-
1
-
-
0033104653
-
Statistical investigation into the structural complementarity of natural products and synthetic compounds
-
Statistically founded analysis of the importance and diversity of natural products
-
Henkel T., Brunne R.M., Müller H., Reichel F. Statistical investigation into the structural complementarity of natural products and synthetic compounds. Angew Chem Int Ed Engl. 38:1999;643-647. Statistically founded analysis of the importance and diversity of natural products.
-
(1999)
Angew Chem Int Ed Engl
, vol.38
, pp. 643-647
-
-
Henkel, T.1
Brunne, R.M.2
Müller, H.3
Reichel, F.4
-
2
-
-
0032076563
-
Exploration of nature's chemodiversity: The role of secondary metabolites as leads in drug development
-
Verpoorte R. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discov Today. 3:1998;232-238.
-
(1998)
Drug Discov Today
, vol.3
, pp. 232-238
-
-
Verpoorte, R.1
-
4
-
-
33750085801
-
Synthesis of C-2-analog taxols
-
Nicolaou K.C., Couladouros E.A., Nantermet P.G., Renaud J., Guy R.K., Wrasidlo W. Synthesis of C-2-analog taxols. Angew Chem Int Ed Engl. 33:1994;1581-1583.
-
(1994)
Angew Chem Int Ed Engl
, vol.33
, pp. 1581-1583
-
-
Nicolaou, K.C.1
Couladouros, E.A.2
Nantermet, P.G.3
Renaud, J.4
Guy, R.K.5
Wrasidlo, W.6
-
5
-
-
0000922774
-
The first total syntheses of Taxol
-
Wessjohann L. The first total syntheses of Taxol. Angew Chem. 106:1994;1011-1013.
-
(1994)
Angew Chem
, vol.106
, pp. 1011-1013
-
-
Wessjohann, L.1
-
6
-
-
84889618147
-
The first total syntheses of Taxol
-
J. Mulzer, & H. Waldmann. Weinheim: Wiley-VCH
-
Wessjohann L. The first total syntheses of Taxol. Mulzer J., Waldmann H. Organic Synthesis Highlights, vol 3. 1998;295-305 Wiley-VCH, Weinheim.
-
(1998)
Organic Synthesis Highlights, Vol 3
, pp. 295-305
-
-
Wessjohann, L.1
-
7
-
-
0033549539
-
Polymer-supported synthesis of non-oligomeric natural products
-
Watson C. Polymer-supported synthesis of non-oligomeric natural products. Angew Chem Int Ed Engl. 38:1999;1903-1908.
-
(1999)
Angew Chem Int Ed Engl
, vol.38
, pp. 1903-1908
-
-
Watson, C.1
-
9
-
-
7044263277
-
Synthesis and applications of small molecule libraries
-
Thompson L.A., Ellman J.A. Synthesis and applications of small molecule libraries. Chem Rev. 96:1996;555-600.
-
(1996)
Chem Rev
, vol.96
, pp. 555-600
-
-
Thompson, L.A.1
Ellman, J.A.2
-
11
-
-
85051687858
-
Synthetic access to epothilones - natural products with extraordinary anticancer activity
-
H-G. Schmalz. Weinheim: Wiley-VCH
-
Wessjohann L.A., Scheid G. Synthetic access to epothilones - natural products with extraordinary anticancer activity. Schmalz H-G. Organic Synthesis Highlights IV, vol 4. 2000;Wiley-VCH, Weinheim.
-
(2000)
Organic Synthesis Highlights IV, Vol 4
-
-
Wessjohann, L.A.1
Scheid, G.2
-
12
-
-
0030843680
-
Epothilones: Promising natural products with taxol-like activity
-
Wessjohann L. Epothilones: promising natural products with taxol-like activity. Angew Chem Int Ed Engl. 36:1997;715-718.
-
(1997)
Angew Chem Int Ed Engl
, vol.36
, pp. 715-718
-
-
Wessjohann, L.1
-
14
-
-
0001087129
-
Substitutions at the thiazole moiety of epothilone
-
Elegant semisynthetic transformations
-
Höfle G., Sefkow M. Substitutions at the thiazole moiety of epothilone. Heterocycles. 48:1998;2485-2488. Elegant semisynthetic transformations.
