The role of natural product chemistry in drug discovery

Journal of Natural Products

Volumn 67, Issue 12, 2004, Pages 2141-2153

  Butler, Mark S ^a  

^a MerLion Pharmaceuticals Pte Ltd   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMRUBICIN; ANIDULAFUNGIN; ARTEETHER; BIAPENEM; CASPOFUNGIN; DALBAVANCIN; DAPTOMYCIN; EDOTECARIN; ERTAPENEM; EVEROLIMUS; EXATECAN; FINGOLIMOD; GALANTAMINE; IXABEPILONE; MICAFUNGIN; MIGLUSTAT; MYCOPHENOLIC ACID; NATURAL PRODUCT; NITISINONE; OMEGA CONOTOXIN MVIIA; OMEGACIN; ORITAVANCIN; PIMECROLIMUS; PITAVASTATIN; RAMOPLANIN; ROSUVASTATIN; RUBITECAN; TELITHROMYCIN; TIGECYCLINE; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINFLUNINE;

ALZHEIMER DISEASE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ATOPIC DERMATITIS; BACTERIAL INFECTION; CANCER; CHEMISTRY; CHRONIC PAIN; CLINICAL TRIAL; CONFERENCE PAPER; CYTOKINE RELEASE; DETOXIFICATION; DNA SYNTHESIS INHIBITION; DRUG DETERMINATION; DRUG INDUSTRY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG MARKETING; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DYSLIPIDEMIA; ENZYME INHIBITION; GAUCHER DISEASE; HUMAN; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INHIBITION KINETICS; MALARIA; METABOLIC DISORDER; MYCOSIS; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ANALYSIS; TYROSINEMIA;

BIOLOGICAL FACTORS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG INDUSTRY; MOLECULAR STRUCTURE;

BACTERIA (MICROORGANISMS);

EID: 11344292132     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np040106y     Document Type: Conference Paper

References (174)

1. Newman, D. J.; Cragg, G. M.; Snader, K. M. Nat. Prod. Rep. 2000, 17, 215-234.
2. Buss, A. D.; Cox, B.; Waigh, R. D. In Burger's Medicinal Chemistry and Drug Discovery, 6th ed.; Volume 1: Drug Discovery; Abraham, D. J., Ed.; Wiley: Hoboken, NJ, 2003; Chapter 20, pp 847-900.
3. Grabley, S.; Thiericke, R. In Drug Discovery from Nature; Grabley, S., Thiericke, R., Eds.; Springer: Berlin, 2000; Chapter 1, pp 3-37.
4. Sneader, W. Drug Prototypes and their Exploitation; Wiley: Chichester, UK, 1996.
5. Mann, J. Murder, Magic and Medicine, 2nd ed.; Oxford University Press: Oxford, UK, 2000.
6. Alder, A. L., Ed. The History of Penicillin Production; American Institute of Chemical Engineers: New York, 1970.
7. Lax, E. The Mold in Dr. Florey's Coat; Henry Holt Publishers: New York, 2004.
8. Wainwright, M. Miracle Cure: The Story of Penicillin and the Golden Age of Antibiotics; Blackwell: Oxford, UK, 1990.
9. Mann, J. The Elusive Magic Bullet: The Search for the Perfect Drug; Oxford University Press: Oxford, UK, 1999; pp 39-78.
10. (a) Brown, A. G.; Butterworth, D.; Cole, M.; Hanscomb, G.; Hood, J. D.; Reading, C.; Rolinson, G. N. J. Antibiot. 1976, 29, 668-669.
11. (b) Howarth, T. T.; Brown, A. G.; King, T. J. J. Chem. Soc., Chem. Commun. 1976, 266-267.
12. (c) Brown, A. G. Drug Des. Delivery 1988, 1, 1-21.
13. (a) Endo, A.; Kuroda, M.; Tsujita, Y. J. Antibiot. 1976, 29, 1346-1348.
14. (b) Endo, A. J. Lipid Res. 1992, 33, 1569-1582.
15. Brown, A. G.; Smale, T. C.; King, T. J.; Hasenkamp, R.; Thompson, J. J. Chem. Soc., Perkin Trans. 1 1976, 1165-1170.
16. Tobert, J. A. Nature Rev. Drug Discovery 2003, 2, 517-526.
17. Gaw, A., Packard, C. J., Shepherd J., Eds. Statins: the HMG CoA Reductase Inhibitors in Perspective, 2nd ed.; Martin Dunitz: London, 2004.
