Current progress in natural product-like libraries for discovery screening

Combinatorial Chemistry and High Throughput Screening

Volumn 7, Issue 7, 2004, Pages 631-643

  Tan, Derek S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chemical biology; Combinatorial chemistry; Diversity oriented synthesis; Drug discovery; High throughput screening; Natural product

Indexed keywords

1,3 DIOXANE DERIVATIVE; ANGIOPOIETIN 2; CERAMIDE; CHOLINESTERASE INHIBITOR; DYSIDIOLIDE; GALANTAMINE; HISTONE DEACETYLASE INHIBITOR; INDOLACTAM V; MEPYRAMINE MALEATE; PROSTAGLANDIN E2; QUINONE DERIVATIVE; SPHINGOSINE DERIVATIVE; TUBACIN; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DEACETYLATION; DIELS ALDER REACTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENANTIOSELECTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE INTERACTION; GENETIC ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CYTOMEGALOVIRUS; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPORTER GENE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS REPLICATION;

BETULACEAE; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 5644294669     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207043328418     Document Type: Article

References (91)

1. Hung, D.T.; Jamison, T.F.; Schreiber, S.L. Chem. Biol. 1996, 3, 623-639.
2. Schreiber, S.L. Chem. Eng. News 2003, 81, 51-61.
3. Newman, D.J.; Cragg, G.M.; Snader, K.M. J. Nat. Prod. 2003, 66, 1022-1037.
4. Newman, D.J.; Cragg, G.M.; Snader, K.M. Nat. Prod. Rep. 2000, 17, 215-234.
5. Kerns, E.H.; Di, L. Drug Discov. Today, 2003, 8, 316-323.
6. Feher, M.; Schmidt, J.M. J. Chem. Inf. Comput. Sci. 2003, 43, 218-227.
7. Henkel, T.; Brunne, R.M.; Muller, H.; Reichel, F. Angew. Chem. Int. Ed. 1999, 38, 643-647.
8. Lee, M.-L.; Schneider, G. J. Comb. Chem. 2001, 3, 284-289.
9. Bajorath, J. J. Comput. Aided Mol. Design 2002, 16, 431-439.
10. Klebe, G.; Boehm, H.-J. J. Recept. Sign. Transduct. Res. 1997, 17, 459-473.
11. Vajda, S.; Wheng, Z.; Rosenfeld, R.; DeLisi, C. Biochemistry 1994, 33, 13977-13988.
12. Searle, M.S.; Williams, D.H. J. Am. Chem. Soc. 1992, 114, 10690-10697.
13. Veber, D.F.; Johnson, S.R.; Cheng, H.-Y.; Smith, B.R.; Ward, K.W.; Kopple, K.D. J. Med. Chem. 2002, 45, 2615-2623.
14. Hall, D.G.; Manku, S.; Wang, F, J. Comb. Chem. 2001, 3, 125-150.
15. Nielsen, J. Curr. Opin. Chem. Biol. 2002, 6, 297-305.
16. Lee, K.J.; Angulo, A.; Ghazal, P.; Janda, K.D. Org. Lett. 1999, 1, 1859-1862.
