Combinatorial synthesis of natural products

Current Opinion in Chemical Biology

Volumn 6, Issue 3, 2002, Pages 297-305

  Nielsen, John ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCT;

COMBINATORIAL CHEMISTRY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HYBRID; INFECTION; MOLECULE; NONHUMAN; ONCOLOGY; REVIEW; SOLID;

EID: 0036603591     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(02)00330-7     Document Type: Review

References (43)

1. Dogger Bank itch. The allergen is (2-hydroxyethyl)dimethylsulfonium ion
2. Total synthesis of taxol
3. Natural products in drug discovery and development
4. The influence of natural products upon drug discovery
5. To market, to market - 2000
6. High-throughput screening in natural product drug discovery in Australia utilising Australia's biodiversity
7. High-throughput natural product chemistry for drug discovery
8. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
9. Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: A comprehensive survey
10. Synthesis of natural-product-based compound libraries
11. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold
12. The role of combichem in antibiotic discovery
13. Combinatorial approaches in anticancer drug discovery: Recent advances in design and synthesis
14. Lead compounds discovered from libraries
15. Natural product-like chiral derivatives by solid-phase synthesis
16. Solid-phase oligosaccharide synthesis and combinatorial carbohydrate libraries
17. Combinatorial chemistry toward understanding the function(s) of carbohydrates and carbohydrate conjugates
18. Click chemistry: Diverse chemical function from a few good reactions
19. Combinatorial biosynthesis of antimicrobials and other natural products
20. Parallel synthesis of a vitamin D-3 library in the solid-phase
21. Novel synthetic approach to 19-nor-1 alpha,25-dihydroxyvitamin D-3 and its derivatives by Suzuki-Miyaura coupling in solution and on solid support
22. Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)
23. Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines
24. Syntheses of hapalosin analogs by solid-phase assembly of acyclic precursors
25. Solid phase synthesis of cyclic peptides by oxidative cyclative cleavage of an aryl hydrazide linker - Synthesis of stylostatin 1
26. Solid-phase synthesis of macrolide analogs
27. A synthetic library of cell-permeable molecules
28. Solid- and solution-phase synthesis of vancomycin and vancomycin analogs with activity against vancomycin-resistant bacteria
29. Parallel solid-phase synthesis of 3 beta-peptido-3 alpha-hydroxy-5 alpha androstan-17-one derivatives for inhibition of type 3 17 beta-hydroxysteroid dehydrogenase
30. Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker
31. A novel diterpenoid lactone-based scaffold for the generation of combinatorial libraries
32. A new bio-compatible pH cleavable linker for solid-phase synthesis of a squalamine analog
33. Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support
34. Solid-phase synthesis of new saphenamycin analogs with antimicrobial activity
35. Nonpeptidal peptidomimetics with a β-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist
36. Development of an efficient, regio- and stereoselective route to libraries based on the beta-D-glucose scaffold
37. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product
38. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin
39. Development of general strategy for the solid supported synthesis of heterocycles: Application to the generation of molecular diversity and drug discovery
40. A solid-phase approach to analogs of the antibiotic mureidomycin
41. Synthesis of new 3- and 4-substituted analogs of acyl homoserine lactone quorum sensing autoinducers
42. Reactivity of alpha-(benzoyloxy) crotylstannane with aldehydes in liquid phase and on solid support. Synthesis of substituted lactones