-
(1998)
Heterocycles
, vol.48
, pp. 2485-2488
-
-
Höfle, G.1
Sefkow, M.2
-
15
-
-
0000777957
-
N-oxidation of epothilone A-C and O-acyl rearrangement to C-19- And C-21-substituted epothilones
-
Höfle G., Glaser N., Kiffe M., Hecht H-J., Sasse F., Reichenbach H. N-oxidation of epothilone A-C and O-acyl rearrangement to C-19- and C-21-substituted epothilones. Angew Chem. 111:1999;2090-2093.
-
(1999)
Angew Chem
, vol.111
, pp. 2090-2093
-
-
Höfle, G.1
Glaser, N.2
Kiffe, M.3
Hecht, H.-J.4
Sasse, F.5
Reichenbach, H.6
-
17
-
-
0032213635
-
Derivatization of the C(12)-C(13) functional groups of epothilones A, B and C
-
Sefkow M., Kiffe M., Höfle G. Derivatization of the C(12)-C(13) functional groups of epothilones A, B and C. Biochem Med Chem Lett. 8:1998;3031-3036.
-
(1998)
Biochem Med Chem Lett
, vol.8
, pp. 3031-3036
-
-
Sefkow, M.1
Kiffe, M.2
Höfle, G.3
-
18
-
-
0030808795
-
Structure-activity relationships of the epothilones and the first in vivo comparison with Paclitaxel
-
Su D-S., Balog A., Meng D., Bertinato P., Danishefsky S.J., Zheng Y-H., Chou T-C., He L., Horwitz S.B. Structure-activity relationships of the epothilones and the first in vivo comparison with Paclitaxel. Angew Chem Int Ed Engl. 36:1997;2093-2096.
-
(1997)
Angew Chem Int Ed Engl
, vol.36
, pp. 2093-2096
-
-
Su, D.-S.1
Balog, A.2
Meng, D.3
Bertinato, P.4
Danishefsky, S.J.5
Zheng, Y.-H.6
Chou, T.-C.7
He, L.8
Horwitz, S.B.9
-
19
-
-
0033551046
-
A common pharmacophore for cytotxic natural products that stabilize microtubules
-
Ojima I., Chakravarty S., Inoue T., Lin S., He L., Horwitz S.B., Kuduk S.D., Danishefsky S.J. A common pharmacophore for cytotxic natural products that stabilize microtubules. Proc Natl Acad Sci USA. 96:1999;4256-4261.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4256-4261
-
-
Ojima, I.1
Chakravarty, S.2
Inoue, T.3
Lin, S.4
He, L.5
Horwitz, S.B.6
Kuduk, S.D.7
Danishefsky, S.J.8
-
20
-
-
0033135050
-
Total synthesis of epothilone E and related sidechain modified analogues via a Stille coupling based strategy
-
Nicolaou K.C., King N.P., Finlay M.R.V., He Y., Roschangar F., Vourloumis D., Vallberg H., Sarabia F., Ninkovic S., Hepworth D. Total synthesis of epothilone E and related sidechain modified analogues via a Stille coupling based strategy. Bioorg Med Chem. 7:1999;665-697.
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 665-697
-
-
Nicolaou, K.C.1
King, N.P.2
Finlay, M.R.V.3
He, Y.4
Roschangar, F.5
Vourloumis, D.6
Vallberg, H.7
Sarabia, F.8
Ninkovic, S.9
Hepworth, D.10
-
21
-
-
0033590797
-
Synthesis of 16-desmethylepothilone B: Improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues
-
Nicolaou K.C., Hepworth D., Finlay M.R.V., King N.P., Werschkun B., Bigot A. Synthesis of 16-desmethylepothilone B: improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues. Chem Commun. 1999;519-520.
-
(1999)
Chem Commun
, pp. 519-520
-
-
Nicolaou, K.C.1
Hepworth, D.2
Finlay, M.R.V.3
King, N.P.4
Werschkun, B.5
Bigot, A.6
-
22
-
-
0031906651
-
Probing the ring size of epothilones: Total synthesis of [14]-, [15]-, [17]-, and [18]- epothilones A
-
Nicolaou K.C., Sarabia F., Ninkovic S., Finlay M.R.V., Boddy C.N.C. Probing the ring size of epothilones: total synthesis of [14]-, [15]-, [17]-, and [18]- epothilones A. Angew Chem Int Ed Engl. 37:1998;81-84.
