Dynamics of proteasome distribution in living cells

EMBO Journal

Volumn 16, Issue 20, 1997, Pages 6087-6094

  Reits, Eric A J ^a   Benham, Adam M ^a   Plougastel, Beatrice ^b   Neefjes, Jacques ^a   Trowsdale, John ^b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Antigen presentation; GFP; Nuclear import; Photobleaching; Proteasome

Indexed keywords

CELL PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PROTEASOME;

ARTICLE; BLEACHING; CELL DIVISION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; CYTOPLASM; DIFFUSION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTIGEN PRESENTATION; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELL DIVISION; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MOVEMENT; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

EID: 0030703686     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.20.6087     Document Type: Article

References (33)

1. Belich,M.P. (1996) Ph.D. thesis. University of London.
2. Belich,M.P., Glynne,R.J., Senger,G., Sheer,D. und Trowsdale,J. (1994) Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr. Biol., 4, 769-776.
3. Boes,B., Hengel,H., Ruppert,T., Multhaup,G., Koszinowski,U.H. and Kloetzel,P.M. (1994) Interferon Y stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasome. J. Exp. Med., 179, 901-909.
4. Cerundolo,V., Benham,A., Braud,V., Mukherjee,S., Gould,K., Macino,B., Neefjes,J. and Townsend,A. (1997) The proteasume-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells. Eur. J. Immunol., 27, 336 -341.
5. Cole,N.B., Smith.C.L., Sciaky,N., Terasaki,M., Edidin,M. and Lippincott-Schwartz,J. (1996) Diffusional mobility of Golgi proteins in membranes of living cells. Science. 273, 797-801.
6. Driscoll.J., Brown,M.G., Finley,D. and Monaco,J.J. (1993) MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature. 365, 262-264.
7. Edidin,M., Zagyansky,Y. and Lardner,T.J. (1976) Measurement of membrane protein lateral diffusion in single cells. Science. 191, 466-468.
8. Endert,P.M. van. Riganelli,D., Greco,G., Fleischhauer,K., Sidney,J., Sette,A. and Bach,J.F. (1995) The peptide-binding motif for the human transporter associated with antigen processing. J. Exp. Med., 182, 1883-1895.
9. Fahre,E. and Hurt,E.C. (1994) Nuclear transport. Curr. Opin. Cell Biol., 6, 335-342.
10. Feldherr,C.M., Kallenbach,E. and Schulz.N. (1984) Movement of a karyophilic protein through the nuclear pores of oocytes. J. Cell Biol., 99, 2216-2222.
11. Gaczynska,M., Rock,K.L. and Goldberg,A.L. (1993) γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 365, 264-267.
12. Gerace,L. (1992) Molecular trafficking across the nuclear pore complex. Curr. Opin. Cell Biol., 4, 637-645.
13. Goldberg,A.L. (1995) Functions of the proteasome: the lysis at the end of the tunnel. Science. 268, 522-523.
14. Groettrup.M.. Soza,A., Eggers,M., Kuchn,L., Dick,T.P., Schild,H., Rammensee,H.G., Koszinowski,U.H. and Kloetzel,P.M. (1996) A role for the proteasome regulator PA28α in antigen presentation. Nature. 381, 166-168.
15. Groll.M., Ditzel,L., Löwe,J., Stock,D., Bochtler,M., Bartunik,H.D. and Huber,R. (1997) Structure of 20S proteasome from yeast at 2.4A resolution. Nature, 386, 463-471.
16. Hendil,K.B., Kristensen,P. and Uerkvitz,W. (1995) Human proteasomes analysed with monoclonal antibodies. Biochem. J., 305, 245-252.
17. Hochstrasser,M. (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol., 7, 215-223.
18. Jentsch,S. and Schlenker,S. (1995) Selective protein degradation: a journey's within the proteasome. Cell. 82, 881-884.
19. Kelly,A.K., Powis,S.H., Glynne,R., Radley,E., Beck,S. and Trowsdale,J. (1991) Second proteasome-related gene in the human MHC class II region. Nature. 353, 667-668.
20. Kuckelkorn,U., Frentzel,S., Kraft,R., Kosta,S., Groettrup,M. and Kloetzel,P.M. (1995) Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-γ. Eur. J. Immunol., 25, 2605-2611.
21. Löwe,L., Stock,D., Jap,B., Zwickl,P., Baurneister,W. and Huber,R. (1995) Crystal structure of the 20S proteasome from the archaeon T.acidophilum at 3.4 A resolution. Science. 268, 533-539.
22. Nandi,D., Jiang,H. and Monaco,J.J. (1996) Identification of MECL-1 (LMP-10) as the third IFNγ inducible proteasome subunit. J. Immunol. 156, 2361-2364.
23. Nederlof,P.M., Wang,H. and Baumeister,W. (1995) Nuclear localization signals of human and Thermoplasma proteasomal α subunits are functional in vitro. Proc. Natl Acad. Sci. USA. 92, 12060-12064.
24. Palmer,A., Mason,G.G.F., Paramio,J.M., Kneeht,E. and Rivett,A.J. (1994) Changes in proteasome localization during the cell cycle. Eur. J. Cell Biol., 64, 163-175.
25. Palmer,A., Rivett,A.J., Thomson,S., Hendil,K.B., Butchers,G.W., Fuertes,G. and Knecht,E. (1996) Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol. Biochem. J., 316, 401-407.
26. Rivett,A.J., Palmer,A. and Knecht,F. (1992) Electron microscopic localization of the multicatalytic proteinase complex in rat liver and in cultured cells. J. Histochem. Cytochem., 40, 1165-1172.
27. Rock,K.L., Giramm,C., Rothstein,L., Clark,K., Stein,R., Dick,L., Hwang,D. and Goldberg,A.L. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 78, 761-771.
28. Schmidtke,G., Kraft,R., Kostka,S., Henklein,P., Frommel,C., Lowe,J., Huber,R., Kloetzel,P.M. and Schmidt,M. (1996) Analysis of mammalian 20S proteasome biogenesis: the maturation of β-subunits is an ordered two-step mechanism involving autocatalysis. EMBO J., 15, 6887-6898.
29. Srivastava,P.K., Udono,H. and Blachere,N.E. (1994) Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. 39, 93-98.
30. Tanaka,K. and Ichihara,A. (1989) Half life of proteasomes (multi protease complex) in rat liver. Biochem. Biophys. Res. Commun., 159, 1309-1315.
31. Tanaka,K., Yoshimura,T., Tamura,T., Fujiwara,T., Kumatori,A. and Ichichara,A. (1990) Possible mechanism of nuclear translocation of proteasomes. FEBS Lett., 271, 41-46.
32. Wubbolts,R., Fernandez-Borja,M., Oomen,L., Verwoerd,D., Janssen,H., Calafat,J., Tulp,A., Dusseljee,S. and Neefjes,J. (1996) Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. J. Cell Biol., 135, 611-622.
33. Yang,Y., Früh,K., Ahn,K. and Peterson,P.A. (1995) In vivo assembly of the proteasomal complexes, implications for antigen processing. J. Biol. Chem. 270, 27687-27694.