Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP

Journal of Neuroscience

Volumn 29, Issue 29, 2009, Pages 9330-9343

  Xu, Jian ^a   Kurup, Pradeep ^a   Zhang, Yongfang ^a   Goebel Goody, Susan M ^a   Wu, Peter H ^b   Hawasli, Ammar H ^c   Baum, Matthew L ^a   Bibb, James A ^c   Lombroso, Paul J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CYCLIN DEPENDENT KINASE 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; STRIATAL ENRICHED PROTEIN TYROSINE PHOSPHATASE; SYNTHETIC PEPTIDE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; EXCITOTOXICITY; MALE; NERVE CELL NECROSIS; NERVE ENDING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; UBIQUITINATION;

ALTERNATIVE SPLICING; ANIMALS; BRAIN; CALPAIN; CELL DEATH; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; ENDOCYTOSIS; GLUTAMIC ACID; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 67651172947     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2212-09.2009     Document Type: Article

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