The impact of combinatorial chemistry on drug discovery

Current Opinion in Drug Discovery and Development

Volumn 6, Issue 4, 2003, Pages 494-508

  Lee, Alice ^a   Breitenbucher, J Guy ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Additivity; Combinatorial chemistry; Drug discovery; Dynamic combinatorial chemistry; Immobilized arrays; Library synthesis

Indexed keywords

11A7B7C7; 17 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITOR; A6B10C4; ACYLTRANSFERASE INHIBITOR; ANTICONVULSIVE AGENT; BLOCKING AGENT; CASPASE 3 INHIBITOR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DIHYDROORATE DEHYDROGENASE INHIBITOR; DOPAMINE RECEPTOR BLOCKING AGENT; ERYTHROPOIETIN RECEPTOR ANTAGONIST; GALNON; GONADORELIN ANTAGONIST; INDINAVIR; INDOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; L 161240; MELANOCORTIN 4 RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR ANTAGONIST; OXAZOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEINASE INHIBITOR; PYRROLE DERIVATIVE; RECEPTOR BLOCKING AGENT; RPR 200765 A; RPR 238677; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST; VITRONECTIN ANTAGONIST;

ANALYTIC METHOD; BINDING AFFINITY; CARBOHYDRATE ANALYSIS; CHEMICAL LABELING; CHEMICAL PROCEDURES; COMBINATORIAL CHEMISTRY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG INDUSTRY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EVALUATION; NONHUMAN; QUANTITATIVE ANALYSIS; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 0042029627     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

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