Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7

Nature Chemical Biology

Volumn 9, Issue 1, 2013, Pages 51-58

  Zhang, Yingnan ^a   Zhou, Lijuan ^a   Rouge, Lionel ^a   Phillips, Aaron H ^a   Lam, Cynthia ^a   Liu, Peter ^a   Sandoval, Wendy ^a   Helgason, Elizabeth ^a   Murray, Jeremy M ^a   Wertz, Ingrid E ^a   Corn, Jacob E ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; UBIQUITIN; UBIQUITIN SPECIFIC PROTEASE 7; UBIQUITIN SPECIFIC PROTEASE 7 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STABILITY; UPREGULATION;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEASE INHIBITORS; PROTEIN CONFORMATION; UBIQUITIN; UBIQUITIN THIOLESTERASE;

EID: 84871298878     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1134     Document Type: Article

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