A synthesis strategy yielding skeletally diverse small molecules combinatorially

Journal of the American Chemical Society

Volumn 126, Issue 43, 2004, Pages 14095-14104

  Burke, Martin D ^a   Berger, Eric M ^a   Schreiber, Stuart L ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MOLECULAR STRUCTURE; POLYPEPTIDES; PROTEINS; SYNTHESIS (CHEMICAL);

DIVERSITY-ORIENTED SYNTHESIS (DOS); REACTION CONDITIONS; SYNTHESIS STRATEGY;

STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; PROTEIN FOLDING; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

CHEMISTRY, ORGANIC; COMBINATORIAL CHEMISTRY TECHNIQUES; FURANS;

EID: 7444242717     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0457415     Document Type: Article

References (58)

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56. Jennifer Raggio, Leticia Castro, and John Tallarico are gratefully acknowledged for providing encoding reagents, and for cleaving and analyzing chemical tags.
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58. Throughout the course of the synthesis, the total mass of macrobeads increased somewhat, reflecting the added mass of the attached compounds. There was also some loss of intact macrobeads throughout the split-pool synthesis due to bead-breakage.