The anaphase-promoting complex: Proteolysis in mitosis and beyond

Molecular Cell

Volumn 9, Issue 5, 2002, Pages 931-943

  Peters, Jan Michael ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN DEPENDENT KINASE 1; CYCLINE; LIGASE; PROTEASOME; REGULATOR PROTEIN; SECURIN; UBIQUITIN; UNCLASSIFIED DRUG;

ANAPHASE; CELL CYCLE; ENZYME INACTIVATION; MITOSIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW;

EID: 0036284778     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00540-3     Document Type: Review

References (115)

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4. Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit
5. Men and sin: What's the difference?
6. A mechanism for coupling exit from mitosis to partitioning of the nucleus
7. Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae
8. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a
9. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation
10. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
11. D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p
12. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
13. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
14. Temporal and spatial control of cyclin B1 destruction in metaphase
15. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
16. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase
17. SCF and Cullin/Ring H2-based ubiquitin ligases
18. Control of G1 in the developing Drosophila eye: Rca1 regulates Cyclin A
19. Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
20. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
21. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement
22. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
23. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
24. Three-dimensional structure of the anaphase-promoting complex
25. Cyclin is degraded by the ubiquitin pathway
26. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
27. Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p
28. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex
29. Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2
30. APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
31. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
32. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts
33. Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence
34. The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner
35. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
36. Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p
37. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis
38. Budding yeast Cdc20: A target of the spindle checkpoint
39. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S phase
40. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
41. Securin is required for chromosomal stability in human cells
42. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
43. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle
44. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
45. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
46. Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase
47. Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast
48. Mitotic regulation of the APC activator proteins CDC20 and CDH1
49. Fission yeast TPR-family protein nuc2 is required for G1-arrest upon nitrogen starvation and is an inhibitor of septum formation
50. The APC11 RING-H2 finger mediates E2-dependent ubiquitination
51. Mitotic forces control a cell-cycle checkpoint
52. Cdk1 is essential for mammalian cyclosome/APC regulation
53. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
54. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
55. Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
56. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
57. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
58. TGFβ signaling in growth control, cancer, and heritable disorders
59. Regulation of the APC and the exit from mitosis
60. Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis
61. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
62. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex
63. Cell cycle control by ubiquitin-dependent proteolysis
64. Subunits and substrates of the anaphase-promoting complex
65. Identification of BIME as a subunit of the anaphase-promoting complex
66. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
67. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
68. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: A novel mechanism for regulating Cdh1
69. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis
70. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex
71. Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins
72. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
73. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
74. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
75. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
76. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
77. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
78. Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20
79. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
80. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3
81. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
82. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
83. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
84. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase
85. Dual inhibition of sister chromatid separation at metaphase
86. Lack of tension at kinetochores activates the spindle checkpoint in budding yeast
87. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
88. How, when, and why cells get rid of cyclin A
89. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
90. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
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92. The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase
93. Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1
94. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex
95. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition
96. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
97. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
98. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
99. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
100. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
101. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities
102. The anaphase-promoting complex mediates TGFβ signaling by targeting SnoN for destruction
103. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
104. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
105. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex
106. Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation
107. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
108. Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome
109. Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20
110. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation
111. Identification of a cullin homology region in a subunit of the anaphase-promoting complex
112. Whose end is destruction: Cell division and the anaphase-promoting complex
113. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
114. Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins
115. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex