메뉴 건너뛰기




Volumn 9, Issue 3, 2005, Pages 259-265

Natural product-like libraries based on non-aromatic, polycyclic motifs

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO[3.2.1]OCTANE DERIVATIVE; BICYCLO[3.3.1]NONANE DERIVATIVE; CYCLOPENTENONE DERIVATIVE; CYTOCHALASIN A; CYTOCHALASIN B; CYTOCHALASIN DERIVATIVE; FURAN DERIVATIVE; GONIOLACTONE; GONIOTHALENOL; HELENAQUINONE; INDOLE DERIVATIVE; NATURAL PRODUCT; PIPERAZINE DERIVATIVE; POLYCYCLIC HYDROCARBON; QUINOLINE DERIVATIVE; QUINONE DERIVATIVE; SPARTEINE; SUGAR; SWAINSONINE; SWAINSONINE DERIVATIVE; TECOMINE; UNCLASSIFIED DRUG;

EID: 20444400874     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2005.04.002     Document Type: Review
Times cited : (32)

References (52)
  • 1
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • D.J. Newman, G.M. Cragg, and K.M. Snader The influence of natural products upon drug discovery Nat Prod Rep 17 2000 215 234
    • (2000) Nat Prod Rep , vol.17 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 2
    • 1442310071 scopus 로고    scopus 로고
    • Current developments in the discovery and design of new drug candidates from plant natural product leads
    • K.H. Lee Current developments in the discovery and design of new drug candidates from plant natural product leads J Nat Prod 67 2004 273 283
    • (2004) J Nat Prod , vol.67 , pp. 273-283
    • Lee, K.H.1
  • 3
    • 0034237675 scopus 로고    scopus 로고
    • Strategies for discovering drugs from previously unexplored natural products
    • A. Harvey Strategies for discovering drugs from previously unexplored natural products Drug Discov Today 5 2000 294 300
    • (2000) Drug Discov Today , vol.5 , pp. 294-300
    • Harvey, A.1
  • 4
    • 0036570328 scopus 로고    scopus 로고
    • Functional versus chemical diversity: Is biodiversity important for drug discovery?
    • M. Tulp, and L. Bohlin Functional versus chemical diversity: is biodiversity important for drug discovery? Trends Pharmacol Sci 23 2002 225 231
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 225-231
    • Tulp, M.1    Bohlin, L.2
  • 5
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period
    • D.J. Newman, G.M. Cragg, and K.M. Snader Natural products as sources of new drugs over the period J Nat Prod 66 2003 1022 1037 This account provides an excellent overview of the role of natural products on the development of new drugs during the past two decades.
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 7
    • 0035145264 scopus 로고    scopus 로고
    • High-throughput chemistry and structure-based design: Survival of the smartest
    • D. Bailey, and D. Brown High-throughput chemistry and structure-based design: survival of the smartest Drug Discov Today 6 2001 57 59
    • (2001) Drug Discov Today , vol.6 , pp. 57-59
    • Bailey, D.1    Brown, D.2
  • 8
    • 0142121432 scopus 로고    scopus 로고
    • Trends in development and approval times for new therapeutics in the United States
    • J.M. Reichert Trends in development and approval times for new therapeutics in the United States Nat Rev Drug Discov 2 2003 695 702
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 695-702
    • Reichert, J.M.1
  • 9
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates - Natural products as guiding principles in the design and synthesis of compound libraries
    • R. Breinbauer, I.R. Vetter, and H. Waldmann From protein domains to drug candidates - Natural products as guiding principles in the design and synthesis of compound libraries Angew Chem Int Ed Engl 41 2002 2879 2890 The importance of privileged structures and possible reasons for their emergence are discussed.
