Convergent diversity-oriented synthesis of small-molecule hybrids

Angewandte Chemie - International Edition

Volumn 44, Issue 15, 2005, Pages 2249-2252

  Chen, Chuo ^a   Li, Xiaodong ^a   Neumann, Christopher S ^a   Lo, Michael M C ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Convergent synthesis; Diversity oriented synthesis; Polycycles; Small molecule hybrids; Solid phase synthesis

Indexed keywords

MOLECULAR STRUCTURE; SYNTHESIS (CHEMICAL);

CHEMICAL EQUATIONS; COMPLEX SMALL-MOLECULE LIBRARIES; SMALL-MOLECULE HYBRIDS;

ORGANIC COMPOUNDS;

ANTINEOPLASTIC AGENT; CEPHALOSTATIN I; DRUG; PHENAZINE DERIVATIVE; SPIRO COMPOUND; STEROID; VINBLASTINE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHENAZINES; SPIRO COMPOUNDS; STEROIDS; VINBLASTINE;

EID: 17644400733     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200462798     Document Type: Article

References (27)

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23. 1H NMR analyses, performed on eight products of the esterification reaction, revealed that minor stereoisomers made up 15-25% of the product mixtures.
24. 1H NMR spectra (of the crude and purified material), see Supporting Information.
25. 1H NMR spectroscopy.
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