-
(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 81-84
-
-
Nicolaou, K.C.1
Sarabia, F.2
Ninkovic, S.3
Finlay, M.R.V.4
Boddy, C.N.C.5
-
23
-
-
0031881549
-
Total synthesis of epothilone E and analogues with modified side chains through the Stille coupling reaction
-
Nicolaou K.C., He Y., Roschangar F., King N.P., Vourloumis D., Li T. Total synthesis of epothilone E and analogues with modified side chains through the Stille coupling reaction. Angew Chem Int Ed Engl. 37:1998;84-87.
-
(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 84-87
-
-
Nicolaou, K.C.1
He, Y.2
Roschangar, F.3
King, N.P.4
Vourloumis, D.5
Li, T.6
-
24
-
-
0032543528
-
Total synthesis of 26-hydroxy-epothilone B and related analoga via macrolactonization based strategy
-
Nicolaou K.C., Finlay M.R.V., Ninkovic S., Sarabia F. Total synthesis of 26-hydroxy-epothilone B and related analoga via macrolactonization based strategy. Tetrahedron. 54:1998;7127-7166.
-
(1998)
Tetrahedron
, vol.54
, pp. 7127-7166
-
-
Nicolaou, K.C.1
Finlay, M.R.V.2
Ninkovic, S.3
Sarabia, F.4
-
25
-
-
17744405184
-
Synthesis of epothilones A and B in solid and solution phase
-
Nicolaou K.C., Winssinger N., Pastor J., Ninkovic S., Sarabia F., He Y., Vourloumis D., Yang Z., Li T., Giannakakou P., Hamel E. Synthesis of epothilones A and B in solid and solution phase. Nature. 387:1997;268-272.
-
(1997)
Nature
, vol.387
, pp. 268-272
-
-
Nicolaou, K.C.1
Winssinger, N.2
Pastor, J.3
Ninkovic, S.4
Sarabia, F.5
He, Y.6
Vourloumis, D.7
Yang, Z.8
Li, T.9
Giannakakou, P.10
Hamel, E.11
-
26
-
-
0030779208
-
Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against Taxol-resistant tumor cells
-
Nicolaou K.C., Vourloumis D., Li T., Pastor J., Winssinger N., He Y., Ninkovic S., Sarabia F., Vallberg H., Roschangar F.et al. Designed epothilones: combinatorial synthesis, tubulin assembly properties, and cytotoxic action against Taxol-resistant tumor cells. Angew Chem Int Ed Engl. 36:1998;2097-2103.
-
(1998)
Angew Chem Int Ed Engl
, vol.36
, pp. 2097-2103
-
-
Nicolaou, K.C.1
Vourloumis, D.2
Li, T.3
Pastor, J.4
Winssinger, N.5
He, Y.6
Ninkovic, S.7
Sarabia, F.8
Vallberg, H.9
Roschangar, F.10
-
27
-
-
0031882649
-
A convergent route for the total synthesis of the eleuthesides
-
Chen X.T., Gutteridge C.E., Bhattacharya S.K., Zhou B.S., Pettus T.R.R., Hascall T., Danishefsky S.J. A convergent route for the total synthesis of the eleuthesides. Angew Chem Int Ed Engl. 37:1998;185-187.
-
(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 185-187
-
-
Chen, X.T.1
Gutteridge, C.E.2
Bhattacharya, S.K.3
Zhou, B.S.4
Pettus, T.R.R.5
Hascall, T.6
Danishefsky, S.J.7
-
28
-
-
0033609037
-
The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
-
Hamel E., Sacket D.L., Vourloumis D., Nicolaou K.C. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry. 38:1999;5490-5498.
-
(1999)
Biochemistry
, vol.38
, pp. 5490-5498
-
-
Hamel, E.1
Sacket, D.L.2
Vourloumis, D.3
Nicolaou, K.C.4
-
29
-
-
0032576190
-
Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictin libraries
-
Nicolaou K.C., Winssinger N., Vourloumis D., Ohshima T., Kim S., Pfefferkorn J., Xu J-Y., Li T. Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictin libraries. J Am Chem Soc. 120:1998;10814-10826.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 10814-10826
-
-
Nicolaou, K.C.1
Winssinger, N.2
Vourloumis, D.3
Ohshima, T.4
Kim, S.5
Pfefferkorn, J.6
Xu, J.-Y.7
Li, T.8
-
30
-
-
0032486436
-
Synthesis and biological activity of sarcodictyins
-
Nicolaou K.C., Kim S., Pfefferkorn J., Xu J-Y., Ohshima T., Hosokawa S., Vourloumis D., Li T. Synthesis and biological activity of sarcodictyins. Angew Chem Int Ed Engl. 36:1998;1418-1421.