    • (2002) Angew Chem Int Ed Engl , vol.41 , pp. 2879-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 10
    • 2942565810 scopus 로고    scopus 로고
    • Natural products and combinatorial chemistry: Back to the future
    • J.Y. Ortholand, and A. Ganesan Natural products and combinatorial chemistry: back to the future Curr Opin Chem Biol 8 2004 271 280
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 271-280
    • Ortholand, J.Y.1    Ganesan, A.2
  • 11
    • 5644255983 scopus 로고    scopus 로고
    • Quality, not quantity: The role of natural products and chemical proteomics in modern drug discovery
    • A.M. Piggott, and P. Karuso Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery Comb Chem High Throughput Screen 7 2004 607 630
    • (2004) Comb Chem High Throughput Screen , vol.7 , pp. 607-630
    • Piggott, A.M.1    Karuso, P.2
  • 12
    • 3042799070 scopus 로고    scopus 로고
    • A planning strategy for diversity-oriented synthesis
    • M.D. Burke, and S.L. Schreiber A planning strategy for diversity-oriented synthesis Angew Chem Int Ed Engl 43 2004 46 58 The authors discuss and emphasize the relevance of diversity-oriented methods for generating libraries covering chemical space in an optimal way.
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 46-58
    • Burke, M.D.1    Schreiber, S.L.2
  • 13
    • 0344515366 scopus 로고    scopus 로고
    • Diversity-oriented synthesis; A challenge for synthetic chemists
    • D.R. Spring Diversity-oriented synthesis; a challenge for synthetic chemists Org Biomol Chem 1 2003 3867 3870
    • (2003) Org Biomol Chem , vol.1 , pp. 3867-3870
    • Spring, D.R.1
  • 14
    • 0032569205 scopus 로고    scopus 로고
    • Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
    • D.S. Tan, M.A. Foley, M.D. Shair, and S.L. Schreiber Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays J Am Chem Soc 120 1998 8565 8566
    • (1998) J Am Chem Soc , vol.120 , pp. 8565-8566
    • Tan, D.S.1    Foley, M.A.2    Shair, M.D.3    Schreiber, S.L.4
  • 15
    • 0034684250 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
    • K.C. Nicolaou, J.A. Pfefferkorn, A.J. Roecker, G.Q. Cao, S. Barluenga, and H.J. Mitchell Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans J Am Chem Soc 122 2000 9939 9953
    • (2000) J Am Chem Soc , vol.122 , pp. 9939-9953
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Roecker, A.J.3    Cao, G.Q.4    Barluenga, S.5    Mitchell, H.J.6
  • 17
    • 0042121318 scopus 로고    scopus 로고
    • Medicinal chemistry of target family-directed masterkeys
    • G. Muller Medicinal chemistry of target family-directed masterkeys Drug Discov Today 8 2003 681 691
    • (2003) Drug Discov Today , vol.8 , pp. 681-691
    • Muller, G.1
  • 18
    • 0036430152 scopus 로고    scopus 로고
    • Hybrid systems through natural product leads: An approach towards new molecular entities
    • G. Mehta, and V. Singh Hybrid systems through natural product leads: an approach towards new molecular entities Chem Soc Rev 31 2002 324 334
    • (2002) Chem Soc Rev , vol.31 , pp. 324-334
    • Mehta, G.1    Singh, V.2
  • 19
    • 0141427680 scopus 로고    scopus 로고
    • Natural product hybrids as new leads for drug discovery
    • L.F. Tietze, H.P. Bell, and S. Chandrasekhar Natural product hybrids as new leads for drug discovery Angew Chem Int Ed Engl 42 2003 3996 4028 The authors review the structural and functional diversity generated through combinations of different natural product moieties.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 3996-4028
    • Tietze, L.F.1    Bell, H.P.2    Chandrasekhar, S.3
  • 20
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • A.M. Boldi Libraries from natural product-like scaffolds Curr Opin Chem Biol 8 2004 281 286 An excellent review covering recent advances in the synthesis of natural product-like libraries.
