Combinatorial synthesis through bisulfide exchange: Discovery of potent psammaplin A type antibacterial agents active against Methicillin-Resistant Staphylococcus aureus (MRSA)

Chemistry - A European Journal

Volumn 7, Issue 19, 2001, Pages 4280-4295

  Nicolaou, K C ^a,b   Hughes, Robert ^a,b   Pfefferkorn, Jeffrey A ^a,b   Barluenga, Sofia ^a,b   Roecker, A J ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibiotics; Chemical biology; Combinatorial synthesis; Psammaplin A; Total synthesis

Indexed keywords

SULFUR COMPOUNDS;

MARINE NATURAL PRODUCTS;

SYNTHESIS (CHEMICAL);

ANTI INFECTIVE AGENTS; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; DISULFIDE; PSAMMAPLIN A; TYROSINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DIMERIZATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; NONHUMAN; PENICILLIN RESISTANCE; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DIMERIZATION; DISULFIDES; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0035477106     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3     Document Type: Article

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