The angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons

Journal of Neuroscience

Volumn 33, Issue 1, 2013, Pages 327-333

  Miao, Sheng ^a   Chen, Renchao ^a   Ye, Jiahao ^a   Tan, Guo He ^a   Li, Shuai ^a   Zhang, Jing ^a   Jiang, Yong Hui ^b   Xiong, Zhi Qi ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REELIN; SHORT HAIRPIN RNA; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLONING; CONTROLLED STUDY; DENDRITE; ELECTROPORATION; HAPPY PUPPET SYNDROME; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

ANGELMAN SYNDROME; ANIMALS; CELL POLARITY; DENDRITES; GOLGI APPARATUS; MICE; NEUROGENESIS; PYRAMIDAL CELLS; RNA, SMALL INTERFERING; UBIQUITIN-PROTEIN LIGASES;

EID: 84871783676     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2509-12.2013     Document Type: Article

References (24)

1. Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM (2004) Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem 279:41208-41217.CrossRef Medline
2. Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J, Maness PF (2004) Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron 44: 423-437.CrossRef Medline
3. Dindot SV, Antalffy BA, Bhattacharjee MB, Beaudet AL (2008) The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Hum Mol Genet 17:111-118.Medline
4. Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME (2010) The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell 140:704-716.CrossRef Medline
5. Horton AC, Rácz B, Monson EE, Lin AL, Weinberg RJ, Ehlers MD (2005) Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron 48:757-771.CrossRef Medline
6. Jan YN, Jan LY (2010) Branching out: mechanisms of dendritic arborization. Nat Rev Neurosci 11:316-328.CrossRef Medline
7. Jay V, Becker LE, Chan FW, Perry TL Sr (1991) Puppet-like syndrome of Angelman: a pathologic and neurochemical study. Neurology 41:416-422.CrossRef Medline
8. Jeong KW, Kim HZ, Kim S, Kim YS, Choe J (2007) Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulatorassociated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation. Oncogene 26:487-499.CrossRef Medline
9. Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL (1998) Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21:799-811.CrossRef Medline
10. Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J (2005) Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol 19:2451-2465.CrossRef Medline
11. Lu Y, Wang F, Li Y, Ferris J, Lee JA, Gao FB (2009) The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches. Hum Mol Genet 18:454-462.Medline
12. Mabb AM, Judson MC, Zylka MJ, Philpot BD (2011) Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes. Trends Neurosci 34:293-303.CrossRef Medline
13. Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME (2010) EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell 143:442-455.CrossRef Medline
14. Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW (2010) Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell 143:826-836.CrossRef Medline
15. Nakahira E, Yuasa S (2005) Neuronal generation, migration, and differentiation in the mouse hippocampal primoridium as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation. J Comp Neurol 483:329-340.CrossRef Medline
16. Oda H, Kumar S, Howley PM (1999) Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A 96:9557-9562.CrossRef Medline
17. Saito T, Nakatsuji N (2001) Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol 240:237-246.CrossRef Medline
18. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35:907-920.CrossRef Medline
19. Sato M, Stryker MP (2010) Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. Proc Natl Acad Sci U S A 107:5611-5616.CrossRef Medline
20. Tabata H, Nakajima K (2002) Neurons tend to stop migration and differentiate along the cortical internal plexiform zones in the Reelin signaldeficient mice. J Neurosci Res 69:723-730.CrossRef Medline
21. Whitford KL, Dijkhuizen P, Polleux F, Ghosh A (2002) Molecular control of cortical dendrite development. Annu Rev Neurosci 25:127-149.CrossRef Medline
22. Yashiro K, Riday TT, Condon KH, Roberts AC, Bernardo DR, Prakash R, Weinberg RJ, Ehlers MD, Philpot BD (2009) Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci 12: 777-783.CrossRef Medline
23. Zheng L, Ding H, Lu Z, Li Y, Pan Y, Ning T, Ke Y (2008) E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6. Genes Cells 13:285-294.CrossRef Medline
24. Zheng W, Geng AQ, Li PF, Wang Y, Yuan XB (2012) Robo4 regulates the radial migration of newborn neurons in developing neocortex. Cereb Cortex 22:2587-2601.CrossRef Medline