Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: Evidence from calpastatin mutant mice

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 16175-16184

  Takano, Jiro ^a,b   Tomioka, Masanori ^a   Tsubuki, Satoshi ^a   Higuchi, Makoto ^a   Iwata, Nobuhisa ^a   Itohara, Shigeyoshi ^a   Maki, Masatoshi ^a,b   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BRAIN; CELLS; DISEASES; MUTAGENESIS; PATHOLOGY; SYNTHESIS (CHEMICAL);

CALPAIN MEDIATES; MICE; MITOCHONDRIA; PROTEOLYTIC ACTIVATION;

DNA;

CALPAIN; CALPASTATIN; CASPASE 3; DNA FRAGMENT; ENDONUCLEASE; KAINIC ACID; PROTEIN BCL 2; PROTEIN BID;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; HIPPOCAMPUS; MITOCHONDRION; MOUSE; NONHUMAN; PATHOLOGY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PYRAMIDAL NERVE CELL; SYNTHESIS;

ANIMALS; BRAIN; CALCIUM-BINDING PROTEINS; CALPAIN; CATTLE; DNA FRAGMENTATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA;

EID: 18144407551     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414552200     Document Type: Article

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