Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria

Chemistry - A European Journal

Volumn 7, Issue 17, 2001, Pages 3798-3823

  Nicolaou, K C ^a,b   Cho, Suk Young ^a,b   Hughes, Robert ^a,b   Winssinger, Nicolas ^a,b   Smethurst, Christian ^a,b   Labischinski, Harald ^c   Endermann, Rainer ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BAYER AG   (Germany)

Author keywords

Antibiotics; Biological evaluation; Combinatorial synthesis; Synthesis design; Vancomycin

Indexed keywords

BACTERIA; HEALTH CARE; SELENIUM; SYNTHESIS (CHEMICAL);

SAFETY CATCH LINKERS;

ANTIBIOTICS;

ALKENE; ALLYL COMPOUND; ANTI INFECTIVE AGENTS; ANTIINFECTIVE AGENT; PEPTIDE LIBRARY; SELENIUM; THIOACETIC ACID; VANCOMYCIN; VANCOMYCIN DERIVATIVE;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CHEMICAL MODIFICATION; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DEACETYLATION; DRUG EFFECT; DRUG RESISTANCE; DRUG SYNTHESIS; ENTEROCOCCUS FAECIUM; GRAM POSITIVE COCCI; HYDROGEN BOND; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; NONHUMAN; SOLID STATE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG RESISTANCE; ENTEROCOCCUS FAECIUM; GRAM-POSITIVE COCCI; MICROBIAL SENSITIVITY TESTS; PEPTIDE LIBRARY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN;

EID: 3543056384     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20010903)7:17<3798::AID-CHEM3798>3.0.CO;2-6     Document Type: Article

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