Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?

Progress in Neurobiology

Volumn 112, Issue , 2014, Pages 50-69

  Caldeira, Margarida V ^a,b   Salazar, Ivan L ^a,c   Curcio, Michele ^a,d   Canzoniero, Lorella M T ^d   Duarte, Carlos B ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF SANNIO   (Italy)

Author keywords

Brain ischemia; Excitotoxicity; Proteasome inhibitors; Ubiquitin proteasome system

Indexed keywords

CALCIUM; DEUBIQUITINASE; GLUTAMIC ACID; PROTEASOME; UBIQUITIN;

AUTOPHAGY; BRAIN FUNCTION; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; ENDOPLASMIC RETICULUM STRESS; EXCITOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR BIOLOGY; NERVOUS SYSTEM; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; UBIQUITINATION;

15-DEOXY-Δ(12,14)-PROSTAGLANDIN J2; 15D-PHJ(2); 3-MA; 3-METHYLADENINE; ACTIVATING TRANSCRIPTION FACTOR 4; AMPA; AMPA RECEPTORS; AMPAR; ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; APC/C; APV; ATAXIC MOUSE; ATF(4); AX(J); BBB; BCO; BILATERAL CAROTID OCCLUSION; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; C/EBP HOMOLOGUES PROTEIN; CATALYTIC PARTICLE; CDK5; CHOP; CP; CYCLIN-DEPENDENT KINASE-5; D-AMINOPHOSPHONOVALERATE; DEUBIQUITINATING ENZYMES; DUB; E6-AP CARBOXYL TERMINUS; EIF2Α; ENDOPLASMIC RETICULUM; ENDOTHELIAL NOS; ENOS; ER; ER-ASSOCIATED DEGRADATION; ERAD; EUKARYOTIC INITIATION FACTOR 2Α; EXCITOTOXICITY; GKAP; GLUCOSE-REGULATED PROTEIN 78; GRP78; GUANYLATE KINASE-ASSOCIATED PROTEIN; HECT; HERP; HOMOCYSTEINE-INDUCIBLE, ER-STRESS INDUCIBLE PROTEIN; INTRACELLULAR CA(2+) CONCENTRATION; KA; KAINATE; MARKS; MCAO; MDM2; MESPC; MIB2; MIDDLE CEREBRAL ARTERY OCCLUSION; MIND BOMB-2; MINI EXCITATORY POST-SYNAPTIC CURRENT; MURINE-DOUBLE MINUTE 2; MYRISTOYLATED, ALANINE-RICH C-KINASE SUBSTRATE; N-METHYL-D-ASPARTATE; NCX3; NEDD4; NEURONAL-PRECURSOR CELL-EXPRESSED DEVELOPMENTALLY DOWNREGULATED GENE 4; NITRIC OXIDE SYNTHASE; NMDA; NMDA RECEPTORS; NMDAR; NOS; OGD; OXYGEN AND GLUCOSE DEPRIVATION; PDI; PERK; PHOSPHOINOSITIDE 3-KINASE; PI3 K; PKR-LIKE ER KINASE; PLECKSTRIN-LIKE RECEPTOR FOR UBIQUITIN; POST-SYNAPTIC DENSITY; POST-SYNAPTIC DENSITY ASSOCIATED PROTEIN 95; PROTEASOME INHIBITORS; PROTEIN DISULPHIDE ISOMERASE; PRU; PSD; PSD-95; REALLY INTERESTING NEW GENE; REGULATORY PARTICLE; RING; RP; SODIUM-CALCIUM EXCHANGER TYPE-3; TISSUE PLASMINOGEN ACTIVATOR; TPA; TRANSIENT RECEPTOR POTENTIAL MELASTATIN; TRPM; UBA; UBIQUITIN ASSOCIATED DOMAIN; UBIQUITIN C-TERMINAL HYDROLASES; UBIQUITIN SPECIFIC PROTEASE; UBIQUITIN-INTERACTING MOTIF; UBIQUITIN-LIKE DOMAIN; UBIQUITIN-PROTEASOME SYSTEM; UBL; UCH; UIM; UNFOLDED PROTEIN RESPONSE; UPR; UPS; USP; VESICULAR GLUTAMATE TRANSPORTERS; VGLUT; X-BOX BINDING PROTEIN 1; XBP1; [CA(2+)](I); Α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPRIONIC ACID;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; HUMANS; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINATED PROTEINS; UBIQUITINATION;

EID: 84890805926     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.10.003     Document Type: Review

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