-
(1998)
Angew Chem Int Ed Engl
, vol.36
, pp. 1418-1421
-
-
Nicolaou, K.C.1
Kim, S.2
Pfefferkorn, J.3
Xu, J.-Y.4
Ohshima, T.5
Hosokawa, S.6
Vourloumis, D.7
Li, T.8
-
31
-
-
0033223066
-
Parallel synthesis of prostaglandin E1 analogues
-
Rapid parallel approach to prostaglandin derivatives
-
Dragoli D.R., Thompson L.A., O'Brien J., Ellman J.A. Parallel synthesis of prostaglandin E1 analogues. J Comb Chem. 1:1999;534-539. Rapid parallel approach to prostaglandin derivatives.
-
(1999)
J Comb Chem
, vol.1
, pp. 534-539
-
-
Dragoli, D.R.1
Thompson, L.A.2
O'Brien, J.3
Ellman, J.A.4
-
32
-
-
0032478678
-
Solid-phase synthesis of diverse E- And F-series prostaglandins
-
Thompson L.A., Moore F.L., Moon Y-C., Ellman J.A. Solid-phase synthesis of diverse E- and F-series prostaglandins. J Org Chem. 63:1998;2066-2067.
-
(1998)
J Org Chem
, vol.63
, pp. 2066-2067
-
-
Thompson, L.A.1
Moore, F.L.2
Moon, Y.-C.3
Ellman, J.A.4
-
33
-
-
0030883333
-
2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries
-
2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries. J Am Chem Soc. 119:1997;8724-8725.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 8724-8725
-
-
Chen, S.1
Janda, K.D.2
-
34
-
-
0032482532
-
2α) on a non-cross-linked polystyrene support
-
2α) on a non-cross-linked polystyrene support. Tetrahedron Lett. 39:1998;3943-3946.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 3943-3946
-
-
Chen, S.1
Janda, K.D.2
-
35
-
-
0032564564
-
Combinatorial chemistry of natural products: Solid-phase synthesis of D- And L-cycloserine derivatives
-
Gordeev M.F., Luehr G.W., Hui H.C., Gordon E.M., Patel D.V. Combinatorial chemistry of natural products: solid-phase synthesis of D- And L-cycloserine derivatives. Tetrahedron. 54:1998;15879-15890.
-
(1998)
Tetrahedron
, vol.54
, pp. 15879-15890
-
-
Gordeev, M.F.1
Luehr, G.W.2
Hui, H.C.3
Gordon, E.M.4
Patel, D.V.5
-
36
-
-
0000883040
-
Solid-phase total synthesis of oscillamide Y and analogues
-
Marsh I.R., Bradley M., Teague S.J. Solid-phase total synthesis of oscillamide Y and analogues. J Org Chem. 62:1997;6199-6203.
-
(1997)
J Org Chem
, vol.62
, pp. 6199-6203
-
-
Marsh, I.R.1
Bradley, M.2
Teague, S.J.3
-
37
-
-
0033606246
-
Combinatorial library approach for the identification of synthetic receptors targeting vancomycin-resistant bacteria
-
Xu R., Greiveldinger G., Marenus L.E., Cooper A., Ellman J. Combinatorial library approach for the identification of synthetic receptors targeting vancomycin-resistant bacteria. J Am Chem Soc. 121:1999;4898-4899.
-
(1999)
J Am Chem Soc
, vol.121
, pp. 4898-4899
-
-
Xu, R.1
Greiveldinger, G.2
Marenus, L.E.3
Cooper, A.4
Ellman, J.5
-
39
-
-
0030603050
-
Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries
-
Seneci P., Sizemore C., Islam K., Kocis P. Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries. Tetrahedron Lett. 37:1996;6319-6322.
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 6319-6322
-
-
Seneci, P.1
Sizemore, C.2
Islam, K.3
Kocis, P.4
-
40
-
-
0033576637
-
Rolling loop scan: An approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins
-
Reichwein J.F., Wels B., Kruijtzer J.A.W., Versluis C., Liskamp R.M.J. Rolling loop scan: an approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins. Angew Chem Int Ed Engl. 38:1999;3684-3687.
