Generating Diverse Skeletons of Small Molecules Combinatorially

Science

Volumn 302, Issue 5645, 2003, Pages 613-618

  Burke, Martin D ^a   Berger, Eric M ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOMERS; MOLECULES; SYNTHESIS (CHEMICAL);

DIVERSE SKELETONS;

NATURAL SCIENCES;

HYDROXYL GROUP;

BIOLOGY; SKELETON;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DIASTEREOISOMER; ENANTIOMER; ISOMERISM; MACROMOLECULE; OXIDATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SMALL MOLECULE PROTEIN INTERACTION;

ACETYLATION; BENZENESULFONATES; BROMOSUCCINIMIDE; CHEMISTRY, ORGANIC; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; FURANS; HYDROXYLATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STEREOISOMERISM;

EID: 0142147275     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1089946     Document Type: Article

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32. We gratefully acknowledge M. Narovlyansky for providing macrobeads 1; Q. Liao, P. Wang, and J. Dudek for HRMS analysis; J. Raggio, L. Castro, and J. Tallarico for providing encoding reagents and for cleaving and analyzing chemical tags; Y.-K. Kim for helpful discussions regarding the transformation of 3 → 4; and M. Kanan for thoughtful review of this manuscript. Supported by the NIGMS and the NCI. S.L.S. is an investigator at the Howard Hughes Medical Institute at Harvard. M.D.B. is an HHMI predoctoral fellow, and E.M.B. is an HHMI undergraduate fellow.