메뉴 건너뛰기




Volumn 32, Issue 12, 2012, Pages 3992-4003

Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IFENPRODIL; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 84863337898     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4129-11.2012     Document Type: Article
Times cited : (114)

References (74)
  • 3
    • 0021956110 scopus 로고
    • Postnatal development of axosomatic synapses in the rat visual cortex: Morphogenesis and quantitative evaluation
    • Bähr S, Wolff JR (1985) Postnatal development of axosomatic synapses in the rat visual cortex: morphogenesis and quantitative evaluation. J Comp Neurol 233:405-420.
    • (1985) J Comp Neurol , vol.233 , pp. 405-420
    • Bähr, S.1    Wolff, J.R.2
  • 4
    • 0037130451 scopus 로고    scopus 로고
    • Subunit-specific NMDA receptor trafficking to synapses
    • Barria A, Malinow R (2002) Subunit-specific NMDA receptor trafficking to synapses. Neuron 35:345-353.
    • (2002) Neuron , vol.35 , pp. 345-353
    • Barria, A.1    Malinow, R.2
  • 5
    • 78649417803 scopus 로고    scopus 로고
    • Activation of extra-synaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production
    • Bordji K, Becerril-Ortega J, Nicole O, Buisson A (2010) Activation of extra-synaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J Neu-rosci 30:15927-15942.
    • (2010) J Neu-rosci , vol.30 , pp. 15927-15942
    • Bordji, K.1    Becerril-Ortega, J.2    Nicole, O.3    Buisson, A.4
  • 6
    • 33745034018 scopus 로고    scopus 로고
    • The chemical biology of clinically tolerated NMDA receptor antagonists
    • Chen HS, Lipton SA (2006) The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem 97:1611-1626.
    • (2006) J Neurochem , vol.97 , pp. 1611-1626
    • Chen, H.S.1    Lipton, S.A.2
  • 7
    • 0032543788 scopus 로고    scopus 로고
    • Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
    • Chen HS, Wang YF, Rayudu PV, Edgecomb P, Neill JC, Segal MM, Lipton SA, Jensen FE (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86:1121-1132.
    • (1998) Neuroscience , vol.86 , pp. 1121-1132
    • Chen, H.S.1    Wang, Y.F.2    Rayudu, P.V.3    Edgecomb, P.4    Neill, J.C.5    Segal, M.M.6    Lipton, S.A.7    Jensen, F.E.8
  • 8
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379.
    • (1987) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 10
    • 33749648798 scopus 로고    scopus 로고
    • Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    • Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA (2006) Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron 52:307-320.
    • (2006) Neuron , vol.52 , pp. 307-320
    • Elias, G.M.1    Funke, L.2    Stein, V.3    Grant, S.G.4    Bredt, D.S.5    Nicoll, R.A.6
  • 11
    • 77958561819 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95
    • Fan J, Vasuta OC, Zhang LY, Wang L, George A, Raymond LA (2010) N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. J Neurochem 115:1045-1056.
    • (2010) J Neurochem , vol.115 , pp. 1045-1056
    • Fan, J.1    Vasuta, O.C.2    Zhang, L.Y.3    Wang, L.4    George, A.5    Raymond, L.A.6
  • 12
    • 37249083913 scopus 로고    scopus 로고
    • Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease
    • Fernandes HB, Baimbridge KG, Church J, Hayden MR, Raymond LA (2007) Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease. J Neurosci 27:13614-13623.
    • (2007) J Neurosci , vol.27 , pp. 13614-13623
    • Fernandes, H.B.1    Baimbridge, K.G.2    Church, J.3    Hayden, M.R.4    Raymond, L.A.5
  • 13
    • 79961168563 scopus 로고    scopus 로고
    • Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function
    • Gladding CM, and Raymond LA (2011) Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function. Mol Cell Neu-rosci 48:308-320.
    • (2011) Mol Cell Neu-rosci , vol.48 , pp. 308-320
    • Gladding, C.M.1    Raymond, L.A.2
  • 14
    • 62749180788 scopus 로고    scopus 로고
    • Reverse glial glutamate uptake triggers neuronal cell death through extra-synaptic NMDA receptor activation
    • Gouix E, Léveillé F, Nicole O, Melon C, Had-Aissouni L, Buisson A (2009) Reverse glial glutamate uptake triggers neuronal cell death through extra-synaptic NMDA receptor activation. Mol Cell Neurosci 40:463-473.
    • (2009) Mol Cell Neurosci , vol.40 , pp. 463-473
    • Gouix, E.1    Léveillé, F.2    Nicole, O.3    Melon, C.4    Had-Aissouni, L.5    Buisson, A.6
  • 15
    • 52049127039 scopus 로고    scopus 로고
    • From synapse to nucleus: Calcium-dependent gene transcription in the control of synapse development and function
    • Greer PL, Greenberg ME (2008) From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron 59:846-860.