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 281-286
    • Boldi, A.M.1
  • 21
    • 0036603591 scopus 로고    scopus 로고
    • Combinatorial synthesis of natural products
    • J. Nielsen Combinatorial synthesis of natural products Curr Opin Chem Biol 6 2002 297 305
    • (2002) Curr Opin Chem Biol , vol.6 , pp. 297-305
    • Nielsen, J.1
  • 22
    • 0141988625 scopus 로고    scopus 로고
    • Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds
    • Y. Liao, Y.H. Hu, H. Wu, Q. Zhu, M. Donovan, R. Fathi, and Z. Yang Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds Curr Med Chem 10 2003 2285 2316
    • (2003) Curr Med Chem , vol.10 , pp. 2285-2316
    • Liao, Y.1    Hu, Y.H.2    Wu, H.3    Zhu, Q.4    Donovan, M.5    Fathi, R.6    Yang, Z.7
  • 23
    • 0242690225 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries
    • P.M. Abreu, and P.S. Branco Natural product-like combinatorial libraries J Brazilian Chem Soc 14 2003 675 712
    • (2003) J Brazilian Chem Soc , vol.14 , pp. 675-712
    • Abreu, P.M.1    Branco, P.S.2
  • 24
    • 0035688790 scopus 로고    scopus 로고
    • Solid phase synthesis of complex natural products and libraries thereof
    • K.C. Nicolaou, and J.A. Pfefferkorn Solid phase synthesis of complex natural products and libraries thereof Biopolymers 60 2001 171 193
    • (2001) Biopolymers , vol.60 , pp. 171-193
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2
  • 25
    • 0346251241 scopus 로고    scopus 로고
    • Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era
    • K. Knepper, C. Gil, and S. Brase Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era Comb Chem High Throughput Screen 6 2003 673 691
    • (2003) Comb Chem High Throughput Screen , vol.6 , pp. 673-691
    • Knepper, K.1    Gil, C.2    Brase, S.3
  • 26
    • 5644294669 scopus 로고    scopus 로고
    • Current progress in natural product-like libraries for discovery screening
    • D.S. Tan Current progress in natural product-like libraries for discovery screening Comb Chem High Throughput Screen 7 2004 631 643
    • (2004) Comb Chem High Throughput Screen , vol.7 , pp. 631-643
    • Tan, D.S.1
  • 28
    • 1842611075 scopus 로고    scopus 로고
    • The Diels-Alder reaction between deactivated dienes and electron-deficient dienophiles on solid support: Stereoselective synthesis of hexahydro-1,3-dioxoisoindoles
    • A. Kiriazis, T. Leikoski, I. Mutikainen, and J. Yli-Kauhaluoma The Diels-Alder reaction between deactivated dienes and electron-deficient dienophiles on solid support: stereoselective synthesis of hexahydro-1,3- dioxoisoindoles J Comb Chem 6 2004 283 285
    • (2004) J Comb Chem , vol.6 , pp. 283-285
    • Kiriazis, A.1    Leikoski, T.2    Mutikainen, I.3    Yli-Kauhaluoma, J.4
  • 29
    • 0024095187 scopus 로고
    • Actions of cytochalasins on the organization of actin-filaments and microtubules in a neuronal growth cone
    • P. Forscher, and S.J. Smith Actions of cytochalasins on the organization of actin-filaments and microtubules in a neuronal growth cone J Cell Biol 107 1988 1505 1516
    • (1988) J Cell Biol , vol.107 , pp. 1505-1516
    • Forscher, P.1    Smith, S.J.2
  • 30
    • 7744242263 scopus 로고    scopus 로고
    • Quinoline, quinazoline and acridone alkaloids
    • J.P. Michael Quinoline, quinazoline and acridone alkaloids Nat Prod Rep 21 2004 650 668
    • (2004) Nat Prod Rep , vol.21 , pp. 650-668
    • Michael, J.P.1
  • 31
    • 0037529208 scopus 로고    scopus 로고
    • Dihydropyridine-based multicomponent reactions. Efficient entry into new tetrahydroquinoline systems through Lewis acid-catalyzed formal [4 + 2] cycloadditions
    • R. Lavilla, M.C. Bernabeu, I. Carranco, and J.L. Diaz Dihydropyridine-based multicomponent reactions. Efficient entry into new tetrahydroquinoline systems through Lewis acid-catalyzed formal [4 + 2] cycloadditions Org Lett 5 2003 717 720