17. Zhu, H.; Cong, J.-P.; Yu, D.; Bresnahan, W.A.; Shenk, T.E. Proc. Natl. Acad. Sci. USA 2002, 99, 3932-3937.
18. Pelish, H.E.; Westwood, N.J.; Feng, Y.; Kirchhausen, T.; Shair, M.D. J. Am. Chem. Soc. 2001, 123, 6740-6741.
19. Chang, Y.-T.; Choi, J.; Ding, S.; Prieschl, E.E.; Baumruker, T.; Lee, J.-M.; Chung, S.-K.; Schultz, P.G. J. Am. Chem. Soc. 2002, 124, 1856-1857.
20. Nesterenko, V.; Putt, K.S.; Hergenrother, P.J. J. Am. Chem. Soc. 2003, 125, 14672-14673.
21. Brohm, D.; Metzger, S.; Bhargava, A.; Muller, O.; Lieb, F.; Waldmann, H. Angew. Chem. Int. Ed. 2002, 41, 307-311.
22. Koch, M.A.; Breinbauer, R.; Waldmann, H. Biol. Chem. 2003, 384, 1265-1272.
23. Breinbauer, R.; Vetter, I.R.; Waldmann, H. Angew. Chem. Int. Ed. 2002, 41, 2878-2890.
24. Stahl, P.; Kissau, L.; Mazitschek, R.; Huwe, A.; Furet, P.; Giannis, A.; Waldmann, H. J. Am. Chem. Soc. 2001, 123, 11586-11593.
25. Stahl, P.; Kissau, L.; Mazitschek, R.; Giannis, A.; Waldmann, H. Angew. Chem. Int. Ed. 2002, 41, 1174-1178.
26. Kissau, L.; Stahl, P.; Mazitschek, R.; Giannis, A.; Waldmann, H. J. Med. Chem. 2003, 46, 2917-2931.
27. Brohm, D.; Philippe, N.; Metzger, S.; Bhargava, A.; Mueller, O.; Lieb, F.; Waldmann, H. J. Am. Chem. Soc. 2002, 124, 13171-13178.
28. Meseguer, B.; Alonso-Diaz, D.; Griebenow, N.; Herget, T.; Waldmann, H. Angew. Chem. Int. Ed. 1999, 38, 2902-2906.
29. Meseguer, B.; Alonso-Diaz, D.; Griebenow, N.; Herget, T.; Waldmann, H. Chem. Eur. J. 2000, 6, 3943-3957.
30. Marx, M.A.; Grillot, A.-L.; Louer, C.T.; Beaver, K.A.; Bartlett, P.A. J. Am. Chem. Soc. 1997, 119, 6153-6167.
31. Schreiber, S.L. Science 2000, 287, 1964-1969.
32. Burke, M.D.; Schreiber, S.L. Angew. Chem. Int. Ed. 2004, 43, 46-58.
33. Tan, D.S.; Foley, M.A.; Shair, M.D.; Schreiber, S.L. J. Am. Chem. Soc. 1998, 120, 8565-8566.
34. Tan, D.S.; Foley, M.A.; Stockwell, B.R.; Shair, M.D.; Schreiber, S.L. J. Am. Chem. Soc. 1999, 121, 9073-9087.
35. Sternson, S.M.; Louca, J.B.; Wong, J.C.; Schreiber, S.L. J. Am. Chem. Soc. 2001, 123, 1740-1747.
36. Kuruvilla, F.G.; Shamji, A.F.; Sternson, S.M.; Hergenrother, P.J.; Schreiber, S.L. Nature 2002, 416, 653-657.
37. Sternson, S.M.; Wong, J.C.; Grozinger, C.M.; Schreiber, S.L. Org. Lett. 2001, 3, 4239-4242.
38. Stockwell, B.R.; Haggarty, S.J.; Schreiber, S.L. Chem. Biol. 1999, 6, 71-83.
39. Haggarty, S.J.; Koeller, K.M.; Wong, J.C.; Butcher, R.A.; Schreiber, S.L. Chem. Biol. 2003, 10, 383-396.
40. Haggarty, S.J.; Koeller, K.M.; Wong, J.C.; Grozinger, C.M.; Schreiber, S.L. Proc. Natl. Acad. Sci. USA 2003, 100, 4389-4394.