-
(1999)
Angew Chem Int Ed Engl
, vol.38
, pp. 3684-3687
-
-
Reichwein, J.F.1
Wels, B.2
Kruijtzer, J.A.W.3
Versluis, C.4
Liskamp, R.M.J.5
-
42
-
-
33751499427
-
Synthesis of β-resorcylic macrolides via organopalladium chemistry. Application to the total synthesis of (S)-zearalenone
-
Kalivretenos A., Stille J.K., Hegedus L.S. Synthesis of β-resorcylic macrolides via organopalladium chemistry. Application to the total synthesis of (S)-zearalenone. J Org Chem. 56:1991;2883-2894.
-
(1991)
J Org Chem
, vol.56
, pp. 2883-2894
-
-
Kalivretenos, A.1
Stille, J.K.2
Hegedus, L.S.3
-
43
-
-
0032476095
-
Solid-phase synthesis of macrocyclic systems by a cyclorelease strategy: Application of the Stille coupling to a synthesis of (S)-Zearalenone
-
Nicolaou K.C., Winssinger N., Pastor J., Murphy F. Solid-phase synthesis of macrocyclic systems by a cyclorelease strategy: application of the Stille coupling to a synthesis of (S)-Zearalenone. Angew Chem Int Ed Engl. 37:1998;2534-2537.
-
(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 2534-2537
-
-
Nicolaou, K.C.1
Winssinger, N.2
Pastor, J.3
Murphy, F.4
-
44
-
-
0032572123
-
Solid phase synthesis of macrocycles by an intramolecular ketophosphonate reaction. Synthesis of a (dl)-muscone library
-
Nicolaou K.C., Pastor J., Winssinger N., Murphy F. Solid phase synthesis of macrocycles by an intramolecular ketophosphonate reaction. Synthesis of a (dl)-muscone library. J Am Chem Soc. 120:1998;5132-5133.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 5132-5133
-
-
Nicolaou, K.C.1
Pastor, J.2
Winssinger, N.3
Murphy, F.4
-
45
-
-
0030182486
-
Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids
-
Atuegbu A., Maclean D., Nguyen C., Gordon E.M., Jacobs J.W. Combinatorial modification of natural products: preparation of unencoded and encoded libraries of Rauwolfia alkaloids. Bioorg Med Chem. 4:1996;1097-1106.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 1097-1106
-
-
Atuegbu, A.1
Maclean, D.2
Nguyen, C.3
Gordon, E.M.4
Jacobs, J.W.5
-
46
-
-
0030580364
-
Combinatorial solid-phase synthesis of balanol analogues
-
Nielsen J., Lyngsø L.O. Combinatorial solid-phase synthesis of balanol analogues. Tetrahedron Lett. 37:1996;8439-8442.
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 8439-8442
-
-
Nielsen, J.1
Lyngsø, L.O.2
-
48
-
-
0034681559
-
Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules
-
Nicolaou K.C., Cao G-Q., Pfefferkorn J.A. Selenium-based solid-phase synthesis of benzopyrans II: applications to combinatorial synthesis of medicinally relevant small organic molecules. Angew Chem Int Ed Engl. 39:2000;739-743.
-
(2000)
Angew Chem Int Ed Engl
, vol.39
, pp. 739-743
-
-
Nicolaou, K.C.1
Cao, G.-Q.2
Pfefferkorn, J.A.3
-
49
-
-
0032491014
-
Natural product analogs as scaffolds for supramolecular and combinatorial chemistry
-
Mink D., Mecozzi S., Rebek J.J. Natural product analogs as scaffolds for supramolecular and combinatorial chemistry. Tetrahedron Lett. 39:1998;5709-5712.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 5709-5712
-
-
Mink, D.1
Mecozzi, S.2
Rebek, J.J.3
-
50
-
-
0032569205
-
Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniturized cell-based assays
-
Tan D.S., Foley M.A., Shair M.D., Schreiber S.L. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniturized cell-based assays. J Am Chem Soc. 120:1998;8565-8566.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 8565-8566
-
-
Tan, D.S.1
Foley, M.A.2
Shair, M.D.3
Schreiber, S.L.4
-
51
-
-
0033594354
-
Potent, low molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II
-
Haque T.S., Skillman A.G., Lee C.E., Habashita H., Gluzman I.Y., Ewing T.J.A., Goldberg D.E., Kuntz I.D., Ellman J.A. Potent, low molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II. J Med Chem. 42:1999;1428-1440.
