Natural products are biologically validated starting points in structural space for compound library development: Solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

Angewandte Chemie - International Edition

Volumn 41, Issue 2, 2002, Pages 307-311

  Brohm, Dirk ^a,b   Metzger, Susanne ^c   Bhargava, Ajay ^d   Müller, Oliver ^a   Lieb, Folker ^c   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c BAYER AG   (Germany)

^d BAYER CORPORATION   (United States)

Author keywords

Combinatorial chemistry; Natural products; Proteins; Solid phase synthesis; Total synthesis

Indexed keywords

NATURAL PRODUCTS;

BIOASSAY; BIOSYNTHESIS; CELLS; PROTEINS; TUMORS;

ENZYMES;

6 EPIDYSIDIOLIDE; BIOLOGICAL PRODUCT; DRUG DERIVATIVE; DYSIDIOLIDE; ENZYME INHIBITOR; GAMMA BUTYROLACTONE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE CDC25C; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMICAL REACTION; CHEMISTRY; COMBINATORIAL CHEMISTRY; CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYMOLOGY; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; SOLID STATE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VALIDATION PROCESS; DRUG ANTAGONISM;

4-BUTYROLACTONE; BIOLOGICAL PRODUCTS; CDC25 PHOSPHATASE; CELL SURVIVAL; ENZYME INHIBITORS; OXIDATION-REDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0037126836     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20020118)41:2<307::AID-ANIE307>3.0.CO;2-1     Document Type: Article

References (22)