41. Wong, J.C.; Hong, R.; Schreiber, S.L. J. Am. Chem. Soc. 2003, 125, 5586-5587.
42. Haggarty, S.J., Clemons, P.A.; Wong, J.C.; Schreiber, S.L. Comb. Chem. & High Through. Screen. 2004, 7, 669-676.
43. Stavenger, R.A.; Schreiber, S.L. Angew. Chem. Int. Ed. 2001, 40, 3417-3421.
44. Koehler, A.N.; Shamji, A.F.; Schreiber, S.L. J. Am. Chem. Soc. 2003, 125, 8420-8421.
45. Berg, T. Angew. Chem. Int. Ed. 2003, 42, 2462-2481.
46. Spring, D.R.; Krishnan, S.; Schreiber, S.L. J. Am. Chem. Soc. 2000, 122, 5656-5657.
47. Spring, D.R.; Krishnan, S.; Blackwell, H.E.; Schreiber, S.L. J. Am. Chem. Soc., 2002, 124, 1354-1363.
48. Micalizio, G.C.; Schreiber, S.L. Angew. Chem. Int. Ed. 2002, 41, 152-154.
49. Micalizio, G.C.; Schreiber, S.L. Angew. Chem. Int. Ed. 2002, 41, 3272-3276.
50. Burke, M.D.; Berger, E.M.; Schreiber, S.L. Science 2003, 302, 613-618.
51. Sello, J.K.; Andreana, P.R.; Lee, D.; Schreiber, S.L. Org. Lett. 2003, 5, 4125-4127.
52. Gordon, E.M.; Gallop, M.A.; Patel, D.V. Acc. Chem. Res. 1996, 29, 144-154.
53. Keating, T.A.; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574-2583.
54. Tempest, P.A.; Armstrong, R.W. J. Am. Chem. Soc. 1997, 119, 7607-7608.
55. Kwon, O.; Park, S.B.; Schreiber, S.L. J. Am. Chem. Soc. 2002, 124, 13402-13404.
56. Barnes-Seeman, D.; Park, S.B.; Koehler, A.N.; Schreiber, S.L. Angew. Chem. Int. Ed. 2003, 42, 2376-2379.
57. Boger, D.L.; Desharnais, J.; Capps, K. Angew. Chem. Int. Ed. 2003, 42, 4138-4176.
58. Boger, D.L. Bioorg. Med. Chem. 2003, 11, 1607-1613.
59. Boger, D.L.; Tarby, C.M.; Myers, P.L.; Caporale, L.H. J. Am. Chem. Soc. 1996, 118, 2109-2110.
60. Cheng, S.; Comer, D.D.; Williams, J.P.; Myers, P.L.; Boger, D.L. J. Am. Chem. Soc. 1996, 118, 2567-2573.
61. Cheng, S.; Tarby, C.M.; Comer, D.D.; Williams, J.P.; Caporale, L.H.; Myers, P.L.; Boger, D.L. Bioorg. Med. Chem. 1996, 4, 727-737.
62. Boger, D.L.; Goldberg, J.; Silletti, S.; Kessler, T.; Cheresh, D.A. J. Am. Chem. Soc. 2001, 123, 1280-1288.
63. Silletti, S.; Kessler, T.; Goldberg, J.; Boger, D.L.; Cheresh, D.A. Proc. Natl. Acad Sci. USA 2001, 98, 119-124.
64. Goldberg, J.; Jin, Q.; Ambroise, Y.; Satoh, S.; Desharnais, J.; Capps, K.; Boger, D.L. J. Am. Chem. Soc. 2002, 124, 544-555.
65. Boger, D.L.; Goldberg, J.; Satoh, S.; Ambroise, Y.; Cohen, S.B.; Vogt, P.K. Helv. Chim. Acta 2000, 83, 1825-1845.
66. Boger, D.L.; Lee, J.K.; Goldberg, J.; Jin, Q. J. Org. Chem. 2000, 65, 1467-1474.
