276
- VSP, Utrecht, Netherlands
- th International Congress of Biochemistry, Prague, Czechoslovakia (VSP, Utrecht, Netherlands), 1988, 13, 47; A. Furka, F. Sebestyén, M. Asgedom, G. Dibó, Int. J. Pept. Protein Res. 1991, 37, 487; R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Nature 1991, 354, 84; K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp, Nature 1991, 354, 82.
- (1988) th International Congress of Biochemistry, Prague, Czechoslovakia , vol.13 , pp. 47
- Furka, A.¹ Sebestyén, F.² Asgedom, M.³ Dibó, G.⁴

34
- 0025893762
- th International Congress of Biochemistry, Prague, Czechoslovakia (VSP, Utrecht, Netherlands), 1988, 13, 47; A. Furka, F. Sebestyén, M. Asgedom, G. Dibó, Int. J. Pept. Protein Res. 1991, 37, 487; R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Nature 1991, 354, 84; K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp, Nature 1991, 354, 82.
- (1991) Int. J. Pept. Protein Res. , vol.37 , pp. 487
- Furka, A.¹ Sebestyén, F.² Asgedom, M.³ Dibó, G.⁴

35
- 0026419319
- th International Congress of Biochemistry, Prague, Czechoslovakia (VSP, Utrecht, Netherlands), 1988, 13, 47; A. Furka, F. Sebestyén, M. Asgedom, G. Dibó, Int. J. Pept. Protein Res. 1991, 37, 487; R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Nature 1991, 354, 84; K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp, Nature 1991, 354, 82.
- (1991) Nature , vol.354 , pp. 84
- Houghten, R.A.¹ Pinilla, C.² Blondelle, S.E.³ Appel, J.R.⁴ Dooley, C.T.⁵ Cuervo, J.H.⁶

36
- 0026419328
- th International Congress of Biochemistry, Prague, Czechoslovakia (VSP, Utrecht, Netherlands), 1988, 13, 47; A. Furka, F. Sebestyén, M. Asgedom, G. Dibó, Int. J. Pept. Protein Res. 1991, 37, 487; R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Nature 1991, 354, 84; K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp, Nature 1991, 354, 82.
- (1991) Nature , vol.354 , pp. 82
- Lam, K.S.¹ Salmon, S.E.² Hersh, E.M.³ Hruby, V.J.⁴ Kazmierski, W.M.⁵ Knapp, R.J.⁶

37
- 0347688056
- note
- It is useful to describe the molecular skeleton of a small molecule as the combination of rigidifying elements (covalent bonds, noncovalent bonds, and nonbonding interactions) that define its overall three-dimensional shape. In that vein, a complex molecular skeleton is one that is defined by a large number and/or variety of rigidifying elements.

38
- 0346427209
- http://iccb.med.harvard.edu/.

39
- 0001237986
- For a review of such transformations, see L. F. Tietze, U. A. Beifuss, Angew. Chem. 1993, 105, 137; Angew. Chem. Int. Ed. Engl. 1993, 32, 131.
- (1993) Angew. Chem. , vol.105 , pp. 137
- Tietze, L.F.¹ Beifuss, U.A.²

40
- 33750173220
- For a review of such transformations, see L. F. Tietze, U. A. Beifuss, Angew. Chem. 1993, 105, 137; Angew. Chem. Int. Ed. Engl. 1993, 32, 131.
- (1993) Angew. Chem. Int. Ed. Engl. , vol.32 , pp. 131

41
- 0028757621
- I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115.
- (1994) Endeavour , vol.18 , pp. 115
- Ugi, I.¹ Dömling, A.² Hörl, W.³

42
- 0033525660
- K. Paulvannan, Tetrahedron Lett. 1999, 40, 1851; D. Lee, J.K. Sello, S. L. Schreiber, Org. Lett. 2000, 2, 709.
- (1999) Tetrahedron Lett. , vol.40 , pp. 1851
- Paulvannan, K.¹

43
- 0034624574
- K. Paulvannan, Tetrahedron Lett. 1999, 40, 1851; D. Lee, J.K. Sello, S. L. Schreiber, Org. Lett. 2000, 2, 709.
- (2000) Org. Lett. , vol.2 , pp. 709
- Lee, D.¹ Sello, J.K.² Schreiber, S.L.³