    • (2008) Neuron , vol.59 , pp. 846-860
    • Greer, P.L.1    Greenberg, M.E.2
  • 17
    • 77949841510 scopus 로고    scopus 로고
    • Do astrocytes really exocytose neurotrans-mitters?
    • Hamilton NB, Attwell D (2010) Do astrocytes really exocytose neurotrans-mitters? Nat Rev Neurosci 11:227-238.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 227-238
    • Hamilton, N.B.1    Attwell, D.2
  • 18
    • 0037301661 scopus 로고    scopus 로고
    • The yin and yang of NMDA receptor signalling
    • Hardingham GE, Bading H (2003) The yin and yang of NMDA receptor signalling. Trends Neurosci 26:81-89.
    • (2003) Trends Neurosci , vol.26 , pp. 81-89
    • Hardingham, G.E.1    Bading, H.2
  • 19
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • Hardingham GE, Bading H (2010) Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11:682-696.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 20
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414.
    • (2002) Nat Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 21
    • 35348900781 scopus 로고    scopus 로고
    • Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
    • Harris AZ, Pettit DL (2007) Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. J Physiol 584:509-519.
    • (2007) J Physiol , vol.584 , pp. 509-519
    • Harris, A.Z.1    Pettit, D.L.2
  • 22
    • 17444426068 scopus 로고    scopus 로고
    • Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
    • Hatton CJ, Paoletti P (2005) Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 46:261-274.
    • (2005) Neuron , vol.46 , pp. 261-274
    • Hatton, C.J.1    Paoletti, P.2
  • 24
    • 33645837486 scopus 로고    scopus 로고
    • Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons
    • Ivanov A, Pellegrino C, Rama S, Dumalska I, Salyha Y, Ben-Ari Y, Medina I (2006) Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J Physiol 572:789-798.
    • (2006) J Physiol , vol.572 , pp. 789-798
    • Ivanov, A.1    Pellegrino, C.2    Rama, S.3    Dumalska, I.4    Salyha, Y.5    Ben-Ari, Y.6    Medina, I.7
  • 25
    • 34548864370 scopus 로고    scopus 로고
    • Culturing hippocampal neurons
    • Kaech S, Banker G (2006) Culturing hippocampal neurons. Nat Protoc 1:2406-2415.
    • (2006) Nat Protoc , vol.1 , pp. 2406-2415
    • Kaech, S.1    Banker, G.2
  • 26
    • 0032521090 scopus 로고    scopus 로고
    • Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons
    • Kew JN, Richards JG, Mutel V, Kemp JA (1998) Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons. J Neurosci 18:1935-1943.
    • (1998) J Neurosci , vol.18 , pp. 1935-1943
    • Kew, J.N.1    Richards, J.G.2    Mutel, V.3    Kemp, J.A.4
  • 27
    • 19544367458 scopus 로고    scopus 로고
    • Differential rolesofNR2A-and NR2B-containing NMDA receptors inRas-ERK signaling and AMPA receptor trafficking
    • Kim MJ, Dunah AW, Wang YT, Sheng M (2005) Differential rolesofNR2A-and NR2B-containing NMDA receptors inRas-ERK signaling and AMPA receptor trafficking. Neuron 46:745-760.
    • (2005) Neuron , vol.46 , pp. 745-760
    • Kim, M.J.1    Dunah, A.W.2    Wang, Y.T.3    Sheng, M.4
  • 28
    • 33748921093 scopus 로고    scopus 로고
    • NMDA receptor function: Subunit composition versus spatial distribution
    • Köhr G (2006) NMDA receptor function: subunit composition versus spatial distribution. Cell Tissue Res 326:439-446.
    • (2006) Cell Tissue Res , vol.326 , pp. 439-446
    • Köhr, G.1
  • 29
    • 33846908287 scopus 로고    scopus 로고
    • Endocannabinoid-mediated rescueofstri-atal LTD and motor deficits in Parkinson's disease models
    • Kreitzer AC, Malenka RC (2007) Endocannabinoid-mediated rescueofstri-atal LTD and motor deficits in Parkinson's disease models. Nature 445:643-647.
    • (2007) Nature , vol.445 , pp. 643-647
    • Kreitzer, A.C.1    Malenka, R.C.2
  • 30
    • 34249099711 scopus 로고    scopus 로고
    • NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
    • Lau CG, Zukin RS (2007) NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci 8:413-426.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 413-426
    • Lau, C.G.1    Zukin, R.S.2
  • 31
    • 33750378660 scopus 로고    scopus 로고
    • Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease
    • Lee ST, Chu K, Park JE, Kang L, Ko SY, Jung KH, Kim M (2006) Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease. Brain Res 1118:199-207.