-
(1999)
J Med Chem
, vol.42
, pp. 1428-1440
-
-
Haque, T.S.1
Skillman, A.G.2
Lee, C.E.3
Habashita, H.4
Gluzman, I.Y.5
Ewing, T.J.A.6
Goldberg, D.E.7
Kuntz, I.D.8
Ellman, J.A.9
-
52
-
-
0031859262
-
Evolutionary combinatorial chemistry: Application of genetic algorithms
-
Weber L. Evolutionary combinatorial chemistry: application of genetic algorithms. Drug Discov Today. 3:1998;379-385.
-
(1998)
Drug Discov Today
, vol.3
, pp. 379-385
-
-
Weber, L.1
-
53
-
-
0005449318
-
Case histories of peptidomimetics: Progression from peptides to drugs
-
Adang A.A.P., Hermkens P.H.H., Linders J.T.M., Ottenheijm H.C.J., van Staveren C.J. Case histories of peptidomimetics: progression from peptides to drugs. Recl Trav Chim Pays-Bas. 113:1994;63-77.
-
(1994)
Recl Trav Chim Pays-Bas
, vol.113
, pp. 63-77
-
-
Adang, A.A.P.1
Hermkens, P.H.H.2
Linders, J.T.M.3
Ottenheijm, H.C.J.4
Van Staveren, C.J.5
-
55
-
-
0032476153
-
Intermediates for incorporation of tetrahydroxypipecolic acid analogues of α- And β-D-mannopyranose into combinatorial libraries: Unexpected nanomolar range hexoseaminidase inhibitors. Synthesis of α- And β-homomannojirimycin
-
Shilvock J.P., Nash R.J., Lloyd J.D., Winters A.L., Asano N., Fleet G.W.J. Intermediates for incorporation of tetrahydroxypipecolic acid analogues of α- and β-D-mannopyranose into combinatorial libraries: unexpected nanomolar range hexoseaminidase inhibitors. Synthesis of α- and β-homomannojirimycin. Tetrahedron: Asymmetry. 9:1998;3505-3516.
-
(1998)
Tetrahedron: Asymmetry
, vol.9
, pp. 3505-3516
-
-
Shilvock, J.P.1
Nash, R.J.2
Lloyd, J.D.3
Winters, A.L.4
Asano, N.5
Fleet, G.W.J.6
-
56
-
-
0032844077
-
Access to molecular diversity in glycosaminoglycans: Combinatorial synthesis of eight chondroitin sulfate disaccharides
-
Lubineau A., Bonnaffé D. Access to molecular diversity in glycosaminoglycans: combinatorial synthesis of eight chondroitin sulfate disaccharides. Eur J Org Chem. 1999;2523-2532.
-
(1999)
Eur J Org Chem
, pp. 2523-2532
-
-
Lubineau, A.1
Bonnaffé, D.2
-
57
-
-
0034599659
-
Glycopeptide and oligosaccharide libraries
-
Overview of sugar-based libraries
-
St Hilaire P.M., Meldal M. Glycopeptide and oligosaccharide libraries. Angew Chem Int Ed Engl. 39:2000;1162-1179. Overview of sugar-based libraries.
-
(2000)
Angew Chem Int Ed Engl
, vol.39
, pp. 1162-1179
-
-
St Hilaire, P.M.1
Meldal, M.2
-
58
-
-
0029905917
-
Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA rev responsive element
-
Park W.K.C., Auer M., Jaksche H., Wong C-H. Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: use of polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA rev responsive element. J Am Chem Soc. 118:1996;10150-10155.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 10150-10155
-
-
Park, W.K.C.1
Auer, M.2
Jaksche, H.3
Wong, C.-H.4
-
59
-
-
0032493325
-
The synthesis of symmetrical spermine conjugates using solid-phase chemistry
-
Page P., Burrage S., Baldock L., Bradley M. The synthesis of symmetrical spermine conjugates using solid-phase chemistry. Biochem Med Chem Lett. 8:1998;1751-1756.
-
(1998)
Biochem Med Chem Lett
, vol.8
, pp. 1751-1756
-
-
Page, P.1
Burrage, S.2
Baldock, L.3
Bradley, M.4
-
60
-
-
0033019939
-
Discovery of new multi component reactions with combinatorial methods
-
Discovery of new reactions for faster access to complicated structures is crucial for the advancement of natural-product-based libraries
-
Weber L., Illgen K., Almstetter M. Discovery of new multi component reactions with combinatorial methods. Synthesis. 1999;366-374. Discovery of new reactions for faster access to complicated structures is crucial for the advancement of natural-product-based libraries.
-
(1999)
Synthesis
, pp. 366-374
-
-
Weber, L.1
Illgen, K.2
Almstetter, M.3
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