44
- 0029884246
- W. J. Zuercher, M. Hashimoto, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 6634; W. J. Zuercher, M. Scholl, R. H. Grubbs, J. Org. Chem. 1998, 63, 4291; R. Stragies, S. Blechert, Tetrahedron 1999, 55, 8179; O. Arjona, A. G. Csákÿ, M. C. Murcia, J. Plumet, J. Org. Chem. 1999, 64, 9739.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 6634
- Zuercher, W.J.¹ Hashimoto, M.² Grubbs, R.H.³

45
- 0001117364
- W. J. Zuercher, M. Hashimoto, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 6634; W. J. Zuercher, M. Scholl, R. H. Grubbs, J. Org. Chem. 1998, 63, 4291; R. Stragies, S. Blechert, Tetrahedron 1999, 55, 8179; O. Arjona, A. G. Csákÿ, M. C. Murcia, J. Plumet, J. Org. Chem. 1999, 64, 9739.
- (1998) J. Org. Chem. , vol.63 , pp. 4291
- Zuercher, W.J.¹ Scholl, M.² Grubbs, R.H.³

46
- 0033516690
- W. J. Zuercher, M. Hashimoto, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 6634; W. J. Zuercher, M. Scholl, R. H. Grubbs, J. Org. Chem. 1998, 63, 4291; R. Stragies, S. Blechert, Tetrahedron 1999, 55, 8179; O. Arjona, A. G. Csákÿ, M. C. Murcia, J. Plumet, J. Org. Chem. 1999, 64, 9739.
- (1999) Tetrahedron , vol.55 , pp. 8179
- Stragies, R.¹ Blechert, S.²

47
- 0343776189
- W. J. Zuercher, M. Hashimoto, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 6634; W. J. Zuercher, M. Scholl, R. H. Grubbs, J. Org. Chem. 1998, 63, 4291; R. Stragies, S. Blechert, Tetrahedron 1999, 55, 8179; O. Arjona, A. G. Csákÿ, M. C. Murcia, J. Plumet, J. Org. Chem. 1999, 64, 9739.
- (1999) J. Org. Chem. , vol.64 , pp. 9739
- Arjona, O.¹ Csákÿ, A.G.² Murcia, M.C.³ Plumet, J.⁴

48
- 0033598258
- M. Scholl, S. Ding, C. W. Lee, R. H. Grubbs, Org. Lett. 1999, 1, 953; A. K. Chatterjee, R. H. Grubbs, Org. Lett. 1999, 1, 1751.
- (1999) Org. Lett. , vol.1 , pp. 953
- Scholl, M.¹ Ding, S.² Lee, C.W.³ Grubbs, R.H.⁴

49
- 0033518063
- M. Scholl, S. Ding, C. W. Lee, R. H. Grubbs, Org. Lett. 1999, 1, 953; A. K. Chatterjee, R. H. Grubbs, Org. Lett. 1999, 1, 1751.
- (1999) Org. Lett. , vol.1 , pp. 1751
- Chatterjee, A.K.¹ Grubbs, R.H.²

50
- 0032569205
- D. S. Tan, M. A. Foley, M. D. Shair, S. L. Schreiber, J. Am. Chem. Soc. 1998, 120, 8565.
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 8565
- Tan, D.S.¹ Foley, M.A.² Shair, M.D.³ Schreiber, S.L.⁴

51
- 0034809353
- H. E. Pelish, N. J. Westwood, Y. Feng, T. Kirchhausen, M. D. Shair, J. Am. Chem. Soc. 2001, 123, 6740.
- (2001) J. Am. Chem. Soc. , vol.123 , pp. 6740
- Pelish, H.E.¹ Westwood, N.J.² Feng, Y.³ Kirchhausen, T.⁴ Shair, M.D.⁵

52
- 0001452901
- R. Breinbauer, I. R. Vetter, H. Waldmann, Angew. Chem. 2002, 114, 3002; Angew. Chem. Int. Ed. 2002, 41, 2878.
- (2002) Angew. Chem. , vol.114 , pp. 3002
- Breinbauer, R.¹ Vetter, I.R.² Waldmann, H.³

