Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age

Chemistry and Biology

Volumn 9, Issue 2, 2002, Pages 145-156

  Arya, Prabhat ^a   Joseph, Reni ^a   Chou, Doug T H ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; PEPTIDE LIBRARY; POLYCYCLIC HYDROCARBON; PROTEOME;

CHEMISTRY; COMBINATORIAL CHEMISTRY; GENOMICS; MOLECULAR MIMICRY; PROTEIN BINDING; REVIEW; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BIOLOGICAL FACTORS; COMBINATORIAL CHEMISTRY TECHNIQUES; GENOMICS; MOLECULAR MIMICRY; PEPTIDE LIBRARY; POLYCYCLIC COMPOUNDS; PROTEIN BINDING; PROTEOME; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036008841     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(02)00105-9     Document Type: Review

References (63)

1. Statistical investigation into the structural complementarity of natural products and synthetic compounds
2. The influence of natural of products upon drug discovery
3. Natural product as immunosuppressive agents
4. Small molecule inhibitors of the cell cycle
5. Organic synthesis and biological signal transduction
6. The art and science of total synthesis at the dawn of the twenty-first century
7. Recent advances in the preparation of heterocycles on solid support: A review of the literature
8. Carbon-carbon bond forming solid-phase reactions
9. Carbon-carbon bond forming solid-phase reactions. Part II
10. Polymer-supported synthesis of non-oligomeric natural products
11. Comprehensive survey of combinatorial library synthesis
12. Functionalized polymers - Emerging versatile tools for solution-phase chemistry and automated parallel synthesis
13. Natural product-like chiral derivatives by solid phase synthesis
14. Diversity-based organic synthesis in the era of genomics and proteomics, Angew
15. Solution- and solid phase strategies for the design and screening of libraries based on natural product templates
16. Synthesis of diverse and complex molecules on the solid phase
17. Synthesis of natural-product-based compound libraries
18. Recent advances in solid-phase synthesis of natural products
19. High-diversity combinatorial libraries
20. Designing chiral libraries for drug discovery
21. Chemical ligands, genomics and drug discovery
22. Deciphering isozyme function: Exploring cell biology with chemistry in the post-genomic era
23. Chemical genetics resulting from a passion for synthetic organic chemistry
24. Target-oriented and diversity-oriented organic synthesis in drug discovery
25. Chemical genetics: Exploring and controlling cellular processes with chemical probes
26. Frontiers in chemical genetics
27. Chemical genetics: Ligand-based discovery of gene function
28. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
29. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays
30. Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis
31. From isocyanides via four-component condensation to antibiotic syntheses
32. Split-pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotype and protein-binding assays
33. A synthetic library of cell-permeable molecules
34. The total synthesis of carpanone
35. Solid-phase biomimetic synthesis of carpanone-like molecules
36. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of natural products
37. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine
38. Towards diversity-oriented, stereoselective syntheses of biaryl- or bis(aryl)metal-containing medium rings
39. Synthesis of medium-sized rings by ring-closing metathesis reaction
40. A strategy for macrocyclic ring closure and functionalization aimed toward split-pool syntheses
41. Cell cycle control of DNA replication
42. From bench top to bedside
43. Chemical inhibitors of cell cycle
44. Structure-based design of a new class of protein kinase C modulators
45. Studies and perspectives of protein kinase C
46. Natural product synthesis on polymeric supports - Synthesis and biological evaluation of an indolactam library
47. An oxidation-labile traceless linker for solid-phase synthesis
48. Solid-phase synthesis and biological evaluation of teleocidin library - Discovery of a selective PKC δ down regulator
49. Selenium-based solid-phase synthesis of benzopyrans I: Applications to combinatorial synthesis of natural products
50. Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules
51. Solution and solid phase synthesis of functionalized 3-arylbenzofurans by a novel cyclofragmentation-release pathway
52. Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
53. Natural product-like combinatorial libraries based on privileged structures. 2. Construction of 10 000-membered benzopyran library by direct split-and-pool chemistry using nanokans and optical sorting
54. Natural product-like combinatorial libraries based on privileged structures. 3. The "libraries from libraries" principle for diversity enhancement of benzopyran libraries
55. Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase
56. A novel strategy for the solid-phase synthesis of substituted indolines
57. Novel solution- and solid-phase chemistry of α-sulfonated ketones applicable to combinatorial chemistry
58. A structural-based library approach to kinase inhibitors
59. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
60. Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library