18. Newman, D. J.; Cragg, G. M.; Snader, K. M. J. Nat. Prod. 2003, 66, 1022-1037.
19. Cragg, G. M.; Newman, D. J.; Snader, K. M. J. Nat. Prod. 1997, 60, 52-60.
20. Proudfoot, J. R. Bioorg. Med. Chem. Lett. 2002, 12, 1647-1650.
21. Graul, A. I. Drug News Perspect. 2001, 14, 12-31.
22. Gaudillière, B.; Bernardelli, P.; Berna, P. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2001; Vol. 36, Chapter 26, pp 293-318.
23. Graul, A. I. Drug News Perspect. 2002, 15, 29-43.
24. Bernardelli, P.; Gaudillière, B.; Vergne, F. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2002; Vol. 37, Chapter 26, pp 257-277.
25. Graul, A. I. Drug News Perspect. 2003, 16, 22-39.
26. Boyer-Joubert, C.; Lorthiois, E.; Moreau, F. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2003; Vol. 38, Chapter 33, pp 347-374.
27. Frantz, S.; Smith, A. Nature Rev. Drug Discovery 2003, 2, 95-96.
28. Graul, A. I. Drug News Perspect. 2004, 17, 43-57.
29. Frantz, S. Nature Rev. Drug Discovery 2004, 3, 103-105.
30. Anonymous. Scrip 2004, 2916, 21.
31. Heinrich, M.; Teoh, H. L. J. Ethnopharmacol. 2004, 92, 147-162.
32. Raja, A.; LaBonte, J.; Lebbos, J.; Kirkpatrick, P. Nature Rev. Drug Discovery 2003, 2, 943-944.
33. Bentley, R. Chem. Rev. 2000, 100, 3801-3825.
34. Cheng, X.-M. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: Amsterdam, 1996; Vol. 31, Chapter 34, pp 337-355.
35. (a) Mylotarg Package Insert: Wyeth Laboratories, Philadelphia, PA, July 2003 (updated).
36. (b) Giles, F.; Estey, E.; O'Brien, S. Cancer 2003, 98, 2095-2104.
37. (c) Abou-Gharbia, M. In Biodiversity: Biomolecular Aspects of Biodiversity and Innovation Utilization; Şener, B., Ed.; Kluwer Academic: New York, 2002; Chapter 7, pp 63-70.
38. (a) Lee, M. D.; Dunne, T. S.; Siegel, M. M.; Chang, C. C.; Morton, G. O.; Borders, D. B. J. Am. Chem. Soc. 1987, 109, 3464-3466.
39. (b) Lee, M. D.; Dunne, T. S.; Chang, C. C.; Ellestad, G. A.; Siegel, M. M.; Morton, G. O.; McGahren, W. J.; Borders, D. B. J. Am. Chem. Soc. 1987, 109, 3466-3468.
40. (c) Maiese, W. M.; Lechevalier, M. P.; Lechevalier, H. A.; Korshalla, J.; Kuck, N.; Fantini, A.; Wildey, M. J.; Thomas, J.; Greenstein, M. J. Antibiot. 1989, 42, 558-563.
41. (a) Smith, A. L.; Nicolaou, K. C. J. Med. Chem. 1996, 39, 2103-2117.
42. (b) Shen, B.; Lui, W.; Nonaka, K. Curr. Med. Chem. 2003, 10, 2317-2325.
43. Wyeth Pharmaceuticals Press Release. March 31, 2003. http://www.wyeth. com/news/Pressed_and_Released/pr03_31_2003_ 13_11_23.asp.
44. (a) Matthews, T.; Salgo, M.; Greenberg, M.; Chung, J.; DeMasi, R.; Bolognesi, D. Nature Rev. Drug Discovery 2004, 3, 215-225.
45. (b) LaBonte, J.; Lebbos, J.; Kirkpatrick, P. Nature Rev. Drug Discovery 2003, 2, 345-346.