53
- 0037119336
- R. Breinbauer, I. R. Vetter, H. Waldmann, Angew. Chem. 2002, 114, 3002; Angew. Chem. Int. Ed. 2002, 41, 2878.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 2878

54
- 33444462389
- W. S. Knowles, M. J. Sabacky, Chem. Commun. 1968, 1445; T. P. Dang, H. B. Kagan, Chem. Commun. 1971, 481; W. S. Knowles, M. J. Sabacky, B. D. Vineyard, D. J. Weinkauff, J. Am. Chem. Soc. 1975, 97, 2567.
- (1968) Chem. Commun. , pp. 1445
- Knowles, W.S.¹ Sabacky, M.J.²

55
- 37049139019
- W. S. Knowles, M. J. Sabacky, Chem. Commun. 1968, 1445; T. P. Dang, H. B. Kagan, Chem. Commun. 1971, 481; W. S. Knowles, M. J. Sabacky, B. D. Vineyard, D. J. Weinkauff, J. Am. Chem. Soc. 1975, 97, 2567.
- (1971) Chem. Commun. , pp. 481
- Dang, T.P.¹ Kagan, H.B.²

56
- 33847800667
- W. S. Knowles, M. J. Sabacky, Chem. Commun. 1968, 1445; T. P. Dang, H. B. Kagan, Chem. Commun. 1971, 481; W. S. Knowles, M. J. Sabacky, B. D. Vineyard, D. J. Weinkauff, J. Am. Chem. Soc. 1975, 97, 2567.
- (1975) J. Am. Chem. Soc. , vol.97 , pp. 2567
- Knowles, W.S.¹ Sabacky, M.J.² Vineyard, B.D.³ Weinkauff, D.J.⁴

57
- 0013595024
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (1985) Chem. Scr. , vol.25 , pp. 71
- Sharpless, K.B.¹

58
- 0002050576
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (1985) Angew. Chem. , vol.97 , pp. 1
- Masamune, S.¹ Choy, W.² Petersen, J.S.³ Sita, L.R.⁴

59
- 84985530075
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (1985) Angew. Chem. Int. Ed. Engl. , vol.24 , pp. 1

60
- 0347802444
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (1984) Heterocycles , vol.21 , pp. 107
- Masamune, S.¹

61
- 0020645466
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (1983) Science , vol.220 , pp. 949
- Ko, S.Y.¹ Lee, A.W.M.² Masamune, S.³ Reed III, L.A.⁴ Sharpless, K.B.⁵ Walker, F.J.⁶

62
- 0035850267
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (2001) Org. Lett. , vol.3 , pp. 2157
- Harisson, B.A.¹ Verdine, G.L.²

63
- 0037529216
- K. B. Sharpless, Chem. Scr. 1985, 25, 71; S. Masamune, W. Choy, J. S. Petersen, L. R. Sita, Angew. Chem. 1985, 97, 1; Angew. Chem. Int. Ed. Engl. 1985, 24, 1; S. Masamune, Heterocycles 1984, 21, 107; S. Y. Ko, A. W. M. Lee, S. Masamune, L. A. Reed III, K. B. Sharpless, F. J. Walker, Science 1983, 220, 949; B. A. Harisson, G. L. Verdine, Org. Lett. 2001, 3, 2157; T. M. Gierasch, Z. Shi, G. L. Verdine, Org. Lett. 2003, 5, 621.
- (2003) Org. Lett. , vol.5 , pp. 621
- Gierasch, T.M.¹ Shi, Z.² Verdine, G.L.³

64
- 0005335636
- G. C. Micalizio, S. L. Schreiber, Angew. Chem. 2002, 114, 160; Angew. Chem. Int. Ed. 2002, 41, 152.
- (2002) Angew. Chem. , vol.114 , pp. 160
- Micalizio, G.C.¹ Schreiber, S.L.²

65
- 0037016259
- G. C. Micalizio, S. L. Schreiber, Angew. Chem. 2002, 114, 160; Angew. Chem. Int. Ed. 2002, 41, 152.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 152

