Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 47, 2012, Pages 19426-19431

  Lussier, Marc P ^a   Herring, Bruce E ^b   Nasu Nishimura, Yukiko ^a   Neutzner, Albert ^a,c   Karbowski, Mariusz ^a,d   Youle, Richard J ^a   Nicoll, Roger A ^b   Roche, Katherine W ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY EYE CLINIC   (Switzerland)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

GluA2; Glutamate receptor; Hippocampus

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR 2; MEMBRANE PROTEIN; RING FINGER PROTEIN; SHORT HAIRPIN RNA; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE RNF167; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; LYSOSOME; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; RING FINGER MOTIF; SYNAPTIC TRANSMISSION; UBIQUITINATION;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HIPPOCAMPUS; HUMANS; LYSOSOMES; NEURONS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RNA, MESSENGER; SYNAPTIC TRANSMISSION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84869816037     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217477109     Document Type: Article

References (33)

1. Lu W, et al. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron 62(2):254-268.
2. Wenthold RJ, Petralia RS, Blahos J II, Niedzielski AS (1996) Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons. J Neurosci 16(6):1982-1989.
3. Ciechanover A, Heller H, Elias S, Haas AL, Hershko A (1980) ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci USA 77(3):1365-1368.
4. Deshaies RJ, Joazeiro CA (2009) RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399-434.
5. Arancibia-Cárcamo IL, et al. (2009) Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proc Natl Acad Sci USA 106(41):17552-17557.
6. Ciechanover A, Iwai K (2004) The ubiquitin system: From basic mechanisms to the patient bed. IUBMB Life 56(4):193-201.
7. Ehlers MD (2000) Reinsertion or degradation of AMPA receptors determined by activity- dependent endocytic sorting. Neuron 28(2):511-525.
8. Pryor PR, Luzio JP (2009) Delivery of endocytosed membrane proteins to the lysosome. Biochim Biophys Acta 1793(4):615-624.
9. 2+ channels with dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibition. J Biol Chem 284(47):32544-32550.
10. Saliba RS, Michels G, Jacob TC, Pangalos MN, Moss SJ (2007) Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites. J Neurosci 27(48):13341-13351.
11. Schwarz LA, Hall BJ, Patrick GN (2010) Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. J Neurosci 30 (49):16718-16729.
12. Lin A, et al. (2011) Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J Neurochem 119(1):27-39.
13. Lussier MP, Nasu-Nishimura Y, Roche KW (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. J Neurosci 31(8):3077-3081.
14. Neutzner A, et al. (2011) A systematic search for endoplasmic reticulum (ER) membrane- associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem 286(10):8633-8643.
15. Hanley JG (2010) Endosomal sorting of AMPA receptors in hippocampal neurons. Biochem Soc Trans 38(2):460-465.
16. Hirling H (2009) Endosomal trafficking of AMPA-type glutamate receptors. Neuroscience 158(1):36-44.
17. Bottomley MJ, et al. (2005) NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasisectodermal dystrophy (APECED) disease. J Biol Chem 280(12):11505-11512.
18. Karbowski M, Neutzner A, Youle RJ (2007) The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol 178(1):71-84.
19. Pfeffer SR, Dirac-Svejstrup AB, Soldati T (1995) Rab GDP dissociation inhibitor: Putting rab GTPases in the right place. J Biol Chem 270(29):17057-17059.
20. DiAntonio A, Hicke L (2004) Ubiquitin-dependent regulation of the synapse. Annu Rev Neurosci 27:223-246.
21. Ehlers MD (2003) Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nat Neurosci 6(3):231-242.
22. Mabb AM, Ehlers MD (2010) Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol 26:179-210.
23. Hicke L, Dunn R (2003) Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol 19:141-172.
24. Katzmann DJ, Odorizzi G, Emr SD (2002) Receptor downregulation and multivesicular- body sorting. Nat Rev Mol Cell Biol 3(12):893-905.
25. Urbanowski JL, Piper RC (2001) Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole. Traffic 2(9):622-630.
26. Dreier L, Burbea M, Kaplan JM (2005) LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron 46(1):51-64.
27. Greer PL, et al. (2010) The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell 140(5):704-716.
28. Juo P, Kaplan JM (2004) The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol 14(22): 2057-2062.
29. Schaefer H, Rongo C (2006) KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover. Mol Biol Cell 17(3): 1250-1260.
30. Ardley HC, Robinson PA (2005) E3 ubiquitin ligases. Essays Biochem 41:15-30.
31. Yamada HY, Gorbsky GJ (2006) Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Oncogene 25(9):1330-1339.
32. van Wijk SJ, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol 5:295.
33. Kundra R, Kornfeld S (1999) Asparagine-linked oligosaccharides protect Lamp-1 and Lamp-2 from intracellular proteolysis. J Biol Chem 274(43):31039-31046.