46. Shu, Y.-Z. J. Nat. Prod. 1998, 61, 1053-1071.
47. (a) PharmaMar Press Release. November 20, 2003
48. (b) Anonymous. Scrip 2003, 2871, 22.
49. (c) Anonymous. Scrip 2004, 2915, 26.
50. InterMune Press Release. November 21, 2003.
51. Drews, J. Science 2000, 287, 1960-1964.
52. Ng, R. Drugs: From Discovery to Approval; Wiley-Liss; Hoboken, NJ, 2004.
53. Pharmaceutical Industry Profile 2003, PhRMA, 2003, pp 1-19. http://www.phrma.org/publications/publications/profile02/index.cfm.
54. Rawlins, M. D. Nature Rev. Drug Discovery 2004, 3, 360-364.
55. Gershell, L. J.; Atkins, J. H. Nature Rev. Drug Discovery 2003, 2, 321-327.
56. Pharma 2010: The Threshold of Innovation, IBM Consulting Services, 2002. http://www-1.ibm.com/services/strategy/files2/pharma_es.pdf.
57. Drews, J. In Quest of Tomorrow's Medicines; Springer-Verlag: New York, 1999.
58. Wess, G.; Urmann, M.; Sickenberger, B. Angew. Chem., Int. Ed. 2001, 40, 3341-3350.
59. Anonymous. Scrip 2003, 2850, 25.
60. Rouchi, A. M. Chem. Eng. News 2003, October 13, 77-91.
61. Cordell, G. A. Phytochem. Rev. 2002, 1, 261-273.
62. Strohl, W. R. Drug Discovery Today 2000, 5, 39-41.
63. Harvey, A. L. TiPS 1999, 20, 196-198.
64. Rouhi, A. M. Chem. Eng. News 2003, October 13, 93-103.
65. Okuda, T. Trends in Natural Product-Based Drug Discovery, and Roles of Biotech Ventures and Biological Resource Centers. WFCC Newsletter, Vol. 35, July 2002. http://www.wfcc.info/NEWSLETTER/newsletter35/a4.pdf.
66. Harvey, A. Natural Product Pharmaceuticals: A Diverse Approach to Drug Discovery; Scrip Reports, PJB Publications: Richmond, Surrey, UK, 2001.
67. Stewart, M.; Nash, R. J.; Chicarelli-Robinson, M. I. In Saponins in Food, Feedstuffs and Medicinal Plants; Oleszek W., Marston, A., Eds.; Kluwer Academic Publishers: Boston, 2000; Chapter 8, pp 73-77.
68. Bindseil, K. U.; Jakupovic, J.; Wolf, D.; Lavayre, J.; Leboul, J.; van der Pyl, D. Drug Discovery Today 2001, 6, 840-847.
69. Abel, U.; Koch, C.; Speitling, M.; Hansske, F. G. Curr. Opin. Chem. Biol. 2002, 6, 453-457.
70. Anderson, A. C. Chem. Biol. 2003, 10, 787-797.
71. Shen, J.; Xu, X.; Cheng, F.; Liu, H.; Luo, X.; Shen, J.; Chen, K.; Zhao, W.; Shen, X.; Jiang, H. Curr. Med. Chem. 2003, 10, 2327-2342.
72. Muchmore, S. W.; Hajduk, P. J. Curr. Opin. Drug Discovery Devel. 2003, 6, 544-549.
73. Stockman, B. J.; Dalvit, C. Prog. Nucl. Magn. Reson. Spectrosc. 2002, 41, 187-231.
74. Salvatella, X.; Giralt, E. Chem. Soc. Rev. 2003, 32, 365-372.
75. Carr, R.; Jhoti, H. Drug Discovery Today 2002, 7, 522-527.
76. Davis, A. M.; Teague S. J.; Kleywegt, G. J. Angew. Chem., Int. Ed. 2003, 42, 2718-2736.
77. Balkenhohl, F.; von dem Bussche-Hünnefeld, C.; Lansky, A.; Zechel, C. Angew. Chem., Int. Ed. Engl. 1996, 35, 2288-2337.
78. Lee, A.; Breitenbucher, J. G. Curr. Opin. Drug Discovery Dev. 2003, 6, 494-508.
79. Fischli, A. E.; Pandit, U. K.; Black, D. S. Pure Appl. Chem. 2002, 74, 697-702.
80. (a) Rosenthal, J. Nature 2002, 416, 15.