66
- 0041344683
- O. I. Kolodiazhnyi, Tetrahedron 2003, 59, 5953.
- (2003) Tetrahedron , vol.59 , pp. 5953
- Kolodiazhnyi, O.I.¹

67
- 0000442967
- A. G. Dossetter, T. F. Jamison, E. N. Jacobsen, Angew. Chem. 1999, 111, 2549; Angew. Chem. Int. Ed. 1999, 38, 2398; G. D. Joly, E. N. Jacobsen, Org. Lett. 2002, 4, 1795; K. Gademann, D. E. Chavez, E. N. Jacobsen, Angew. Chem. 2002, 114, 3185; Angew. Chem. Int. Ed. 2002, 41, 3059.
- (1999) Angew. Chem. , vol.111 , pp. 2549
- Dossetter, A.G.¹ Jamison, T.F.² Jacobsen, E.N.³

68
- 0033549737
- A. G. Dossetter, T. F. Jamison, E. N. Jacobsen, Angew. Chem. 1999, 111, 2549; Angew. Chem. Int. Ed. 1999, 38, 2398; G. D. Joly, E. N. Jacobsen, Org. Lett. 2002, 4, 1795; K. Gademann, D. E. Chavez, E. N. Jacobsen, Angew. Chem. 2002, 114, 3185; Angew. Chem. Int. Ed. 2002, 41, 3059.
- (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 2398

69
- 0037118311
- A. G. Dossetter, T. F. Jamison, E. N. Jacobsen, Angew. Chem. 1999, 111, 2549; Angew. Chem. Int. Ed. 1999, 38, 2398; G. D. Joly, E. N. Jacobsen, Org. Lett. 2002, 4, 1795; K. Gademann, D. E. Chavez, E. N. Jacobsen, Angew. Chem. 2002, 114, 3185; Angew. Chem. Int. Ed. 2002, 41, 3059.
- (2002) Org. Lett. , vol.4 , pp. 1795
- Joly, G.D.¹ Jacobsen, E.N.²

70
- 0013059152
- A. G. Dossetter, T. F. Jamison, E. N. Jacobsen, Angew. Chem. 1999, 111, 2549; Angew. Chem. Int. Ed. 1999, 38, 2398; G. D. Joly, E. N. Jacobsen, Org. Lett. 2002, 4, 1795; K. Gademann, D. E. Chavez, E. N. Jacobsen, Angew. Chem. 2002, 114, 3185; Angew. Chem. Int. Ed. 2002, 41, 3059.
- (2002) Angew. Chem. , vol.114 , pp. 3185
- Gademann, K.¹ Chavez, D.E.² Jacobsen, E.N.³

71
- 0037118895
- A. G. Dossetter, T. F. Jamison, E. N. Jacobsen, Angew. Chem. 1999, 111, 2549; Angew. Chem. Int. Ed. 1999, 38, 2398; G. D. Joly, E. N. Jacobsen, Org. Lett. 2002, 4, 1795; K. Gademann, D. E. Chavez, E. N. Jacobsen, Angew. Chem. 2002, 114, 3185; Angew. Chem. Int. Ed. 2002, 41, 3059.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 3059

72
- 0141630721
- D. E. Chavez, E. N. Jacobsen, Org. Lett. 2003, 5, 2563.
- (2003) Org. Lett. , vol.5 , pp. 2563
- Chavez, D.E.¹ Jacobsen, E.N.²

73
- 0001588214
- W. R. Roush, S. M. Peseckis, J. Am. Chem. Soc. 1981, 103, 6696.
- (1981) J. Am. Chem. Soc. , vol.103 , pp. 6696
- Roush, W.R.¹ Peseckis, S.M.²

74
- 33845183407
- J. W. Coe, W. R. Roush, J. Org. Chem. 1989, 54, 915; F. K. Brown, K. N. Houk, Tetrahedron Lett. 1985, 26, 2297; J. D. White, B. G. Sheldon, J. Org. Chem. 1981, 46, 2273; D. F. Taber, C. Campbell, B. P. Gunn, C. I. Chiu, Tetrahedron Lett. 1981, 22, 5141; for a review on diastereofacial selection in ring-closing reactions, see T. Tokoroyama, Chem. Eur. J. 1998, 4, 2397.
- (1989) J. Org. Chem. , vol.54 , pp. 915
- Coe, J.W.¹ Roush, W.R.²

75
- 0000299517
- J. W. Coe, W. R. Roush, J. Org. Chem. 1989, 54, 915; F. K. Brown, K. N. Houk, Tetrahedron Lett. 1985, 26, 2297; J. D. White, B. G. Sheldon, J. Org. Chem. 1981, 46, 2273; D. F. Taber, C. Campbell, B. P. Gunn, C. I. Chiu, Tetrahedron Lett. 1981, 22, 5141; for a review on diastereofacial selection in ring-closing reactions, see T. Tokoroyama, Chem. Eur. J. 1998, 4, 2397.
- (1985) Tetrahedron Lett. , vol.26 , pp. 2297
- Brown, F.K.¹ Houk, K.N.²

76
- 0000515321
- J. W. Coe, W. R. Roush, J. Org. Chem. 1989, 54, 915; F. K. Brown, K. N. Houk, Tetrahedron Lett. 1985, 26, 2297; J. D. White, B. G. Sheldon, J. Org. Chem. 1981, 46, 2273; D. F. Taber, C. Campbell, B. P. Gunn, C. I. Chiu, Tetrahedron Lett. 1981, 22, 5141; for a review on diastereofacial selection in ring-closing reactions, see T. Tokoroyama, Chem. Eur. J. 1998, 4, 2397.
- (1981) J. Org. Chem. , vol.46 , pp. 2273
- White, J.D.¹ Sheldon, B.G.²

77
- 0001326527
- J. W. Coe, W. R. Roush, J. Org. Chem. 1989, 54, 915; F. K. Brown, K. N. Houk, Tetrahedron Lett. 1985, 26, 2297; J. D. White, B. G. Sheldon, J. Org. Chem. 1981, 46, 2273; D. F. Taber, C. Campbell, B. P. Gunn, C. I. Chiu, Tetrahedron Lett. 1981, 22, 5141; for a review on diastereofacial selection in ring-closing reactions, see T. Tokoroyama, Chem. Eur. J. 1998, 4, 2397.
- (1981) Tetrahedron Lett. , vol.22 , pp. 5141
- Taber, D.F.¹ Campbell, C.² Gunn, B.P.³ Chiu, C.I.⁴

78
- 0031741997
- J. W. Coe, W. R. Roush, J. Org. Chem. 1989, 54, 915; F. K. Brown, K. N. Houk, Tetrahedron Lett. 1985, 26, 2297; J. D. White, B. G. Sheldon, J. Org. Chem. 1981, 46, 2273; D. F. Taber, C. Campbell, B. P. Gunn, C. I. Chiu, Tetrahedron Lett. 1981, 22, 5141; for a review on diastereofacial selection in ring-closing reactions, see T. Tokoroyama, Chem. Eur. J. 1998, 4, 2397.
- (1998) Chem. Eur. J. , vol.4 , pp. 2397
- Tokoroyama, T.¹

79
- 0141520628
- K. Kim, U. S. M. Maharoof, J. Raushel, G. A. Sulikowski, Org. Lett. 2003, 5, 2777.
- (2003) Org. Lett. , vol.5 , pp. 2777
- Kim, K.¹ Maharoof, U.S.M.² Raushel, J.³ Sulikowski, G.A.⁴

80
- 0003330307
- R. A. Stavenger, S. L. Schreiber, Angew. Chem. 2001, 113, 3525; Angew. Chem. Int. Ed. 2001, 40, 3417.
- (2001) Angew. Chem. , vol.113 , pp. 3525
- Stavenger, R.A.¹ Schreiber, S.L.²

81
- 0035903515
- R. A. Stavenger, S. L. Schreiber, Angew. Chem. 2001, 113, 3525; Angew. Chem. Int. Ed. 2001, 40, 3417.
- (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 3417

82
- 0033579147
- D. Lee, J. Sello, S. L. Schreiber, J. Am. Chem. Soc. 1999, 121, 10648.
- (1999) J. Am. Chem. Soc. , vol.121 , pp. 10648
- Lee, D.¹ Sello, J.² Schreiber, S.L.³

