Target-oriented and diversity-oriented organic synthesis in drug discovery

Science

Volumn 287, Issue 5460, 2000, Pages 1964-1969

  Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PHTHALASCIDIN; UNCLASSIFIED DRUG; ZINOSTATIN CHROMOPHORE;

ACYLATION; ALKYLATION; CHEMICAL REACTION; CYCLIZATION; DRUG RESEARCH; DRUG STRUCTURE; MOLECULAR BIOLOGY; ORGANIC CHEMISTRY; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SCREENING; SYNTHESIS;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MODELS, CHEMICAL; ORGANIC CHEMICALS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEINS;

EID: 0034678033     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5460.1964     Document Type: Review

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45. Colleagues at Harvard University's Department of Chemistry and Chemical Biology and Institute of Chemistry and Cell Biology, especially M. D. Shair and E. J. Corey, are thanked for their insights and suggestions. The National Institute of General Medical Sciences, the National Cancer Institute, and Merck and Co. are gratefully acknowledged for their support of organic synthesis relevant to drug discovery.