81. (b) Pethiyagoda, R. Nature 2004, 429, 129.
82. (c) Dalton, R. Nature 2004, 429, 598-600.
83. Myers, P. L. Curr. Opin. Biotechnol. 1997, 8, 701-707.
84. Henkel, T.; Brunne, R. M.; Müller, H.; Reichel, F. Angew. Chem., Int. Ed. 1999, 38, 643-647.
85. Stahura, F.; Godden, J. W.; Xue, L.; Bajorath, J. J. Chem. Inf. Comput. Sci. 2000, 40, 1245-1252.
86. Lee, M.-L.; Schneiber, G. J. Comb. Chem. 2001, 3, 284-289.
87. Feher, M.; Schmidt J. M. J. Chem. Inf. Comput. Sci. 2003, 43, 218-227.
88. (a) Burke, M. D.; Berger, E. M.; Schreiber, S. L. Science 2003, 302, 613-618.
89. (b) Schreiber, S. L. Science 2000, 287, 1964-1969.
90. Arya, P.; Joseph, R.; Chou, D. T. H. Chem. Biol. 2002, 9, 145-156.
91. Abreu, P. M.; Branco, P. S. J. Braz. Chem. Soc. 2003, 14, 675-712.
92. Rouhi, A. M. Chem. Eng. News 2003, October 13, 104-107.
93. Breinbauer, R.; Vetter, I. R.; Waldmann, H. Angew. Chem., Int. Ed. 2002, 41, 2878-2890.
94. Kingston, D. G. I.; Newman, D. J. Curr. Opin. Drug Discovery Dev. 2002, 5, 304-316.
95. Wessjohann, L. A. Curr. Opin. Chem. Biol. 2000, 4, 303-309.
96. Horton, D. A.; Bourne, G. T.; Smythe, M. L. Chem. Rev. 2003, 103, 893-930.
97. Hall, D. G.; Manku, S. Wang, F. J. Comb. Chem. 2001, 3, 125-150.
98. Seethala, R.; Fernandas, P. B., Eds. Handbook of Drug Screening; Drugs and the Pharmaceutical Sciences; Marcel Dekker: New York, 2001; Vol. 114.
99. Carrano, L.; Donadio, S. In Combinatorial Chemistry and Technology: Principles, Methods, and Applications; Miertus, S., Fassina, G., Eds.; Marcel Dekker: New York, 1999; Chapter 10, pp 233-250.
100. Devlin, J. P., Ed. High Throughput Screening: The Discovery of Bioactive Substances; Marcel Dekker: New York, 1997.
101. Vaschetto, M.; Weissbrod, T.; Brole, D.; Güner, O. Curr. Opin. Drug. Discovery Dev. 2003, 6, 377-383.
102. Entzeroth, M. Curr. Opin. Pharmacol. 2003, 3, 522-529.
103. Knowles, J.; Gromo, G. Nat. Rev. Drug Discovery 2003, 2, 63-69.
104. Hopkins, A. L.; Groom, C. R. Nat. Rev. Drug Discovery 2002, 1, 727-730.
105. Hopkins, A. L.; Groom, C. R. In Small Molecule-Protein Interaction; Waldmann, H., Koppitz, M., Eds.; Springer-Verlag: Berlin, 2003; Ernst Schering Research Foundation Workshop, Vol. 42, Chapter 2, pp 11-17.
106. Hopkins, A. L.; Groom, C. R. In Small Molecule-Protein Interaction; Waldmann, H., Koppitz, M., Eds.; Springer-Verlag: Berlin, 2003; Ernst Schering Research Foundation Workshop, Vol. 42, Chapter 2, pp 11-17.
107. Hardy, L. W.; Peet, N. P. Drug Discovery Today 2004, 9, 117-126.
108. New, D. C.; Miller-Martini, D. M.; Wong, Y. H. Phytother. Res. 2003, 17, 439-448.
109. Thiericke, R.; Grabley, S.; Geschwill, K. In Drug Discovery from Nature; Grabley, S., Thiericke, R., Eds.; Springer: Berlin, 2000; Chapter 4, pp 56-71.
