Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons

Journal of Neuroscience

Volumn 32, Issue 13, 2012, Pages 4610-4622

  Gomes, João R ^a   Costa, João T ^a   Melo, Carlos V ^a   Felizzi, Federico ^b   Monteiro, Patrícia ^c   Pinto, Maria J ^a   Inácio, Ana R ^d   Wieloch, Tadeusz ^d   Almeida, Ramiro D ^a   Grãos, Mário ^c   Duarte, Carlos B ^a,c,e  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b ETH ZURICH   (Switzerland)

^c Biocant ^*  (Portugal)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE B; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; CONTROLLED STUDY; EMBRYO; EXCITOTOXICITY; GENE EXPRESSION; HIPPOCAMPUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRIATE CORTEX; WESTERN BLOTTING;

ANIMALS; ANISOMYCIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALPAIN; CELL DEATH; CORPUS STRIATUM; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HIPPOCAMPUS; ISOENZYMES; KAINIC ACID; NEURONS; NEUROPROTECTIVE AGENTS; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; RECEPTOR, TRKB; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84859013000     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0374-12.2012     Document Type: Article

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