    • (2003) Org Lett , vol.5 , pp. 717-720
    • Lavilla, R.1    Bernabeu, M.C.2    Carranco, I.3    Diaz, J.L.4
  • 32
    • 13544253604 scopus 로고    scopus 로고
    • Multicomponent reactions with dihydroazines: Efficient synthesis of a diverse set of pyrido-fused tetrahydroquinolines
    • I. Carranco, J.L. Diaz, O. Jimenez, M. Vendrell, F. Albericio, M. Royo, and R. Lavilla Multicomponent reactions with dihydroazines: efficient synthesis of a diverse set of pyrido-fused tetrahydroquinolines J Comb Chem 7 2005 33 41
    • (2005) J Comb Chem , vol.7 , pp. 33-41
    • Carranco, I.1    Diaz, J.L.2    Jimenez, O.3    Vendrell, M.4    Albericio, F.5    Royo, M.6    Lavilla, R.7
  • 33
    • 4944223351 scopus 로고    scopus 로고
    • Solution- and solid-phase synthesis of natural product-like tetrahydroquinoline-based polycyclics having a medium size ring
    • P. Arya, S. Couve-Bonnaire, P. Durieux, D. Laforce, R. Kumar, and D.M. Leek Solution- and solid-phase synthesis of natural product-like tetrahydroquinoline-based polycyclics having a medium size ring J Comb Chem 6 2004 735 745
    • (2004) J Comb Chem , vol.6 , pp. 735-745
    • Arya, P.1    Couve-Bonnaire, S.2    Durieux, P.3    Laforce, D.4    Kumar, R.5    Leek, D.M.6
  • 35
    • 0036300524 scopus 로고    scopus 로고
    • Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis
    • S. Wang, Y.J. Zhang, R.Y. Chen, and D.Q. Yu Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis J Nat Prod 65 2002 835 841
    • (2002) J Nat Prod , vol.65 , pp. 835-841
    • Wang, S.1    Zhang, Y.J.2    Chen, R.Y.3    Yu, D.Q.4
  • 36
    • 0037188449 scopus 로고    scopus 로고
    • Altholactone, a novel styryl-lactone induces apoptosis via oxidative stress in human HL-60 leukemia cells
    • S.H. Inayat-Hussain, A. Bin Osman, L. Bin Din, and N. Taniguchi Altholactone, a novel styryl-lactone induces apoptosis via oxidative stress in human HL-60 leukemia cells Toxicol Lett 131 2002 153 159
    • (2002) Toxicol Lett , vol.131 , pp. 153-159
    • Inayat-Hussain, S.H.1    Bin Osman, A.2    Bin Din, L.3    Taniguchi, N.4
  • 37
    • 1642282627 scopus 로고    scopus 로고
    • Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via stereoselective Mannich reaction
    • T. Fujita, H. Nagasawa, Y. Uto, T. Hashimoto, Y. Asakawa, and H. Hori Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via stereoselective Mannich reaction Org Lett 6 2004 827 830
    • (2004) Org Lett , vol.6 , pp. 827-830
    • Fujita, T.1    Nagasawa, H.2    Uto, Y.3    Hashimoto, T.4    Asakawa, Y.5    Hori, H.6
  • 39
    • 0028830908 scopus 로고
    • Bioactive cyclic dipeptides
    • C. Prasad Bioactive cyclic dipeptides Peptides 16 1995 151 164
    • (1995) Peptides , vol.16 , pp. 151-164
    • Prasad, C.1
  • 41
    • 8644255065 scopus 로고    scopus 로고
    • Synthesis of a new class of furan-fused tetracyclic compounds using o-quinodimethane chemistry and investigation of their antiviral activity
    • Y. Matsuya, K. Sasaki, M. Nagaoka, H. Kakuda, N. Toyooka, N. Imanishi, H. Ochiai, and H. Nemoto Synthesis of a new class of furan-fused tetracyclic compounds using o-quinodimethane chemistry and investigation of their antiviral activity J Org Chem 69 2004 7989 7993
    • (2004) J Org Chem , vol.69 , pp. 7989-7993
    • Matsuya, Y.1    Sasaki, K.2    Nagaoka, M.3    Kakuda, H.4    Toyooka, N.5    Imanishi, N.6    Ochiai, H.7    Nemoto, H.8
  • 42
    • 0035830639 scopus 로고    scopus 로고
    • Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
    • H. Fujiwara, K. Matsunaga, M. Saito, S. Hagiya, K.I. Furukawa, H. Nakamura, and Y. Ohizumi Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells Eur J Pharmacol 413 2001 37 45
    • (2001) Eur J Pharmacol , vol.413 , pp. 37-45
    • Fujiwara, H.1    Matsunaga, K.2    Saito, M.3    Hagiya, S.4    Furukawa, K.I.5    Nakamura, H.6    Ohizumi, Y.7
