Medicinals for the millennia: The historical record

Annals of the New York Academy of Sciences

Volumn 953, Issue , 2001, Pages 3-25

  Cragg, Gordon M ^a   Newman, David J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anticancer agents; Biodiversity; Combinatorial biosynthesis chemistry; Drug discovery; Herbal drugs; Natural products; Synthesis; Traditional medicine

Indexed keywords

ANALGESIC AGENT; ANTIMALARIAL AGENT; ARTEMISININ; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRENORPHINE; CAMPTOTHECIN; CATHARANTHUS ROSEUS EXTRACT; CHLOROQUINE; CINCHONA EXTRACT; CURARE DERIVATIVE; DIGITALIS PURPUREA EXTRACT; DIGOXIN; DOCETAXEL; EPHEDRA EXTRACT; EPIPODOPHYLLOTOXIN; HERBACEOUS AGENT; IRINOTECAN; MEFLOQUINE; MORPHINE; OPIATE; PACLITAXEL; PODOPHYLLOTOXIN; RAUWOLFIA EXTRACT; SALBUTAMOL; SALMETEROL; TAXUS BREVIFOLIA EXTRACT; TOPOTECAN; TUBOCURARINE CHLORIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BACTERIUM CULTURE; BIOSYNTHESIS; BIOTECHNOLOGY; CANCER; CLINICAL TRIAL; CONFERENCE PAPER; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOPHYTE; ENVIRONMENTAL FACTOR; HISTORY OF MEDICINE; HUMAN; MALARIA; MARINE ENVIRONMENT; NEUROLOGIC DISEASE; RESPIRATORY TRACT DISEASE; SAMPLING; TRADITIONAL MEDICINE;

BACTERIA (MICROORGANISMS); CATHARANTHUS ROSEUS; CINCHONA; DIGITALIS; DIGITALIS PURPUREA; EPHEDRA; RAUVOLFIA; TAXUS; TAXUS BREVIFOLIA;

EID: 0035695659     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb11356.x     Document Type: Conference Paper

References (90)

1. A pictorial history of herbs in medicine and pharmacy
2. Medicinal plants in therapy
3. Natural products as leads for new pharmaceuticals
4. Carbohydrate-based therapeutics
5. Ethnobotany and the search for new drugs
6. The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents
7. Docetaxel
8. Discovery and development of major drugs currently in use
9. The role of plant-derived drugs and herbal medicine in healthcare
10. Medicinal herbs in the United States
11. Discovery of a small molecule insulin mimetic with anti-diabetic activity in mice
12. The discovery of marine natural products with therapeutic potential
13. Marine natural products
14. Biomedical potential of marine natural products
15. Bryostatin - From bryozoan to cancer drug
16. Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo
17. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1
18. The discovery and development of marine compounds with pharmaceutical potential
19. Synthetic macrocyclic ketone analogs of halichondrin B: Structure-activity relationships
20. Highly potent in vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogs of halichondrin B
21. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
22. Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitxel
23. Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns
24. Thirty years of discovering arthropod alkaloids in amphibian skin
25. The influence of natural products on drug discovery
26. Natural products in drug discovery and development
27. Ecology of deep-sea hydrothermal vent communities: A review
28. Rapid growth at deep sea vents
29. Plant-derived natural products in drug discovery and development: An overview
30. Major microbial diversity initiative recommended
31. Molecular biological access to the chemistry of unknown soil microbes: A new frontier for natural products
32. Extremophiles
33. Life at the freezing point
34. Finding and using hyperthermophilic enzymes
35. Microbial diversity: The importance of exploration and conservation
36. Microbial polyketide synthases: More and more prolific
37. Natural product biosynthesis: A new interface between enzymology and medicine
38. Polyketide biosynthesis: A millenium review
39. Dissecting and exploiting intermodular communication in polyketide synthases
40. The biosynthetic gene cluster for the microtubule-stabilizing agents spothilones A and B from Sorangium cellulosum So ce90
41. Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
42. The genetic manipulation of polyketide gene clusters as an approach to drug discovery
43. Development of a scalable epothilone D fermentation process using a heterologous host
44. Drug industry looks to the lab instead of rainforest and reef
45. The design, computer modeling solution structure, and biological evaluation of synthetic analogs of bryostatin 1
46. Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743
47. Chemical biology of the epothilones
48. A novel application of a Pd(0)-catalyzed nucelophilic substitution reaction to the regio- and stereoselective synthesis of lactam analogues of the epithilone natural products
49. On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: Total synthesis and comparative in vivo evaluations of the 15-aza_epothilones
50. A common pharmacophore for cytotoxic natural products that stabilize microtubules
51. A common pharmacophore for epithilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
52. Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13 cyclobutyl epothilones
53. Synthesis and biological activity of sarcodictyins
54. Natural product-like combinatorial libraries based on privileged structures. 3. The "libaries from libraries" principle for diversity enhancement of benzopyran libraries
55. Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using Nano-Kans and optical encoding
56. Natural product-like combinatorial libraries based on privileged structures. 1. General prinicples and solid-phase synthesis of benzopyrans
57. Polymer-supported selenium reagents for organic synthesis
58. Solid and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
59. Chemical genetics resulting from a passion for synthetic organic chemistry
60. Stereoselective synthesis of over two million compounds having structural features both eminiscent of natural products and compatible with miniaturized cell-based assays
61. Use of biomimetic-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product
62. Targeted toxins
63. Enediyne research continues apace
64. Eradication of large colon tumor xenografts by targeted delivery of maytansanoids
65. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents - Drug-polymer conjugates
66. Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine
67. Antibody-enzyme conjugates for cancer therapy
68. Actinomycetes