    • (2006) Brain Res , vol.1118 , pp. 199-207
    • Lee, S.T.1    Chu, K.2    Park, J.E.3    Kang, L.4    Ko, S.Y.5    Jung, K.H.6    Kim, M.7
  • 32
    • 57349135887 scopus 로고    scopus 로고
    • Neuronal viability is controlled by a functional relation between syn-aptic and extrasynaptic NMDA receptors
    • Léveillé F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, Buisson A (2008) Neuronal viability is controlled by a functional relation between syn-aptic and extrasynaptic NMDA receptors. FASEB J 22:4258-4271.
    • (2008) FASEB J , vol.22 , pp. 4258-4271
    • Léveillé, F.1    El-Gaamouch, F.2    Gouix, E.3    Lecocq, M.4    Lobner, D.5    Nicole, O.6    Buisson, A.7
  • 34
    • 0036728049 scopus 로고    scopus 로고
    • Differential regulation of synaptic and extra-synaptic NMDA receptors
    • Li B, Chen N, Luo T, Otsu Y, Murphy TH, Raymond LA (2002) Differential regulation of synaptic and extra-synaptic NMDA receptors. Nat Neurosci 5:833-834.
    • (2002) Nat Neurosci , vol.5 , pp. 833-834
    • Li, B.1    Chen, N.2    Luo, T.3    Otsu, Y.4    Murphy, T.H.5    Raymond, L.A.6
  • 36
    • 32544453670 scopus 로고    scopus 로고
    • Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression
    • Li S, Tian X, Hartley DM, Feig LA (2006) Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression. J Neurosci 26:1721-1729.
    • (2006) J Neurosci , vol.26 , pp. 1721-1729
    • Li, S.1    Tian, X.2    Hartley, D.M.3    Feig, L.A.4
  • 37
    • 79955769953 scopus 로고    scopus 로고
    • Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
    • Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ (2011) Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 31:6627-6638.
    • (2011) J Neurosci , vol.31 , pp. 6627-6638
    • Li, S.1    Jin, M.2    Koeglsperger, T.3    Shepardson, N.E.4    Shankar, G.M.5    Selkoe, D.J.6
  • 40
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 41
    • 4344700666 scopus 로고    scopus 로고
    • Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus
    • Lozovaya NA, Grebenyuk SE, Tsintsadze TSh, Feng B, Monaghan DT, Krishtal OA (2004) Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol 558:451-463.
    • (2004) J Physiol , vol.558 , pp. 451-463
    • Lozovaya, N.A.1    Grebenyuk, S.E.2    Tsintsadze, T.3    Feng, B.4    Monaghan, D.T.5    Krishtal, O.A.6
  • 42
    • 58149476292 scopus 로고    scopus 로고
    • In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    • Martel MA, Wyllie DJ, Hardingham GE (2009) In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 158:334-343.
    • (2009) Neuroscience , vol.158 , pp. 334-343
    • Martel, M.A.1    Wyllie, D.J.2    Hardingham, G.E.3
  • 45
    • 77958192164 scopus 로고    scopus 로고
    • Early synaptic pathophysiology in neurodegeneration: Insights from Huntington's disease
    • Milnerwood AJ, Raymond LA (2010) Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease. Trends Neurosci 33:513-523.
    • (2010) Trends Neurosci , vol.33 , pp. 513-523
    • Milnerwood, A.J.1    Raymond, L.A.2
  • 48
    • 0030052030 scopus 로고    scopus 로고
    • Learning deficits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine
    • Misztal M, Frankiewicz T, Parsons CG, Danysz W (1996) Learning deficits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine. Eur J Pharmacol 296:1-8.
    • (1996) Eur J Pharmacol , vol.296 , pp. 1-8
    • Misztal, M.1    Frankiewicz, T.2    Parsons, C.G.3    Danysz, W.4
  • 49
    • 33845872541 scopus 로고    scopus 로고
    • Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
    • Morishita W, Lu W, Smith GB, Nicoll RA, Bear MF, Malenka RC (2007) Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology 52:71-76.
    • (2007) Neuropharmacology , vol.52 , pp. 71-76
    • Morishita, W.1    Lu, W.2    Smith, G.B.3    Nicoll, R.A.4    Bear, M.F.5    Malenka, R.C.6
  • 50
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199.
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 52
  • 56
    • 79959648329 scopus 로고    scopus 로고
    • Synaptically driven state transitions in distal dendrites of striatal spiny neurons
    • Plotkin JL, Day M, Surmeier DJ (2011) Synaptically driven state transitions in distal dendrites of striatal spiny neurons. Nat Neurosci 14:881-888.
