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The authors provide an excellent overview of natural-product library approaches. The review contains many leading references and a rather comprehensive table of natural product and natural-product-like libraries prepared by total synthesis and semi-synthesis.
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Abel U., Koch C., Speitling M., Hansske F.G. Modern methods to produce natural-product libraries. Curr Opin Chem Biol. 6:2002;453-458 The authors provide an excellent overview of natural-product library approaches. The review contains many leading references and a rather comprehensive table of natural product and natural-product-like libraries prepared by total synthesis and semi-synthesis.
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Abreu P.M., Branco P.S. Natural product-like combinatorial libraries. J Braz Chem Soc. 14:2003;675-712 A survey of combinatorial techniques applied to a wide range of natural-product-like libraries described in this review is summarized in Table 1. Earlier reviews of the two main strategies of integrating natural products into combinatorial chemistry, total synthesis of natural products, and natural products as templates for the construction of libraries, are cited.
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An excellent comprehensive review of libraries based on natural product templates.
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Hall D.G., Manku S., Wang F. Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: a comprehensive survey. J Comb Chem. 3:2001;125-150 An excellent comprehensive review of libraries based on natural product templates.
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The author provides a good review of approaches to natural products by high-throughput organic synthesis. Key leading reviews are cited.
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Nielsen J. Combinatorial synthesis of natural products. Curr Opin Chem Biol. 6:2002;297-305 The author provides a good review of approaches to natural products by high-throughput organic synthesis. Key leading reviews are cited.
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Lee M.-L., Schneider G. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries. J Comb Chem. 3:2001;284-289
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The authors describe several types of natural-product-like libraries.
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Breinbauer R., Manger M., Scheck M., Waldmann H. Natural product guided compound library development. Curr Med Chem. 9:2002;2129-2145 The authors describe several types of natural-product-like libraries.
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The authors describe a method for generating diverse structures by transforming substrates encoded with structural information, σ elements, into molecules with diverse structures.
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Burke M.D., Berger E.M., Schreiber S.L. Generating diverse skeletons of small molecules combinatorially. Science. 302:2003;613-618 The authors describe a method for generating diverse structures by transforming substrates encoded with structural information, σ elements, into molecules with diverse structures.
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Brohm D., Metzger S., Bhargava A., Müller O., Lieb F., Waldmann H. Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors. Angew Chem Int Ed Engl. 41:2002;307-311
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Brohm D., Philippe N., Metzger S., Bhargava A., Müller O., Lieb F., Waldmann H. Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors. J Am Chem Soc. 124:2002;13171-13178
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Kissau L., Stahl P., Mazitschek R., Giannis A., Waldmann H. Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold. J Med Chem. 46:2003;2917-2931
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Zou N., Liu J.-F., Jiang B. Solution-phase synthesis of a thiazoyl-substituted indolyl library via Suzuki cross coupling. J Comb Chem. 5:2003;754-755
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Pirrung M.C., Den L., Li Z., Park K. Synthesis of 2, 5-dihydroxy-3- (indol-3-yl)benzoquinones by acid-catalyzed condensation of indoles with 2, 5-dichlorobenzoquinone. J Org Chem. 67:2002;8374-8388
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Orain D., Koch G., Giger R. From solution-phase studies to solid-phase synthesis: a new indole based scaffold for combinatorial chemistry. Chimia (Aarau). 57:2003;255-261
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Zhang W., Luo Z., Chen C.H.-T., Curran D.P. Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis. J Am Chem Soc. 124:2002;10443-10450
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Synthesis of biaryl-containing medium rings on solid-phase mimicking the structurally complexity of such natural products like pterocaryanin c and vancomycin.
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Spring D.R., Krishnan S., Blackwell H.E., Schreiber S.L. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. J. Am. Chem. Soc. 124:2002;1354-1363 Synthesis of biaryl-containing medium rings on solid-phase mimicking the structurally complexity of such natural products like pterocaryanin c and vancomycin.
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Iodophenols were used to generate several types of natural-product-like libraries.
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Liao Y., Hu Y., Wu J., Zhu Q., Donovan M., Fathi R., Yang Z. Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds. Current Med Chem. 10:2003;2285-2316 Iodophenols were used to generate several types of natural-product-like libraries.
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Liao, Y.1
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Liao Y., Reitman M., Zhang Y., Fathi R., Yang Z. Palladium(II)-mediated cascade carbonylative annulation of o-alkynyl-phenols on silyl linker-based macrobeads: a combinatorial synthesis of a 2, 3-disubstituted benzo[b]furan library. Org Lett. 4:2002;2607-2609
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Boldi A.M., Dener J.M., Hopkins T.P. Solid-phase library synthesis of alkoxyprolines. J Comb Chem. 3:2001;367-373
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Vergnon A.L., Pottorf R.S., Player M.R. Solid-phase synthesis of a library of hydroxyproline derivatives. J Comb Chem. 6:2004;91-98
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Seeberger P.H., Haase W.-C. Solid-phase oligosaccharide synthesis and combinatorial carbohydrate libraries. Chem Rev. 100:2000;4349-4393
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Walters M.A., La F., Deshmukh P., Omecinsky D.O. Templates for exploratory library preparation. derivatization of a functionalized spirocyclic 3, 6-dihydro-2H-pyran formed by ring-closing metathesis reaction. J Comb Chem. 3:2001;125-130
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Kulkarni B.A., Roth G.P., Lobkovsky E., Porco J.A. Jr. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. J Comb Chem. 4:2002;56-72
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Krueger E.B., Hopkins T.P., Keaney M.T., Walters M.A., Boldi A.M. Solution-phase library synthesis of furanoses. J Comb Chem. 4:2002;229-238
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J Comb Chem
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41
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Arya P., Durieux P., Chen Z.-X., Joseph R., Leek D.M. Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline- based polycyclic derivatives. J Comb Chem. 6:2004;54-64
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Arya P., Wei C.-Q., Barnes M.L., Daroszewska M. A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by mitsunobu approach. J Comb Chem. 6:2004;65-72
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Couve-Bonnaire S., Chou D.T.H., Gan Z., Arya P. A solid-phase, library synthesis of natural-product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold. J Comb Chem. 6:2004;73-77
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