110. Houghton, P. J. Phytother. Res. 2000, 14, 419-423.
111. Bohlin, L., Bruhn, J. G., Eds. Bioassay Methods in Natural Product Research and Drug Development; Kluwer Academic Press: Dordrecht, The Netherlands, 1999.
112. Hill, D. C. In Advances in Drug Discovery Techniques; Harvey, A. L., Ed.; John Wiley: Chiehester, UK, 1998; Chapter 3, pp 25-38.
113. Sills, M. A. Strategic Decisions for Screening Natural Products; Network Science: Internet, 1996. http://www.netsci.org/Science/Screening/feature10.html.
114. VanMiddlesworth, N.; Cannell, R. J. P. In Natural Product Isolation; Methods in Biotechnology, Vol. 4; Cannell, R. J. P., Ed.; Humana Press: Totowa, NJ, 1998; Chapter 10, pp 279-327.
115. Tan, G. T.; Pezzuto, J. M.; Kinghorn, A. D.; Hughes, S. H. J. Nat. Prod. 1991, 54, 143-154.
116. Ingkaninan, K.; von Frijtag Drabbe Künzel J. K.; IJzerman, A. P.; Verpoorte, R. J. Nat. Prod. 1999, 62, 912-914.
117. Seidler, J.; McGovern, S. L.; Doman, T. N.; Shoichet, B. K. J. Med. Chem. 2003, 46, 4477-4486.
118. McGovern, S. L.; Helfand, B. T.; Feng, B.; Shoichet, B. K. J. Med. Chem. 2003, 46, 4265-4272.
119. Ryan, A. J.; Gray, N. M.; Lowe, P. N.; Chung, C. J. Med. Chem. 2003, 46, 3448-3451.
120. McGovern, S. L.; Caselli, E.; Grigorieff, N.; Shoichet, B. K. J. Med. Chem. 2002, 45, 1712-1722.
121. Walters, W. P.; Namchuk, M. Nat. Rev. Drug Discovery 2003, 2, 259-266.
122. (a) David, C. A.; Middleton, T.; Montgomery, D.; Lim, H. B.; Kati, W.; Molla, A.; Xuei, X.; Warrior, U.; Kofron, J. L.; Burns, D. J. J. Biomol. Screening 2002, 7, 259-266.
123. (b) Hoever, M.; Zbinden, P. Drug Discovery Today 2004, 9, 358-365.
124. (a) van Elswijk, D. A.; Schobel, U. P.; Lansky, E. P.; Irth, H.; van der Greef, J. Phytochemistry 2004, 65, 233-241.
125. (b) van Elswijk, D. A.; Diefenbach, O.; van der Berg, S.; Irth, H.; Tjaden, U. R.; van der Greef, J. J. Chromatogr. A 2003, 1020, 45-58.
126. (c) Schenk, T.; Breel, G. J.; Koevoets, P.; van den Berg, S.; Hogenboom, A. C.; Irth, H.; Tjaden, U. R.; van der Greef, J. J. Biomol. Screening 2003, 8, 421-429.
127. Flotow, H.; Leong, C.-Y.; Buss, A. D. J. Biomol. Screening 2002, 7, 367-371.
128. Ovenden, S. P. B.; Cao, S.; Leong, C.; Flotow, H.; Gupta, M. P.; Buss, A. D.; Butler, M. S. Phytochemistry 2002, 60, 175-177.
129. Eldridge, G. R.; Vervoort, H. C.; Lee, C. M.; Cremin, P. A.; Williams, C. T.; Hart, S. M.; Goering, M. G.; O'Neill-Johnson, M.; Zeng, L. Anal. Chem. 2002, 74, 3963-3971.
130. Jia, Q. In Studies in Natural Products Chemistry: Bioactive Natural Products (Part J); Atta-ur-Rahman, Ed.; Elsevier: Amsterdam, 2003; pp 643-718.
131. Koch, C.; Neumann, T.; Thiericke, R.; Grabley, S. In Drug Discovery from Nature; Grabley, S., Thiericke, R., Eds.; Springer: Berlin, 2000; Chapter 3, pp 51-55.
132. Schmid, I.; Sattler, I.; Grabley, S.; Thiericke, R. J. Biomol. Screening 1999, 4, 15-25.
133. (a) Alvi, K. A. In Biologically Active Natural Products: Pharmaceuticals; Cutler, S. J., Cutler H. G., Eds.; CRC Press: New York, 2000; Chapter14, pp 185-195.