    • (2011) Nat Neurosci , vol.14 , pp. 881-888
    • Plotkin, J.L.1    Day, M.2    Surmeier, D.J.3
  • 57
    • 0038345688 scopus 로고    scopus 로고
    • Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity
    • Segal M, Greenberger V, Korkotian E (2003) Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity. Eur J Neurosci 17:2573-2585.
    • (2003) Eur J Neurosci , vol.17 , pp. 2573-2585
    • Segal, M.1    Greenberger, V.2    Korkotian, E.3
  • 58
    • 30744437894 scopus 로고    scopus 로고
    • Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
    • Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA (2006) Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiol Dis 21:392-403.
    • (2006) Neurobiol Dis , vol.21 , pp. 392-403
    • Shehadeh, J.1    Fernandes, H.B.2    Zeron Mullins, M.M.3    Graham, R.K.4    Leavitt, B.R.5    Hayden, M.R.6    Raymond, L.A.7
  • 59
    • 0025371482 scopus 로고
    • The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
    • Smith AD, Bolam JP (1990) The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends Neurosci 13:259-265.
    • (1990) Trends Neurosci , vol.13 , pp. 259-265
    • Smith, A.D.1    Bolam, J.P.2
  • 61
    • 77953766302 scopus 로고    scopus 로고
    • Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum core-lease glutamate
    • Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A (2010) Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum core-lease glutamate. J Neurosci 30:8229-8233.
    • (2010) J Neurosci , vol.30 , pp. 8229-8233
    • Stuber, G.D.1    Hnasko, T.S.2    Britt, J.P.3    Edwards, R.H.4    Bonci, A.5
  • 63
    • 33645822456 scopus 로고    scopus 로고
    • Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons
    • Thomas CG, Miller AJ, Westbrook GL (2006) Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. J Neu-rophysiol 95:1727-1734.
    • (2006) J Neu-rophysiol , vol.95 , pp. 1727-1734
    • Thomas, C.G.1    Miller, A.J.2    Westbrook, G.L.3
  • 64
    • 0033562610 scopus 로고    scopus 로고
    • The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
    • Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19:4180-4188.
    • (1999) J Neurosci , vol.19 , pp. 4180-4188
    • Tovar, K.R.1    Westbrook, G.L.2
  • 66
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski M, Charlton MP, Carlen PL, Tator CH (1993) Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 13:2085-2104.
    • (1993) J Neurosci , vol.13 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 67
    • 36348975209 scopus 로고    scopus 로고
    • Glutamate transporters: Confining runaway excitation by shaping synaptic transmission
    • Tzingounis AV, Wadiche JI (2007) Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci 8:935-947.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 935-947
    • Tzingounis, A.V.1    Wadiche, J.I.2
  • 69
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant hetero-meric receptors
    • Williams K (1993) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant hetero-meric receptors. Mol Pharmacol 44:851-859.
    • (1993) Mol Pharmacol , vol.44 , pp. 851-859
    • Williams, K.1
  • 70
    • 0029886175 scopus 로고    scopus 로고
    • The originsoftwo-state spontaneous membrane potential fluctuations of neostriatal spiny neurons
    • Wilson CJ, Kawaguchi Y (1996) The originsoftwo-state spontaneous membrane potential fluctuations of neostriatal spiny neurons. J Neurosci 16:2397-2410.
    • (1996) J Neurosci , vol.16 , pp. 2397-2410
    • Wilson, C.J.1    Kawaguchi, Y.2
  • 71
    • 72449176346 scopus 로고    scopus 로고
    • Synaptic activity induces dramatic changes in the geometry of the cell nucleus: Interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling
    • Wittmann M, Queisser G, Eder A, Wiegert JS, Bengtson CP, Hellwig A, Wit-tum G, Bading H (2009) Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29:14687-14700.
    • (2009) J Neurosci , vol.29 , pp. 14687-14700
    • Wittmann, M.1    Queisser, G.2    Eder, A.3    Wiegert, J.S.4    Bengtson, C.P.5    Hellwig, A.6    Wit-Tum, G.7    Bading, H.8
  • 72
    • 27144432080 scopus 로고    scopus 로고
    • NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron
    • Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neuro-sci 25:9080-9095.
    • (2005) J Neuro-sci , vol.25 , pp. 9080-9095
    • Wolf, J.A.1    Moyer, J.T.2    Lazarewicz, M.T.3    Contreras, D.4    Benoit-Marand, M.5    O'Donnell, P.6    Finkel, L.H.7
  • 73
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hip-pocampal autapses
    • Xia P, Chen HS, Zhang D, Lipton SA (2010) Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hip-pocampal autapses. J Neurosci 30:11246-11250.
    • (2010) J Neurosci , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.S.2    Zhang, D.3    Lipton, S.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.