Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5797-5805

  Wei, Gengze ^a   Yin, Yue ^b   Li, Wenming ^a   Bito, Haruhiko ^c   She, Hua ^a   Mao, Zixu ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAINS; CORTICAL NEURONS; EXCITOTOXICITY; IN-VITRO; MYOCYTE ENHANCER FACTORS; N METHYL D ASPARTATE RECEPTOR; NEURONAL SURVIVAL; NMDA RECEPTOR; PROTEASE ACTIVITIES; SURVIVAL FACTOR; TRANSACTIVATION ACTIVITY;

ENZYME INHIBITION;

DEGRADATION;

CALPAIN; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL MATURATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME INHIBITION; EXCITOTOXICITY; IN VITRO STUDY; NERVE CELL SURVIVAL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANIMALS; CALPAIN; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; ENZYME ACTIVATION; GLUCOSE; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; PROTEOLYSIS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPSES; TRANSCRIPTION FACTORS;

EID: 84863176806     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.260109     Document Type: Article

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