134. (b) Alvi, K. A.; Peterson, J.; Hofmann, B. J. Ind. Microbiol. 1995, 15, 80-84.
135. Armbruster, J. A.; Borris, R. P.; Jiminez, Q.; Zamora, N.; Tamayo-Castillo, G.; Harris, G. H. J. Liq. Chromatogr. Relat. Technol. 2001, 24, 1827-1840.
136. Ingkaninan, K.; Hazekamp, A.; Hoek, A. C.; Balconi, S.; Verpoorte, R. J. Liq. Chromatogr. Relat. Technol. 2000, 23, 2195-2208.
137. Cordell, G. A.; Shin, Y. G. Pure Appl. Chem. 1999, 71, 1089-1094.
138. Cordell, G. A.; Beecher, C. W. W.; Kinghorn, A. D.; Pezzuto, J. M.; Constant, H. L.; Chai, H. B.; Fang, L.; Seo, E.-K.; Long, L.; Cui, B.; Slowing-Barillas, K. In Studies in Natural Products Chemistry: Bioactive Natural Products, Vol. 19, Structure and Chemistry (Part E); Atta-ur-Rahman, Ed.; Elsevier: Amsterdam, 1997; pp 749-791.
139. Constant, H. L.; Beecher, C. W. W. Nat. Prod. Lett. 1995, 6, 193-196.
140. Cardellina, J. H., II; Munro, M. H. G.; Fuller, R. W.; Manfredi, K. P.; McKee, T. C.; Tischler, M.; Bokesch, H. R.; Gustafson, K. R.; Beutler, J. A.; Boyd, M. R. J. Nat. Prod. 1993, 56, 1123-1129.
141. Phillipson, D. W.; Milgram, K. E.; Yanovsky, A. I.; Rusnak, L. S.; Haggerty, D. A.; Farrell, W. P.; Greig, M. J.; Xiong, X.; Proefke, M. L. J. Comb. Chem. 2002, 4, 591-599.
142. Pierceall, W. E.; Zhang, L.; Hughes, D. E. In Protein-Protein Interactions, Methods in Molecular Biology, Vol. 261; Fu, H., Ed.; Humana Press: Totowa, NJ, 2004; Chapter 14, pp 187-198.
143. Corcoran, O.; Spraul, M. Drug Discovery Today 2003, 8, 624-631.
144. Bobzin, S. C.; Yang, S.; Kasten, T. P. J. Ind. Microbiol. Biotechnol. 2000, 25, 342-345.
145. Weifender, J.-L.; Terreaux, C.; Hostettmann, K. Pharm. Biol. 2000, 38, 41-54.
146. Keifer, P. A. Curr. Opin. Chem. Biol. 2003, 7, 388-394.
147. (a) Reynolds, W. F.; Enriquez, R. G. J. Nat. Prod. 2002, 65, 221-244.
148. (b) Neri, P.; Tringali, C. In Bioactive Compounds from Natural Sources: Isolation, Characterisation, and Biological Properties; Tringali, C., Ed.; Taylor & Francis: New York, 2000; Chapter 3, pp 69-127.
149. (c) Crews, P.; Rodríguez, J.; Jaspars, M. Organic Structure Analysis; Oxford University Press: New York, 1998.
150. (a) Elyashberg, M. E.; Blinov, K. A.; Williams, A. J.; Molodtsov, S. G.; Martin, G. E.; Martirosian, E. R. J. Chem. Inf. Comput. Sci. 2004, 44, 771-792.
151. (a) Lindel, T.; Junker, J. Köck, M. Eur. J. Org. Chem. 1999, 599, 573-577.
152. (b) Meiler, J.; Sanli, E.; Junker J.; Meusinger, R.; Lindel, T.; Will, M.; Maier, W.; Köck, M. J. Chem. Inf. Comput. Sci. 2002, 42, 241-248.
153. Steinbeck, C. J. Chem. Inf. Comput. Sci. 2001, 41, 1500-1507.
154. Bode, H. B.; Bethe, B.; Höfs, R.; Zeeke, A. ChemBioChem 2002, 3, 619-627.
155. (a) García-Junceda, E.; Garcia-Garcia, J. F.; Bastida, A.; Fernández-Mayoralas, A. Bioorg. Med. Chem. 2004, 12, 1817-1834.