67. Berg, T.; Cohen, S.B.; Desharnais, J.; Sonderegger, C.; Maslyar, D.J.; Goldberg, J.; Boger, D.L.; Vogt, P.K. Proc. Natl. Acad. Sci. USA 2002, 99, 3830-3835.
68. Rouhi, A.M. Chem. Eng. News 2003, 81, 104-107.
69. Nicolaou, K.C.; Pfefferkorn, J.A.; Roecker, A. J.; Cao, G.Q.; Barluenga, S.; Mitchell, H.J. J. Am. Chem. Soc. 2000, 122, 9939-9953.
70. Nicolaou, K.C.; Pfefferkorn, J.A.; Mitchell, H.J.; Roecker, A.J.; Barluenga, S.; Cao, G.Q.; Affleck, R.L.; Lillig, J.E. J. Am. Chem. Soc. 2000, 122, 9954-9967.
71. Nicolaou, K.C.; Pfefferkorn, J.A.; Barluenga, S.; Mitchell, H.J.; Roecker, A.J.; Cao, G.Q. J. Am. Chem. Soc. 2000, 122, 9968-9976.
72. Nicolaou, K.C.; Roecker, A.J.; Barluenga, S.; Pfefferkorn, J.A.; Cao, G.-Q. ChemBioChem. 2001, 2, 460-465.
73. Nicolaou, K.C.; Evans, R.M.; Roecker, A.J.; Hughes, R.; Downes, M.; Pfefferkorn, J.A. Org. Biomol. Chem. 2003, 1, 908-920.
74. Nicolaou, K.C.; Pfefferkorn, J.A.; Schuler, F.; Roecker, A.J.; Cao, G.Q.; Casida, J.E. Chem. Biol. 2000, 7, 979-992.
75. Khersonsky, S.M.; Chang, Y.-T. Comb. Chem. & High Through. Screen. 2004, 7, 645-652.
76. Horton, D.A.; Bourne, G.T.; Smythe, M.L. J. Comput. Aided Mol. Design 2002, 16, 415-431.
77. Peterson, J.R.; Lokey, R.S.; Mitchison, T.J.; Kirschner, M.W. Proc. Natl. Acad Sci. USA 2001, 98:10624-10629.
78. Boger, D.L.; Fink, B.E.; Hedrick, M.P. J. Am. Chem. Soc. 2000, 122, 6382-6394.
79. Ambroise, Y.; Yaspan, B.; Ginsberg, M.H.; Boger, D.L. Chem. Biol. 2002, 9, 1219-1226.
80. Paterson, I.; Donghi, M.; Gerlach, K. Angew. Chem. Int. Ed. 2000, 39, 3315-3319.
81. Reggelin, M.; Brenig, V.; Welcker, R. Tetrahedron Lett. 1998, 39, 4801-4804.
82. Misske, A.M.; Hoffmann, H.M.R. Chem. Eur. J. 2000, 6, 3313-3320.
83. Arjona, O.; Menchaca, R.; Plumet, J. J. Org. Chem. 2001, 66, 2400-2413.
84. Hoffmann, R.W. Angew. Chem. Int. Ed. 2000, 39, 2055-2070.
85. Shi, Z.; Harrison, B.A.; Verdine, G.L. Org. Lett. 2003, 5, 633-636.
86. Gierasch, T.M.; Shi, Z.; Verdine, G.L. Org. Lett. 2003, 5, 621-624.
87. Harrison, B.A.; Gierasch, T.M.; Neilan, C.; Pasternak, G.W.; Verdine, G.L. J. Am. Chem. Soc. 2002, 124, 13352-13353.
88. Kohli, R.M.; Burke, M.D.; Tao, J.; Walsh, C.T. J. Am. Chem. Soc. 2003, 125, 7160-7161.
89. Kulkarni, B.A.; Roth, G.P.; Lobkovsky, E.; Porco, J.A., Jr. J. Comb. Chem. 2002, 4, 56-72.
90. Niggemann, J.; Michaelis, K.; Frank, R.; Zander, N.; Hoefle, G. J. Chem. Soc. Perkin Trans. 1, 2002, 2490-2503.
91. Rouhi, A.M. Chem. Eng. News 2003, 81, 77-91.