  • 43
    • 0345871008 scopus 로고    scopus 로고
    • A solid-phase approach towards the development of 3-aza-6,8- dioxabicyclo[3. 2. 1]octane scaffolds
    • A. Trabocchi, F. Mancini, G. Menchi, and A. Guarna A solid-phase approach towards the development of 3-aza-6,8-dioxabicyclo[3. 2. 1]octane scaffolds Mol Divers 6 2003 245 250
    • (2003) Mol Divers , vol.6 , pp. 245-250
    • Trabocchi, A.1    Mancini, F.2    Menchi, G.3    Guarna, A.4
  • 44
    • 9344228493 scopus 로고    scopus 로고
    • Elaboration of D-(-)-ribose into a tricyclic, natural product-like scaffold
    • R. Messer, A. Schmitz, L. Moesch, and R. Häner Elaboration of D-(-)-ribose into a tricyclic, natural product-like scaffold J Org Chem 69 2004 8558 8560
    • (2004) J Org Chem , vol.69 , pp. 8558-8560
    • Messer, R.1    Schmitz, A.2    Moesch, L.3    Häner, R.4
  • 45
    • 0027262957 scopus 로고
    • Cytotoxicity of ent-udoteatrial diacetate and its analogs 4
    • Y. Ge, K. Nakatani, and S. Isoe Cytotoxicity of ent-udoteatrial diacetate and its analogs 4 Bioorg Med Chem Lett 3 1993 1085 1088
    • (1993) Bioorg Med Chem Lett , vol.3 , pp. 1085-1088
    • Ge, Y.1    Nakatani, K.2    Isoe, S.3
  • 46
    • 0030006861 scopus 로고    scopus 로고
    • Hydrolytic breakdown of the euplotins, highly strained, adaptive, hemiacetal esters of the marine ciliate Euplotes crassus: A mimic of degradative pathways in nature and a trick for the assignment of the absolute configuration
    • G. Guella, F. Dini, and F. Pietra Hydrolytic breakdown of the euplotins, highly strained, adaptive, hemiacetal esters of the marine ciliate Euplotes crassus: a mimic of degradative pathways in nature and a trick for the assignment of the absolute configuration Helv Chim Acta 79 1996 710 717
    • (1996) Helv Chim Acta , vol.79 , pp. 710-717
    • Guella, G.1    Dini, F.2    Pietra, F.3
  • 48
    • 0017720843 scopus 로고
    • Analogs of sparteine. 5. Antiarrhythmic activity of selected N,N'-disubstituted bispidines
    • P.C. Ruenitz, and C.M. Mokler Analogs of sparteine. 5. Antiarrhythmic activity of selected N,N'-disubstituted bispidines J Med Chem 20 1977 1668 1671
    • (1977) J Med Chem , vol.20 , pp. 1668-1671
    • Ruenitz, P.C.1    Mokler, C.M.2
  • 49
    • 13544273419 scopus 로고    scopus 로고
    • Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyed [2+2+1] cycloaddition of alkynyl allenes
    • S. Manku, and D.P. Curran Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyed [2+2+1] cycloaddition of alkynyl allenes J Comb Chem 7 2005 63 68 The authors describe a very elegant method of generating diversity oriented, natural product-like libraries via a mixed-synthesis strategy.
    • (2005) J Comb Chem , vol.7 , pp. 63-68
    • Manku, S.1    Curran, D.P.2
  • 50
    • 11144311139 scopus 로고    scopus 로고
    • Lessons from natural molecules
    • J. Clardy, and C. Walsh Lessons from natural molecules Nature 432 2004 829 837 The impact of functional group diversity and architectural platforms of natural products on medicinal chemistry is outlined in an expert way.
    • (2004) Nature , vol.432 , pp. 829-837
    • Clardy, J.1    Walsh, C.2
  • 51
    • 11144320699 scopus 로고    scopus 로고
    • Navigating chemical space for biology and medicine
    • C. Lipinski, and A. Hopkins Navigating chemical space for biology and medicine Nature 432 2004 855 861 The authors give their opinion on how to identify the right chemical entity for addressing a given biological question.
    • (2004) Nature , vol.432 , pp. 855-861
    • Lipinski, C.1    Hopkins, A.2
  • 52
    • 11144341956 scopus 로고    scopus 로고
    • Chemical space and biology
    • C.M. Dobson Chemical space and biology Nature 432 2004 824 828
    • (2004) Nature , vol.432 , pp. 824-828
    • Dobson, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.