156. (b) Mootz, H. D.; Schwarzer, D.; Marahiel, M. A. ChemBioChem 2002, 3, 490-504.
157. (c) Rodriguez, E.; McDaniel, R. Curr. Opin. Microbiol. 2001, 4, 526-534.
158. Knight, V.; Sanglier, J. J.; DiTullio, D.; Braccili, S.; Bonner, P.; Waters, J.; Hughes, D.; Zhang, L. Appl. Microbiol. Biotechnol. 2003, 62, 446-458.
159. Kirakosyan, A.; Sirvent, T. M.; Gibson, D. M.; Kaufman, P. B. Biotechnol. Appl. Biochem. 2004, 39, 71-81.
160. (a) Verpoorte, R.; Memelink, J. Curr. Opin. Biotechnol. 2002, 13, 181-187.
161. (b) Goossens, A.; Hakkinen, S. T.; Laakso, I.; Seppanen-Laakso, T.; Biondi, S.; De Sutler, V.; Lammertyn, F.; Nuutila, A. M.; Soderlund, H.; Zabeau, M.; Inze, D.; Oksman-Caldentey, K. M. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 8595-8600.
162. (a) Mendola, D. Biomol. Eng. 2003, 20, 441-458.
163. (b) el Belarbi, H.; Contreras Gómez, A.; Chisti, Y.; Garcia Camacho, F.; Molina Grima, E. Biotechnol. Adv. 2003, 21, 585-598.
164. Hildebrand, M.; Waggoner, L. E.; Lim, G. E.; Sharp, K. H.; Ridley, C. P.; Haygood, M. G. Nat. Prod. Rev. 2004, 21, 122-142.
165. (a) Eisai Pharmaceuticals Annual Report 2003, pp 18-19. http://www.eisai.co.jp/pdf/eannual/epdf200307an.pdf.
166. (b) Choi, H.-W.; Demeke, D.; Kang, F.-A.; Kishi, Y.; Nakajima, K.; Nowak, P.; Wan, Z.-K.; Xie, C. Pure Appl. Chem. 2003, 75, 1-17.
167. Loganzo, F.; Discafani, C. M.; Annable, T.; Beyer, C.; Musto, S.; Hari, M.; Tan, X.; Hardy, C.; Hernandez, R.; Baxter, M.; Singanallore, T.; Khafizova, G.; Poruchynsky, M. S.; Fojo, T.; Nieman, J. A.; Ayral-Kaloustian, S.; Zask, A.; Andersen R. J.; Greenberger, L. M. Cancer Res. 2003, 63, 1838-1845.
168. (a) Freemantle, M. Chem. Eng. News 2004, March 1, 33-35.
169. (b) Mickel, S. J.; Niederer, D.; Daeffier, R.; Osmani, A.; Kuesters, E.; Schmid, E.; Schaer, K.; Gamboni, R.; Chen, W.; Loeser, E.; Kinder, F. R., Jr.; Konigsberger, K.; Prasad, K.; Ramsey, T. M.; Repič, O.; Wang, R.-M.; Florence, G.; Lyothier, I.; Paterson, I. Org. Process Res. Den. 2004, 8, 122-130, and the preceding four papers in the journal.
170. Bosslet, K. R&D Day 2003 (25 July 03) Turning off the lifelines-Schering's solid tumor pipeline. http://www.schering.de/html/de/ 50_media/download/_files/2003/pres_speech/an_con/030626_bosslet_onco.pdf.
171. (a) Jimeno, J.; Faircloth, G.; Fernández Sousa-Faro, J. M.; Scheuer, P.; Rinehart, K. Mar. Drugs 2004, 1, 14-29.
172. (b) Bonnard, I.; Manzanares, I.; Rinehart, K. L. J. Nat. Prod. 2003, 66, 1466-1470.
173. (a) Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Craske, M. L.; Horan, J. C.; Meyer, T. Curr. Drug Discovery Technol. 2004, 1, 1-11.
174. (b) Wender, P. A.; DeBrabander, J.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Park, C.-M.; Siedenbiedel, C.; Pettit, G. R. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 6624-6629.