83
- 0011751046
- G. C. Micalizio, S. L. Schreiber, Angew. Chem. 2002, 114, 3406; Angew. Chem. Int. Ed. 2002, 41, 3272.
- (2002) Angew. Chem. , vol.114 , pp. 3406
- Micalizio, G.C.¹ Schreiber, S.L.²

84
- 0037009053
- G. C. Micalizio, S. L. Schreiber, Angew. Chem. 2002, 114, 3406; Angew. Chem. Int. Ed. 2002, 41, 3272.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 3272

85
- 0000439081
- S. Woo, N. Squires, A. G. Fallis, Org. Lett. 1999, 1, 573.
- (1999) Org. Lett. , vol.1 , pp. 573
- Woo, S.¹ Squires, N.² Fallis, A.G.³

86
- 0037073206
- O. Kwon, S. B. Park, S. L. Schreiber, J. Am. Chem. Soc. 2002,124, 13402.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 13402
- Kwon, O.¹ Park, S.B.² Schreiber, S.L.³

87
- 0142147275
- M. D. Burke, E. M. Berger, S. L. Schreiber, Science 2003, 302, 613.
- (2003) Science , vol.302 , pp. 613
- Burke, M.D.¹ Berger, E.M.² Schreiber, S.L.³

88
- 0015859467
- C. B. Anfinsen, Science 1973, 181, 223.
- (1973) Science , vol.181 , pp. 223
- Anfinsen, C.B.¹

89
- 0142173784
- N. Clauson-Kaas, P. Dietrich, J. T. Nielson, Acta Chem. Scand. 1953, 7, 845; N. Elming, Adv. Org. Chem. 1960, 2, 67.
- (1953) Acta Chem. Scand. , vol.7 , pp. 845
- Clauson-Kaas, N.¹ Dietrich, P.² Nielson, J.T.³

90
- 0012953442
- N. Clauson-Kaas, P. Dietrich, J. T. Nielson, Acta Chem. Scand. 1953, 7, 845; N. Elming, Adv. Org. Chem. 1960, 2, 67.
- (1960) Adv. Org. Chem. , vol.2 , pp. 67
- Elming, N.¹

91
- 0001462758
- O. Achmatowicz, Jr., P. Bukowski, B. Szechner, Z. Zwierzchowska, A. Zamojski, Tetrahedron 1971, 27, 1973; J. M. Harris, G. A. O'Doherty, Tetrahedron Lett. 2000, 41, 183.
- (1971) Tetrahedron , vol.27 , pp. 1973
- Achmatowicz Jr., O.¹ Bukowski, P.² Szechner, B.³ Zwierzchowska, Z.⁴ Zamojski, A.⁵

92
- 0034620205
- O. Achmatowicz, Jr., P. Bukowski, B. Szechner, Z. Zwierzchowska, A. Zamojski, Tetrahedron 1971, 27, 1973; J. M. Harris, G. A. O'Doherty, Tetrahedron Lett. 2000, 41, 183.
- (2000) Tetrahedron Lett. , vol.41 , pp. 183
- Harris, J.M.¹ O'Doherty, G.A.²

93
- 0000510466
- Y. Kobayashi, M. Nakano, G. B. Kumar, K. Kishihara, J. Org. Chem. 1998, 63, 7505.
- (1998) J. Org. Chem. , vol.63 , pp. 7505
- Kobayashi, Y.¹ Nakano, M.² Kumar, G.B.³ Kishihara, K.⁴

94
- 0344514145
- J. K. Sello, P. R. Andreana, D. Lee, S. L. Schreiber, Org. Lett. 2003, 5, 4125.
- (2003) Org. Lett. , vol.5 , pp. 4125
- Sello, J.K.¹ Andreana, P.R.² Lee, D.³ Schreiber, S.L.⁴

95
- 0347057452
- note
- Realizing the goals of DOS will require organic chemists to adopt computational tools from computer and information science, since the complexities of multidimensional (chemical and biological) descriptor space can only be tackled using these tools.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.